Full Text Journal Articles by
Author Jennifer S Graves

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Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis.

Kristen M Krysko, Jennifer S Graves, Mary Rensel, Bianca Weinstock-Guttman, Alice Rutatangwa, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu S Goyal, Yolanda Harris, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To assess real-world effectiveness of initial treatment with newer compared to injectable disease-modifying therapies (DMTs) on disease activity in pediatric multiple sclerosis (MS) and clinically isolated syndrome (CIS). METHODS:This is a cohort study of children with MS/CIS followed at 12 clinics in the US Network of Pediatric MS Centers, who ... Read more >>

Ann. Neurol. (Annals of neurology)
[2020, :]

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Novel MS vital sign: multi-sensor captures upper and lower limb dysfunction.

Alireza Akhbardeh, Jennifer K Arjona, Kristen M Krysko, Bardia Nourbakhsh, Pierre Antoine Gourraud, Jennifer S Graves,

OBJECTIVE:To create a novel neurological vital sign and reliably capture MS-related limb disability in less than 5 min. METHODS:Consecutive patients meeting the 2010 MS diagnostic criteria and healthy controls were offered enrollment. Participants completed finger and foot taps wearing the MYO-band© (accelerometer, gyroscope, and surface electromyogram sensors). Signal processing was performed ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(3):288-295]

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Biosensors to monitor MS activity.

Jennifer S Graves, Xavier Montalban,

Advances in wearable and wireless biosensing technology pave the way for a brave new world of novel multiple sclerosis (MS) outcome measures. Our current tools for examining patients date back to the 19th century and while invaluable to the neurologist invite accompaniment from these new technologies and artificial intelligence (AI) ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2020, 26(5):605-608]

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Optical Coherence Tomography in Multiple Sclerosis.

Jennifer S Graves,

Optical coherence tomography (OCT) grew out of a convergence of rapid advancements in femtoseconds optics research and fiber optic commercial technology. The basic concept of OCT is to "see" into tissues using light echoes, analogous to the sound echoes of ultrasonography. Multiple A-scans are assembled into a B-scan two-dimensional image ... Read more >>

Semin Neurol (Seminars in neurology)
[2019, 39(6):711-717]

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Telomere Length Is Associated with Disability Progression in Multiple Sclerosis.

Kristen M Krysko, Roland G Henry, Bruce A C Cree, Jue Lin, , Stacy Caillier, Adam Santaniello, Chao Zhao, Refujia Gomez, Carolyn Bevan, Dana L Smith, William Stern, Gina Kirkish, Stephen L Hauser, Jorge R Oksenberg, Jennifer S Graves,

OBJECTIVE:To assess whether biological aging as measured by leukocyte telomere length (LTL) is associated with clinical disability and brain volume loss in multiple sclerosis (MS). METHODS:Adults with MS/clinically isolated syndrome in the University of California, San Francisco EPIC cohort study were included. LTL was measured on DNA samples by quantitative ... Read more >>

Ann. Neurol. (Annals of neurology)
[2019, 86(5):671-682]

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Clinical Features and Outcomes of Pediatric Monophasic and Recurrent Idiopathic Optic Neuritis.

Soren Jonzzon, Leena Suleiman, Andrew Yousef, Brenda Young, Janace Hart, Patrick Peschl, Markus Reindl, Kristin L Schaller, Jeffrey L Bennett, Emmanuelle Waubant, Jennifer S Graves,

Limited data exist on isolated optic neuritis in children. We report the clinical features and treatment of pediatric subjects with monophasic and recurrent idiopathic optic neuritis. This retrospective cohort study of patients with isolated optic neuritis identified 10 monophasic and 7 recurrent optic neuritis cases. Monophasic optic neuritis patients were ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, 35(1):77-83]

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A retrospective cohort study of plasma exchange in central nervous system demyelinating events in children.

