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Author Jenny Ostrop

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A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial maturation

Jenny Ostrop, Rosalie Zwiggelaar, Marianne Terndrup Pedersen, François Gerbe, Korbinian Bösl, Håvard Lindholm, Alberto Díez-Sánchez, Naveen Parmar, Silke Radetzki, Jens Peter von Kries, Philippe Jay, Kim Jensen, Cheryl Arrowsmith, Menno Oudhoff,

Abstract Intestinal organoids are an excellent model to study epithelial biology. Yet, the selection of analytical tools to accurately quantify heterogeneous organoid cultures remains limited. Here, we developed a semi-automated organoid screening method, which we applied to a library of highly specific chemical probes to identify epigenetic regulators of intestinal ... Read more >>

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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.

Rosalie T Zwiggelaar, Håvard T Lindholm, Madeleine Fosslie, Marianne Terndrup Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos R Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim B Jensen, Toshiro Sato, Menno J Oudhoff,

Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that lysine-specific demethylase ... Read more >>

Sci Adv (Science advances)
[2020, 6(37):]

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Developmental pathways regulate cytokine-driven effector and feedback responses in the intestinal epithelium

Håvard Lindholm, Naveen Parmar, Claire Drurey, Jenny Ostrop, Alberto Díez-Sanchez, Rick Maizels, Menno Oudhoff,

Abstract The intestinal tract is a common site for infection, and it relies on an appropriate immune response to defend against pathogens. The intestinal epithelium has an important role in effector responses, which is coordinated by immune-type specific cytokines. It is incompletely understood how cytokines drive epithelial responses. Here, using ... Read more >>

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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium

Rosalie Zwiggelaar, Håvard Lindholm, Madeleine Fosslie, Marianne Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim Jensen, Toshiro Sato, Menno Oudhoff,

ABSTRACT Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify new regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that ... Read more >>

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Contact, Collaboration, and Conflict: Signal Integration of Syk-Coupled C-Type Lectin Receptors.

Jenny Ostrop, Roland Lang,

Several spleen tyrosine kinase-coupled C-type lectin receptors (CLRs) have emerged as important pattern recognition receptors for infectious danger. Because encounter with microbial pathogens leads to the simultaneous ligation of several CLRs and TLRs, the signals emanating from different pattern recognition receptors have to be integrated to achieve appropriate biological responses. ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2017, 198(4):1403-1414]

Cited: 19 times

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Stat6-Dependent Inhibition of Mincle Expression in Mouse and Human Antigen-Presenting Cells by the Th2 Cytokine IL-4.

Thomas Hupfer, Judith Schick, Katrin Jozefowski, David Voehringer, Jenny Ostrop, Roland Lang,

The C-type lectin receptors (CLRs) Mincle, Mcl, and Dectin-2 bind mycobacterial and fungal cell wall glycolipids and carbohydrates. Recently, we described that expression of these CLR is downregulated during differentiation of human monocytes to dendritic cells (DC) in the presence of GM-CSF and IL-4. Here, we demonstrate that the Th2 ... Read more >>

Front Immunol (Frontiers in immunology)
[2016, 7:423]

Cited: 6 times

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Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB.

Jenny Ostrop, Katrin Jozefowski, Stephanie Zimmermann, Katharina Hofmann, Erwin Strasser, Bernd Lepenies, Roland Lang,

Trehalose-6,6-dimycolate (TDM), the mycobacterial cord factor, is an abundant cell wall glycolipid and major virulence factor of Mycobacterium tuberculosis. Its synthetic analog trehalose-6,6-dibehenate (TDB) is a new adjuvant currently in phase I clinical trials. In rodents, the C-type lectin receptors Mincle and Mcl bind TDB/TDM and activate macrophages and dendritic ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2015, 195(5):2417-2428]

Cited: 40 times

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Heterogeneity of host TLR2 stimulation by Staphylocoocus aureus isolates.

Dina Hilmi, Marijo Parcina, Daniel Stollewerk, Jenny Ostrop, Michaele Josten, Alina Meilaender, Ulrich Zaehringer, Thomas A Wichelhaus, Gabriele Bierbaum, Klaus Heeg, Christiane Wolz, Isabelle Bekeredjian-Ding,

High lipoprotein expression and potent activation of host Toll-like receptor-2 (TLR2) are characteristic features of the staphylococcal species. Expression of TLR2 in the host is important for clearance of Staphylococcus aureus infection and host survival. Thus, we hypothesized that bacterial regulation of its intrinsic TLR2-stimulatory capacity could represent a means ... Read more >>

PLoS One (PloS one)
[2014, 9(5):e96416]

Cited: 17 times

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Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interaction.

Dina Hilmi, Marijo Parcina, Konrad Bode, Jenny Ostrop, Sabine Schuett, Klaus Heeg, Wilma Ziebuhr, Olaf Sommerburg, Isabelle Bekeredjian-Ding,

It is well acknowledged that genetic variation accounts for the intra-species variability in Staphylococcus aureus isolates. Similarly, deficiency in DNA repair and the resulting increase in genomic mutations determine intra-strain variability in S. aureus small colony variants (SCV). The aim of this study was to investigate whether intra-strain diversity would ... Read more >>

Int J Med Microbiol (International journal of medical microbiology : IJMM)
[2013, 303(2):61-69]

Cited: 6 times

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Induction of type I IFN is a physiological immune reaction to apoptotic cell-derived membrane microparticles.

Martin Schiller, Marijo Parcina, Petra Heyder, Sandra Foermer, Jenny Ostrop, Albrecht Leo, Klaus Heeg, Martin Herrmann, Hanns-Martin Lorenz, Isabelle Bekeredjian-Ding,

Membrane microparticles (MMP) released from apoptotic cells deliver signals that secure the anti-inflammatory response beyond the nearest proximity of the apoptotic cell. Plasmacytoid dendritic cells (pDC) are sentinels prepared to detect cellular processes that endanger the organism. They play a key role in the regulation of both pro- and anti-inflammatory ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2012, 189(4):1747-1756]

Cited: 29 times

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