Full Text Journal Articles by
Author Jeffrey Perl

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Supportive care for end-stage kidney disease: an integral part of kidney services across a range of income settings around the world.

Barnaby Hole, Brenda Hemmelgarn, Edwina Brown, Mark Brown, Mignon I McCulloch, Carlos Zuniga, Sharon P Andreoli, Peter G Blake, Cécile Couchoud, Alfonso M Cueto-Manzano, Gavin Dreyer, Guillermo Garcia Garcia, Kitty J Jager, Marla McKnight, Rachael L Morton, Fliss E M Murtagh, Saraladevi Naicker, Gregorio T Obrador, Jeffrey Perl, Muhibur Rahman, Kamal D Shah, Wim Van Biesen, Rachael C Walker, Karen Yeates, Alexander Zemchenkov, Ming-Hui Zhao, Simon J Davies, Fergus J Caskey,

A key component of treatment for all people with advanced kidney disease is supportive care, which aims to improve quality of life and can be provided alongside therapies intended to prolong life, such as dialysis. This article addresses the key considerations of supportive care as part of integrated end-stage kidney ... Read more >>

Kidney Int Suppl (2011) (Kidney international supplements)
[2020, 10(1):e86-e94]

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Challenges for sustainable end-stage kidney disease care in low-middle-income countries: the problem of the workforce.

Charles R Swanepoel, Mignon I McCulloch, Georgi Abraham, Jo-Ann Donner, Mona N Alrukhaimi, Peter G Blake, Sakarn Bunnag, Stefaan Claus, Gavin Dreyer, Mohammad A Ghnaimat, Fuad M Ibhais, Adrian Liew, Marla McKnight, Yewondwossen Tadesse Mengistu, Saraladevi Naicker, Abdou Niang, Gregorio T Obrador, Jeffrey Perl, Harun Ur Rashid, Marcello Tonelli, Kriang Tungsanga, Tushar Vachharajani, Elena Zakharova, Carlos Zuniga, Fredric O Finkelstein,

Prevention and early detection of kidney diseases in adults and children should be a priority for any government health department. This is particularly pertinent in the low-middle-income countries, mostly in Asia, Africa, Latin America, and the Caribbean, where up to 7 million people die because of lack of end-stage kidney ... Read more >>

Kidney Int Suppl (2011) (Kidney international supplements)
[2020, 10(1):e49-e54]

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International comparison of peritoneal dialysis prescriptions from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).

Angela Yee-Moon Wang, Junhui Zhao, Brian Bieber, Talerngsak Kanjanabuch, Martin Wilkie, Mark R Marshall, Hideki Kawanishi, Jeffrey Perl, Simon Davies, ,

BACKGROUND:We describe peritoneal dialysis (PD) prescription variations among Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) participants on continuous ambulatory PD (CAPD) and automated PD (APD; n = 4657) from Australia/New Zealand (A/NZ), Canada, Japan, Thailand, United Kingdom (UK), and United States (US). RESULTS:CAPD was more commonly used in Thailand ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2020, 40(3):310-319]

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Establishing a Core Outcome Set for Peritoneal Dialysis: Report of the SONG-PD (Standardized Outcomes in Nephrology-Peritoneal Dialysis) Consensus Workshop.

Karine E Manera, David W Johnson, Jonathan C Craig, Jenny I Shen, Talia Gutman, Yeoungjee Cho, Angela Yee-Moon Wang, Edwina A Brown, Gillian Brunier, Jie Dong, Tony Dunning, Rajnish Mehrotra, Saraladevi Naicker, Roberto Pecoits-Filho, Jeffrey Perl, Martin Wilkie, Allison Tong, ,

Outcomes reported in randomized controlled trials in peritoneal dialysis (PD) are diverse, are measured inconsistently, and may not be important to patients, families, and clinicians. The Standardized Outcomes in Nephrology-Peritoneal Dialysis (SONG-PD) initiative aims to establish a core outcome set for trials in PD based on the shared priorities of ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, 75(3):404-412]

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Prescribing high-quality peritoneal dialysis: Moving beyond urea clearance.

