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Author Jehonathan H Pinthus

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Editorial Comment.

Jehonathan H Pinthus, Harkanwal Randhawa,

J Urol (The Journal of urology)
[2021, :101097JU000000000000178502]

Cited: 0 times

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Psychological morbidity associated with prostate cancer: Rates and predictors of depression in the RADICAL PC study.

Gagan Fervaha, Jason P Izard, Dean A Tripp, Nazanin Aghel, Bobby Shayegan, Laurence Klotz, Tamim Niazi, Vincent Fradet, Daniel Taussky, Luke T Lavallée, Robert J Hamilton, Ian Brown, Joseph Chin, Darin Gopaul, Philippe D Violette, Margot K Davis, Sarah Karampatos, Jehonathan H Pinthus, Darryl P Leong, D Robert Siemens, ,

<h4>Introduction</h4>Across all cancer sites and stages, prostate cancer has one of the greatest median five-year survival rates, highlighting the important focus on survivorship issues following diagnosis and treatment. In the current study, we sought to evaluate the prevalence and predictors of depression in a large, multicenter, contemporary, prospectively collected sample ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, 15(6):181-186]

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Protective effect of pharmacological castration on metabolic perturbations and cardiovascular disease in the hyperglycemic male ApoE-/-:Ins2+/Akita mouse model.

Wilhelmina C M Duivenvoorden, Magda Naeim, Sarah N Hopmans, Sadiya Yousef, Geoff H Werstuck, Shawn Dason, Jehonathan H Pinthus,

<h4>Background</h4>Unlike in other mouse models of atherogenesis, it has recently been suggested that orchiectomy plays a role in accelerating atherosclerosis and inhibiting the progression of cardiovascular disease in the ApoE<sup>-/-</sup>:Ins2<sup>+/Akita</sup> mouse model of hyperglycemia. Androgen-deprivation therapy (ADT) is a common treatment for prostate cancer, a population with high prevalence of ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, 24(2):389-397]

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Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS): an international prospective cohort study establishing diagnostic criteria and prognostic importance.

Pavel S Roshanov, John W Eikelboom, Daniel I Sessler, Clive Kearon, Gordon H Guyatt, Mark Crowther, Vikas Tandon, Flavia Kessler Borges, Andre Lamy, Richard Whitlock, Bruce M Biccard, Wojciech Szczeklik, Mohamed Panju, Jessica Spence, Amit X Garg, Michael McGillion, Tomas VanHelder, Peter A Kavsak, Justin de Beer, Mitchell Winemaker, Yannick Le Manach, Tej Sheth, Jehonathan H Pinthus, Deborah Siegal, Lehana Thabane, Marko R I Simunovic, Ryszard Mizera, Sebastian Ribas, Philip J Devereaux,

<h4>Background</h4>We aimed to establish diagnostic criteria for bleeding independently associated with mortality after noncardiac surgery (BIMS) defined as bleeding during or within 30 days after noncardiac surgery that is independently associated with mortality within 30 days of surgery, and to estimate the proportion of 30-day postoperative mortality potentially attributable to ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(1):163-171]

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Cardiac biomarkers in patients with prostate cancer and cardiovascular disease receiving gonadotrophin releasing hormone agonist vs antagonist.

David Margel, Yaara Ber, Avivit Peer, Liat Shavit-Grievink, Jehonathan H Pinthus, Guy Witberg, Jack Baniel, Daniel Kedar, Eli Rosenbaum,

<h4>Background</h4>Gonadotrophin releasing hormone (GnRH) agonists and antagonists reduce testosterone levels for the treatment of advanced and metastatic prostate cancer. Androgen deprivation therapy (ADT) is associated with increased risk of cardiovascular (CV) events and CV disease (CVD), especially in patients with preexisting CVD treated with GnRH agonists. Here, we investigated the ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, 24(1):177-185]

Cited: 1 time

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Preoperative prediction of Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS): an international prospective cohort study.

