Full Text Journal Articles by
Author Jessica E Ericson

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Severe Pediatric Mycoplasma pneumoniae Infection Requiring Veno-venous Extracorporeal Membrane Oxygenation.

Joshua Davis, Jessica E Ericson, Robert Kavanagh,

Mycoplasma pneumoniae (MP) is an atypical bacterial pathogen that typically causes mild respiratory symptoms. Rarely, MP is associated with acute respiratory distress syndrome, a condition marked by widespread inflammation in the lungs that often requires invasive support. We report a case of severe acute respiratory distress syndrome requiring veno-venous extracorporeal ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, Publish Ahead of Print:]

Cited: 0 times

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Reduced Vancomycin Susceptibility, MRSA and Treatment Failure in Pediatric Staphylococcus aureus Bloodstream Infections.

Ethan Canty, Benjamin Carnahan, Tara Curley, Emily Anususinha, Rana F Hamdy, Jessica E Ericson,

<h4>Background</h4>Clinical implications of reduced vancomycin susceptibility (RVS) among pediatric Staphylococcus aureus bloodstream infections are unknown.<h4>Methods</h4>We identified all children at 2 children's hospitals with ≥1 blood culture positive for S. aureus. We compared patient and clinical factors for RVS and non-RVS infections using Wilcoxon rank-sum and chi-squared tests. Treatment failure and ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, :]

Cited: 0 times

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Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants.

Joseph N Paulson, Brent L Williams, Christine Hehnly, Nischay Mishra, Shamim A Sinnar, Lijun Zhang, Paddy Ssentongo, Edith Mbabazi-Kabachelor, Dona S S Wijetunge, Benjamin von Bredow, Ronnie Mulondo, Julius Kiwanuka, Francis Bajunirwe, Joel Bazira, Lisa M Bebell, Kathy Burgoine, Mara Couto-Rodriguez, Jessica E Ericson, Tim Erickson, Matthew Ferrari, Melissa Gladstone, Cheng Guo, Murali Haran, Mady Hornig, Albert M Isaacs, Brian Nsubuga Kaaya, Sheila M Kangere, Abhaya V Kulkarni, Elias Kumbakumba, Xiaoxiao Li, David D Limbrick, Joshua Magombe, Sarah U Morton, John Mugamba, James Ng, Peter Olupot-Olupot, Justin Onen, Mallory R Peterson, Farrah Roy, Kathryn Sheldon, Reid Townsend, Andrew D Weeks, Andrew J Whalen, John Quackenbush, Peter Ssenyonga, Michael Y Galperin, Mathieu Almeida, Hannah Atkins, Benjamin C Warf, W Ian Lipkin, James R Broach, Steven J Schiff,

Postinfectious hydrocephalus (PIH), which often follows neonatal sepsis, is the most common cause of pediatric hydrocephalus worldwide, yet the microbial pathogens underlying this disease remain to be elucidated. Characterization of the microbial agents causing PIH would enable a shift from surgical palliation of cerebrospinal fluid (CSF) accumulation to prevention of ... Read more >>

Sci Transl Med (Science translational medicine)
[2020, 12(563):]

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Paradoxical Antibiotic Effect of Ampicillin: Use of a Population Pharmacokinetic Model to Evaluate a Clinical Correlate of the Eagle Effect in Infants With Bacteremia.

Jessica E Ericson, Christoph P Hornik, Rachel G Greenberg, Reese H Clark, Adriana H Tremoulet, Jennifer Le, Michael Cohen-Wolkowiez, P Brian Smith, Daniel K Benjamin, ,

<h4>Background</h4>High doses of ampicillin are often used to achieve therapeutic drug concentrations in infants. A paradoxical antibiotic effect, often called the Eagle effect, occurs when increasing concentrations of antibiotic above a threshold results in decreased efficacy. It is unknown if infants treated with ampicillin are at risk for this paradoxical ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(8):725-729]

Cited: 1 time

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Hospital-acquired Pneumonia and Ventilator-associated Pneumonia in Children: A Prospective Natural History and Case-Control Study.

Jessica E Ericson, John McGuire, Marian G Michaels, Adam Schwarz, Robert Frenck, Jaime G Deville, Swati Agarwal, Adam M Bressler, Jamie Gao, Tracy Spears, Daniel K Benjamin, P Brian Smith, John S Bradley, ,

BACKGROUND:Clinical trials for antibiotics designed to treat hospital-acquired and ventilator-associated bacterial pneumonias (HABP/VABP) are hampered by making these diagnoses in a way that is acceptable to the United States Food and Drug Administration and consistent with standards of care. We examined laboratory and clinical features that might improve pediatric HABP/VABP ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(8):658-664]

Cited: 0 times

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Associations of malaria, HIV, and coinfection, with anemia in pregnancy in sub-Saharan Africa: a population-based cross-sectional study.

