Full Text Journal Articles by
Author Jeffrey W Pennington


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Evaluating commercially available wireless cardiovascular monitors for measuring and transmitting real-time physiological responses in children with autism.

Heather J Nuske, Matthew S Goodwin, Yelena Kushleyeva, Daniel Forsyth, Jeffrey W Pennington, Aaron J Masino, Emma Finkel, Anushua Bhattacharya, Jessica Tan, Hungtzu Tai, Zabryna Atkinson-Diaz, Christopher P Bonafide, John D Herrington,

Commercially available wearable biosensors have the potential to enhance psychophysiology research and digital health technologies for autism by enabling stress or arousal monitoring in naturalistic settings. However, such monitors may not be comfortable for children with autism due to sensory sensitivities. To determine the feasibility of wearable technology in children ... Read more >>

Autism Res (Autism research : official journal of the International Society for Autism Research)
[2021, :]

Cited: 0 times

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SARS-CoV-2 Infection in Public School District Employees Following a District-Wide Vaccination Program - Philadelphia County, Pennsylvania, March 21-April 23, 2021.

David Rubin, Maggie Eisen, Sophia Collins, Jeffrey W Pennington, Xi Wang, Susan Coffin,

The School District of Philadelphia reopened for in-school instruction the week of March 21, 2021, and required weekly testing for SARS-CoV-2, the virus that causes COVID-19, for all employees returning to in-school responsibilities. The resumption of in-school instruction followed a mass vaccination program using the Pfizer-BioNTech 2-dose vaccine offered under ... Read more >>

MMWR Morb Mortal Wkly Rep (MMWR. Morbidity and mortality weekly report)
[2021, 70(30):1040-1043]

Cited: 0 times

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Identification of Pediatric Sepsis for Epidemiologic Surveillance Using Electronic Clinical Data.

Scott L Weiss, Fran Balamuth, Marianne Chilutti, Mark Jason Ramos, Peter McBride, Nancy-Ann Kelly, K Joy Payton, Julie C Fitzgerald, Jeffrey W Pennington,

<h4>Objectives</h4>A method to identify pediatric sepsis episodes that is not affected by changing diagnosis and claims-based coding practices does not exist. We derived and validated a surveillance algorithm to identify pediatric sepsis using routine clinical data and applied the algorithm to study longitudinal trends in sepsis epidemiology.<h4>Design</h4>Retrospective observational study.<h4>Setting</h4>Single academic ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(2):113-121]

Cited: 3 times

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Perspective on the Development of a Large-Scale Clinical Data Repository for Pediatric Hearing Research.

Jeffrey W Pennington, Byron Ruth, Jeffrey M Miller, Joy Peterson, Baichen Xu, Aaron J Masino, Ian Krantz, Juliana Manganella, Tamar Gomes, Derek Stiles, Margaret Kenna, Linda J Hood, John Germiller, E Bryan Crenshaw,

The use of "big data" for pediatric hearing research requires new approaches to both data collection and research methods. The widespread deployment of electronic health record systems creates new opportunities and corresponding challenges in the secondary use of large volumes of audiological and medical data. Opportunities include cost-effective hypothesis generation, ... Read more >>

Ear Hear (Ear and hearing)
[2020, 41(2):231-238]

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Anticipated responses of early adopter genetic specialists and nongenetic specialists to unsolicited genomic secondary findings.

Kurt D Christensen, Barbara A Bernhardt, Gail P Jarvik, Lucia A Hindorff, Jeffrey Ou, Sawona Biswas, Bradford C Powell, Robert W Grundmeier, Kalotina Machini, Dean J Karavite, Jeffrey W Pennington, Ian D Krantz, Jonathan S Berg, Katrina A B Goddard,

<h4>Purpose</h4>Secondary findings from genomic sequencing are becoming more common. We compared how health-care providers with and without specialized genetics training anticipated responding to different types of secondary findings.<h4>Methods</h4>Providers with genomic sequencing experience reviewed five secondary-findings reports and reported attitudes and potential clinical follow-up. Analyses compared genetic specialists and physicians without ... Read more >>

Genet Med (Genetics in medicine : official journal of the American College of Medical Genetics)
[2018, 20(10):1186-1195]

Cited: 6 times

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Utility and limitations of exome sequencing as a genetic diagnostic tool for children with hearing loss.

Sarah Sheppard, Sawona Biswas, Mindy H Li, Vijayakumar Jayaraman, Ian Slack, Edward J Romasko, Ariella Sasson, Joshua Brunton, Ramakrishnan Rajagopalan, Mahdi Sarmady, Jenica L Abrudan, Sowmya Jairam, Elizabeth T DeChene, Xiahoan Ying, Jiwon Choi, Alisha Wilkens, Sarah E Raible, Maria I Scarano, Avni Santani, Jeffrey W Pennington, Minjie Luo, Laura K Conlin, Batsal Devkota, Matthew C Dulik, Nancy B Spinner, Ian D Krantz,

<h4>Purpose</h4>Hearing loss (HL) is the most common sensory disorder in children. Prompt molecular diagnosis may guide screening and management, especially in syndromic cases when HL is the single presenting feature. Exome sequencing (ES) is an appealing diagnostic tool for HL as the genetic causes are highly heterogeneous.<h4>Methods</h4>ES was performed on ... Read more >>

Genet Med (Genetics in medicine : official journal of the American College of Medical Genetics)
[2018, 20(12):1663-1676]

Cited: 10 times

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Utilization of the Tablet Application Proband in Pedigree Construction and Assessment.

