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DDAH2 (-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study.

Ying Fan, Qiang Gao, Jia-Xin Guan, Lei Liu, Ming Hong, Li Jun, Li Wang, Hai-Feng Ding, Li-Hong Jiang, Bo-Yu Hou, Mei Li, Zhi-Qiang Song, De-Qin Sun, Chao-Qi Yan, Lan Ma,

Cerebrovascular endothelial dysfunction is involved in the progression of leukoaraiosis. Asymmetric dimethylarginine is a competitive inhibitor of nitric oxide, which is highly expressed in patients with leukoaraiosis. Dimethylarginine dimethylaminohydrolase (DDAH) is a hydrolytic enzyme that is primarily responsible for eliminating asymmetric dimethylarginine, and it plays a role in the pathogenesis ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(8):1592-1597]

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