Pavel S Roshanov, Gordon H Guyatt, Vikas Tandon, Flavia K Borges, Andre Lamy, Richard Whitlock, Bruce M Biccard, Wojciech Szczeklik, Mohamed Panju, Jessica Spence, Amit X Garg, Michael McGillion, John W Eikelboom, Daniel I Sessler, Clive Kearon, Mark Crowther, Tomas VanHelder, Peter A Kavsak, Justin de Beer, Mitchell Winemaker, Yannick Le Manach, Tej Sheth, Jehonathan H Pinthus, Deborah Siegal, Lehana Thabane, Marko R I Simunovic, Ryszard Mizera, Sebastian Ribas, Philip J Devereaux,

<h4>Background</h4>Diagnostic criteria for Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS) have been defined as bleeding that leads to a postoperative haemoglobin <70 g L<sup>-1</sup>, leads to blood transfusion, or is judged to be the direct cause of death. Preoperative prediction guides for BIMS can facilitate informed consent and ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(1):172-180]

Cited: 0 times

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Outcomes of trimodality bladder-sparing therapy for muscle-invasive bladder cancer.

Eric K Nguyen, Hang Yu, Gregory Pond, Bobby Shayegan, Jehonathan H Pinthus, Anil Kapoor, Som D Mukherjee, Alan Neville, Aly-Khan A Lalani, Sebastien J Hotte, Thomas B Corbett, Ian S Dayes, Himanshu R Lukka,

INTRODUCTION:Although radical cystectomy is considered the standard of care for muscle-invasive bladder cancer (MIBC), recent data has suggested comparable survival outcomes for bladder-sparing trimodality therapy (TMT). We conducted a retrospective, single-institution analysis of MIBC patients to evaluate the efficacy of TMT as an alternative, curative approach to surgical intervention. METHODS:We ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2020, 14(4):122-129]

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Reply By Authors.

David Margel, Avivit Peer, Yaara Ber, Liat Shavit-Grievink, Tzlil Tabachnik, Sivan Sela, Guy Witberg, Jack Baniel, Daniel Kedar, Wilhelmina C M Duivenvoorden, Eli Rosenbaum, Jehonathan H Pinthus,

J Urol (The Journal of urology)
[2019, 202(6):1208]

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Clinical significance of the LacdiNAc-glycosylated prostate-specific antigen assay for prostate cancer detection.

Tohru Yoneyama, Yuki Tobisawa, Tomonori Kaneko, Takatoshi Kaya, Shingo Hatakeyama, Kazuyuki Mori, Mihoko Sutoh Yoneyama, Teppei Okubo, Koji Mitsuzuka, Wilhelmina Duivenvoorden, Jehonathan H Pinthus, Yasuhiro Hashimoto, Akihiro Ito, Takuya Koie, Yoshihiko Suda, Robert A Gardiner, Chikara Ohyama,

To reduce unnecessary prostate biopsies (Pbx), better discrimination is needed. To identify clinically significant prostate cancer (CSPC) we determined the performance of LacdiNAc-glycosylated prostate-specific antigen (LDN-PSA) and LDN-PSA normalized by prostate volume (LDN-PSAD). We retrospectively measured LDN-PSA, total PSA (tPSA), and free PSA/tPSA (F/T PSA) values in 718 men who ... Read more >>

Cancer Sci (Cancer science)
[2019, 110(8):2573-2589]

Cited: 5 times

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Cardiovascular Morbidity in a Randomized Trial Comparing GnRH Agonist and GnRH Antagonist among Patients with Advanced Prostate Cancer and Preexisting Cardiovascular Disease.

