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Author Jia Feng Lin

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Dexmedetomidine Exerted Anti-arrhythmic Effects in Rat With Ischemic Cardiomyopathy via Upregulation of Connexin 43 and Reduction of Fibrosis and Inflammation.

Shu-Jie Wu, Zhong-Hao Lin, Yuan-Zheng Lin, Zhi-Heng Rao, Jia-Feng Lin, Lian-Pin Wu, Lei Li,

Background:Persistent myocardial ischemia post-myocardial infarction can lead to fatal ventricular arrhythmias such as ventricular tachycardia and fibrillation, both of which carry high mortality rates. Dexmedetomidine (Dex) is a highly selective α2-agonist used in surgery for congenital cardiac disease because of its antiarrhythmic properties. Dex has previously been reported to prevent ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:33]

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An electrocardiographic sign of idiopathic ventricular tachycardia ablatable from the distal great cardiac vein.

Yuan-Nan Lin, Jing Xu, Yang-Qi Pan, Cheng Zheng, Jia-Xuan Lin, Jin Li, Jia Li, Jia-Feng Lin, Yue-Chun Li,

BACKGROUND:Idiopathic ventricular arrhythmias (IVAs) can originate from the distal great cardiac vein (DGCV). However, inadequate distinction sometimes occurs when electrocardiographic (ECG) characteristics are used to distinguish ventricular arrhythmias (VAs) arising from the DGCV from those arising from the adjacent left ventricular endocardium (LV ENDO). OBJECTIVE:The purpose of this study was ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(6):905-914]

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Radiofrequency catheter ablation of ventricular arrhythmias arising from the region above pulmonary valve.

Jin Li, Cheng Zheng, Zhi-Rui Liu, Jun Ma, Ge Jin, Wei-Qian Lin, Yao-Yao Wang, Jia-Feng Lin,

BACKGROUND:Ventricular arrhythmias (VAs) arising from the origin above pulmonary valve lack comprehensive investigation. This study aimed to disclose the characteristics and radiofrequency catheter ablation (RFCA) outcomes for those VAs. METHODS:One hundred six VAs arising from the region above pulmonary valve treated with RFCA were included in this study. RESULTS:Seventy-five cases ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2019, 19(1):233]

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The safety of catheter ablation for premature ventricular contractions in patients without structural heart disease.

Jin-Sheng Wang, Yi-Gen Shen, Ri-Peng Yin, Saroj Thapa, Yang-Pei Peng, Kang-Ting Ji, Lian-Ming Liao, Jia-Feng Lin, Yang-Jing Xue,

BACKGROUND:Patients with frequent premature ventricular contractions (PVCs) are often symptomatic. Catheter ablation was usually indicated to eliminate symptoms in patients with PVCs-induced cardiomyopathy. Currently, PVCs-ablation is also applied for patients with PVCs and no structural heart diseases (SHD); however, the safety and efficacy of ablation in these patients remains unclear. ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2018, 18(1):177]

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Corrigendum: Ivabradine Treatment Reduces Cardiomyocyte Apoptosis in a Murine Model of Chronic Viral Myocarditis.

Ge Li-Sha, Liu Li, Zhou De-Pu, Shi Zhe-Wei, Gu Xiaohong, Chen Guang-Yi, Li Jia, Lin Jia-Feng, Chu Maoping, Li Yue-Chun,

[This corrects the article DOI: 10.3389/fphar.2018.00182.]. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1126]

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Early postoperative stimulated serum thyroglobulin quantifies risk of recurrence in papillary thyroid cancer.

Jayani Jayasekara, Pascal Jonker, Jia Feng Lin, Anton F Engelsman, Man-Shun Wong, Schelto Kruijff, Ahmad Aniss, Diana Learoyd, Roderick Clifton Bligh, Anthony Glover, Leigh Delbridge, Stan Sidhu, Mark Sywak,

BACKGROUND:Postoperative follow-up of papillary thyroid cancer includes serial serum thyroglobulin levels. This study aimed to determine whether stimulated thyroglobulin levels measured in the early postoperative period can accurately quantify the risk of recurrence in papillary thyroid cancer. METHODS:We undertook a cohort study of patients who underwent total thyroidectomy for papillary ... Read more >>

Surgery (Surgery)
[2020, 167(1):40-45]

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Eliciting α7-nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling.

