Full Text Journal Articles by
Author Jeffrey M Miller

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Brain 5-HT1A Receptor PET Binding, Cortisol Responses to Stress, and the Familial Transmission of Suicidal Behavior.

Nadine M Melhem, Yongqi Zhong, Jeffrey M Miller, Francesca Zanderigo, R Todd Ogden, M Elizabeth Sublette, Madison Newell, Ainsley Burke, John G Keilp, Mohammad Lesanpezeshki, Elizabeth Bartlett, David A Brent, J John Mann,

<h4>Background</h4>The serotonin 1A (5-HT1A) receptor has been implicated in depression and suicidal behavior. Lower resting cortisol levels are associated with higher 5-HT1A receptor binding, and both differentiate suicide attempters with depression. However, it is not clear whether 5-HT1A receptor binding and cortisol responses to stress are related to familial risk ... Read more >>

Int J Neuropsychopharmacol (The international journal of neuropsychopharmacology)
[2021, :]

Cited: 0 times

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Influences of dopaminergic system dysfunction on late-life depression.

Warren D Taylor, David H Zald, Jennifer C Felger, Seth Christman, Daniel O Claassen, Guillermo Horga, Jeffrey M Miller, Katherine Gifford, Baxter Rogers, Sarah M Szymkowicz, Bret R Rutherford,

Deficits in cognition, reward processing, and motor function are clinical features relevant to both aging and depression. Individuals with late-life depression often show impairment across these domains, all of which are moderated by the functioning of dopaminergic circuits. As dopaminergic function declines with normal aging and increased inflammatory burden, the ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2021, :]

Cited: 0 times

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Neural predictors and effects of cognitive behavioral therapy for depression: the role of emotional reactivity and regulation - CORRIGENDUM.

Harry Rubin-Falcone, Jochen Weber, Ronit Kishon, Kevin Ochsner, Lauren Delaparte, Bruce Doré, Sudha Raman, Bryan T Denny, Maria A Oquendo, J John Mann, Jeffrey M Miller,

Psychol Med (Psychological medicine)
[2021, :1-2]

Cited: 0 times

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Diffusion tensor imaging brain structural clustering patterns in major depressive disorder.

Dongrong Xu, Guojun Xu, Zhiyong Zhao, M Elizabeth Sublette, Jeffrey M Miller, J John Mann,

Using magnetic resonance diffusion tensor imaging data from 45 patients with major depressive disorder (MDD) and 41 healthy controls (HCs), network indices based on a 246-region Brainnetcome Atlas were investigated in the two groups, and in the MDD subgroups that were subgrouped based on their duration of the disease. Correlation ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2021, 42(15):5023-5036]

Cited: 1 time

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Human-centered development of an electronic health record-embedded, interactive information visualization in the emergency department using fast healthcare interoperability resources.

Jeritt G Thayer, Daria F Ferro, Jeffrey M Miller, Dean Karavite, Robert W Grundmeier, Levon Utidjian, Joseph J Zorc,

<h4>Objective</h4>Develop and evaluate an interactive information visualization embedded within the electronic health record (EHR) by following human-centered design (HCD) processes and leveraging modern health information exchange standards.<h4>Materials and methods</h4>We applied an HCD process to develop a Fast Healthcare Interoperability Resources (FHIR) application that displays a patient's asthma history to clinicians ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2021, 28(7):1401-1410]

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Bipolar disorder and the gut microbiome: A systematic review.

M Elizabeth Sublette, Stephanie Cheung, Evan Lieberman, Shaohua Hu, J John Mann, Anne-Catrin Uhlemann, Jeffrey M Miller,

<h4>Objectives</h4>The microbiome is a rapidly advancing biomedical frontier with relevance for psychiatric illness. The gut microbiota interact with the central nervous system bidirectionally through the gut-brain axis and generate substances that may influence host metabolism, including short-chain fatty acids such as butyrate. Understanding gut microbiota in bipolar disorder (BD) may ... Read more >>

Bipolar Disord (Bipolar disorders)
[2021, 23(6):544-564]

Cited: 3 times

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Examining the relationship between gray matter volume and a continuous measure of bipolarity in unmedicated unipolar and bipolar depression.