Tamara Glavinovic, Helen Hurst, Alastair Hutchison, Lina Johansson, Nicola Ruddock, Jeffrey Perl,

Urea removal in peritoneal dialysis (PD) has been a primary measure of dialysis adequacy, but its utility remains limited due to its poor correlation with the clearance of other important uraemic retention solutes and the low certainty of evidence relating peritoneal urea clearance and survival of individuals doing PD. Indeed, ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2020, 40(3):293-301]

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Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis.

Michael Walsh, Peter A Merkel, Chen-Au Peh, Wladimir M Szpirt, Xavier Puéchal, Shouichi Fujimoto, Carmel M Hawley, Nader Khalidi, Oliver Floßmann, Ron Wald, Louis P Girard, Adeera Levin, Gina Gregorini, Lorraine Harper, William F Clark, Christian Pagnoux, Ulrich Specks, Lucy Smyth, Vladimir Tesar, Toshiko Ito-Ihara, Janak Rashme de Zoysa, Wojciech Szczeklik, Luis Felipe Flores-Suárez, Simon Carette, Loïc Guillevin, Charles D Pusey, Alina L Casian, Biljana Brezina, Andrea Mazzetti, Carol A McAlear, Elizabeth Broadhurst, Donna Reidlinger, Samir Mehta, Natalie Ives, David R W Jayne, ,

BACKGROUND:More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. METHODS:We conducted a randomized trial with a 2-by-2 factorial design to evaluate the use of plasma exchange and two regimens of oral glucocorticoids in patients with severe ANCA-associated vasculitis (defined by an estimated glomerular filtration rate of ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2020, 382(7):622-631]

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Peritoneal Dialysis-Related Infection Rates and Outcomes: Results From the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).

Jeffrey Perl, Douglas S Fuller, Brian A Bieber, Neil Boudville, Talerngsak Kanjanabuch, Yasuhiko Ito, Sharon J Nessim, Beth M Piraino, Ronald L Pisoni, Bruce M Robinson, Douglas E Schaubel, Martin J Schreiber, Isaac Teitelbaum, Graham Woodrow, Junhui Zhao, David W Johnson,

RATIONALE & OBJECTIVE:Peritoneal dialysis (PD)-related peritonitis carries high morbidity for PD patients. Understanding the characteristics and risk factors for peritonitis can guide regional development of prevention strategies. We describe peritonitis rates and the associations of selected facility practices with peritonitis risk among countries participating in the Peritoneal Dialysis Outcomes and ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, 76(1):42-53]

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Peritoneal dialysis-associated peritonitis outcomes reported in trials and observational studies: A systematic review.

Muthana Al Sahlawi, Gregory Wilson, Belinda Stallard, Karine E Manera, Allison Tong, Ronald L Pisoni, Douglas S Fuller, Yeoungjee Cho, David W Johnson, Beth Piraino, Martin J Schreiber, Neil C Boudville, Isaac Teitelbaum, Jeffrey Perl,

BACKGROUND:Peritoneal dialysis (PD)-associated peritonitis carries significant morbidity, mortality, and is a leading cause of PD technique failure. This study aimed to assess the scope and variability of PD-associated peritonitis reported in randomized trials and observational studies. METHODS:Cochrane Controlled Register of Trials, MEDLINE, and Embase were searched from 2007 to June ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2020, 40(2):132-140]

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"Can I go to Glasgow?" Learnings from patient involvement at the 17th Congress of the International Society for Peritoneal Dialysis (ISPD).

Talia Gutman, Karine E Manera, Amanda Baumgart, David W Johnson, Martin Wilkie, Neil Boudville, Jonathan C Craig, Jie Dong, Shilpa Jesudason, Rajnish Mehrotra, Alicia Neu, Jenny I Shen, Wim Van Biesen, Peter G Blake, Gillian Brunier, Yeoungjee Cho, Nichole Jefferson, Ilan Lenga, Neelem Mann, Asher A Mendelson, Jeffrey Perl, Rafael Mauricio Sanabria, Nicole Scholes-Roberston, Daniel Schwartz, Isaac Teitelbaum, Allison Tong,

BACKGROUND:Recognition of the discrepancy between the research priorities of patients and health professionals has prompted efforts to involve patients as active contributors in research activities, including scientific conferences. However, there is limited evidence about the experience, challenges, and impacts of patient involvement to inform best practice. This study aims to ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2020, 40(1):12-25]

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DAMPAned Methotrexate: A Case Report and Review of the Management of Acute Methotrexate Toxicity.