Zhong-Hao Lin, Yue-Chun Li, Shu-Jie Wu, Cheng Zheng, Yuan-Zheng Lin, Hao Lian, Wei-Qian Lin, Jia-Feng Lin,

Our previous studies have reported that agonist of α7 nicotinic acetylcholine receptors prevented electrophysiological dysfunction of rats with ischaemic cardiomyopathy (ICM) by eliciting the cholinergic anti-inflammatory pathway (CAP). Adenosine monophosphate-activated protein kinase (AMPK) signalling is widely recognized exerting cardioprotective effect in various cardiomyopathy. Here, we aimed to investigate whether the ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2019, 23(7):4746-4758]

Cited: 2 times

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Low-intensity pulsed ultrasound attenuates cardiac inflammation of CVB3-induced viral myocarditis via regulation of caveolin-1 and MAPK pathways.

Cheng Zheng, Sen-Min Wu, Hao Lian, Yuan-Zheng Lin, Rong Zhuang, Saroj Thapa, Quan-Zhi Chen, Yi-Fan Chen, Jia-Feng Lin,

The aggressive immunological activity elicited by acute viral myocarditis contributes to a large amount of cardiomyocytes loss and poor prognosis of patients in clinic. Low-intensity pulsed ultrasound (LIPUS), which is an effective treatment modality for osteoarthropathy, has been recently illustrated regulating the overactive inflammatory response in various diseases. Here, we ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2019, 23(3):1963-1975]

Cited: 4 times

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Elderly Woman With Severe Dyspnea.

Li Yue-Chun, Zhang Wen-Wu, Lin Jia-Feng,

Ann Emerg Med (Annals of emergency medicine)
[2018, 72(5):562-566]

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Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress.

Shao-Ze Wu, Lu-Yuan Tao, Jiao-Ni Wang, Zhi-Qiang Xu, Jie Wang, Yang-Jing Xue, Kai-Yu Huang, Jia-Feng Lin, Lei Li, Kang-Ting Ji,

The present study was aimed at investigating the effect of amifostine on myocardial ischemia/reperfusion (I/R) injury of mice and H9c2 cells cultured with TBHP (tert-butyl hydroperoxide). The results showed that pretreatment with amifostine significantly attenuated cell apoptosis and death, accompanied by decreased reactive oxygen species (ROS) production and lower mitochondrial ... Read more >>

Oxid Med Cell Longev (Oxidative Medicine and Cellular Longevity)
[2017, 2017:4130824]

Cited: 6 times

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Sodium Houttuyfonate Alleviates Post-infarct Remodeling in Rats via AMP-Activated Protein Kinase Pathway.

Cheng Zheng, Jia-Feng Lin, Zhong-Hao Lin, Wei-Qian Lin, Saroj Thapa, Yuan-Zheng Lin, Hao Lian, Zhi-Rui Liu, Jia-Hui Chen, Xiao-Wei Li,

With the chronic ischemia persisting after acute myocardial infarction, the accompanying low-degree inflammation and subsequent fibrosis result in progression of cardiac remodeling and heart failure. Recently, Sodium Houttuyfonate (SH), a pure compound extracted from Houttuynia cordata, has been confirmed exerting anti-inflammatory and anti-fibrotic effects under diseased situations. Here, we aimed ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:1092]

Cited: 2 times

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Common and distinctive electrocardiographic characteristics and effective catheter ablation of idiopathic ventricular arrhythmias originating from different areas of ventricular septum adjacent to atrioventricular annulus.

Su-Qin Zhang, Cheng Zheng, Yue-Chun Li, Kang-Ting Ji, Ri-Peng Yin, Jia-Feng Lin, Jia Li,

OBJECTIVE:To investigate electrocardiographic (ECG) characteristics and radiofrequency catheter ablation (RFCA) efficacy for premature ventricular complexes (PVCs) and idiopathic ventricular tachycardias (IVTs) originating from ventricular septum areas adjacent to atrioventricular annulus (VS-AVA). METHODS:Among 1,505 consecutive PVCs/IVTs cases, 106 (7.04%) were confirmed as origin of VS-AVA guided by both fluoroscopy and three-dimensional ... Read more >>

J. Cardiovasc. Electrophysiol. (Journal of cardiovascular electrophysiology)
[2018, 29(8):1104-1112]

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Ivabradine Treatment Reduces Cardiomyocyte Apoptosis in a Murine Model of Chronic Viral Myocarditis.

