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Author Jia Li

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Point-of-care testing system for digital single cell detection of MRSA directly from nasal swabs.

Martin Schulz, Silvia Calabrese, Florian Hausladen, Holger Wurm, Dominik Drossart, Karl Stock, Anna M Sobieraj, Fritz Eichenseher, Martin J Loessner, Mathias Schmelcher, Anja Gerhardts, Ulrike Goetz, Marina Handel, Annerose Serr, Georg Haecker, Jia Li, Mara Specht, Philip Koch, Martin Meyer, Philipp Tepper, Raimund Rother, Michael Jehle, Simon Wadle, Roland Zengerle, Felix von Stetten, Nils Paust, Nadine Borst,

We present an automated point-of-care testing (POCT) system for rapid detection of species- and resistance markers in methicillin-resistant Staphylococcus aureus (MRSA) at the level of single cells, directly from nasal swab samples. Our novel system allows clear differentiation between MRSA, methicillin-sensitive S. aureus (MSSA) and methicillin-resistant coagulase-negative staphylococci (MR-CoNS), which ... Read more >>

Lab Chip (Lab on a chip)
[2020, 20(14):2549-2561]

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N-Promoted Ru1/TiO2 single-atom catalysts for photocatalytic water splitting for hydrogen production: a density functional theory study.

Zhibo Luo, Zhijie Wang, Jia Li, Kang Yang, Gang Zhou,

We propose a universal dimer-doping strategy to improve the photocatalytic water splitting activity of Ru1/TiO2 single-atom catalysts, in which the N atom is simultaneously doped. First-principles calculations show that the N dopants promote the substitution of Ti with Ru on the anatase TiO2(101) surface by chemical bonding between Ru and ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(20):11392-11399]

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Current commercialization status of electrowetting-on-dielectric (EWOD) digital microfluidics.

Jia Li, Chang-Jin Cj Kim,

The emergence of electrowetting-on-dielectric (EWOD) in the early 2000s made the once-obscure electrowetting phenomenon practical and led to numerous activities over the last two decades. As an eloquent microscale liquid handling technology that gave birth to digital microfluidics, EWOD has served as the basis for many commercial products over two ... Read more >>

Lab Chip (Lab on a chip)
[2020, 20(10):1705-1712]

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Ternary heterogeneous Pt-Ni-Au nanowires with enhanced activity and stability for PEMFCs.

Zhicheng Lin, Yuan Sheng, Jia Li, Zhiyan Rui, Yide Liu, Jianguo Liu, Zhigang Zou,

Heterogeneous ternary Pt-Ni-Au nanowires (NWs) with randomly distributed Pt-Ni and Pt-Au micro phases were successfully synthesized following an oriented attachment mechanism. The as-prepared NWs exhibit enhanced activity and durability in both a rotating disk electrode (RDE) and single-cell, originating from the one dimensional (1D) heterogeneous structure. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(31):4276-4279]

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Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation.

Lin Han, Jie Li, Jia Li, Chuaying Pan, Yao Xiao, Xianyong Lan, Min Wang,

As a dihydrochalcone, phloretin was reported to effectively attenuate palmitic acid (PA)-induced oxidative stress in endothelial cells. In the present study, we further investigated the antioxidant capacity of phloretin via restoring the activity of MnSOD through deacetylation in vitro and in vivo. The results revealed that phloretin (50 μM) treatment ... Read more >>

Food Funct (Food & function)
[2020, 11(4):3073-3083]

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Alternative processing technology for the preparation of carbonized Zingiberis Rhizoma by stir-frying with sand.

Shen Mei-Yu, Wang Jia-Li, Shi Hai-Pei, Yan Hui, Chen Pei-Dong, Yao Wei-Feng, Bao Bei-Hua, Zhang Li,

Context: Carbonized ginger, a type of charry herb, has been used as a hemostatic medicine since ancient times. However, there are some serious problems such as inhomogeneous heating and emitting smoke during processing with traditional stir-frying method.Objective: To investigate the feasibility to obtain carbonized ginger by stir-frying with sand instead ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):131-137]

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A fluorogenic probe for tracking GSH flux in developing neurons.