Ann Young, Daniel Beriault, Benjamin Jung, Anna Nikonova, Dory Abosh, Samantha Lee, Jeff Zaltzman, Jeffrey Perl,

Rationale:Consensus guidelines on the management of methotrexate-induced nephrotoxicity using glucarpidase (Voraxaze) may be relatively unfamiliar to the nephrology community. Presenting concerns of the patient:A 61-year-old man with intravascular large B-cell lymphoma was admitted for cycle #1 of high-dose methotrexate (HDMTX) following 2 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and ... Read more >>

Can J Kidney Health Dis (Canadian Journal of Kidney Health and Disease)
[2019, 6:2054358119895078]

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Regional variation in the treatment and prevention of peritoneal dialysis-related infections in the Peritoneal Dialysis Outcomes and Practice Patterns Study.

Neil Boudville, David W Johnson, Junhui Zhao, Brian A Bieber, Ronald L Pisoni, Beth Piraino, Judith Bernardini, Sharon J Nessim, Yasuhiko Ito, Graham Woodrow, Fiona Brown, John Collins, Talerngsak Kanjanabuch, Cheuk-Chun Szeto, Jeffrey Perl,

BACKGROUND:Peritoneal dialysis (PD)-related infections lead to significant morbidity. The International Society for Peritoneal Dialysis (ISPD) guidelines for the prevention and treatment of PD-related infections are based on variable evidence. We describe practice patterns across facilities participating in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS). METHODS:PDOPPS, a prospective cohort ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2019, 34(12):2118-2126]

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Don't Interrupt! A Case Report of Continuing Peritoneal Dialysis After Endoscopic Gastric Tumor Resection.

William K Silverstein, Christopher Teshima, Simran Jolly, Jeffrey Perl,

Rationale:The evidence supporting the safety of restarting peritoneal dialysis (PD) immediately after abdominal surgery and interventions is scant. In particular, there are no reported cases characterizing periprocedural management of PD for patients undergoing endoscopic submucosal dissection for gastric intramucosal tumor removal. Presenting concerns of the patient:A 66-year-old female with end-stage ... Read more >>

Can J Kidney Health Dis (Canadian Journal of Kidney Health and Disease)
[2019, 6:2054358119887147]

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The Frequency of Routine Blood Sampling and Patient Outcomes Among Maintenance Hemodialysis Recipients.

Alison Thomas, Samuel A Silver, Jeffrey Perl, Megan Freeman, Justin J Slater, Danielle M Nash, Marlee Vinegar, Eric McArthur, Amit X Garg, Ziv Harel, Rahul Chanchlani, Michael Zappitelli, Eduard Iliescu, Abhijat Kitchlu, Daniel Blum, William Beaubien-Souligny, Ron Wald,

RATIONALE & OBJECTIVE:Surveillance blood work is routinely performed in maintenance hemodialysis (HD) recipients. Although more frequent blood testing may confer better outcomes, there is little evidence to support any particular monitoring interval. STUDY DESIGN:Retrospective population-based cohort study. SETTING & PARTICIPANTS:All prevalent HD recipients in Ontario, Canada, as of April 1, ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, 75(4):471-479]

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International Anemia Prevalence and Management in Peritoneal Dialysis Patients.

Rachel L Perlman, Junhui Zhao, Douglas S Fuller, Brian Bieber, Yun Li, Ronald L Pisoni, Bruce M Robinson, David W Johnson, Hideki Kawanishi, Simon J Davies, Martin J Schreiber, Jeffrey Perl,

Background:The optimal treatment for managing anemia in peritoneal dialysis (PD) patients and best clinical practices are not completely understood. We sought to characterize international variations in anemia measures and management among PD patients.Methods:The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) enrolled adult PD patients from 6 countries from 2014 ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2019, 39(6):539-546]

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Status of care for end stage kidney disease in countries and regions worldwide: international cross sectional survey.

