Full Text Journal Articles by
Author Jessica Adams

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Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer.

Nathan F Schachter, Jessica R Adams, Patryk Skowron, Katelyn J Kozma, Christian A Lee, Nandini Raghuram, Joanna Yang, Amanda J Loch, Wei Wang, Aaron Kucharczuk, Katherine L Wright, Rita M Quintana, Yeji An, Daniel Dotzko, Jennifer L Gorman, Daria Wojtal, Juhi S Shah, Paul Leon-Gomez, Giovanna Pellecchia, Adam J Dupuy, Charles M Perou, Ittai Ben-Porath, Rotem Karni, Eldad Zacksenhaus, Jim R Woodgett, Susan J Done, Livia Garzia, A Sorana Morrissy, Jüri Reimand, Michael D Taylor, Sean E Egan,

The most common events in breast cancer (BC) involve chromosome arm losses and gains. Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in 8 mouse models of BC. Some gCIS are driver-specific, others driver non-specific, and still others associated with tumor histology. Processes affected ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):5238]

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Comprehensive nodal breast VMAT: solving the low-dose wash dilemma using an iterative knowledge-based radiotherapy planning solution.

Cameron Stanton, Linda J Bell, Andrew Le, Brooke Griffiths, Kenny Wu, Jessica Adams, Leigh Ambrose, Denise Andree-Evarts, Brian Porter, Regina Bromley, Kirsten van Gysen, Marita Morgia, Gillian Lamoury, Thomas Eade, Jeremy T Booth, Susan Carroll,

<h4>Introduction</h4>Aimed to develop a simple and robust volumetric modulated arc radiotherapy (VMAT) solution for comprehensive lymph node (CLN) breast cancer without increase in low-dose wash.<h4>Methods</h4>Forty CLN-breast patient data sets were utilised to develop a knowledge-based planning (KBP) VMAT model, which limits low-dose wash using iterative learning and base-tangential methods as ... Read more >>

J Med Radiat Sci (Journal of medical radiation sciences)
[2021, :]

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Outbreak or pseudo-outbreak? Integrating SARS-CoV-2 sequencing to validate infection control practices in a dialysis facility.

Bridget L Pfaff, Craig S Richmond, Arick P Sabin, Deena M Athas, Jessica C Adams, Megan E Meller, Kumari Usha, Sarah A Schmitz, Brian J Simmons, Andrew J Borgert, Paraic A Kenny,

<h4>Background</h4>The COVID-19 pandemic poses a particularly high risk for End Stage Renal Disease (ESRD) patients so rapid identification of case clusters in ESRD facilities is essential. Nevertheless, with high community prevalence, a series of ESRD patients may test positive contemporaneously for reasons unrelated to their shared ESRD facility. Here we ... Read more >>

Am J Infect Control (American journal of infection control)
[2021, :]

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Volumetric Response of Brain Oligometastatic Disease to Focal Hypofractionated Radiation Therapy

Asanka Wijetunga, Dasantha Jayamanne, Jessica Adams, Michael Back,

<h4>Background: </h4> This study aimed to assess the volumetric response, morbidity and failure rates of hypofractionated radiation therapy (HFRT) for definitive focal management of brain oligometastatic disease. <h4>Methods: </h4> Patients managed with HFRT for unresected oligometastatic brain disease were entered into an ethics-approved database. HFRT was delivered using IMRT or ... Read more >>

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Determining patient needs to enhance exercise program implementation and uptake in rural settings for women after a cancer diagnosis.

Jessica L Adams, Michelle Y Martin, Maria Pisu, Robert A Oster, Haiyan Qu, Richard M Shewchuk, Mary E Sheffield, Alex Minter, Ana A Baumann, Laura Q Rogers,

<h4>Purpose</h4>To qualitatively explore exercise barriers and facilitators experienced by rural female cancer survivors from the program interventionist and recipient perspective for the purpose of enhancing exercise program implementation and uptake in rural settings.<h4>Methods</h4>A descriptive qualitative study design was utilized. Focus groups were conducted prior to implementation of an evidence-based exercise ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2021, 29(8):4641-4649]

Cited: 1 time

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GFRAL-expressing neurons suppress food intake via aversive pathways.

