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Author Jennifer J Kurinczuk

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Management of Gastroschisis: Results From the NETS2G Study, a Joint British, Irish, and Canadian Prospective Cohort Study of 1268 Infants.

Benjamin S R Allin, Charles Opondo, Jennifer J Kurinczuk, Rob Baird, P Puligandla, Erik Skarsgard, Marian Knight, ,

OBJECTIVE:In infants with gastroschisis, outcomes were compared between those where operative reduction and fascial closure were attempted ≤24 hours of age (PC), and those who underwent planned closure of their defect >24 hours of age following reduction with a pre-formed silo (SR). SUMMARY OF BACKGROUND DATA:Inadequate evidence exists to determine how best ... Read more >>

Ann Surg (Annals of surgery)
[2020, :]

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Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance.

Chris Gale, Maria A Quigley, Anna Placzek, Marian Knight, Shamez Ladhani, Elizabeth S Draper, Don Sharkey, Cora Doherty, Helen Mactier, Jennifer J Kurinczuk,

BACKGROUND:Babies differ from older children with regard to their exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data describing the effect of SARS-CoV-2 in this group are scarce, and guidance is variable. We aimed to describe the incidence, characteristics, transmission, and outcomes of SARS-CoV-2 infection in neonates who ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, :]

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Outcomes at five to eight years of age for children with Hirschsprung's disease.

Benjamin Saul Raywood Allin, Charles Opondo, Timothy John Bradnock, Simon Edward Kenny, Jennifer J Kurinczuk, Gregor M Walker, Marian Knight, ,

OBJECTIVE:This study describes core outcomes of Hirschsprung's disease (HD) in a UK-wide cohort of primary school-aged children. DESIGN:A prospective cohort study conducted from 1 October 2010 to 30 September 2012. Outcomes data were collected from parents and clinicians when children were 5-8 years of age, and combined with data collected ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, :]

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Neonatal admission and mortality in babies born in UK alongside midwifery units: a national population-based case-control study using the UK Midwifery Study System (UKMidSS).

Rachel Rowe, Aung Soe, Marian Knight, Jennifer J Kurinczuk, ,

OBJECTIVES:To determine the incidence of and risk factors for neonatal unit admission, intrapartum stillbirth or neonatal death without admission, and describe outcomes, in babies born in an alongside midwifery unit (AMU). DESIGN:National population-based case-control study. METHOD:We used the UK Midwifery Study System to identify and collect data about 1041 women ... Read more >>

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2020, :]

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Systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy.

Sinaida Cherubin, Taylar Peoples, Jessica Gillard, Samira Lakhal-Littleton, Jennifer J Kurinczuk, Manisha Nair,

OBJECTIVES:We conducted a systematic review and meta-analysis of studies that compared levels of molecular biomarkers in women with peripartum cardiomyopathy (PPCM) to those in healthy pregnant and postpartum women to: (1) assess the evidence for prolactin (PRL) metabolism in PPCM, (2) ascertain the evidence for biomarkers of iron deficiency in ... Read more >>

Open Heart (Open heart)
[2020, 7(2):]

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National active surveillance to understand and inform neonatal care in COVID-19.

Chris Gale, Marian Knight, Shamez Ladhani, Elizabeth S Draper, Don Sharkey, Cora Doherty, Helen Mactier, Jennifer J Kurinczuk, ,

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2020, 105(4):346-347]

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Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study.