Andrew Joseph McCarty, Jeffrey M Miller, Heather Fecteau, Jeffrey W Pennington, Lisa Kessler,

Many medical institutions have converted to a digital model for record keeping due to the Health Information Technology for Economic and Clinical Health Act. This Act provides incentives to health care systems to accelerate and encourage the adoption of electronic health record (EHR) systems. The pedigree as a tool in ... Read more >>

J Genet Couns (Journal of genetic counseling)
[2018, 27(2):406-415]

Cited: 1 time

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Genomic decision support needs in pediatric primary care.

Jeffrey W Pennington, Dean J Karavite, Edward M Krause, Jeffrey Miller, Barbara A Bernhardt, Robert W Grundmeier,

Clinical genome and exome sequencing can diagnose pediatric patients with complex conditions that often require follow-up care with multiple specialties. The American Academy of Pediatrics emphasizes the role of the medical home and the primary care pediatrician in coordinating care for patients who need multidisciplinary support. In addition, the electronic ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2017, 24(4):851-856]

Cited: 3 times

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The biorepository portal toolkit: an honest brokered, modular service oriented software tool set for biospecimen-driven translational research.

Alex S Felmeister, Aaron J Masino, Tyler J Rivera, Adam C Resnick, Jeffrey W Pennington,

<h4>Background</h4>High throughput molecular sequencing and increased biospecimen variety have introduced significant informatics challenges for research biorepository infrastructures. We applied a modular system integration approach to develop an operational biorepository management system. This method enables aggregation of the clinical, specimen and genomic data collected for biorepository resources.<h4>Methods</h4>We introduce an electronic Honest ... Read more >>

BMC Genomics (BMC genomics)
[2016, 17 Suppl 4:434]

Cited: 4 times

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Temporal bone radiology report classification using open source machine learning and natural langue processing libraries.

Aaron J Masino, Robert W Grundmeier, Jeffrey W Pennington, John A Germiller, E Bryan Crenshaw,

<h4>Background</h4>Radiology reports are a rich resource for biomedical research. Prior to utilization, trained experts must manually review reports to identify discrete outcomes. The Audiological and Genetic Database (AudGenDB) is a public, de-identified research database that contains over 16,000 radiology reports. Because the reports are unlabeled, it is difficult to select ... Read more >>

BMC Med Inform Decis Mak (BMC medical informatics and decision making)
[2016, 16:65]

Cited: 6 times

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Increasing cumulative exposure to volatile anesthetic agents is associated with poorer neurodevelopmental outcomes in children with hypoplastic left heart syndrome.

Laura K Diaz, J William Gaynor, Shannon J Koh, Richard F Ittenbach, Marsha Gerdes, Judy C Bernbaum, Elaine H Zackai, Robert R Clancy, Mohamed A Rehman, Jeffrey W Pennington, Nancy Burnham, Thomas L Spray, Susan C Nicolson,

<h4>Objectives</h4>Despite improved survival in children with hypoplastic left heart syndrome (HLHS), significant concern persists regarding their neurodevelopmental (ND) outcomes. Previous studies have identified patient factors, such as prematurity and genetic syndromes, to be associated with worse ND outcomes. However, no consistent relationships have been identified among modifiable management factors, including ... Read more >>

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2016, 152(2):482-489]

Cited: 17 times

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Clinical phenotype-based gene prioritization: an initial study using semantic similarity and the human phenotype ontology.

Aaron J Masino, Elizabeth T Dechene, Matthew C Dulik, Alisha Wilkens, Nancy B Spinner, Ian D Krantz, Jeffrey W Pennington, Peter N Robinson, Peter S White,

<h4>Background</h4>Exome sequencing is a promising method for diagnosing patients with a complex phenotype. However, variant interpretation relative to patient phenotype can be challenging in some scenarios, particularly clinical assessment of rare complex phenotypes. Each patient's sequence reveals many possibly damaging variants that must be individually assessed to establish clear association ... Read more >>

BMC Bioinformatics (BMC bioinformatics)
[2014, 15:248]

Cited: 24 times

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Harvest: an open platform for developing web-based biomedical data discovery and reporting applications.

Jeffrey W Pennington, Byron Ruth, Michael J Italia, Jeffrey Miller, Stacey Wrazien, Jennifer G Loutrel, E Bryan Crenshaw, Peter S White,

Biomedical researchers share a common challenge of making complex data understandable and accessible as they seek inherent relationships between attributes in disparate data types. Data discovery in this context is limited by a lack of query systems that efficiently show relationships between individual variables, but without the need to navigate ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2014, 21(2):379-383]

Cited: 11 times

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Harvest: a web-based biomedical data discovery and reporting application development platform.

Michael J Italia, Jeffrey W Pennington, Byron Ruth, Stacey Wrazien, Jennifer G Loutrel, E Bryan Crenshaw, Jeffrey Miller, Peter S White,

Biomedical researchers share a common challenge of making complex data understandable and accessible. This need is increasingly acute as investigators seek opportunities for discovery amidst an exponential growth in the volume and complexity of laboratory and clinical data. To address this need, we developed Harvest, an open source framework that ... Read more >>

AMIA Jt Summits Transl Sci Proc (AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science)
[2013, 2013:82]

Cited: 0 times

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