Paul V Sabatini, Henriette Frikke-Schmidt, Joe Arthurs, Desiree Gordian, Anita Patel, Alan C Rupp, Jessica M Adams, Jine Wang, Sebastian Beck Jørgensen, David P Olson, Richard D Palmiter, Martin G Myers, Randy J Seeley,

The TGFβ cytokine family member, GDF-15, reduces food intake and body weight and represents a potential treatment for obesity. Because the brainstem-restricted expression pattern of its receptor, GDNF Family Receptor α-like (GFRAL), presents an exciting opportunity to understand mechanisms of action for area postrema neurons in food intake; we generated ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(8):]

Cited: 2 times

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Outbreak or pseudo-outbreak? Integrating SARS-CoV-2 sequencing to validate infection control practices in an end stage renal disease facility

Bridget Pfaff, Craig Richmond, Arick Sabin, Deena Athas, Jessica Adams, Megan Meller, Kumari Usha, Sarah Schmitz, Brian Simmons, Andrew Borgert, Paraic Kenny,

<h4>ABSTRACT</h4> <h4>Background</h4> The COVID-19 pandemic of 2020 poses a particularly high risk for End Stage Renal Disease (ESRD) patients and led to a need for facility-wide control plans to prevent introduction and spread of infection within ESRD facilities. Rapid identification of clusters of contemporaneous cases is essential, as these may ... Read more >>

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Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer.

Elisa S Na, Daniel D Lam, Eva Yokosawa, Jessica M Adams, David P Olson, Malcolm J Low,

Enhancer redundancy has been postulated to provide a buffer for gene expression against genetic and environmental perturbations. While work in Drosophila has identified functionally overlapping enhancers, work in mammalian models has been limited. Recently, we have identified two partially redundant enhancers, nPE1 and nPE2, that drive proopiomelanocortin gene expression in ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0244793]

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Changes in neurocognitive assessment scores after initiating dolutegravir- versus elvitegravir-based antiretroviral therapy.

Jessica L Adams, Yookyung Christy Choi, Michael West, Laura Pontiggia, John Baxter, Jomy George,

This prospective cohort study enrolled people living with HIV initiating antiretroviral therapy (ART) containing the integrase inhibitors, dolutegravir (DTG) or elvitegravir (EVG) and administered the Montreal Cognitive Assessment (MoCA) at baseline and again after approximately six months to compare changes in MoCA scores. The proportion of patients found to have ... Read more >>

AIDS Care (AIDS care)
[2020, :1-7]

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Sedative Load in Community-Dwelling Older Adults with Mild-Moderate Alzheimer's Disease: Longitudinal Relationships with Adverse Events, Delirium and Falls.

Adam H Dyer, Claire Murphy, Brian Lawlor, Sean P Kennelly, ,

<h4>Background</h4>Older adults are frequently prescribed medications with sedative effects, which are associated with numerous adverse consequences. However, the prevalence and longitudinal associations of sedative medication use in community-dwelling older adults with mild-moderate Alzheimer's disease (AD) has not been explored to date.<h4>Objectives</h4>Our objective was to assess the prevalence of sedative medication ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(11):829-837]

Cited: 1 time

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Arthroscopic thermal stabilization for distal radioulnar joint instability: 3 to 19 years follow-up.

Elizabeth A Helsper, Lisa M Frantz, Jessica M Adams, Harry A Morris, Bernard F Hearon,

This retrospective study investigated the clinical outcomes of patients treated for chronic distal radioulnar joint instability with arthroscopic thermal annealing of the superficial radioulnar ligaments, ulnar palmar wrist ligaments, and dorsoulnar wrist capsule using a radiofrequency probe. Sixty patients (62 wrists) were treated over an 18-year period. At mean follow-up ... Read more >>

J Hand Surg Eur Vol (The Journal of hand surgery, European volume)
[2020, 45(9):916-922]

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Gfral-expressing Neurons Suppress Food Intake via Aversive Pathways

Paul Sabatini, Henriette Frikke-Schmidt, Joe Arthurs, Desiree Gordian, Anita Patel, Jessica Adams, Jine Wang, Sebastien Beck Jørgensen, David Olson, Richard Palmiter, Martin Myers, Randy Seeley,

To determine the function and mechanisms of action for hindbrain neurons that express GFRAL, the receptor for the anorexigenic peptide, GDF-15, we generated Gfral cre and conditional Gfral CreERT mice. While signals of infection or pathophysiologic states (rather than meal ingestion) stimulate GFRAL neurons, the artificial activation of Gfral Cre ... Read more >>

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A Call to Action: The Role of Antiretroviral Stewardship in Inpatient Practice, a Joint Policy Paper of the Infectious Diseases Society of America, HIV Medicine Association, and American Academy of HIV Medicine.