Marian Knight, Kathryn Bunch, Nicola Vousden, Edward Morris, Nigel Simpson, Chris Gale, Patrick O'Brien, Maria Quigley, Peter Brocklehurst, Jennifer J Kurinczuk, ,

OBJECTIVES:To describe a national cohort of pregnant women admitted to hospital with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, identify factors associated with infection, and describe outcomes, including transmission of infection, for mothers and infants. DESIGN:Prospective national population based cohort study using the UK Obstetric Surveillance ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2020, 369:m2107]

Cited: 26 times

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Characteristics and outcomes of pregnant women hospitalised with confirmed SARS-CoV-2 infection in the UK: a national cohort study using the UK Obstetric Surveillance System (UKOSS)

Marian Knight, Kathryn Bunch, Nicola Vousden, Edward Morris, Nigel Simpson, Christopher Gale, Patrick O'Brien, Maria Quigley, Peter Brocklehurst, Jennifer Kurinczuk,

Objective: To describe a national cohort of pregnant women hospitalised with SARS-CoV-2 infection in the UK, identify factors associated with infection and describe outcomes, including transmission of infection, for mother and infant. Design: Prospective national population-based cohort study using the UK Obstetric Surveillance System (UKOSS). Setting: All 194 obstetric units ... Read more >>

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Multilevel analyses of related public health indicators: The European Surveillance of Congenital Anomalies (EUROCAT) Public Health Indicators.

Kate E Best, Judith Rankin, Helen Dolk, Maria Loane, Martin Haeusler, Vera Nelen, Christine Verellen-Dumoulin, Ester Garne, Gerardine Sayers, Carmel Mullaney, Mary T O'Mahony, Miriam Gatt, Hermien De Walle, Kari Klungsoyr, Olatz Mokoroa Carolla, Clara Cavero-Carbonell, Jennifer J Kurinczuk, Elizabeth S Draper, David Tucker, Diana Wellesley, Nataliia Zymak-Zakutnia, Nathalie Lelong, Babak Khoshnood,

BACKGROUND:Public health organisations use public health indicators to guide health policy. Joint analysis of multiple public health indicators can provide a more comprehensive understanding of what they are intended to evaluate. OBJECTIVE:To analyse variaitons in the prevalence of congenital anomaly-related perinatal mortality attributable to termination of pregnancy for foetal anomaly ... Read more >>

Paediatr Perinat Epidemiol (Paediatric and perinatal epidemiology)
[2020, 34(2):122-129]

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A national population-based cohort study to investigate inequalities in maternal mortality in the United Kingdom, 2009-17.

Marian Knight, Kathryn Bunch, Sara Kenyon, Derek Tuffnell, Jennifer J Kurinczuk,

BACKGROUND:Disparities have been documented in maternal mortality rates between women from different ethnic, age and socio-economic groups in the UK. It is unclear whether there are differential changes in these rates amongst women from different groups over time. The objectives of this analysis were to describe UK maternal mortality rates in different ... Read more >>

Paediatr Perinat Epidemiol (Paediatric and perinatal epidemiology)
[2020, 34(4):392-398]

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Variations in neonatal mortality, infant mortality, preterm birth and birth weight in England and Wales according to ethnicity and maternal country or region of birth: an analysis of linked national data from 2006 to 2012.

Charles Opondo, Hiranthi Jayaweera, Jennifer Hollowell, Yangmei Li, Jennifer J Kurinczuk, Maria A Quigley,

BACKGROUND:Risks of adverse birth outcomes in England and Wales are relatively low but vary across ethnic groups. We aimed to explore the role of mother's country of birth on birth outcomes across ethnic groups using a large population-based linked data set. METHODS:We used a cohort of 4.6 million singleton live births ... Read more >>

J Epidemiol Community Health (Journal of epidemiology and community health)
[2020, 74(4):336-345]

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Ethnic differences in singleton preterm birth in England and Wales, 2006-12: Analysis of national routinely collected data.

Yangmei Li, Maria A Quigley, Alison Macfarlane, Hiranthi Jayaweera, Jennifer J Kurinczuk, Jennifer Hollowell,

BACKGROUND:Data recorded at birth and death registration in England and Wales have been routinely linked with data recorded at birth notification since 2006. These provide scope for detailed analyses on ethnic differences in preterm birth (PTB). OBJECTIVES:We aimed to investigate ethnic differences in PTB and degree of prematurity in England ... Read more >>

Paediatr Perinat Epidemiol (Paediatric and perinatal epidemiology)
[2019, 33(6):449-458]

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Planned mode of delivery after previous cesarean section and short-term maternal and perinatal outcomes: A population-based record linkage cohort study in Scotland.