Paddy Ssentongo, Djibril M Ba, Anna E Ssentongo, Jessica E Ericson, Ming Wang, Duanping Liao, Vernon M Chinchilli,

<h4>Background</h4>Malaria and HIV are common infections in Africa and cause substantial morbidity and mortality in pregnant women. We aimed to assess the association of malaria with anemia in pregnant women and to explore the joint effects of malaria and HIV infection on anemia in pregnant women.<h4>Methods</h4>We used nationally representative, cross-sectional ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2020, 20(1):379]

Cited: 0 times

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Management of newborns exposed to mothers with confirmed or suspected COVID-19.

Shaili Amatya, Tammy E Corr, Chintan K Gandhi, Kristen M Glass, Mitchell J Kresch, Dennis J Mujsce, Christiana N Oji-Mmuo, Sara J Mola, Yuanyi L Murray, Timothy W Palmer, Meenakshi Singh, Ashley Fricchione, Jill Arnold, Danielle Prentice, Colin R Bridgeman, Brandon M Smith, Patrick J Gavigan, Jessica E Ericson, Jennifer R Miller, Jaimey M Pauli, Duane C Williams, George D McSherry, Richard S Legro, Sarah M Iriana, Jeffrey R Kaiser,

There is limited information about newborns with confirmed or suspected COVID-19. Particularly in the hospital after delivery, clinicians have refined practices in order to prevent secondary infection. While guidance from international associations is continuously being updated, all facets of care of neonates born to women with confirmed or suspected COVID-19 ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, 40(7):987-996]

Cited: 4 times

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Association of vitamin A deficiency with early childhood stunting in Uganda: A population-based cross-sectional study.

Paddy Ssentongo, Djibril M Ba, Anna E Ssentongo, Claudio Fronterre, Andrew Whalen, Yanxu Yang, Jessica E Ericson, Vernon M Chinchilli,

BACKGROUND:Despite the high prevalence of childhood protein-energy malnutrition and vitamin A deficiency in sub-Saharan Africa, their association has not been explored in this region. A better understanding of the epidemiologic link could help define effective preventive strategies. We aimed to explore the association of vitamin A deficiency (VAD) with stunting, ... Read more >>

PLoS One (PloS one)
[2020, 15(5):e0233615]

Cited: 1 time

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Mycoplasma pneumoniae Presenting With Pericardial Tamponade.

Harish Rao, Jessica E Ericson, Christopher O'Hara,

Clin Pediatr (Phila) (Clinical pediatrics)
[2020, 59(2):198-200]

Cited: 0 times

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136. Factors Associated with Reduced Vancomycin Susceptibility in Pediatric Staphylococcus aureus Bacteremia.

Jessica E Ericson, Tara E Curley, Ethan A Canty, Emily Ansusinha, Rana F Hamdy,

AbstractBackgroundVancomycin is often used empirically for treatment of pediatric Staphylococcus aureus bacteremia while susceptibility testing is being performed. Reduced vancomycin susceptibility (RVS) occurs when the minimum inhibitory concentration (MIC) for vancomycin is elevated, potentially resulting in decreased efficacy. Patient factors associated with RVS in pediatric S. aureus infections have not ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S96-S96]

Cited: 0 times

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Pediatric Tetanus in Central Pennsylvania.

Bilaal S Ahmed, Michael J Beck, Gregory Williamson, Jessica E Ericson, Parvathi Kumar,

Approximately 20% of the nationally reported tetanus infections in children aged 0 to 14 years that occurred in the United States between 2005 and 2015 were treated at Penn State Children's Hospital. With an electronic medical record search, we identified 5 cases of pediatric tetanus; 100% of these cases occurred ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, 8(4):358-360]

Cited: 0 times

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Vaccine-Preventable Diseases Requiring Hospitalization.

Gregory Williamson, Bilaal Ahmed, Parvathi S Kumar, Barbara E Ostrov, Jessica E Ericson,

<h4>Background</h4>Plain children often have lower immunization rates than non-Plain children. Penn State Health Children's Hospital is a tertiary medical center with large nearby Plain (Amish and Mennonite) communities. We sought to describe the characteristics of children hospitalized with vaccine-preventable diseases (VPDs). We hypothesized that Amish children would have a higher ... Read more >>

Pediatrics (Pediatrics)
[2017, 140(3):]

Cited: 1 time

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Safety of High-dose Acyclovir in Infants With Suspected and Confirmed Neonatal Herpes Simplex Virus Infections.