Michael Manguinao, Kristen M Krysko, Sai Maddike, Alice Rutatangwa, Carla Francisco, Janace Hart, Janet Chong, Jennifer S Graves, Emmanuelle Waubant,

BACKGROUND:Plasma exchange (PLEX) may improve recovery of acute central nervous system (CNS) demyelinating events related to multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), transverse myelitis (TM), acute disseminated encephalomyelitis (ADEM), and MOG-antibody associated demyelination (MOG) if recovery with pulse steroids (PS) is incomplete. Although there is a single randomized ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2019, 35:50-54]

Cited: 1 time

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miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.

Brooke Rhead, Xiaorong Shao, Jennifer S Graves, Tanuja Chitnis, Amy T Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Lauren Krupp, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Moses Rodriguez, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan S Candee, Mark Gorman, Leslie Benson, Soe Mar, Ilana Kahn, John Rose, T Charles Casper, Hong Quach, Diana Quach, Catherine Schaefer, Emmanuelle Waubant, Lisa F Barcellos, ,

Objective:Onset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small noncoding RNAs that affect gene expression by binding target gene mRNAs. Few studies have specifically examined ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(6):1053-1061]

Cited: 1 time

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Mitochondrial Dysfunction and Multiple Sclerosis.

Isabella Peixoto de Barcelos, Regina M Troxell, Jennifer S Graves,

In recent years, several studies have examined the potential associations between mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS), Parkinson's disease and Alzheimer's disease. In MS, neurological disability results from inflammation, demyelination, and ultimately, axonal damage within the central nervous system. The sustained inflammatory phase of the disease ... Read more >>

Biology (Basel) (Biology)
[2019, 8(2):]

Cited: 2 times

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Vitamin D genes influence MS relapses in children.

Jennifer S Graves, Lisa F Barcellos, Lauren Krupp, Anita Belman, Xiaorong Shao, Hong Quach, Janace Hart, Tanuja Chitnis, Bianca Weinstock-Guttman, Gregory Aaen, Leslie Benson, Mark Gorman, Benjamin Greenberg, Timothy Lotze, Mar Soe, Jayne Ness, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, T Charles Casper, Emmanuelle Waubant,

OBJECTIVE:The aim of this study was to determine whether a vitamin D genetic risk score (vitDGRS) is associated with 25-hydroxyvitamin D (25(OH)D) level and multiple sclerosis (MS) relapses in children. METHODS:DNA samples were typed for single nucleotide polymorphisms (SNPs) from four genes previously identified to be associated with 25(OH)D levels. ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, :1352458519845842]

Cited: 1 time

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Can Visual Testing Be Used to Distinguish Neuromyelitis Optica and Multiple Sclerosis?

Jennifer S Graves,

Ophthalmology (Ophthalmology)
[2019, 126(3):454-455]

Cited: 0 times

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Subclinical Saccadic Eye Movement Dysfunction in Pediatric Multiple Sclerosis.

Andrew Yousef, Michael Devereux, Pierre-Antoine Gourraud, Soren Jonzzon, Leena Suleiman, Emmanuelle Waubant, Ari Green, Jennifer S Graves,

BACKGROUND:Efferent visual dysfunction in children could lead to impaired quality of life at home and school. Eye-tracking can detect subtle efferent dysfunction missed on bedside examination but has not been validated in the pediatric multiple sclerosis population. OBJECTIVE:We sought to determine the feasibility of eye-tracking in children and associations with ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2019, 34(1):38-43]

Cited: 0 times

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Detection of HHV-6 and EBV and Cytokine Levels in Saliva From Children With Seizures: Results of a Multi-Center Cross-Sectional Study.

Luca Bartolini, Eleonora Piras, Kathryn Sullivan, Sean Gillen, Adrian Bumbut, Cheng-Te Major Lin, Emily C Leibovitch, Jennifer S Graves, Emmanuelle L Waubant, James M Chamberlain, William D Gaillard, Steven Jacobson,

Background and Objective: One third of children with epilepsy are refractory to medications. Growing data support a role of common childhood infections with neurotropic viruses and inflammation in epileptogenesis. Our objective was to determine the frequency of Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) infection and cytokine levels in saliva ... Read more >>

Front Neurol (Frontiers in neurology)
[2018, 9:834]

Cited: 0 times

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Gender bias in American Academy of Neurology recognition awards?

