Full Text Journal Articles by
Author Jerrold S Levine

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Oral high dose vitamin B12 decreases renal superoxide and post-ischemia/reperfusion injury in mice.

Feng Li, Edward M Bahnson, Jennifer Wilder, Robin Siletzky, John Hagaman, Volker Nickekeit, Sylvia Hiller, Azraa Ayesha, Lanfei Feng, Jerrold S Levine, Nobuyuki Takahashi, Nobuyo Maeda-Smithies,

Renal ischemia/reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), a potentially fatal syndrome characterized by a rapid decline in kidney function. Excess production of superoxide contributes to the injury. We hypothesized that oral administration of a high dose of vitamin B12 (B12 - cyanocobalamin), which possesses ... Read more >>

Redox Biol (Redox biology)
[2020, 32:101504]

Cited: 0 times

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Necroptotic cell binding of β2 -glycoprotein I provides a potential autoantigenic stimulus in systemic lupus erythematosus.

David Salem, Rebecca Subang, Erwan Pernet, Maziar Divangahi, Christian Pineau, Romain Cayrol, Jerrold S Levine, Joyce Rauch,

Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies against diverse self-antigens with damage to multiple organs. Immunization with the SLE autoantigen β2 -glycoprotein I (β2 GPI) and lipopolysaccharide (LPS), a known trigger of necroptosis, induces a murine model of SLE. We hypothesized that necroptotic cells, like apoptotic ... Read more >>

Immunol. Cell Biol. (Immunology and cell biology)
[2019, 97(9):799-814]

Cited: 0 times

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Voices from the dead: The complex vocabulary and intricate grammar of dead cells.

Jerrold S Levine, David S Ucker,

Of the roughly one million cells per second dying throughout the body, the vast majority dies by apoptosis, the predominant form of regulated cell death in higher organisms. Long regarded as mere waste, apoptotic cells are now recognized as playing a prominent and active role in homeostatic maintenance, especially resolution ... Read more >>

Adv Protein Chem Struct Biol (Advances in protein chemistry and structural biology)
[2019, 116:1-90]

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Interactive and potentially independent roles of renin-angiotensin-aldosterone system blockade and the development of cardiorenal syndrome type 1 on in-hospital mortality among elderly patients admitted with acute decompensated congestive heart failure.

Jose Iglesias, Savan Ghetiya, Kandria J Ledesma, Chirag S Patel, Jerrold S Levine,

Purpose:Cardiorenal syndrome type 1 (CRS1), defined as worsening renal function from acute decompensated congestive heart failure (ADCHF), is complicated by the fact that CRS1 limits the use of common therapeutic strategies, such as angiotensin converting-enzyme inhibitors (ACEIs) or angiotensin II-receptor blockers (A2RB). The present study examines retrospectively the role of ... Read more >>

Int J Nephrol Renovasc Dis (International journal of nephrology and renovascular disease)
[2019, 12:33-48]

Cited: 0 times

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AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo.

Wilfred Lieberthal, Meiyi Tang, Mersema Abate, Mark Lusco, Jerrold S Levine,

We have reported that preconditioning renal tubular cells (RTCs) with A-769662 [a pharmacological activator of AMP-activated protein kinase (AMPK)] reduces apoptosis of RTCs induced by subsequent stress and ameliorates the severity of ischemic acute kidney injury (AKI) in mice. In the present study, we examined the role of the phosphoinositide ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2019, 317(7):F1-F11]

Cited: 1 time

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Repeated exposure of epithelial cells to apoptotic cells induces the specific selection of an adaptive phenotype: Implications for tumorigenesis.

Lanfei Feng, Snezana Vujicic, Michael E Dietrich, Natalia Litbarg, Suman Setty, Angelika Antoni, Joyce Rauch, Jerrold S Levine,

The consequences of apoptosis extend beyond the mere death of the cell. We have shown that receptor-mediated recognition of apoptotic target cells by viable kidney proximal tubular epithelial cells (PTECs) inhibits PTEC proliferation, growth, and survival. Here, we tested the hypothesis that continual exposure to apoptotic targets can induce a ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2018, 293(26):10245-10263]

Cited: 0 times

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Exploitation of Apoptotic Regulation in Cancer.