Jessica E Ericson, Martyn Gostelow, Julie Autmizguine, Christoph P Hornik, Reese H Clark, Daniel K Benjamin, P Brian Smith, ,

<h4>Background</h4>Acyclovir is used to treat herpes simplex virus disease in infants. Treatment with high-dose acyclovir, 60 mg/kg/d, is recommended; however, the safety of this dosage has not been assessed in the past 15 years, and this dosage is not currently approved for infants by the US Food and Drug Administration.<h4>Methods</h4>We included ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2017, 36(4):369-373]

Cited: 3 times

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A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation.

Jessica E Ericson, Kanecia O Zimmerman, Daniel Gonzalez, Chiara Melloni, Jeffrey T Guptill, Kevin D Hill, Huali Wu, Michael Cohen-Wolkowiez,

<h4>Background</h4>Drugs that exhibit close margins between therapeutic and toxic blood concentrations are considered to have a narrow therapeutic index (NTI). The Food and Drug Administration has proposed that NTI drugs should have more stringent bioequivalence standards for approval of generic formulations. However, many immunosuppressant drugs do not have a well-defined ... Read more >>

Ther Drug Monit (Therapeutic drug monitoring)
[2017, 39(1):13-20]

Cited: 4 times

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Effectiveness of Granulocyte Colony-Stimulating Factor in Hospitalized Infants with Neutropenia.

Jin A Lee, Brooke Sauer, William Tuminski, Jiyu Cheong, John Fitz-Henley, Megan Mayers, Chidera Ezuma-Igwe, Christopher Arnold, Christoph P Hornik, Reese H Clark, Daniel K Benjamin, P Brian Smith, Jessica E Ericson, ,

<b>Objective</b> The objective of this study was to determine the time to hematologic recovery and the incidence of secondary sepsis and mortality among neutropenic infants treated or not treated with granulocyte colony-stimulating factor (G-CSF). <b>Study Design</b> We identified all neutropenic infants discharged from 348 neonatal intensive care units from 1997 to 2012. ... Read more >>

Am J Perinatol (American journal of perinatology)
[2017, 34(5):458-464]

Cited: 4 times

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Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates.

Christoph P Hornik, Daniel K Benjamin, P Brian Smith, Michael J Pencina, Adriana H Tremoulet, Edmund V Capparelli, Jessica E Ericson, Reese H Clark, Michael Cohen-Wolkowiez, ,

<h4>Objective</h4>To evaluate the relationship between ampicillin dosing, exposure, and seizures.<h4>Study design</h4>This was a retrospective observational cohort study of electronic health record (EHR) data combined with pharmacokinetic model derived drug exposure predictions. We used the EHR from 348 Pediatrix Medical Group neonatal intensive care units from 1997 to 2012. We included ... Read more >>

J Pediatr (The Journal of pediatrics)
[2016, 178:125-129.e1]

Cited: 9 times

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Fluconazole Prophylaxis for the Prevention of Candidiasis in Premature Infants: A Meta-analysis Using Patient-level Data.

Jessica E Ericson, David A Kaufman, Stephen D Kicklighter, Jatinder Bhatia, Daniela Testoni, Jamie Gao, P Brian Smith, Kristi O Prather, Daniel K Benjamin, , ,

<h4>Background</h4>Invasive candidiasis (IC) is an important cause of sepsis in premature infants and is associated with a high risk of death and neurodevelopmental impairment. Prevention of IC has become a major focus in very low birth weight infants, with fluconazole increasingly used as prophylaxis.<h4>Methods</h4>We identified all randomized, placebo-controlled trials evaluating ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2016, 63(5):604-610]

Cited: 7 times

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Sustained Reduction in Bloodstream Infections in Infants at a Large Tertiary Care Neonatal Intensive Care Unit.

Sara Neill, Sarah Haithcock, P Brian Smith, Ronald Goldberg, Margarita Bidegain, David Tanaka, Charlene Carriker, Jessica E Ericson,

<h4>Background</h4>Bloodstream infections (BSI) cause significant morbidity and mortality among hospitalized infants.<h4>Purpose</h4>Reduction of BSIs has emerged as an important patient safety goal. Implementation of central line insertion bundles, standardized line care protocols, and health care provider education programs have reduced BSI in NICUs around the country. The ability of large tertiary ... Read more >>

Adv Neonatal Care (Advances in neonatal care : official journal of the National Association of Neonatal Nurses)
[2016, 16(1):52-59]

Cited: 4 times

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Burden of Invasive Staphylococcus aureus Infections in Hospitalized Infants.