Haichao Zong, Jiayi Peng, Xiao-Rong Li, Meng Liu, Yongzhou Hu, Jia Li, Yi Zang, Xin Li, Tony D James,

Understanding GSH flux in developing neurons is prerequisite to reveal its role in neuronal development but necessiates an ultrasensitive assay. By systematically exploring key structural factors determing probe sensitivity in live cells, we developed a fluorogenic probe capable of imaging subtle GSH fluctuations in developing neurons. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(4):515-518]

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Impulsive releases of sterile mosquitoes and interactive dynamics with time delay.

Jia Li, Shangbing Ai,

To investigate the impact of periodic and impulsive releases of sterile mosquitoes on the interactive dynamics between wild and sterile mosquitoes, we adapt the new idea where only those sexually active sterile mosquitoes are included in the modelling process and formulate new models with time delay. We consider different release ... Read more >>

J Biol Dyn (Journal of biological dynamics)
[2020, 14(1):313-331]

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Fluctuation-dissipation analysis of nonequilibrium thermal transport at the hydrate dissociation interface.

Jia Li, Zhao-Liang Wang,

Herein, a nonequilibrium molecular-dynamics simulation in an NVE ensemble was performed to investigate the spontaneous dissociation of methane-hydrate when it came in contact with liquid water. The nonequilibrium in the interface region is linked to the dissociation process of the hydrate near the interface according to the Onsager's hypothesis. The ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(42):23492-23500]

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A biotinylated ruthenium(ii) photosensitizer for tumor-targeted two-photon photodynamic therapy.

Jia Li, Leli Zeng, Kai Xiong, Thomas W Rees, Chengzhi Jin, Weijun Wu, Yu Chen, Liangnian Ji, Hui Chao,

Platinum-resistant cancer cells are sensitive to changes in the levels of reactive oxidative species (ROS). Herein, we design a biotin-modified Ru(ii) complex as a photosensitizer (denoted as Ru-Biotin). Ru-Biotin can selectively target cancer cells and produce vast amounts of singlet oxygen under two-photon excitation at 820 nm leading to cell ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(73):10972-10975]

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SAUR15 promotes lateral and adventitious root development via activating H+-ATPases and auxin biosynthesis1.

Hongju Yin, Mengzhan Li, Minghui Lv, Shelley R Hepworth, Dingding Li, Chaofan Ma, Jia Li, Suo-Min Wang,

SMALL AUXIN-UP RNAs (SAURs) comprise the largest family of early auxin response genes. Some SAURs have been reported to play important roles in plant growth and development, but their functional relationships with auxin signaling remain unestablished. Here, we report Arabidopsis (Arabidopsis thaliana) SAUR15 acts downstream of the auxin response factors ... Read more >>

Plant Physiol. (Plant physiology)
[2020, :]

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MKL-1 is a coactivator for STAT5b, the regulator of Treg cell development and function.

Yuan Xiang, Jun Wang, Jia Peng Li, Wei Guo, Feng Huang, Hui Min Zhang, Han Han Li, Zhou Tong Dai, Zi Jian Zhang, Hui Li, Le Yuan Bao, Chao Jiang Gu, Kun Chen, Tong Cun Zhang, Xing Hua Liao,

BACKGROUND:Foxp3+CD4+ regulatory T cells (Treg) constitutes a key event in autoimmune diseases. STAT5b is the critical link between the IL-2/15 and FOXP3, the master regulator of Treg cells. METHODS:The CD3+T cell and Foxp3+CD4+ regulatory T cells were overexpressioned or knockdown MKL-1 and STAT5a and tested for Treg cell development and ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):107]

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First case of Shewanella indica isolated from a Bryde's whale (Balaenoptera edeni) stranded in the northern Beibu Gulf, China.