David S Ucker, Jerrold S Levine,

Within an organism, environmental stresses can trigger cell death, particularly apoptotic cell death. Apoptotic cells, themselves, are potent regulators of their cellular environment, involved primarily in effecting homeostatic control. Tumors, especially, exist in a dynamic balance of cell proliferation and cell death. This special feature of the tumorous microenvironment-namely, the ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:241]

Cited: 6 times

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T cells from induced and spontaneous models of SLE recognize a common T cell epitope on β2-glycoprotein I.

David Salem, Rebecca Subang, Masataka Kuwana, Jerrold S Levine, Joyce Rauch,

Systemic lupus erythematosus is a prototypic model for B-cell epitope spread in autoimmunity. Autoantibodies to numerous molecularly distinct self-antigens emerge in a sequential manner over several years, leading to disease manifestations. Among the earliest autoantibodies to appear are those targeting phospholipid-binding proteins, particularly β2-glycoprotein I. Notably, mice immunized with β2-glycoprotein ... Read more >>

Cell. Mol. Immunol. (Cellular and Molecular Immunology)
[2019, 16(8):685-693]

Cited: 2 times

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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death.

Snezana Vujicic, Lanfei Feng, Angelika Antoni, Joyce Rauch, Jerrold S Levine,

Cells dying by apoptosis, also referred to as regulated cell death, acquire multiple new activities that enable them to influence the function of adjacent live cells. Vital activities, such as survival, proliferation, growth, and differentiation, are among the many cellular functions modulated by apoptotic cells. The ability to recognize and ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2016, (118):]

Cited: 2 times

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Preconditioning mice with activators of AMPK ameliorates ischemic acute kidney injury in vivo.

Wilfred Lieberthal, Meiyi Tang, Mark Lusco, Mersema Abate, Jerrold S Levine,

This study had two objectives: 1) to determine whether preconditioning cultured proximal tubular cells (PTCs) with pharmacological activators of AMP-activated protein kinase (AMPK) protects these cells from apoptosis induced by metabolic stress in vitro and 2) to assess the effects of preconditioning mice with these agents on the severity of ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2016, 311(4):F731-F739]

Cited: 4 times

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β2-Glycoprotein I-specific T cells are associated with epitope spread to lupus-related autoantibodies.

David Salem, Rebecca Subang, Yuka Okazaki, Patrick Laplante, Jerrold S Levine, Masataka Kuwana, Joyce Rauch,

Systemic lupus erythematosus (SLE) is a prototypic model for B cell epitope spread in autoimmunity. Autoantibodies to numerous and molecularly distinct self-antigens emerge in a sequential manner over several years, leading to disease manifestations. Among the earliest autoantibodies to appear are those targeting the apoptotic cell-binding protein β2-glycoprotein I (β2GPI). ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2015, 290(9):5543-5555]

Cited: 4 times

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Susceptibility to ATP depletion of primary proximal tubular cell cultures derived from mice lacking either the α1 or the α2 isoform of the catalytic domain of AMPK.

Wilfred Lieberthal, Meiyi Tang, Leiqing Zhang, Benoit Viollet, Vimal Patel, Jerrold S Levine,

BACKGROUND: The purpose of this study was to determine whether AMPK influences the survival of primary cultures of mouse proximal tubular (MPT) cells subjected to metabolic stress. Previous studies, using an immortalized MPT cell line, suggest that AMPK is activated during metabolic stress, and ameliorates stress-induced apoptosis of these cells. ... Read more >>

BMC Nephrol (BMC nephrology)
[2013, 14:251]

Cited: 2 times

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Predictors of renal recovery in patients with pre-orthotopic liver transplant (OLT) renal dysfunction.