David E Koren, Kimberly K Scarsi, Eric K Farmer, Agnes Cha, Jessica L Adams, Neha Sheth Pandit, Jennifer Chang, James Scott, W David Hardy,

Persons living with human immunodeficiency virus (HIV) and others receiving antiretrovirals are at risk for medication errors during hospitalization and at transitions of care. These errors may result in adverse effects or viral resistance, limiting future treatment options. A range of interventions is described in the literature to decrease the ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(11):2241-2246]

Cited: 2 times

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OR04-03 Calcitonin Receptor Expressing Neurons in the PVH Regulate Feeding Behavior

Ian Enrique Gonzalez, Wenwen Cheng, Warren Pan, Chunxia Lu, Julliana Ramirez-Matias, Hongjuan Pei, Jessica Adams, Allen Zhu, Latrice Doreen Faulkner, Martin Grosvenor Myers, David P Olson,

Abstract The paraventricular nucleus of the hypothalamus (PVH) is a brain region crucial for energy homeostasis. Abnormal PVH development or damage leads to hyperphagic obesity and energy expenditure deficits underscoring the importance of PVH neuronal activity in energy balance control. Application of salmon calcitonin (sCT) to the PVH suppresses feeding ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

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Gait speed, cognition and falls in people living with mild-to-moderate Alzheimer disease: data from NILVAD.

Adam H Dyer, Brian Lawlor, Sean P Kennelly, ,

<h4>Background</h4>Previous evidence suggests that slower gait speed is longitudinally associated with cognitive impairment, dementia and falls in older adults. Despite this, the longitudinal relationship between gait speed, cognition and falls in those with a diagnosis of dementia remains poorly explored. We sought to assess this longitudinal relationship in a cohort ... Read more >>

BMC Geriatr (BMC geriatrics)
[2020, 20(1):117]

Cited: 4 times

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Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance.

Amy K Sutton, Ian E Gonzalez, Marianna Sadagurski, Michael Rajala, Chunxia Lu, Margaret B Allison, Jessica M Adams, Martin G Myers, Morris F White, David P Olson,

Understanding the neural components modulating feeding-related behavior and energy expenditure is crucial to combating obesity and its comorbidities. Neurons within the paraventricular nucleus of the hypothalamus (PVH) are a key component of the satiety response; activation of the PVH decreases feeding and increases energy expenditure, thereby promoting negative energy balance. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5546]

Cited: 3 times

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Guide RNA Engineering Enables Dual Purpose CRISPR-Cpf1 for Simultaneous Gene Editing and Gene Regulation in Yarrowia lipolytica.

Adithya Ramesh, Thomas Ong, Jaime A Garcia, Jessica Adams, Ian Wheeldon,

<i>Yarrowia lipolytica</i> has fast become a biotechnologically significant yeast for its ability to accumulate lipids to high levels. While there exists a suite of synthetic biology tools for genetic engineering in this yeast, there is a need for multipurposed tools for rapid strain generation. Here, we describe a dual purpose ... Read more >>

ACS Synth Biol (ACS synthetic biology)
[2020, 9(4):967-971]

Cited: 3 times

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Delphi assessment of audit and research priorities in an emergency department.

Sinéad M O'Donnell, Anna Carison, Jessica Adams, Elliot Long, Franz E Babl,

<h4>Objective</h4>Audit and research projects in the ED are important to improve patient care but can be time and resource consuming. We identified and prioritised audit and research topics among multidisciplinary ED staff to fill perceived knowledge gaps, encourage engagement, reduce duplication and facilitate translation of evidence into clinical practice.<h4>Methods</h4>A two-stage ... Read more >>

Emerg Med Australas (Emergency medicine Australasia : EMA)
[2020, 32(4):556-561]

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Decreased Tenofovir Diphosphate Concentrations in a Transgender Female Cohort: Implications for Human Immunodeficiency Virus Preexposure Prophylaxis.