David Margel, Avivit Peer, Yaara Ber, Liat Shavit-Grievink, Tzlil Tabachnik, Sivan Sela, Guy Witberg, Jack Baniel, Daniel Kedar, Wilhelmina C M Duivenvoorden, Eli Rosenbaum, Jehonathan H Pinthus,

<h4>Purpose</h4>Androgen deprivation therapy may increase the risk of cardiovascular disease. Limited data suggest that GnRH (gonadotropin-releasing hormone) antagonist may be associated with a lower risk of cardiovascular disease than GnRH agonist.<h4>Materials and methods</h4>We performed a phase II, randomized, open label study in men with prostate cancer and preexisting cardiovascular disease ... Read more >>

J Urol (The Journal of urology)
[2019, 202(6):1199-1208]

Cited: 10 times

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The contemporary role of lymph node dissection in the management of renal cell carcinoma.

Piotr Zareba, Jehonathan H Pinthus, Paul Russo,

The appropriate role of lymph node dissection (LND) in the management of patients with renal cell carcinoma (RCC) is still a matter of debate. There is ample evidence that LND is the most accurate modality for staging the regional lymph nodes (LNs), which may harbor metastatic disease in greater than ... Read more >>

Ther Adv Urol (Therapeutic advances in urology)
[2018, 10(11):335-342]

Cited: 1 time

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Editorial Comment.

Jehonathan H Pinthus,

J Urol (The Journal of urology)
[2018, 200(3):580]

Cited: 0 times

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Thromboembolism in Patients with Bladder Cancer: Incidence, Risk Factors and Prevention.

Piotr Zareba, Wilhelmina C M Duivenvoorden, Jehonathan H Pinthus,

Patients with bladder cancer are at high risk of developing both venous and arterial thromboembolic events. Factors that contribute to this phenomenon include the hypercoagulable state induced by the malignancy itself, medical comorbidities that are common in this predominantly elderly patient population as well as treatments such as prolonged pelvic ... Read more >>

Bladder Cancer (Bladder cancer (Amsterdam, Netherlands))
[2018, 4(2):139-147]

Cited: 1 time

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Bleeding impacting mortality after noncardiac surgery: a protocol to establish diagnostic criteria, estimate prognostic importance, and develop and validate a prediction guide in an international prospective cohort study.

Pavel S Roshanov, John W Eikelboom, Mark Crowther, Vikas Tandon, Flavia K Borges, Clive Kearon, Andre Lamy, Richard Whitlock, Bruce M Biccard, Wojciech Szczeklik, Gordon H Guyatt, Mohamed Panju, Jessica Spence, Amit X Garg, Michael McGillion, Tomas VanHelder, Peter A Kavsak, Justin de Beer, Mitchell Winemaker, Daniel I Sessler, Yannick Le Manach, Tej Sheth, Jehonathan H Pinthus, Lehana Thabane, Marko R I Simunovic, Ryszard Mizera, Sebastian Ribas, P J Devereaux, ,

<h4>Introduction</h4>Various definitions of bleeding have been used in perioperative studies without systematic assessment of the diagnostic criteria for their independent association with outcomes important to patients. Our proposed definition of bleeding impacting mortality after noncardiac surgery (BIMS) is bleeding that is independently associated with death during or within 30 days ... Read more >>

CMAJ Open (CMAJ open)
[2017, 5(3):E594-E603]

Cited: 3 times

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Endoplasmic reticulum protein ERp46 in prostate adenocarcinoma.

Wilhelmina C M Duivenvoorden, Sarah N Hopmans, Richard C Austin, Jehonathan H Pinthus,

Endoplasmic reticulum (ER) protein ERp46 is a member of the protein disulfide isomerase family of oxidoreductases, which facilitates the reduction of disulfides in proteins and their folding. Accumulation of misfolded proteins has been implicated in cancer. The objectives of the present study were to investigate the role of ERp46 in ... Read more >>

Oncol Lett (Oncology letters)
[2017, 13(5):3624-3630]

Cited: 2 times

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The potential role of follicle-stimulating hormone in the cardiovascular, metabolic, skeletal, and cognitive effects associated with androgen deprivation therapy.

