Full Text Journal Articles by
Author Jenny Higham

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Taking the Pressure off the Patient - Understanding Digital Rectal Examinations on a Real Subject.

Alejandro Granados, Seth Cox, Naomi Low-Beer, Jenny Higham, Roger Kneebone, Fernando Bello,

Better understanding of palpation techniques during unsighted physical examinations has mostly been limited to qualitative and quantitative studies of performance of experts whilst conducting examinations on plastic benchtop models. However, little is known about their performance when conducting such examinations on real subjects. OBJECTIVE:The aim of this paper is to ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2020, :]

Cited: 0 times

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Real-time Visualisation and Analysis of Clinicians' Performance during Palpation in Physical Examinations.

Alejandro Granados, Naomi Low-Beer, Jenny Higham, Roger Kneebone, Fernando Bello,

OBJECTIVE:Motivated by the fact that palpation skills are challenging to learn and teach, particularly during Digital Rectal Examinations (DRE), and the lack of understanding of what constitutes adequate performance, we present a visualisation and analysis system that uses small position and pressure sensors located on the examining finger, allowing the ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2018, 65(9):2042-2051]

Cited: 0 times

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Standardizing bimanual vaginal examination using cognitive task analysis.

Isabella Plumptre, Omar Mulki, Alejandro Granados, Claudine Gayle, Shahla Ahmed, Naomi Low-Beer, Jenny Higham, Fernando Bello,

To create a standardized universal list of procedural steps for bimanual vaginal examination (BVE) for teaching, assessment, and simulator development.This observational study, conducted from June-July 2012 and July-December 2014, collected video data of 10 expert clinicians performing BVE in a nonclinical environment. Video data were analyzed to produce a cognitive ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2017, 139(1):114-119]

Cited: 0 times

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Outcome measures for heavy menstrual bleeding.

Stephen D Quinn, Jenny Higham,

Heavy menstrual bleeding is one of the most commonly encountered gynecological problems. While accurate objective quantification of menstrual blood loss is of value in the research setting, it is the subjective assessment of blood loss that is of greater importance when assessing the severity of heavy menstrual bleeding and any ... Read more >>

Womens Health (Lond) (Women's health (London, England))
[2016, 12(1):21-26]

Cited: 2 times

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Real-time visualisation and analysis of internal examinations--seeing the unseen.

Alejandro Granados, Niels Hald, Aimee Di Marco, Shahla Ahmed, Naomi Low-Beer, Jenny Higham, Roger Kneebone, Fernando Bello,

Internal examinations such as Digital Rectal Examination (DRE) and bimanual Vaginal Examination (BVE) are routinely performed for early diagnosis of cancer and other diseases. Although they are recognised as core skills to be taught on a medical curriculum, they are difficult to learn and teach due to their unsighted nature. ... Read more >>

Med Image Comput Comput Assist Interv (Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention)
[2014, 17(Pt 1):617-625]

Cited: 1 time

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Estimating and comparing the reliability of a suite of workplace-based assessments: an obstetrics and gynaecology setting.

Matt Homer, Zeryab Setna, Vikram Jha, Jenny Higham, Trudie Roberts, Katherine Boursicot,

This paper reports on a study that compares estimates of the reliability of a suite of workplace based assessment forms as employed to formatively assess the progress of trainee obstetricians and gynaecologists. The use of such forms of assessment is growing nationally and internationally in many specialties, but there is ... Read more >>

Med Teach (Medical teacher)
[2013, 35(8):684-691]

Cited: 2 times

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Progestogens with or without oestrogen for irregular uterine bleeding associated with anovulation.

Martha Hickey, Jenny M Higham, Ian Fraser,

BACKGROUND:Irregular menstrual bleeding may arise due to exogenous sex steroids, lesions of the genital tract or be associated with anovulation. Irregular bleeding due to oligo/anovulation (previously called dysfunctional uterine bleeding or DUB) is more common at the extremes of reproductive life, and in women with ovulatory disorders such as polycystic ... Read more >>

Cochrane Database Syst Rev (The Cochrane Database of Systematic Reviews)
[2012, (9):CD001895]

Cited: 3 times

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Key challenges in simulated patient programs: an international comparative case study.

Debra Nestel, Diana Tabak, Tanya Tierney, Carine Layat-Burn, Anja Robb, Susan Clark, Tracy Morrison, Norma Jones, Rachel Ellis, Cathy Smith, Nancy McNaughton, Kerry Knickle, Jenny Higham, Roger Kneebone,

The literature on simulated or standardized patient (SP) methodology is expanding. However, at the level of the program, there are several gaps in the literature. We seek to fill this gap through documenting experiences from four programs in Australia, Canada, Switzerland and the United Kingdom. We focused on challenges in ... Read more >>

BMC Med Educ (BMC medical education)
[2011, 11:69]

Cited: 9 times

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A toolkit to meet Tomorrow's Doctors standards.

Aaron Vallance, Jenny Higham,

Med Educ (Medical education)
[2011, 45(5):508]

Cited: 2 times

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The poly(c)-binding protein-1 regulates expression of the androgen receptor.