Jia Li, Richard W McLaughlin, Mo Chen, Ying Li Liu, Hia Xia Xie, Xiao Ling Wan, Jun Ying Zhou, Jin Song Zheng,

The purpose of this study was to culture and characterise bacteria from an intact abscess on the skin of a dead Bryde's whale (Balaenoptera edeni) which stranded in the northern Beibu Gulf, China. To grow bacteria, samples from the abscess were added to blood agar. After incubation, yellowish mucous colonies ... Read more >>

Antonie Van Leeuwenhoek (Antonie van Leeuwenhoek)
[2020, :]

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MicroRNA-148a-3p alleviates high glucose-induced diabetic retinopathy by targeting TGFB2 and FGF2.

Jihong Wang, Yong Yao, Kelei Wang, Jia Li, Ting Chu, Haicui Shen,

AIMS:Diabetic retinopathy (DR), a common complication of type 1 or type 2 diabetes mellitus, has become the leading cause of blindness among adults in working age. The dysregulation of microRNA has been reported to be strongly related to the initiation or progression of DR. However, neither the biological role nor ... Read more >>

Acta Diabetol (Acta diabetologica)
[2020, :]

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Retraction Note: Chondro-protective effects of polydatin in osteoarthritis through its effect on restoring dysregulated autophagy via modulating MAPK, and PI3K/Akt signaling pathways.

Zhengyuan Wu, Zhiwei Luan, Xiaohan Zhang, Kai Zou, Shiting Ma, Zhenyi Yang, Wenyu Feng, Mingwei He, Linhua Jiang, Jia Li, Jun Yao,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):11511]

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Designing AI-aided analysis and prediction models for nonprecious metal electrocatalyst-based proton exchange membrane fuel cells.

Rui Ding, Ran Wang, Yiqin Ding, Wenjuan Yin, Yide Liu, Jia Li, Jianguo Liu,

Traditionally, lots of experiments are needed to optimize the performance of membrane electrode assembly (MEA) in proton exchange membrane fuel cells (PEMFCs) since it involves complex electrochemical, thermodynamic and hydrodynamic processes. Herein, we introduce artificial intelligence (AI)-aided models for the first time to determine key parameters for nonprecious metal electrocatalyst-based ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, :]

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The low fresh gas flow anesthesia and hypothermia in neonates undergoing digestive surgeries: A retrospective before-after study

Yu Cui, Yu Wang, Rong Cao, Gen Li, Lingmei Deng, Jia Li,

Abstract Background : Based on the previous investigation in our institution, the incidence of intraoperative hypothermia in neonates was high. Since September 1 st , 2019, the recommendation had been launched to utilize ≤1 L/min fresh gas flow during the neonates’ surgical procedure. We therefore intended to evaluate the association ... Read more >>

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Application of Ultrasound Artificial Intelligence in the Differential Diagnosis Between Benign and Malignant Breast Lesions of BI-RADS 4A

SIHUA Niu, Jianhua Huang, Jia Li, Xueling Liu, Dan Wang, Ruifang Zhang, Yingyan Wang, Huiming Shen, Min Qi, Yi Xiao, Mengyao Guan, Haiyan Liu, Diancheng Li, Feifei Liu, Xiuming Wang, Yu Xiong, Siqi Gao, Xue Wang, Jiaan Zhu,

Abstract Background: The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is entirely based on the personal experience of doctors and lacks specific and clear classification standards. The development of artificial intelligence (AI) provides a new method for BI-RADS category. We analysed the morphological and texture ... Read more >>

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Neddylation activity modulates the neurodegeneration associated with fragile X associated tremor/ataxia syndrome (FXTAS) through regulating Sima.

Yunting Lin, Jin Xue, Jing Deng, Hua He, Shiyu Luo, Jia Chen, Jia Li, Li Yu, Juan Zhao, Jing Chen, Emily G Allen, Peng Jin, Ranhui Duan,

Fragile X associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by expansion of CGG repeats in the 5' UTR of the fragile X mental retardation 1 (FMR1) gene. Using the well-established FXTAS Drosophila model, we performed a high-throughput chemical screen using 3200 small molecules. NSC363998 was identified to ... Read more >>

Neurobiol. Dis. (Neurobiology of disease)
[2020, :105013]

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Ethylene promotes seed iron storage during Arabidopsis seed maturation via ERF95 transcription factor.