Ge Li-Sha, Liu Li, Zhou De-Pu, Shi Zhe-Wei, Gu Xiaohong, Chen Guang-Yi, Li Jia, Lin Jia-Feng, Chu Maoping, Li Yue-Chun,

This study was designed to explore the effects of ivabradine on cardiomyocyte apoptosis in a murine model of chronic viral myocarditis (CVMC). Mice were inoculated intraperitoneally with Coxsackievirus B3 at days 1, 14, and 28, respectively. On day 42, the mice were gavaged with ivabradine for 30 days until the ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:182]

Cited: 1 time

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Case presentation: implantation of cardiac resynchronization therapy pacemaker via the coronary sinus in a patient with triple valve replacement.

Cheng Zheng, Wei-Qian Lin, Yuan-Zheng Lin, Hao Lian, Zhi-Rui Liu, Jia-Hui Chen, Jia-Feng Lin,

BACKGROUND:In patients with triple valve replacement developing third-degree atrioventricular block (AVB), the most appropriate approach for permanent pacemaker implantation remains questionable. CASE PRESENTATION:In this case presentation, we first described the approach of implantation of the cardiac resynchronization therapy pacemaker (CRT-P) via one bipolar pacing lead in middle cardiac vein (MCV) ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2018, 18(1):37]

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The cholinergic anti-inflammatory pathway ameliorates acute viral myocarditis in mice by regulating CD4+ T cell differentiation.

Zhou De-Pu, Ge Li-Sha, Chen Guang-Yi, Gu Xiaohong, Xing Chao, Zheng Cheng, Zhang Wen-Wu, Li Jia, Lin Jia-Feng, Chu Maoping, Li Yue-Chun,

Many studies have found that abnormalities in the proportion and differentiation of CD4+ T cells (Th cells) are closely related to the pathogenesis of viral myocarditis (VMC). Our previous research indicates that the cholinergic anti-inflammatory pathway (CAP) attenuates the inflammatory response of VMC and downregulates the expression of cytokines in ... Read more >>

Virulence (Virulence)
[2018, 9(1):1364-1376]

Cited: 1 time

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Alteration of Cholinergic Anti-Inflammatory Pathway in Rat With Ischemic Cardiomyopathy-Modified Electrophysiological Function of Heart.

Shu-Jie Wu, Yue-Chun Li, Zhe-Wei Shi, Zhong-Hao Lin, Zhi-Heng Rao, Si-Chao Tai, Mao-Ping Chu, Lei Li, Jia-Feng Lin,

With chronic ischemia after myocardial infarction, the resulting scar tissue result in electrical and structural remodeling vulnerable to an arrhythmogenic substrate. The cholinergic anti-inflammatory pathway elicited by vagal nerve via α7 nicotinic acetylcholine receptors (α7-nAChR) can modulate local and systemic inflammatory responses. Here, we aimed to clarify a novel mechanism ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(9):]

Cited: 4 times

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Approach selection of radiofrequency catheter ablation for ventricular arrhythmias originating from the left ventricular summit: potential relevance of Pseudo Delta wave, Intrinsicoid deflection time, maximal deflection index.

Cheng Zheng, Jin Li, Jia Li, De-Pu Zhou, Xiao-Wei Li, Shu-Jie Wu, Jia-Feng Lin,

Ventricular arrhythmias (VAs) originating from the left ventricular summit is a challenge for radiofrequency catheter ablation (RFCA). The present study aimed to investigate the appropriate RFCA strategy for VAs originating from the left ventricular summit.Forty-five consecutive patients with VAs arising from the left ventricular summit were successfully ablated at our ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2017, 17(1):140]

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Origins location of the outflow tract ventricular arrhythmias exhibiting qrS pattern or QS pattern with a notch on the descending limb in lead V1.

Cong Lin, Cheng Zheng, De-Pu Zhou, Xiao-Wei Li, Shu-Jie Wu, Jia-Feng Lin,

Ventricular outflow tract(VOT) ventricular arrhythmias(VAs) presenting qrS pattern or QS pattern with a notch on the descending limb in lead V1 were consistently thought of arising from the commissure between left and right coronary cusp (L-RCC) by previous studies. However, we found they could originate from other anatomic structures in ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2017, 17(1):124]

Cited: 1 time

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Right Cervical Vagotomy Aggravates Viral Myocarditis in Mice Via the Cholinergic Anti-inflammatory Pathway.