Jessica E Ericson, Victor O Popoola, P Brian Smith, Daniel K Benjamin, Vance G Fowler, Daniel K Benjamin, Reese H Clark, Aaron M Milstone,

IMPORTANCE:Staphylococcus aureus is a frequent cause of infection in hospitalized infants. These infections are associated with increased mortality and morbidity and longer hospital stays, but data on the burden of S aureus disease in hospitalized infants are limited. OBJECTIVES:To compare demographics and mortality of infants with invasive methicillin-resistant S aureus ... Read more >>

JAMA Pediatr (JAMA pediatrics)
[2015, 169(12):1105-1111]

Cited: 23 times

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Use and Safety of Erythromycin and Metoclopramide in Hospitalized Infants.

Jessica E Ericson, Christopher Arnold, Jomani Cheeseman, Jordan Cho, Sarah Kaneko, Ele'na Wilson, Reese H Clark, Daniel K Benjamin, Vivian Chu, P Brian Smith, Christoph P Hornik, ,

<h4>Objective</h4>Prokinetic medications are used in premature infants to promote motility and decrease time to full enteral feeding. Erythromycin and metoclopramide are the most commonly used prokinetic medications in the neonatal intensive care unit (NICU), but their safety profile is not well defined.<h4>Methods</h4>We conducted a large retrospective cohort study using data ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2015, 61(3):334-339]

Cited: 6 times

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Survival Benefit of Empirical Therapy for Staphylococcus aureus Bloodstream Infections in Infants.

Joshua T Thaden, Jessica E Ericson, Heather Cross, Stephen P Bergin, Julia A Messina, Vance G Fowler, Daniel K Benjamin, Reese H Clark, Christoph P Hornik, P Brian Smith, ,

<h4>Background</h4>The impact of early adequate empirical antibiotic therapy on outcomes of infants in the neonatal intensive care unit (NICU) who develop Staphylococcus aureus bloodstream infections (BSI) is unknown.<h4>Methods</h4>Infants with S. aureus BSI discharged in 1997-2012 from 348 NICUs managed by the Pediatrix Medical Group were identified. Early adequate empirical antibiotic ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2015, 34(11):1175-1179]

Cited: 12 times

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Neonatal Escherichia coli Bloodstream Infections: Clinical Outcomes and Impact of Initial Antibiotic Therapy.

Stephen P Bergin, Joshua T Thaden, Jessica E Ericson, Heather Cross, Julia Messina, Reese H Clark, Vance G Fowler, Daniel K Benjamin, Christoph P Hornik, P Brian Smith, ,

<h4>Background</h4>Escherichia coli is a common cause of bloodstream infections (BSIs) in infants and is associated with high mortality and morbidity among survivors. The clinical significance of antibiotic resistance and timing of appropriate antimicrobial therapy in this population is poorly understood.<h4>Methods</h4>We identified all infants with E. coli BSIs discharged from 77 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2015, 34(9):933-936]

Cited: 8 times

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No survival benefit with empirical vancomycin therapy for coagulase-negative staphylococcal bloodstream infections in infants.

Jessica E Ericson, Joshua Thaden, Heather R Cross, Reese H Clark, Vance G Fowler, Daniel K Benjamin, Michael Cohen-Wolkowiez, Christoph P Hornik, P Brian Smith, ,

<h4>Background</h4>Coagulase-negative Staphylococcus (CoNS) is the most common cause of bloodstream infections (BSI) in hospitalized infants. CoNS BSI is most reliably treated with vancomycin; however, concerns about side effects and promoting resistance often delay empirical vancomycin therapy until culture results become available.<h4>Methods</h4>All infants with CoNS BSI discharged from 348 neonatal intensive ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2015, 34(4):371-375]

Cited: 12 times

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Chorioamnionitis: implications for the neonate.

Jessica E Ericson, Matthew M Laughon,

Chorioamnionitis (CA) is characterized by inflammation of the fetal membranes. The incidence increases with decreasing gestational age at birth. When suspected on clinical criteria, pathologic assessment of the placenta should be performed. Although the mechanisms are not entirely clear, CA predisposes to premature birth, neonatal sepsis, and intraventricular hemorrhage. Its ... Read more >>

Clin Perinatol (Clinics in perinatology)
[2015, 42(1):155-65, ix]

Cited: 15 times

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Fluconazole prophylaxis for prevention of invasive candidiasis in infants.

Jessica E Ericson, Daniel K Benjamin,

<h4>Purpose of review</h4>Invasive candidiasis is a serious infection in hospitalized infants that results in significant mortality and morbidity. Fluconazole is approved by the US Food and Drug Administration for prophylaxis of invasive candidiasis in patients undergoing bone marrow transplantation but is not approved for use in infants. This review will ... Read more >>

Curr Opin Pediatr (Current opinion in pediatrics)
[2014, 26(2):151-156]

Cited: 3 times

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