Kathryn E Fitzpatrick, Jennifer J Kurinczuk, Sohinee Bhattacharya, Maria A Quigley,

BACKGROUND:Policy consensus in high-income countries supports offering pregnant women with previous cesarean section a choice between planning an elective repeat cesarean section (ERCS) or attempting a vaginal birth, known as a planned vaginal birth after previous cesarean (VBAC), provided they do not have contraindications to planned VBAC. However, robust comprehensive ... Read more >>

PLoS Med (PLoS medicine)
[2019, 16(9):e1002913]

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Epidemiology of achondroplasia: A population-based study in Europe.

Alessio Coi, Michele Santoro, Ester Garne, Anna Pierini, Marie-Claude Addor, Jean-Luc Alessandri, Jorieke E H Bergman, Fabrizio Bianchi, Ljubica Boban, Paula Braz, Clara Cavero-Carbonell, Miriam Gatt, Martin Haeusler, Kari Klungsøyr, Jennifer J Kurinczuk, Monica Lanzoni, Nathalie Lelong, Karen Luyt, Olatz Mokoroa, Carmel Mullaney, Vera Nelen, Amanda J Neville, Mary T O'Mahony, Isabelle Perthus, Judith Rankin, Anke Rissmann, Florence Rouget, Bruno Schaub, David Tucker, Diana Wellesley, Katarzyna Wisniewska, Nataliia Zymak-Zakutnia, Ingeborg Barišić,

Achondroplasia is a rare genetic disorder resulting in short-limb skeletal dysplasia. We present the largest European population-based epidemiological study to date using data provided by the European Surveillance of Congenital Anomalies (EUROCAT) network. All cases of achondroplasia notified to 28 EUROCAT registries (1991-2015) were included in the study. Prevalence, birth ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2019, 179(9):1791-1798]

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Epidemiology of congenital cerebral anomalies in Europe: a multicentre, population-based EUROCAT study.

Joan K Morris, Diana G Wellesley, Ingeborg Barisic, Marie-Claude Addor, Jorieke E H Bergman, Paula Braz, Clara Cavero-Carbonell, Elizabeth S Draper, Miriam Gatt, Martin Haeusler, Kari Klungsoyr, Jennifer J Kurinczuk, Natalie Lelong, Karen Luyt, Catherine Lynch, Mary T O'Mahony, Olatz Mokoroa, Vera Nelen, Amanda J Neville, Anna Pierini, Hanitra Randrianaivo, Judith Rankin, Anke Rissmann, Florence Rouget, Bruno Schaub, David F Tucker, Christine Verellen-Dumoulin, Awi Wiesel, Natalia Zymak-Zakutnia, Monica Lanzoni, Ester Garne,

OBJECTIVES:To describe the epidemiology and geographical differences in prevalence of congenital cerebral anomalies in Europe. DESIGN AND SETTING:Congenital cerebral anomalies (International Classification of Diseases, 10th Revision code Q04) recorded in 29 population-based EUROCAT registries conducting surveillance of 1.7 million births per annum (29% of all European births). PARTICIPANTS:All birth outcomes ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2019, 104(12):1181-1187]

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Epidemiology of Dandy-Walker Malformation in Europe: A EUROCAT Population-Based Registry Study.