Jennifer S Graves, Allison Brashear,

Neurology (Neurology)
[2018, 91(7):291-292]

Cited: 0 times

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Several household chemical exposures are associated with pediatric-onset multiple sclerosis.

Soe Mar, Shannon Liang, Michael Waltz, T Charles Casper, Manu Goyal, Benjamin Greenberg, Bianca Weinstock-Guttman, Moses Rodriguez, Gregory Aaen, Anita Belman, Lisa F Barcellos, John Rose, Mark Gorman, Leslie Benson, Meghan Candee, Tanjua Chitnis, Yolanda Harris, Ilana Kahn, Shelly Roalsted, Janace Hart, Timothy Lotze, Manikum Moodley, Jayne Ness, Mary Rensel, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Lauren Krupp, Jennifer S Graves, Emmanuelle Waubant, ,

Background:There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods:We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(12):1513-1521]

Cited: 1 time

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Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis.

Leena Suleiman, Emmanuelle Waubant, Gregory Aaen, Anita Belman, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Manu Goyal, Benjamin Greenberg, Yolanda Harris, Janace Hart, Ilana Kahn, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Bardia Nourbakhsh, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, T Charles Casper, Michael Waltz, Jennifer S Graves, ,

OBJECTIVE:We sought to determine if early infectious exposures such as daycare, early use of antibiotics, vaccinations and other germ exposures including pacifier use and playing on grass are associated with multiple sclerosis (MS) risk in children. METHODS:This was a case-control study of children with MS or clinically isolated syndrome (CIS) ... Read more >>

Mult Scler Relat Disord (Multiple Sclerosis and Related Disorders)
[2018, 22:103-107]

Cited: 0 times

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The multiple sclerosis risk allele within the AHI1 gene is associated with relapses in children and adults.

Jennifer S Graves, Lisa F Barcellos, Steve Simpson, Anita Belman, Rui Lin, Bruce V Taylor, Anne-Louise Ponsonby, Terence Dwyer, Lauren Krupp, Emmanuelle Waubant, Ingrid A F van der Mei,

BACKGROUND:While common variant non-HLA (human leukocyte antigen) alleles have been associated with MS risk, their role in disease course is less clear. We sought to determine whether established multiple sclerosis (MS) genetic susceptibility factors are associated with relapse rate in children and an independent cohort of adults with MS. METHODS:Genotyping ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2018, 19:161-165]

Cited: 4 times

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Genetic variation in the gene LRP2 increases relapse risk in multiple sclerosis.

Yuan Zhou, Jennifer S Graves, Steve Simpson, Jac C Charlesworth, Ingrid van der Mei, Emmanuelle Waubant, Lisa F Barcellos, Anita Belman, Lauren Krupp, Robyn Lucas, Anne-Louise Ponsonby, Bruce V Taylor, ,

BACKGROUND:Due to the lack of prospective studies with longitudinal data on relapse, past genetic studies have not attempted to identify genetic factors that predict relapse risk (the primary endpoint of many pivotal clinical trials testing the efficacy of multiple sclerosis (MS) disease-modifying drugs) at a genome-wide scale. METHODS:We conducted a ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2017, 88(10):864-868]

Cited: 6 times

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Ovarian aging is associated with gray matter volume and disability in women with MS.

Jennifer S Graves, Roland G Henry, Bruce A C Cree, Geralyn Lambert-Messerlian, Ruth M Greenblatt, Emmanuelle Waubant, Marcelle I Cedars, Alyssa Zhu, , Peter Bacchetti, Stephen L Hauser, Jorge R Oksenberg,

OBJECTIVE:To determine if ovarian aging as measured by levels of anti-Müllerian hormone (AMH) is associated with pattern of multiple sclerosis (MS) progression in women. METHODS:Women with MS and healthy controls were included from a longitudinal research cohort with up to 10 years follow-up. Plasma AMH levels were measured by ELISA ... Read more >>

Neurology (Neurology)
[2018, 90(3):e254-e260]

Cited: 1 time

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Genetic risk factors for pediatric-onset multiple sclerosis.

