Full Text Journal Articles by
Author Jenny Epstein

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Adaptations to the current ECCO/ESPGHAN guidelines on the management of paediatric acute severe colitis in the context of the COVID-19 pandemic: a RAND appropriateness panel.

Richard Hansen, Susanna Meade, R Mark Beattie, Marcus Kh Auth, Nick Croft, Philip Davies, David Devadason, Conor Doherty, Jenny Epstein, Lucy Howarth, Fevronia Kiparissi, Rafeeq Muhammed, Vinay Shivamurthy, Christine Spray, Michael P Stanton, Franco Torrente, Arun Urs, David Wilson, Peter M Irving, Mark Samaan, Jochen Kammermeier,

<h4>Objective</h4>Paediatric acute severe colitis (ASC) management during the novel SARS-CoV-2/COVID-19 pandemic is challenging due to reliance on immunosuppression and the potential for surgery. We aimed to provide COVID-19-specific guidance using the European Crohn's and Colitis Organisation/European Society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines for comparison.<h4>Design</h4>We convened a RAND appropriateness ... Read more >>

Gut (Gut)
[2020, :]

Cited: 0 times

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Multiomic features associated with mucosal healing and inflammation in paediatric Crohn's disease.

Henry Taylor, Jose Ivan Serrano-Contreras, Julie A K McDonald, Jenny Epstein, J M Fell, Rocio C Seoane, Jia V Li, Julian R Marchesi, Ailsa L Hart,

<h4>Background</h4>The gastrointestinal microbiota has an important role in mucosal immune homoeostasis and may contribute to maintaining mucosal healing in Crohn's disease (CD).<h4>Aim</h4>To identify changes in the microbiota, metabolome and protease activity associated with mucosal healing in established paediatric CD METHODS: Twenty-five participants aged 3-18 years with CD, disease duration of ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2020, 52(9):1491-1502]

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Impact of COVID-19 on diagnosis and management of paediatric inflammatory bowel disease during lockdown: a UK nationwide study.

James John Ashton, Jochen Kammermeier, Christine Spray, Richard K Russell, Richard Hansen, Lucy J Howarth, Franco Torrente, Protima Deb, Elizabeth Renji, Rafeeq Muhammed, Thankam Paul, Fevronia Kiparissi, Jenny Epstein, Maureen Lawson, Ben Hope, Veena Zamvar, Priya Narula, Ahmed Kadir, David Devadason, Hemant Bhavsar, Robert Mark Beattie,

<h4>Background</h4>COVID-19 has impacted on healthcare provision. Anecdotally, investigations for children with inflammatory bowel disease (IBD) have been restricted, resulting in diagnosis with no histological confirmation and potential secondary morbidity. In this study, we detail practice across the UK to assess impact on services and document the impact of the pandemic.<h4>Methods</h4>For ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, 105(12):1186-1191]

Cited: 1 time

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Management of Crohn's disease: summary of updated NICE guidance.

Rui Martins, Chris Carmona, Bruce George, Jenny Epstein, ,

BMJ (BMJ (Clinical research ed.))
[2019, 367:l5940]

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Management of ulcerative colitis: summary of updated NICE guidance.

Omnia Abdulrazeg, Bernadette Li, Jenny Epstein, ,

BMJ (BMJ (Clinical research ed.))
[2019, 367:l5897]

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Consensus standards of healthcare for adults and children with inflammatory bowel disease in the UK.

Rukshana Kapasi, Jackie Glatter, Christopher A Lamb, Austin G Acheson, Charles Andrews, Ian D Arnott, Kevin J Barrett, Graham Bell, Guaraang Bhatnagar, Stuart Bloom, Matthew James Brookes, Steven R Brown, Nicola Burch, Andy Burman, Kay Crook, Jr Fraser Cummings, Justin Davies, Anne Demick, Jenny Epstein, Omar Faiz, Roger Feakins, Melissa Fletcher, Vikki Garrick, Bruce Jaffray, Matthew Johnson, Katie Keetarut, Jimmy Limdi, Uchu Meade, Rafeeq Muhammed, Andrew Murdock, Nick Posford, Georgina Rowse, Ian Shaw, Anja St Clair Jones, Stuart Taylor, Sean Weaver, Lisa Younge, Antony Barney Hawthorne,

Objective:Symptoms and clinical course during inflammatory bowel disease (IBD) vary among individuals. Personalised care is therefore essential to effective management, delivered by a strong patient-centred multidisciplinary team, working within a well-designed service. This study aimed to fully rewrite the UK Standards for the healthcare of adults and children with IBD, ... Read more >>

Frontline Gastroenterol (Frontline gastroenterology)
[2020, 11(3):178-187]

Cited: 2 times

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Safety and efficacy of parenteral iron in children with inflammatory bowel disease.