E David Crawford, Andrew V Schally, Jehonathan H Pinthus, Norman L Block, Ferenc G Rick, Marc B Garnick, Robert H Eckel, Thomas E Keane, Neal D Shore, David N Dahdal, Thomas J R Beveridge, Dennis C Marshall,

<h4>Purpose</h4>To explore how follicle-stimulating hormone (FSH) may contribute to cardiovascular, metabolic, skeletal, and cognitive events in men treated for prostate cancer, with various forms of androgen deprivation therapy (ADT).<h4>Materials and methods</h4>A colloquium of prostate cancer experts was convened in May 2015, to discuss the role of FSH in the development ... Read more >>

Urol Oncol (Urologic oncology)
[2017, 35(5):183-191]

Cited: 20 times

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An Automated Micro-Total Immunoassay System for Measuring Cancer-Associated α2,3-linked Sialyl N-Glycan-Carrying Prostate-Specific Antigen May Improve the Accuracy of Prostate Cancer Diagnosis.

Tomokazu Ishikawa, Tohru Yoneyama, Yuki Tobisawa, Shingo Hatakeyama, Tatsuo Kurosawa, Kenji Nakamura, Shintaro Narita, Koji Mitsuzuka, Wilhelmina Duivenvoorden, Jehonathan H Pinthus, Yasuhiro Hashimoto, Takuya Koie, Tomonori Habuchi, Yoichi Arai, Chikara Ohyama,

The low specificity of the prostate-specific antigen (PSA) for early detection of prostate cancer (PCa) is a major issue worldwide. The aim of this study to examine whether the serum PCa-associated α2,3-linked sialyl <i>N</i>-glycan-carrying PSA (S2,3PSA) ratio measured by automated micro-total immunoassay systems (μTAS system) can be applied as a ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(2):]

Cited: 12 times

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Does androgen-deprivation therapy for prostate cancer increase the risk for thromboembolic disease?

Jehonathan H Pinthus, Wilhelmina C Duivenvoorden,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2017, 11(1-2):39-40]

Cited: 0 times

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Elevated C-Peptides, Abdominal Obesity, and Abnormal Adipokine Profile are Associated With Higher Gleason Scores in Prostate Cancer.

Katie M Di Sebastiano, Jehonathan H Pinthus, Wilhelmina C M Duivenvoorden, Laurel Patterson, Joel A Dubin, Marina Mourtzakis,

<h4>Background</h4>Prostate cancer development is associated with numerous lifestyle factors (i.e., physical activity, nutrition intake) and metabolic perturbations. These factors have been studied independently; here, we used an integrative approach to characterize these lifestyle and metabolic parameters in men undergoing diagnostic prostate biopsies.<h4>Methods</h4>We prospectively evaluated 51 consecutive men for body composition, ... Read more >>

Prostate (The Prostate)
[2017, 77(2):211-221]

Cited: 7 times

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Incidence, Characteristics and Implications of Thromboembolic Events in Patients with Muscle Invasive Urothelial Carcinoma of the Bladder Undergoing Neoadjuvant Chemotherapy.

Wilhelmina C M Duivenvoorden, Siamak Daneshmand, Daniel Canter, Yair Lotan, Peter C Black, Hamidreza Abdi, Bas W G van Rhijn, Elisabeth E Fransen van de Putte, Piotr Zareba, Ilmari Koskinen, Wassim Kassouf, Samer L Traboulsi, Janet E Kukreja, Peter J Boström, Bobby Shayegan, Jehonathan H Pinthus,

<h4>Purpose</h4>Neoadjuvant chemotherapy and pelvic surgery are significant risk factors for thromboembolic events. Our study objectives were to investigate the timing, incidence and characteristics of thromboembolic events during and after neoadjuvant chemotherapy and subsequent radical cystectomy in patients with muscle invasive bladder cancer.<h4>Materials and methods</h4>We performed a multi-institutional retrospective analysis of ... Read more >>

J Urol (The Journal of urology)
[2016, 196(6):1627-1633]

Cited: 8 times

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Neural Cell Adhesion Protein CNTN1 Promotes the Metastatic Progression of Prostate Cancer.