Jose Iglesias, Elliot Frank, Sushil Mehandru, John M Davis, Jerrold S Levine,

BACKGROUND: Renal dysfunction occurs commonly in patients awaiting orthotopic liver transplantation (OLT) for end-stage liver disease. The use of simultaneous liver-kidney transplantation has increased in the MELD scoring era. As patients may recover renal function after OLT, identifying factors predictive of renal recovery is a critical issue, especially given the ... Read more >>

BMC Nephrol (BMC nephrology)
[2013, 14:147]

Cited: 6 times

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Mammalian target of rapamycin and the kidney. I. The signaling pathway.

Wilfred Lieberthal, Jerrold S Levine,

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a fundamental role in regulating cellular homeostasis and metabolism. In a two-part review, we examine the complex molecular events involved in the regulation and downstream effects of mTOR, as well as the pivotal role played by this kinase ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2012, 303(1):F1-10]

Cited: 37 times

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Recognition-dependent signaling events in response to apoptotic targets inhibit epithelial cell viability by multiple mechanisms: implications for non-immune tissue homeostasis.

Vimal A Patel, Lanfei Feng, Daniel J Lee, Donald Massenburg, Goutham Pattabiraman, Angelika Antoni, John H Schwartz, Wilfred Lieberthal, Joyce Rauch, David S Ucker, Jerrold S Levine,

Apoptosis allows for the removal of damaged, aged, and/or excess cells without harm to surrounding tissue. To accomplish this, cells undergoing apoptosis acquire new activities that enable them to modulate the fate and function of nearby cells. We have shown that receptor-mediated recognition of apoptotic versus necrotic target cells by ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2012, 287(17):13761-13777]

Cited: 5 times

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Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implications.

Wilfred Lieberthal, Jerrold S Levine,

The mTOR pathway plays an important role in a number of common renal diseases, including acute kidney injury (AKI), diabetic nephropathy (DN), and polycystic kidney diseases (PKD). The activity of mTOR complex 1 (mTORC1) is necessary for renal regeneration and repair after AKI, and inhibition of mTORC1 by rapamycin has ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2012, 303(2):F180-91]

Cited: 28 times

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AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation.

Wilfred Lieberthal, Leiqing Zhang, Vimal A Patel, Jerrold S Levine,

We examined the role of AMP-activated protein kinase (AMPK) in modulating the viability of cultured kidney proximal tubular cells subjected to metabolic stress induced by either dextrose deprivation, inhibition of glycolysis, or inhibition of mitochondrial respiration. We used BU.MPT cells, a conditionally immortalized kidney epithelial cell line derived from the ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2011, 301(6):F1177-92]

Cited: 22 times

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Association of autoantibodies to heat-shock protein 60 with arterial vascular events in patients with antiphospholipid antibodies.

Mélanie Dieudé, José A Correa, Carolyn Neville, Christian Pineau, Jerrold S Levine, Rebecca Subang, Carolina Landolt-Marticorena, Jiandong Su, Jeannine Kassis, Susan Solymoss, Paul R Fortin, Joyce Rauch,

Anti-heat shock protein 60 autoantibodies (anti-Hsp60) are associated with cardiovascular disease and are known to affect endothelial cells in vitro, and we have recently shown that anti-Hsp60 promote thrombosis in a murine model of arterial injury. Based on those findings, we undertook the present study to investigate the hypothesis that ... Read more >>

Arthritis Rheum. (Arthritis and rheumatism)
[2011, 63(8):2416-2424]

Cited: 6 times

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Macrophages from lupus-prone MRL mice have a conditional signaling abnormality that leads to dysregulated expression of numerous genes.

Angelika Antoni, Vimal A Patel, Hanli Fan, Daniel J Lee, Lee H Graham, Cristen L Rosch, Daniel S Spiegel, Joyce Rauch, Jerrold S Levine,

Macrophages (mϕ) from pre-diseased mice of the major murine inbred models of spontaneous autoimmunity (AI), including multiple lupus-prone strains and the type I diabetes-prone NOD (non-obese diabetic) strain, have identical apoptotic target-dependent abnormalities. This characteristic feature of mϕ from AI-prone mice suggests that abnormal signaling events induced within mϕ following ... Read more >>

Immunogenetics (Immunogenetics)
[2011, 63(5):291-308]

Cited: 2 times

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Cardiolipin binds to CD1d and stimulates CD1d-restricted γδ T cells in the normal murine repertoire.