Michael Papadopoulos, Deepa Patel, Roxanna Korologou-Linden, Eunice Goto, Krishna Soondrum, John M E Fell, Jenny Epstein,

<h4>Aims</h4>Iron deficiency anaemia frequently complicates inflammatory bowel disease (IBD) in children and adults. Oral iron may exacerbate gastrointestinal symptoms and absorption may be insufficient in intestinal inflammation. Even where oral iron is successful, repletion of iron stores can be unacceptably slow. Intravenous iron compounds were in the past associated with ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2018, 84(4):694-699]

Cited: 3 times

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Oral Iron Treatment Response and Predictors in Anaemic Adolescents and Adults with IBD: A Prospective Controlled Open-Label Trial.

David S Rampton, James R Goodhand, Neerav M Joshi, Abu-Bakarr Karim, Yasmine Koodun, Farah M Barakat, Lucia Macken, Douglas G Ward, Tariq H Iqbal, Jenny Epstein, John M Fell, Ian R Sanderson,

<h4>Background</h4>Because of previous concerns about the efficacy and safety of oral iron for treating iron deficiency anaemia in inflammatory bowel disease [IBD], particularly in young people, we compared the effects of ferrous sulphate on haemoglobin response, disease activity and psychometric scores in adolescents and adults with IBD. We also assessed ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2017, 11(6):706-715]

Cited: 6 times

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Local chemokine profiling in eosinophilic esophagitis: The synthetic absorptive matrix test.

Eleanor Minshall, Harsita Patel, Nicholas Francis, Trevor T Hansel, John O Warner, Robert J Boyle, John Fell, Jenny Epstein,

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2017, 28(1):100-102]

Cited: 0 times

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Assessing the Colonic Microbiota in Children: Effects of Sample Site and Bowel Preparation.

Alexander G Shaw, Naomi Black, Azelea Rushd, Kathleen Sim, Paul Randell, J Simon Kroll, Jenny Epstein,

<h4>Objectives</h4>Inflammatory bowel disease states are associated with gastrointestinal dysbiosis. Mucosal biopsy sampling, retrieving the bacterial community that most directly interacts with the host, is an invasive procedure that, we hypothesis, may be sufficiently approximated by other sampling methods. We investigate the relatedness of samples obtained by different methods and the ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2017, 64(2):230-237]

Cited: 3 times

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Chronic recurrent multifocal osteomyelitis and inflammatory bowel disease.

Grace K Audu, Kornilia Nikaki, Daniel Crespi, Christine Spray, Jenny Epstein,

Chronic recurrent multifocal osteomyelitis (CRMO) has been reported in association with inflammatory bowel disease (IBD), mostly in children. We describe the UK paediatric experience of CRMO and IBD and review the global literature. Three cases of CRMO and IBD were identified in UK children during the last 10 years. This ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2015, 60(5):586-591]

Cited: 7 times

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Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies.

Jenny Epstein, Ian R Sanderson, Thomas T Macdonald,

Curcumin is the active ingredient of turmeric. It is widely used as a kitchen spice and food colorant throughout India, Asia and the Western world. Curcumin is a major constituent of curry powder, to which it imparts its characteristic yellow colour. For over 4000 years, curcumin has been used in ... Read more >>

Br J Nutr (The British journal of nutrition)
[2010, 103(11):1545-1557]

Cited: 190 times

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Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease.

Jenny Epstein, Guillermo Docena, Thomas T MacDonald, Ian R Sanderson,

Inflammatory bowel disease (IBD) is a major source of morbidity in children and adults. Its incidence is rising, particularly in young people. IBD carries a lifelong risk of cancer, which is proportional to disease duration. Drug and surgical treatments rarely offer cure and often carry a high side effect burden. ... Read more >>

Br J Nutr (The British journal of nutrition)
[2010, 103(6):824-832]

Cited: 47 times

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