Ying Sun, Jia Qi Li, Jing Ying Yan, Jun Jie Yuan, Gui Xin Li, Yun Rong Wu, Ji Ming Xu, Rong Feng Huang, Nicholas P Harberd, Zhong Jie Ding, Shao Jian Zheng,

Because Iron (Fe) is an essential element, Fe storage in plant seeds is necessary for seedling establishment following germination. However, the mechanisms controlling seed Fe storage during seed development remain largely unknown. Here we reveal that an ERF95 transcription factor regulates Arabidopsis seed Fe accumulation. We show that expression of ... Read more >>

J Integr Plant Biol (Journal of integrative plant biology)
[2020, :]

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Atomic Imaging of Subsurface Interstitial Hydrogen and Insights into Surface Reactivity of Palladium Hydrides.

Bingqing Lin, Xi Wu, Lin Xie, Yongqiang Kang, Hongda Du, Feiyu Kang, Jia Li, Lin Gan,

Resolving interstitial hydrogen atoms at the surfaces and interfaces is crucial for understanding the mechanical and physicochemical properties of metal hydrides. Although palladium (Pd) hydrides hold important applications in hydrogen storage and electrocatalysis, the atomic position of interstitial hydrogen at Pd hydride near surfaces still remains undetermined. We report here ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, :]

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Application of Physiologically-based Pharmacokinetic Modeling to Predict Gastric pH-dependent Drug-drug Interactions for Weak Base Drugs.

Zhongqi Dong, Jia Li, Fang Wu, Ping Zhao, Sue-Chih Lee, Lillian Zhang, Paul Seo, Lei Zhang,

Weak base drugs (WBDs) are susceptible to drug-drug interactions (DDIs) when co-administered with gastric acid reducing agents (ARAs). We developed PBPK models to evaluate the potential of such pH-dependent DDIs for 4 WBDs, i.e., tapentadol, darunavir, erlotinib, and saxagliptin. The PBPK models of these drugs were first optimized using PK ... Read more >>

CPT Pharmacometrics Syst Pharmacol (CPT: pharmacometrics & systems pharmacology)
[2020, :]

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Highly enhanced durability of a graphitic carbon layer decorated PtNi3 alloy electrocatalyst toward the oxygen reduction reaction.

Kui Sun, Jia Li, Feng Wang, Wenxiang He, Minfei Fei, Zhenda Lu, Huigang Zhang, Jianguo Liu, Zhigang Zou,

The durability issue of a carbon supported PtNi3 alloy catalyst (PtNi3/C) under acidic conditions has been solved by introducing an N-doped graphitic carbon (NGC) layer to coat the surface of the PtNi3/C catalyst. The as-prepared PtNi3/[email protected] catalyst exhibits superior durability, being able to undergo 10 000 voltage cycles with negligible activity ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(40):5693-5696]

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Breastfeeding practices and associated factors at the individual, family, health facility and environmental levels in China.

Jia Li, Tuan T Nguyen, Xiaobei Wang, Roger Mathisen, Jin Fang,

We examined the association between breastfeeding practices and associated factors using cross-sectional data from face-to-face interviews with 9,745 mother-child dyads in China. The study collected information on breastfeeding practices and potential associated factors at the individual, family, health facility and environmental levels in China. We used survey commands in Stata ... Read more >>

Matern Child Nutr (Maternal & child nutrition)
[2020, :e13002]

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Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation

Yuejing Jiang, Xiaoji Cong, Shangwen Jiang, Ying Dong, Lei Zhao, Yi Zang, Minjia Tan, Jia Li,

Abstract AMPK is a conservative energy sensor that plays roles in diverse biologic processes via direct phosphorylation on various substrates. Emerging studies have demonstrated the regulatory roles of AMPK in DNA repair, but the underlying mechanisms remain to be fully understood. Herein, using mass spectrometry-based proteomic technologies, we systematically investigate ... Read more >>

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