Aminu K Bello, Adeera Levin, Meaghan Lunney, Mohamed A Osman, Feng Ye, Gloria E Ashuntantang, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Sara N Davison, Mohammad Ghnaimat, Paul Harden, Htay Htay, Vivekanand Jha, Kamyar Kalantar-Zadeh, Peter G Kerr, Scott Klarenbach, Csaba P Kovesdy, Valerie A Luyckx, Brendon L Neuen, Donal O'Donoghue, Shahrzad Ossareh, Jeffrey Perl, Harun Ur Rashid, Eric Rondeau, Emily See, Syed Saad, Laura Sola, Irma Tchokhonelidze, Vladimir Tesar, Kriang Tungsanga, Rumeyza Turan Kazancioglu, Angela Yee-Moon Wang, Natasha Wiebe, Chih-Wei Yang, Alexander Zemchenkov, Ming-Hui Zhao, Kitty J Jager, Fergus Caskey, Vlado Perkovic, Kailash K Jindal, Ikechi G Okpechi, Marcello Tonelli, John Feehally, David C Harris, David W Johnson,

OBJECTIVE:To determine the global capacity (availability, accessibility, quality, and affordability) to deliver kidney replacement therapy (dialysis and transplantation) and conservative kidney management. DESIGN:International cross sectional survey. SETTING:International Society of Nephrology (ISN) survey of 182 countries from July to September 2018. PARTICIPANTS:Key stakeholders identified by ISN's national and regional leaders. MAIN ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2019, 367:l5873]

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A comparison of technique survival in Canadian peritoneal dialysis and home hemodialysis patients.

Emilie Trinh, James A Hanley, Annie-Claire Nadeau-Fredette, Jeffrey Perl, Christopher T Chan,

BACKGROUND:High discontinuation rates remain a challenge for home hemodialysis (HHD) and peritoneal dialysis (PD). We compared technique failure risks among Canadian patients receiving HHD and PD. METHODS:Using the Canadian Organ Replacement Register, we studied adult patients who initiated HHD or PD within 1 year of beginning dialysis between 2000 and 2012, ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2019, 34(11):1941-1949]

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Predictors of Care Gaps in Home Dialysis: The Home Dialysis Virtual Ward Study.

Annie-Claire Nadeau-Fredette, Christopher T Chan, Joanne M Bargman, Michael A Copland, S Neil Finkle, Matthew J Oliver, Robert P Pauly, Jeffrey Perl, Nikhil A Shah, Deborah L Zimmerman, Karthik K Tennankore,

BACKGROUND:Home dialysis patients may be at an increased risk of adverse events after transitional states. The home dialysis virtual ward (HDVW) trial was conducted in Canadian dialysis centers and aimed to evaluate potential care gaps and patient satisfaction during the HDVW. METHODS:The HDVW was a multicenter single-arm trial including peritoneal ... Read more >>

Am. J. Nephrol. (American journal of nephrology)
[2019, 50(5):392-400]

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Cefepime as Empirical Peritoneal Dialysis-Associated Peritonitis Treatment: Something to Dwell On?

Muthana Al Sahlawi, Adrian Liew, Jeffrey Perl,

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2019, 74(5):579-582]

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Expanded Prospective Payment System and Use of and Outcomes with Home Dialysis by Race and Ethnicity in the United States.

Jenny I Shen, Kevin F Erickson, Lucia Chen, Sitaram Vangala, Lynn Leng, Anuja Shah, Anjali B Saxena, Jeffrey Perl, Keith C Norris,

BACKGROUND AND OBJECTIVES:We investigated whether the recent growth in home dialysis use was proportional among all racial/ethnic groups and also whether there were changes in racial/ethnic differences in home dialysis outcomes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:This observational cohort study of US Renal Data System patients initiating dialysis from 2005 to ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2019, 14(8):1200-1212]

Cited: 1 time

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Attitudes toward Peritoneal Dialysis among Peritoneal Dialysis and Hemodialysis Medical Directors: Are We Preaching to the Right Choir?