Reuben Heyman-Kantor, Mina Rizk, M Elizabeth Sublette, Harry Rubin-Falcone, Yashar Yousefzadeh Fard, Ainsley K Burke, Maria A Oquendo, Gregory M Sullivan, Matthew S Milak, Francesca Zanderigo, J John Mann, Jeffrey M Miller,

<h4>Background</h4>It has been argued that unipolar major depressive disorder (MDD) and bipolar disorder (BD) exist on a continuous spectrum, given their overlapping symptomatology and genetic diatheses. The Bipolarity Index (BI) is a scale that considers bipolarity as a continuous construct and was developed to assess confidence in bipolar diagnosis. Here ... Read more >>

J Affect Disord (Journal of affective disorders)
[2021, 280(Pt A):105-113]

Cited: 0 times

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Characteristics of depressed suicide attempters with remitted substance use disorders.

Mina M Rizk, Hanga Galfalvy, Jeffrey M Miller, Matthew Milak, Ramin Parsey, Michael Grunebaum, Ainsley Burke, M Elizabeth Sublette, Maria A Oquendo, Barbara Stanley, J John Mann,

Substance use disorder (SUD) comorbidity in mood disorders increases suicide risk. Suicide attempters with active SUD appear to have distinct characteristics but little is known whether these characteristics persist during remission and if they are related to different aspects of suicidal behavior. In this study, suicide attempters with a DSM ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2021, 137:572-578]

Cited: 1 time

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Depression-related anterior cingulate prefrontal resting state connectivity normalizes following cognitive behavioral therapy - CORRIGENDUM.

Spiro P Pantazatos, Ashley Yttredahl, Harry Rubin-Falcone, Ronit Kishon, Maria A Oquendo, J John Mann, Jeffrey M Miller,

Eur Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2020, 63(1):e66]

Cited: 0 times

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Adherence to Pediatric Universal Cholesterol Testing Guidelines Across Body Mass Index Categories: A CER2 Cohort Study.

Emily F Gregory, Jeffrey M Miller, Richard C Wasserman, Roopa Seshadri, Robert W Grundmeier, David M Rubin, Alexander G Fiks,

Circ Cardiovasc Qual Outcomes (Circulation. Cardiovascular quality and outcomes)
[2020, 13(8):e006519]

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Highly variable suicidal ideation: a phenotypic marker for stress induced suicide risk.

Maria A Oquendo, Hanga C Galfalvy, Tse-Hwei Choo, Raksha Kandlur, Ainsley K Burke, M Elizabeth Sublette, Jeffrey M Miller, J John Mann, Barbara H Stanley,

Suicidal behavior (SB) can be impulsive or methodical; violent or not; follow a stressor or no obvious precipitant. This study tested whether childhood trauma, affective lability, and aggressive and impulsive traits predicted greater SI variability. We also assessed whether affective lability, aggressive or impulsive traits explain childhood trauma's effects on ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, :]

Cited: 2 times

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Identification of temporal condition patterns associated with pediatric obesity incidence using sequence mining and big data.

Elizabeth A Campbell, Ting Qian, Jeffrey M Miller, Ellen J Bass, Aaron J Masino,

<h4>Background</h4>Electronic health records (EHRs) are potentially important components in addressing pediatric obesity in clinical settings and at the population level. This work aims to identify temporal condition patterns surrounding obesity incidence in a large pediatric population that may inform clinical care and childhood obesity policy and prevention efforts.<h4>Methods</h4>EHR data from ... Read more >>

Int J Obes (Lond) (International journal of obesity (2005))
[2020, 44(8):1753-1765]

Cited: 0 times

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Large-scale network dynamics in neural response to emotionally negative stimuli linked to serotonin 1A binding in major depressive disorder.

Noam Schneck, Tao Tu, Harry Rubin Falcone, Jeffrey M Miller, Francesca Zanderigo, M Elizabeth Sublette, Maria A Oquendo, Barbara Stanley, Ainsley Burke, Kevin Ochsner, Paul Sajda, J John Mann,

Serotonergic dysfunction is implicated in major depressive disorder (MDD), but the mechanisms of this relationship remain elusive. Serotonin 1A (5-HT<sub>1A</sub>) autoreceptors regulate brain-wide serotonin neuron firing and are positioned to assert large-scale effects on negative emotion. Here we investigated the relationship between raphe 5-HT<sub>1A</sub> binding and brain-wide network dynamics of ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2021, 26(6):2393-2401]

Cited: 0 times

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Smaller left hippocampal subfield CA1 volume is associated with reported childhood physical and/or sexual abuse in major depression: A pilot study.