Mackenzie L Cottrell, Heather M A Prince, Amanda P Schauer, Craig Sykes, Kaitlyn Maffuid, Amanda Poliseno, Tae-Wook Chun, Erin Huiting, Frank Z Stanczyk, Anne F Peery, Evan S Dellon, Jessica L Adams, Cindy Gay, Angela D M Kashuba,

Feminizing hormone therapy (FHT) may interact with human immunodeficiency virus preexposure prophylaxis (PrEP). We found that transgender women who took FHT exhibited a 7-fold lower rectal tissue ratio of PrEP's active metabolites vs competing deoxynucleotides compared to cisgender women and men (P = .03) that inversely correlated with estradiol (ρ ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 69(12):2201-2204]

Cited: 13 times

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Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.

Wenwen Cheng, Ian Gonzalez, Warren Pan, Anthony H Tsang, Jessica Adams, Ermelinda Ndoka, Desiree Gordian, Basma Khoury, Karen Roelofs, Simon S Evers, Andrew MacKinnon, Shuangcheng Wu, Henriette Frikke-Schmidt, Jonathan N Flak, James L Trevaskis, Christopher J Rhodes, So-Ichiro Fukada, Randy J Seeley, Darleen A Sandoval, David P Olson, Clemence Blouet, Martin G Myers,

To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake, but not aversive responses, by CALCR agonists. Similarly, activating Calcr<sup>NTS</sup> neurons decreased food intake and body weight but ... Read more >>

Cell Metab (Cell metabolism)
[2020, 31(2):301-312.e5]

Cited: 11 times

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Comparison of psychiatric comorbidities and impact on quality of life in patients with epilepsy or psychogenic nonepileptic spells.

Caroline Abe, David Denney, Alexander Doyle, Munro Cullum, Jessica Adams, Ghazala Perven, Hina Dave, Marisara Dieppa, Ryan Hays, Mark Agostini, Kan Ding,

<h4>Objectives</h4>Psychiatric comorbidity is common in people with epilepsy (PWE) and psychogenic nonepileptic spells (PNES). These comorbidities can be detrimental to quality of life (QOL) and are often underdiagnosed and undertreated. Some types of epilepsy, such as focal temporal lobe epilepsy (TLE), have been associated with higher rates of psychiatric comorbidity. ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 102:106649]

Cited: 1 time

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Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living With Mild to Moderate Alzheimer's Disease: Results From NILVAD.

Adam H Dyer, Claire Murphy, Brian Lawlor, Sean P Kennelly, ,

<h4>Objective</h4>Benzodiazepines and related drugs (BDZRs) have been associated with an increased risk of Alzheimer's disease (AD) in later life. Despite this, it remains unclear whether ongoing BDZR use may further accelerate cognitive decline in those diagnosed with mild to moderate AD.<h4>Design</h4>This study was embedded within NILVAD, a randomized controlled trial ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2020, 21(2):194-200]

Cited: 4 times

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Diet, digestion and energy intake in captive common marmosets (Callithrix jacchus): research and management implications.

Michael L Power, Jessica Adams, Kirsten Solonika, Ricki J Colman, Corinna Ross, Suzette D Tardif,

Common marmosets (Callithrix jacchus) are susceptible to intestinal inflammation which leads to chronic diarrhea, weight loss, and vitamin D deficiency. We examined food intake and digestion in three mixed-sex groups of adult marmosets maintained on three commercial base diets. Animals underwent two consecutive 4-day digestion trials. Body mass stayed constant. ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):12134]

Cited: 2 times

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Development of a drug repressible β-catenin mutant mouse to examine effect of activated β-catenin signaling on long-term maintenance of mammary tumor growth

Jennifer Gorman, Jessica Adams, Emma Jones, Sean Egan, James Woodgett,

Stabilized β-catenin expression is a well described initiator of mammary tumorigenesis in the mouse and elevated nuclear expression of this protein has been observed in human triple-negative tumor samples. However, the importance of stabilized β-catenin to continued tumor growth after initiation, and in the context of other driver mutations, has ... Read more >>

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Outcomes of ulnar nerve anterior transmuscular transposition and significance of ulnar nerve instability in cubital tunnel syndrome.

Lisa M Frantz, Jessica M Adams, G Stephen Granberry, Sarah M Johnson, Bernard F Hearon,

<h4>Background</h4>We investigated the experience of a single surgeon with ulnar nerve anterior transmuscular transposition with the patient in the lateral decubitus position for cubital tunnel syndrome.<h4>Methods</h4>The medical records of all patients who underwent primary or revision ulnar nerve anterior transmuscular transposition were screened to define a cohort of 156 patients ... Read more >>

J Shoulder Elbow Surg (Journal of shoulder and elbow surgery)
[2019, 28(6):1120-1129]

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