Ge Li-Sha, Chen Xing-Xing, Wu Lian-Pin, Zhou De-Pu, Li Xiao-Wei, Lin Jia-Feng, Li Yue-Chun,

The autonomic nervous system dysfunction with increased sympathetic activity and withdrawal of vagal activity may play an important role in the pathogenesis of viral myocarditis. The vagus nerve can modulate the immune response and control inflammation through a 'cholinergic anti-inflammatory pathway' dependent on the α7-nicotinic acetylcholine receptor (α7nAChR). Although the ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2017, 8:25]

Cited: 9 times

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An Unusually Wide QRS Complex Tachycardia in a Patient With Hemodynamic Instability.

Yue-Chun Li, Jia-Feng Lin, Peng Chen,

JAMA Intern Med (JAMA internal medicine)
[2016, 176(12):1857-1859]

Cited: 0 times

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Evaluation of Safety and Efficacy of Qinming8631 DR Implantable Cardiac Pacemaker in Chinese Patients: A Prospective, Multicenter, Randomized Controlled Trial of the First Domestically Developed Pacemaker of China.

Mei-Xiang Xiang, Dong-Qi Wang, Jing Xu, Zheng Zhang, Jian-Xin Hu, Dong-Mei Wang, Xiang Gu, He-Ping Liu, Tao Guo, Xiang-Jun Yang, Feng Ling, Jia-Feng Lin, Shang-Lang Cai, Guo-Bin Zhu, Jian-An Wang,

High cost of imported pacemakers is a main obstacle for Chinese patients suffering from bradyarrhythmia, and a domestically developed pacemaker will help lower the burden. This study aimed to evaluate the safety and efficacy of Qinming8631 DR (Qinming Medical, Baoji, China), the first domestically developed dual-chamber pacemaker of China, compared ... Read more >>

Chin. Med. J. (Chinese medical journal)
[2016, 129(22):2659-2665]

Cited: 0 times

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Chronic Left Coronary Artery Stenosis After Radiofrequency Ablation of Idiopathic Premature Ventricular Contraction Originating From Left Coronary Sinus Cusp.

Li Yue-Chun, Lin Jia-Feng, Guan Xue-Qiang, Chen Peng,

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2016, 9(8):e004353]

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Where is the exact origin of narrow premature ventricular contractions manifesting qR in inferior wall leads?

Cheng Zheng, Jin Li, Jia-Xuan Lin, Lu-Ping Wang, Jia-Feng Lin,

In recent years, radiofrequency catheter ablation(RFCA) has been established as an effective therapy for idiopathic premature ventricular contractions (PVCs), however, its effect on the narrow PVCs (QRS duration < 130 msec) with qR pattern in inferior leads, may not been fully concluded.Characteristics of 12-lead electrocardiogram (ECG) and electrophysiologic recordings were ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2016, 16:64]

Cited: 1 time

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Catheter Ablation of Idiopathic Epicardial Ventricular Arrhythmias Originating from the Vicinity of the Coronary Sinus System.

Yi-He Chen, Jia-Feng Lin,

Catheter Ablation of Idiopathic Epicardial Ventricular Arrhythmias. Idiopathic epicardial ventricular arrhythmias (IEVAs) originating from the vicinity of the coronary sinus system are not uncommon, accounting for about 9% of idiopathic ventricular arrhythmia cases. IEVAs share clinical presentation and electrophysiological characteristics with ventricular arrhythmias arising from the right ventricular outflow tract ... Read more >>

J. Cardiovasc. Electrophysiol. (Journal of cardiovascular electrophysiology)
[2015, 26(10):1160-1167]

Cited: 5 times

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Dynamic Changes of QRS Morphology of Premature Ventricular Contractions During Ablation in the Right Ventricular Outflow Tract: A Case Report.

Li Yue-Chun, Lin Jia-Feng, Lin Jia-Xuan,

Electrocardiographic characteristics can be useful in differentiating between right ventricular outflow tract (RVOT) and aortic sinus cusp (ASC) ventricular arrhythmias. Ventricular arrhythmias originating from ASC, however, show preferential conduction to RVOT that may render the algorithms of electrocardiographic characteristics less reliable. Even though there are few reports describing ventricular arrhythmias ... Read more >>

Medicine (Madr) (Medicine)
[2015, 94(42):e1885]

Cited: 0 times

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