Brianna Cloke, Kunal Shah, Hiroshi Kaneda, Stuart Lavery, Geoffrey Trew, Luca Fusi, Jenny Higham, Roberto E Dina, Sadaf Ghaem-Maghami, Patricia Ellis, Jan J Brosens, Mark Christian,

The androgen receptor (AR) is a ligand-dependent transcription factor, expressed in male and female reproductive organs, and essential for normal reproduction in both sexes. The levels of AR are tightly controlled in androgen-responsive cells in which it plays a central role in the regulation of target gene expression. The AR ... Read more >>

Endocrinology (Endocrinology)
[2010, 151(8):3954-3964]

Cited: 19 times

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Hidden practice revealed: using task analysis and novel simulator design to evaluate the teaching of digital rectal examination.

Naomi Low-Beer, Tierney Kinnison, Sarah Baillie, Fernando Bello, Roger Kneebone, Jenny Higham,

BACKGROUND: during traditional teaching of digital rectal examination (DRE), accurate visual demonstration is not possible, because the examining finger is hidden from view. The aim of this study was to identify the steps involved in performing DRE and the ability of teachers to verbalize and demonstrate these steps. METHODS: a ... Read more >>

Am. J. Surg. (American journal of surgery)
[2011, 201(1):46-53]

Cited: 10 times

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NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling.

Marwa Al-Sabbagh, Luca Fusi, Jenny Higham, Yun Lee, Kaiyu Lei, Aylin C Hanyaloglu, Eric W-F Lam, Mark Christian, Jan J Brosens,

Differentiation of human endometrial stromal cells into specialized decidual cells is critical for embryo implantation and survival of the conceptus. Initiation of this differentiation process is strictly dependent on elevated cAMP levels, but the signal intermediates that control the expression of decidual marker genes, such as prolactin (PRL) and IGFBP1, ... Read more >>

Endocrinology (Endocrinology)
[2011, 152(2):730-740]

Cited: 19 times

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A novel method of defining the core objectives of a specialty undergraduate curriculum.

Naomi Low-Beer, Martin Lupton, Jenny Higham,

Med Educ (Medical education)
[2010, 44(11):1120]

Cited: 0 times

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Defining responsibilities of simulated patients in medical education.

Debra Nestel, Susan Clark, Diana Tabak, Victoria Ashwell, Elizabeth Muir, Paraskeva Paraskevas, Jenny Higham,

BACKGROUND: Simulated patients (SPs) play a critical role in medical education. The development of SP methodology has resulted in wide ranging responsibilities. For SPs to work effectively, we believed it was important to clearly articulate their responsibilities, and that this would be best achieved by consultation with all stakeholders-SPs, students, ... Read more >>

Simul Healthc (Simulation in healthcare : journal of the Society for Simulation in Healthcare)
[2010, 5(3):161-168]

Cited: 11 times

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Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals.

Beatriz Leitao, Marius C Jones, Luca Fusi, Jenny Higham, Yun Lee, Masashi Takano, Tomoko Goto, Mark Christian, Eric W-F Lam, Jan J Brosens,

Survival of the conceptus is dependent on continuous progesterone signaling in the maternal decidua but how this is achieved under conditions of oxidative stress that characterize early pregnancy is unknown. Using primary cultures, we show that modest levels of reactive oxygen species (ROS) increase sumoylation in human endometrial stromal cells ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2010, 24(5):1541-1551]

Cited: 36 times

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Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis.

Jan J Brosens, Andrea Hodgetts, Fahkera Feroze-Zaidi, J Robert A Sherwin, Luca Fusi, Madhuri S Salker, Jenny Higham, Gillian L Rose, Takeshi Kajihara, Steven L Young, Bruce A Lessey, Patrick Henriet, Paul R Langford, Asgerally T Fazleabas,

Pregnancy is dependent upon the endometrium acquiring a receptive phenotype that facilitates apposition, adhesion and invasion of a developmentally competent embryo. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry of mid-secretory endometrial biopsies revealed a 28 kDa protein peak that discriminated highly between samples obtained from women with recurrent implantation failure and ... Read more >>

Mol. Hum. Reprod. (Molecular human reproduction)
[2010, 16(4):273-285]

Cited: 25 times

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Role and regulation of the serum- and glucocorticoid-regulated kinase 1 in fertile and infertile human endometrium.

Fakhera Feroze-Zaidi, Luca Fusi, Masashi Takano, Jenny Higham, Madhuri S Salker, Tomoko Goto, Seby Edassery, Karin Klingel, Krishna Murthy Boini, Monica Palmada, Rick Kamps, Patrick G Groothuis, Eric W-F Lam, Stephen K Smith, Florian Lang, Andrew M Sharkey, Jan J Brosens,

Using cDNA microarray analysis, we identified SGK1 (serum- and glucocorticoid-regulated kinase 1) as a gene aberrantly expressed in midsecretory endometrium of women with unexplained infertility. SGK1 is a serine/threonine kinase involved primarily in epithelial ion transport and cell survival responses. Real-time quantitative PCR analysis of a larger, independent sample set ... Read more >>

Endocrinology (Endocrinology)
[2007, 148(10):5020-5029]

Cited: 36 times

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Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells.