Mélanie Dieudé, Harald Striegl, Aaron J Tyznik, Jing Wang, Samuel M Behar, Ciriaco A Piccirillo, Jerrold S Levine, Dirk M Zajonc, Joyce Rauch,

Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune system in mammalian mitochondria and is, therefore, a potential danger signal. Based on growing evidence that phospholipids constitute natural ligands for CD1 and that CD1d-restricted T cells recognize phospholipids, we hypothesized that CD1d binds and presents ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2011, 186(8):4771-4781]

Cited: 55 times

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IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.

Nadera J Sweiss, Ronghai Bo, Reena Kapadia, Deborah Manst, Farzan Mahmood, Tara Adhikari, Suncica Volkov, Maria Badaracco, Mary Smaron, Anthony Chang, Joseph Baron, Jerrold S Levine,

BACKGROUND:The clinical utility of testing for antiphospholipid antibodies (aPL) of IgA isotype remains controversial. METHODOLOGY/PRINCIPAL FINDINGS:To address this issue, we reasoned that if IgA aPL contribute to the clinical manifestations of the antiphospholipid syndrome, then an association with thromboembolic events should manifest in patients whose only aPL is of IgA ... Read more >>

PLoS ONE (PloS one)
[2010, 5(8):e12280]

Cited: 25 times

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Risk factors for acute kidney injury following orthotopic liver transplantation: the impact of changes in renal function while patients await transplantation.

Jose I Iglesias, John A DePalma, Jerrold S Levine,

BACKGROUND: Acute kidney injury (AKI) occurs commonly in the setting of orthotopic liver transplantation (OLT). To date, the correlation between AKI post-OLT and pre-operative changes in renal function has not been rigorously examined. METHODS: To determine the impact of pre-OLT changes in renal function on AKI post-OLT, as well as ... Read more >>

BMC Nephrol (BMC nephrology)
[2010, 11:30]

Cited: 19 times

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The role of the mammalian target of rapamycin (mTOR) in renal disease.

Wilfred Lieberthal, Jerrold S Levine,

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a pivotal role in mediating cell size and mass, proliferation, and survival. mTOR has also emerged as an important modulator of several forms of renal disease. mTOR is activated after acute kidney injury and contributes to renal regeneration ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2009, 20(12):2493-2502]

Cited: 137 times

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Altered cell-cell and cell-matrix interactions in the development of systemic autoimmunity.

Angelika Antoni, Lee H Graham, Joyce Rauch, Jerrold S Levine,

MPhi of mice from the major inbred models of systemic lupus erythematosus (SLE) have an identical defect affecting the activity of the cytoskeletal regulator and G-protein Rho. This abnormality is triggered by apo cells. Strikingly, SLE-prone MPhi show normal Rho activity when cultured in the absence of apo cells. We ... Read more >>

Autoimmunity (Autoimmunity)
[2009, 42(4):278-281]

Cited: 1 time

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T cells demonstrate a Th1-biased response to native beta2-glycoprotein I in a murine model of anti-phospholipid antibody induction.

Tanya Tolomeo, Angela Rico De Souza, Evan Roter, Mélanie Dieudé, Pascal Amireault, Rebecca Subang, Jerrold S Levine, Joyce Rauch,

Anti-phospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of autoantibody (AAb) to phospholipid (PL)-binding proteins, such as beta2-glycoprotein I (beta2GPI), and clinical manifestations including thrombosis and/or recurrent pregnancy loss. beta2GPI-reactive T cells are clearly implicated in the generation of these AAb, but the mechanism responsible for their ... Read more >>

Autoimmunity (Autoimmunity)
[2009, 42(4):292-295]

Cited: 14 times

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