Jenny I Shen, Martin J Schreiber, Junhui Zhao, Bruce M Robinson, Ronald L Pisoni, Rajnish Mehrotra, Matthew J Oliver, Tadashi Tomo, Kriang Tungsanga, Isaac Teitelbaum, Arshia Ghaffari, Mark Lambie, Jeffrey Perl,

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2019, 14(7):1067-1070]

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Survival Comparisons of Home Dialysis Versus In-Center Hemodialysis: A Narrative Review.

Amanda J Vinson, Jeffrey Perl, Karthik K Tennankore,

Purpose of review:Many observational studies have demonstrated a survival benefit with home dialysis compared with in-center dialysis; however, results have been conflicting. The purpose of this review was to identify pitfalls and limitations in existing literature and examine the challenges of studying home and in-center dialysis populations. Sources of information:Original ... Read more >>

Can J Kidney Health Dis (Canadian Journal of Kidney Health and Disease)
[2019, 6:2054358119861941]

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A Peritoneal Dialysis Access Quality Improvement Initiative: A Single-Center Experience.

Tamara Glavinovic, Mina Kashani, Muthana Al-Sahlawi, Elizabeth Anderson, Megan Freeman, Niki Dacouris, Andrea Rathe-Skafel, Jason Y Lee, Monica Farcas, Andrew Common, Philip McFarlane, Jeffrey Perl,

Background:Little evidence exists regarding optimal peritoneal dialysis (PD) access insertion pathways, benchmarking for patency targets, and definitions of access dysfunction.Methods:This quality improvement (QI) project evaluated patients with PD catheters inserted at a single center in Toronto, Canada, following: establishment of PD catheter insertion protocols, a PD access coordinator, PD access ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2019, 39(5):437-446]

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Global Health Training Opportunities in North American Nephrology Fellowships.

Robert Rope, Jeffrey Perl, Shuchi Anand, ,

Kidney Int Rep (Kidney International Reports)
[2019, 4(7):904-907]

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Increasing access to integrated ESKD care as part of universal health coverage.

David C H Harris, Simon J Davies, Fredric O Finkelstein, Vivekanand Jha, Jo-Ann Donner, Georgi Abraham, Aminu K Bello, Fergus J Caskey, Guillermo Garcia Garcia, Paul Harden, Brenda Hemmelgarn, David W Johnson, Nathan W Levin, Valerie A Luyckx, Dominique E Martin, Mignon I McCulloch, Mohammed Rafique Moosa, Philip J O'Connell, Ikechi G Okpechi, Roberto Pecoits Filho, Kamal D Shah, Laura Sola, Charles Swanepoel, Marcello Tonelli, Ahmed Twahir, Wim van Biesen, Cherian Varghese, Chih-Wei Yang, Carlos Zuniga, ,

The global nephrology community recognizes the need for a cohesive strategy to address the growing problem of end-stage kidney disease (ESKD). In March 2018, the International Society of Nephrology hosted a summit on integrated ESKD care, including 92 individuals from around the globe with diverse expertise and professional backgrounds. The ... Read more >>

Kidney Int. (Kidney international)
[2019, 95(4S):S1-S33]

Cited: 2 times

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Patient-reported advantages and disadvantages of peritoneal dialysis: results from the PDOPPS.

Nidhi Sukul, Junhui Zhao, Douglas S Fuller, Angelo Karaboyas, Brian Bieber, James A Sloand, Lalita Subramanian, David W Johnson, Matthew J Oliver, Kriang Tungsanga, Tadashi Tomo, Rachael L Morton, Hal Morgenstern, Bruce M Robinson, Jeffrey Perl, ,

BACKGROUND:Patient-reported measures are increasingly recognized as important predictors of clinical outcomes in peritoneal dialysis (PD). We sought to understand associations between patient-reported perceptions of the advantages and disadvantages of PD and clinical outcomes. METHODS:In this cohort study, 2760 PD patients in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) ... Read more >>

BMC Nephrol (BMC nephrology)
[2019, 20(1):116]

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