Full Text Journal Articles by
Author Jennifer A Samson

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Peroxisome compartmentalization of a toxic enzyme improves alkaloid production.

Parbir S Grewal, Jennifer A Samson, Jordan J Baker, Brian Choi, John E Dueber,

Eukaryotic cells compartmentalize metabolic pathways in organelles to achieve optimal reaction conditions and avoid crosstalk with cytosolic factors. We found that cytosolic expression of norcoclaurine synthase (NCS), the enzyme that catalyzes the first committed reaction in benzylisoquinoline alkaloid biosynthesis, is toxic in Saccharomyces cerevisiae and, consequently, restricts (S)-reticuline production. We ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

Cited: 0 times

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Publisher Correction: Modular and tunable biological feedback control using a de novo protein switch.

Andrew H Ng, Taylor H Nguyen, Mariana Gómez-Schiavon, Galen Dods, Robert A Langan, Scott E Boyken, Jennifer A Samson, Lucas M Waldburger, John E Dueber, David Baker, Hana El-Samad,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nature (Nature)
[2020, 579(7798):E8]

Cited: 0 times

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Modular and tunable biological feedback control using a de novo protein switch.

Andrew H Ng, Taylor H Nguyen, Mariana Gómez-Schiavon, Galen Dods, Robert A Langan, Scott E Boyken, Jennifer A Samson, Lucas M Waldburger, John E Dueber, David Baker, Hana El-Samad,

De novo-designed proteins1-3 hold great promise as building blocks for synthetic circuits, and can complement the use of engineered variants of natural proteins4-7. One such designer protein-degronLOCKR, which is based on 'latching orthogonal cage-key proteins' (LOCKR) technology8-is a switch that degrades a protein of interest in vivo upon induction by ... Read more >>

Nature (Nature)
[2019, 572(7768):265-269]

Cited: 1 time

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De novo design of bioactive protein switches.

Robert A Langan, Scott E Boyken, Andrew H Ng, Jennifer A Samson, Galen Dods, Alexandra M Westbrook, Taylor H Nguyen, Marc J Lajoie, Zibo Chen, Stephanie Berger, Vikram Khipple Mulligan, John E Dueber, Walter R P Novak, Hana El-Samad, David Baker,

Allosteric regulation of protein function is widespread in biology, but is challenging for de novo protein design as it requires the explicit design of multiple states with comparable free energies. Here we explore the possibility of designing switchable protein systems de novo, through the modulation of competing inter- and intramolecular ... Read more >>

Nature (Nature)
[2019, 572(7768):205-210]

Cited: 4 times

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