Michele Santoro, Alessio Coi, Ingeborg Barišić, Ester Garne, Marie-Claude Addor, Jorieke E H Bergman, Fabrizio Bianchi, Ljubica Boban, Paula Braz, Clara Cavero-Carbonell, Miriam Gatt, Martin Haeusler, Agnieszka Kinsner-Ovaskainen, Kari Klungsøyr, Jennifer J Kurinczuk, Nathalie Lelong, Karen Luyt, Anna Materna-Kiryluk, Olatz Mokoroa, Carmel Mullaney, Vera Nelen, Amanda Julie Neville, Mary T O'Mahony, Isabelle Perthus, Hanitra Randrianaivo, Judith Rankin, Anke Rissmann, Florence Rouget, Bruno Schaub, David Tucker, Diana Wellesley, Lyubov Yevtushok, Anna Pierini,

BACKGROUND:Dandy-Walker (DW) malformation is a rare and severe congenital anomaly of the posterior fossa affecting the development of the cerebellum and the fourth ventricle. OBJECTIVE:The aim of this study was to investigate the epidemiology of DW malformation, using data from the European population-based registries of congenital anomalies in the European ... Read more >>

Neuroepidemiology (Neuroepidemiology)
[2019, 53(3-4):169-179]

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Joint contribution of socioeconomic circumstances and ethnic group to variations in preterm birth, neonatal mortality and infant mortality in England and Wales: a population-based retrospective cohort study using routine data from 2006 to 2012.

Charles Opondo, Ron Gray, Jennifer Hollowell, Yangmei Li, Jennifer J Kurinczuk, Maria A Quigley,

OBJECTIVES:This study aimed to describe the variation in risks of adverse birth outcomes across ethnic groups and socioeconomic circumstances, and to explore the evidence of mediation by socioeconomic circumstances of the effect of ethnicity on birth outcomes. SETTING:England and Wales. PARTICIPANTS:The data came from the 4.6 million singleton live births ... Read more >>

BMJ Open (BMJ open)
[2019, 9(7):e028227]

Cited: 2 times

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Study protocol: E-freeze - freezing of embryos in assisted conception: a randomised controlled trial evaluating the clinical and cost effectiveness of a policy of freezing embryos followed by thawed frozen embryo transfer compared with a policy of fresh embryo transfer, in women undergoing in vitro fertilisation.

Abha Maheshwari, Siladitya Bhattacharya, Ursula Bowler, Daniel Brison, Tim Child, Christina Cole, Arri Coomarasamy, Rachel Cutting, Stephen Harbottle, Pollyanna Hardy, Edmund Juszczak, Yacoub Khalaf, Jennifer J Kurinczuk, Stuart Lavery, Clare Lewis-Jones, Nick Macklon, Nick J Raine-Fenning, Madhurima Rajkohwa, Graham Scotland, Stephen Troup,

BACKGROUND:Infertility affects one in seven couples; many of these need in vitro fertilisation (IVF). IVF involves external hormones to stimulate a woman's ovaries to produce eggs which are harvested surgically. Embryos, created in the laboratory by mixing eggs with sperm, are grown in culture for a few days before being ... Read more >>

Reprod Health (Reproductive health)
[2019, 16(1):81]

Cited: 3 times

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One-year outcomes of infants born with congenital diaphragmatic hernia: a national population cohort study.

Anna-May Long, Kathryn J Bunch, Marian Knight, Jennifer J Kurinczuk, Paul Damian Losty, ,

OBJECTIVE:To report outcomes to 1 year, in infants born with congenital diaphragmatic hernia (CDH), explore factors associated with infant mortality and examine the relationship between surgical techniques and postoperative morbidity. DESIGN:Prospective national population cohort study. SETTING:Paediatric surgical centres in the UK and Ireland. METHOD:Data were collected to 1 year for infants with ... Read more >>

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2019, 104(6):F643-F647]

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Ethnic and socioeconomic variation in cause-specific preterm infant mortality by gestational age at birth: national cohort study.