Milena A Gianfrancesco, Pernilla Stridh, Xiaorong Shao, Brooke Rhead, Jennifer S Graves, Tanuja Chitnis, Amy Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Benjamin Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Soe Mar, Ilana Kahn, John Rose, Shelly Roalstad, T Charles Casper, Ling Shen, Hong Quach, Diana Quach, Jan Hillert, Anna Hedstrom, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Catherine Schaefer, Lisa F Barcellos, Emmanuelle Waubant, ,

BACKGROUND:Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. OBJECTIVE:We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS. METHODS:Cases with onset <18 years (n = 569) and controls (n = 16,251) were included from ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(14):1825-1834]

Cited: 4 times

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Biosensing in multiple sclerosis.

Andrew Yousef, Soren Jonzzon, Leena Suleiman, Jennifer Arjona, Jennifer S Graves,

The goal of using wearable biosensors in multiple sclerosis (MS) is to provide outcome metrics with higher sensitivity to deficits and better inter-test and inter-rater reliability than standard neurological exam bedside maneuvers. A wearable biosensor not only has the potential to enhance physical exams, but also offers the promise of ... Read more >>

Expert Rev Med Devices (Expert review of medical devices)
[2017, 14(11):901-912]

Cited: 2 times

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Dietary factors and pediatric multiple sclerosis: A case-control study.

Julia Pakpoor, Brandon Seminatore, Jennifer S Graves, Teri Schreiner, Amy T Waldman, Timothy E Lotze, Anita Belman, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan-Mendelt Tillema, Jamie C McDonald, Janace Hart, Jayne M Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, Soe Mar, Ilana Kahn, John Rose, Suzan L Carmichael, Shelly Roalstad, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

BACKGROUND:The role of diet in multiple sclerosis (MS) is largely uncharacterized, particularly as it pertains to pediatric-onset disease. OBJECTIVE:To determine the association between dietary factors and MS in children. METHODS:Pediatric MS patients and controls were recruited from 16 US centers (MS or clinically isolated syndrome onset before age 18, <4 years ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(8):1067-1076]

Cited: 6 times

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Cultivating the Multiple Sclerosis Workforce of the Future.

Gabriele C DeLuca, Guy Buckle, Irene Cortese, Jennifer S Graves, June Halper, Scott D Newsome, Nancy Sicotte, Corey C Ford, ,

Multiple sclerosis (MS) is a complex neurologic disorder that affects people with ever-changing needs. The MS health-care field has entered an era of exponential knowledge growth in which better understanding of the immunologic dysregulation of the disease has translated into an expanding array of treatment options. It is estimated that, ... Read more >>

Int J MS Care (International journal of MS care)
[2017, 19(3):123-130]

Cited: 0 times

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Maternal and Perinatal Exposures Are Associated With Risk for Pediatric-Onset Multiple Sclerosis.

Jennifer S Graves, Tanuja Chitnis, Bianca Weinstock-Guttman, Jennifer Rubin, Aaron S Zelikovitch, Bardia Nourbakhsh, Timothy Simmons, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To determine if prenatal, pregnancy, or postpartum-related environmental factors are associated with multiple sclerosis (MS) risk in children. METHODS:This is a case-control study of children with MS or clinically isolated syndrome and healthy controls enrolled at 16 clinics participating in the US Network of Pediatric MS Centers. Parents completed a ... Read more >>

Pediatrics (Pediatrics)
[2017, 139(4):]

Cited: 7 times

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Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.

Milena A Gianfrancesco, Pernilla Stridh, Brooke Rhead, Xiaorong Shao, Edison Xu, Jennifer S Graves, Tanuja Chitnis, Amy Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Benjamin Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Soe Mar, Ilana Kahn, John Rose, Shelly Roalstad, T Charles Casper, Ling Shen, Hong Quach, Diana Quach, Jan Hillert, Maria Bäärnhielm, Anna Hedstrom, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Catherine Metayer, Catherine Schaefer, Lisa F Barcellos, Emmanuelle Waubant, ,

To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS).We constructed an instrumental variable for vitamin D (vitD GRS) by computing a GRS for 3 genetic variants associated with levels ... Read more >>

Neurology (Neurology)
[2017, 88(17):1623-1629]

Cited: 25 times

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