Masashi Takano, Zhenxiao Lu, Tomoko Goto, Luca Fusi, Jenny Higham, Julia Francis, Anna Withey, Jennifer Hardt, Brianna Cloke, Alexandra V Stavropoulou, Osamu Ishihara, Eric W-F Lam, Terry G Unterman, Jan J Brosens, J Julie Kim,

Differentiation of human endometrial stromal cells (HESCs) into decidual cells is associated with induction of the forkhead transcription factor forkhead box O1A (FOXO1). We performed a genomic screen to identify decidua-specific genes under FOXO1 control. Primary HESCs were transfected with small interfering RNA targeting FOXO1 or with nontargeting control small ... Read more >>

Mol. Endocrinol. (Molecular endocrinology (Baltimore, Md.))
[2007, 21(10):2334-2349]

Cited: 102 times

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Diagnosis of abnormal uterine bleeding.

Shruti Mohan, Louise M Page, Jenny M Higham,

Abnormal uterine bleeding is an extremely common indication for referral to a gynaecologist. This chapter examines the modes of presentation and the causes of such symptoms, which range from physiological variations to more sinister underlying pathology. A thorough understanding of these causes is required to direct investigation in an appropriate ... Read more >>

Best Pract Res Clin Obstet Gynaecol (Best practice & research. Clinical obstetrics & gynaecology)
[2007, 21(6):891-903]

Cited: 4 times

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Exploring the underperformance of male and minority ethnic medical students in first year clinical examinations.

Katherine Woolf, Inam Haq, I Chris McManus, Jenny Higham, Jane Dacre,

Evidence shows that medical students from Minority Ethnic (ME) backgrounds and male medical students underperform in undergraduate examinations. Our study confirmed these findings in first year clinical (year 3) medical students, and further explored this disparity in performance. We conducted a series of meta-analyses to measure the effects of sex ... Read more >>

Adv Health Sci Educ Theory Pract (Advances in health sciences education : theory and practice)
[2008, 13(5):607-616]

Cited: 32 times

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Effect of ethnicity and gender on performance in undergraduate medical examinations.

Inam Haq, Jenny Higham, Richard Morris, Jane Dacre,

OBJECTIVE: To assess the effect of ethnicity and gender on medical student examination performance. DESIGN: Cohort study of Year 3 medical students in 2002 and 2003. SETTING: Royal Free and University College Medical School, Imperial College School of Medicine. SUBJECTS: A total of 1216 Year 3 medical students, of whom ... Read more >>

Med Educ (Medical education)
[2005, 39(11):1126-1128]

Cited: 55 times

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Current themes in the teaching of obstetrics and gynaecology in the United Kingdom.

Jenny Higham,

Med Teach (Medical teacher)
[2006, 28(6):495-496]

Cited: 2 times

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Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone.

Marius C Jones, Luca Fusi, Jenny H Higham, Hany Abdel-Hafiz, Kathryn B Horwitz, Eric W-F Lam, Jan J Brosens,

cAMP is required for differentiation of human endometrial stromal cells (HESCs) into decidual cells in response to progesterone, although the underlying mechanism is not well understood. We now demonstrate that cAMP signaling attenuates ligand-dependent sumoylation of the progesterone receptor (PR) in HESCs. In fact, decidualization is associated with global hyposumoylation ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2006, 103(44):16272-16277]

Cited: 62 times

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Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization.

Takeshi Kajihara, Marius Jones, Luca Fusi, Masashi Takano, Fakhera Feroze-Zaidi, Grisha Pirianov, Huseyin Mehmet, Osamu Ishihara, Jenny M Higham, Eric W-F Lam, Jan J Brosens,

The integrity of the feto-maternal interface is critical for survival of the conceptus. This interface, consisting of the maternal decidua and the invading placental trophoblast, is exposed to profound changes in oxygen tension during pregnancy. We demonstrate that human endometrial stromal cells become extraordinarily resistant to oxidative stress-induced apoptosis upon ... Read more >>

Mol. Endocrinol. (Molecular endocrinology (Baltimore, Md.))
[2006, 20(10):2444-2455]

Cited: 85 times

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Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium.

Soraya Labied, Takeshi Kajihara, Patricia A Madureira, Luca Fusi, Marius C Jones, Jenny M Higham, Rana Varshochi, Julia M Francis, Georgia Zoumpoulidou, Abdelkader Essafi, Silvia Fernandez de Mattos, Eric W-F Lam, Jan J Brosens,

Menstruation, or cyclic shedding of nonpregnant endometrial tissue with associated bleeding, occurs only in humans and a few other species. This breakdown of the endometrium in response to falling ovarian progesterone levels is a complex process, characterized by local leukocyte infiltration, expression and activation of matrix metalloproteinases, and apoptosis. Spontaneous ... Read more >>

Mol. Endocrinol. (Molecular endocrinology (Baltimore, Md.))
[2006, 20(1):35-44]

Cited: 67 times

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