Mary E Kroll, Jennifer J Kurinczuk, Jennifer Hollowell, Alison Macfarlane, Yangmei Li, Maria A Quigley,

OBJECTIVE:To describe ethnic and socioeconomic variation in cause-specific infant mortality of preterm babies by gestational age at birth. DESIGN:National birth cohort study. SETTING:England and Wales 2006-2012. SUBJECTS:Singleton live births at 24-36 completed weeks' gestation (n=256 142). OUTCOME MEASURES:Adjusted rate ratios for death in infancy by cause (three groups), within categories of ... Read more >>

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2020, 105(1):56-63]

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Anaphylaxis in Pregnancy in the United States: Risk Factors and Temporal Trends Using National Routinely Collected Data.

Stephen J McCall, Jennifer J Kurinczuk, Marian Knight,

BACKGROUND:Anaphylaxis in pregnancy is an understudied, rare, and severe complication of pregnancy. OBJECTIVE:To describe the incidence and temporal trends, and to identify potential risk factors for anaphylaxis-related hospitalizations while pregnant in the United States. METHODS:All hospitalizations while pregnant and any anaphylactic reactions were identified using International Classification of Diseases, Ninth ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2019, 7(8):2606-2612.e3]

Cited: 1 time

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Assessing the deprivation gap in stillbirths and neonatal deaths by cause of death: a national population-based study.

Kate E Best, Sarah E Seaton, Elizabeth S Draper, David J Field, Jennifer J Kurinczuk, Bradley N Manktelow, Lucy K Smith,

OBJECTIVE:To investigate socioeconomic inequalities in cause-specific stillbirth and neonatal mortality to identify key areas of focus for future intervention strategies to achieve government ambitions to reduce mortality rates. DESIGN:Retrospective cohort study. SETTING:England, Wales, Scotland and the UK Crown Dependencies. PARTICIPANTS:All singleton births between 1 January 2014 and 31 December 2015 ... Read more >>

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2019, 104(6):F624-F630]

Cited: 1 time

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Twenty-five-year trends in breastfeeding initiation: The effects of sociodemographic changes in Great Britain, 1985-2010.

Deon A Simpson, Maria A Quigley, Jennifer J Kurinczuk, Claire Carson,

BACKGROUND:Data from the UK Infant Feeding Surveys indicate that breastfeeding initiation increased between 1985 and 2010. During this period, societal changes in GB also influenced the sociodemographic characteristics of women in the childbearing population. As breastfeeding behaviour is highly socially patterned in GB, the increasing trend in breastfeeding initiation may ... Read more >>

PLoS One (PloS one)
[2019, 14(1):e0210838]

Cited: 3 times

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Maternal and perinatal outcomes in pregnant women with BMI >50: An international collaborative study.

Stephen J McCall, Zhuoyang Li, Jennifer J Kurinczuk, Elizabeth Sullivan, Marian Knight,

OBJECTIVE:To examine the association between maternal BMI>50kg/m2 during pregnancy and maternal and perinatal outcomes. MATERIALS AND METHODS:An international cohort study was conducted using data from separate national studies in the UK and Australia. Outcomes of pregnant women with BMI>50 were compared to those of pregnant women with BMI<50. Multivariable logistic ... Read more >>

PLoS One (PloS one)
[2019, 14(2):e0211278]

Cited: 2 times

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Early Childhood Outcomes After Neonatal Encephalopathy in Uganda: A Cohort Study.

Cally J Tann, Emily L Webb, Rachel Lassman, Julius Ssekyewa, Margaret Sewegaba, Margaret Musoke, Kathy Burgoine, Cornelia Hagmann, Eleanor Deane-Bowers, Kerstin Norman, Jack Milln, Jennifer J Kurinczuk, Alison M Elliott, Miriam Martinez-Biarge, Margaret Nakakeeto, Nicola J Robertson, Frances M Cowan,

Background:Neonatal encephalopathy (NE) is a leading cause of global child mortality. Survivor outcomes in low-resource settings are poorly described. We present early childhood outcomes after NE in Uganda. Methods:We conducted a prospective cohort study of term-born infants with NE (n = 210) and a comparison group of term non-encephalopathic (non-NE) infants (n = 409), ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2018, 6:26-35]

Cited: 3 times

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