Judy Yan, Diane Ojo, Anil Kapoor, Xiaozeng Lin, Jehonathan H Pinthus, Tariq Aziz, Tarek A Bismar, Fengxiang Wei, Nicholas Wong, Jason De Melo, Jean-Claude Cutz, Pierre Major, Geoffrey Wood, Hao Peng, Damu Tang,

Prostate cancer metastasis is the main cause of disease-related mortality. Elucidating the mechanisms underlying prostate cancer metastasis is critical for effective therapeutic intervention. In this study, we performed gene-expression profiling of prostate cancer stem-like cells (PCSC) derived from DU145 human prostate cancer cells to identify factors involved in metastatic progression. ... Read more >>

Cancer Res (Cancer research)
[2016, 76(6):1603-1614]

Cited: 23 times

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Androgen deprivation therapy and cardiovascular disease: what is the linking mechanism?

Piotr Zareba, Wilhelmina Duivenvoorden, Darryl P Leong, Jehonathan H Pinthus,

The past decade has brought increased awareness of the potential adverse effects of androgen deprivation therapy (ADT) in men with prostate cancer. Arguably the most important and controversial of these is the increased risk of cardiovascular morbidity and mortality. Although multiple observational studies have shown that men treated with ADT ... Read more >>

Ther Adv Urol (Therapeutic advances in urology)
[2016, 8(2):118-129]

Cited: 18 times

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Inhibition of carbonic anhydrase IX (CA9) sensitizes renal cell carcinoma to ionizing radiation.

Wilhelmina C M Duivenvoorden, Sarah N Hopmans, Daniel Gallino, Thomas Farrell, Carrie Gerdes, Diana Glennie, Himu Lukka, Jehonathan H Pinthus,

While normal kidneys are relatively sensitive to ionizing radiation (IR), renal cell carcinoma (RCC) is considered radioresistant. Carbonic anhydrase IX (CA9), an enzyme that maintains intracellular pH by carbon dioxide dissolution, is upregulated in the majority of RCC, but not in normal kidneys. Since regulation of intracellular pH may enhance ... Read more >>

Oncol Rep (Oncology reports)
[2015, 34(4):1968-1976]

Cited: 6 times

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Cardiovascular risk with androgen deprivation therapy for prostate cancer: potential mechanisms.

Åsa Tivesten, Jehonathan H Pinthus, Noel Clarke, Wilhelmina Duivenvoorden, Jan Nilsson,

Androgen deprivation therapy (ADT) is frequently used for the treatment of advanced prostate cancer. ADT is associated with numerous side effects related to its mode of action, namely the suppression of testosterone to castrate levels. Recently, several large retrospective studies have also reported an increased risk of diabetes and cardiovascular ... Read more >>

Urol Oncol (Urologic oncology)
[2015, 33(11):464-475]

Cited: 10 times

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The relative contribution of urine extravasation to elevate plasma creatinine levels in acute unilateral ureteral obstruction.

Barak Rosenzweig, Jehonathan H Pinthus, Nir Kleinmann, Erel Joffe, Tomer Erlich, Eddie Fridman, Harry Winkler, Yoram Mor, Jacob Ramon, Zohar A Dotan,

<h4>Introduction</h4>Rising levels of plasma creatinine in the setting of acute unilateral ureteral obstruction (AUUO) often reflects acute renal failure, mandating kidney drainage. We hypothesize that re-absorption of peri-renal urine extravasation (PUE), a common result of UUO, contributes significantly to the elevation in plasma creatinine, rendering the latter an inaccurate benchmark ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2015, 9(7-8):E428-33]

Cited: 2 times

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