Minlan Yuan, Harry Rubin-Falcone, Xuejing Lin, Mina M Rizk, Jeffrey M Miller, M Elizabeth Sublette, Maria A Oquendo, Ainsley Burke, R Todd Ogden, J John Mann,

<h4>Background</h4>Smaller hippocampal volumes are reported in adults with major depressive disorder (MDD) and in reported childhood abuse. The hippocampus is a complex structure with distinct functional subfields. We sought to examine the effect of MDD diagnosis and childhood abuse on hippocampal subfields.<h4>Methods</h4>Forty-one MDD participants (17 reported abuse and 24 did ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 272:348-354]

Cited: 1 time

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Depression-related anterior cingulate prefrontal resting state connectivity normalizes following cognitive behavioral therapy.

Spiro P Pantazatos, Ashley Yttredahl, Harry Rubin-Falcone, Ronit Kishon, Maria A Oquendo, J John Mann, Jeffrey M Miller,

<h4>Background</h4>Aberrant activity of the subcallosal cingulate (SCC) is a common theme across pharmacologic treatment efficacy prediction studies. The functioning of the SCC in psychotherapeutic interventions is relatively understudied, as are functional differences among SCC subdivisions. We conducted functional connectivity analyses (rsFC) on resting-state functional magnetic resonance imaging (fMRI) data, collected ... Read more >>

Eur Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2020, 63(1):e37]

Cited: 2 times

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Perspective on the Development of a Large-Scale Clinical Data Repository for Pediatric Hearing Research.

Jeffrey W Pennington, Byron Ruth, Jeffrey M Miller, Joy Peterson, Baichen Xu, Aaron J Masino, Ian Krantz, Juliana Manganella, Tamar Gomes, Derek Stiles, Margaret Kenna, Linda J Hood, John Germiller, E Bryan Crenshaw,

The use of "big data" for pediatric hearing research requires new approaches to both data collection and research methods. The widespread deployment of electronic health record systems creates new opportunities and corresponding challenges in the secondary use of large volumes of audiological and medical data. Opportunities include cost-effective hypothesis generation, ... Read more >>

Ear Hear (Ear and hearing)
[2020, 41(2):231-238]

Cited: 0 times

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Association Between Mobile Telephone Interruptions and Medication Administration Errors in a Pediatric Intensive Care Unit.

Christopher P Bonafide, Jeffrey M Miller, A Russell Localio, Amina Khan, Adam C Dziorny, Mark Mai, Shannon Stemler, Wanxin Chen, John H Holmes, Vinay M Nadkarni, Ron Keren,

<h4>Importance</h4>Incoming text messages and calls on nurses' mobile telephones may interrupt medication administration, but whether such interruptions are associated with errors has not been established.<h4>Objective</h4>To assess whether a temporal association exists between mobile telephone interruptions and subsequent errors by pediatric intensive care unit (PICU) nurses during medication administration.<h4>Design, setting, and ... Read more >>

JAMA Pediatr (JAMA pediatrics)
[2020, 174(2):162-169]

Cited: 2 times

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Altered amygdala subregion-related circuits in treatment-naïve post-traumatic stress disorder comorbid with major depressive disorder.

Minlan Yuan, Spiro P Pantazatos, Hongru Zhu, Yuchen Li, Jeffrey M Miller, Harry Rubin-Falcone, Francesca Zanderigo, Zhengjia Ren, Cui Yuan, Su Lui, Qiyong Gong, Changjian Qiu, Wei Zhang, J John Mann,

Individuals with both post-traumatic stress disorder and major depressive disorder (PTSD+MDD) often show greater social and occupational impairment and poorer treatment response than individuals with PTSD alone. Increasing evidence reveals that the amygdala, a brain region implicated in the pathophysiology of both of these conditions, is a complex of structurally ... Read more >>

Eur Neuropsychopharmacol (European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology)
[2019, 29(10):1092-1101]

Cited: 4 times

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Cortisol Stress Response and in Vivo PET Imaging of Human Brain Serotonin 1A Receptor Binding.

Louisa J Steinberg, Harry Rubin-Falcone, Hanga C Galfalvy, Joshua Kaufman, Jeffrey M Miller, M Elizabeth Sublette, Thomas B Cooper, Eli Min, John G Keilp, Barbara H Stanley, Maria A Oquendo, R Todd Ogden, J John Mann,

BACKGROUND:Abnormalities in the hypothalamic-pituitary-adrenal axis, serotonergic system, and stress response have been linked to the pathogenesis of major depressive disorder. State-dependent hyper-reactivity of the hypothalamic-pituitary-adrenal axis is seen in major depressive disorder, and higher binding to the serotonin 1A receptor is observed as a trait in both currently depressed and ... Read more >>

Int J Neuropsychopharmacol (The international journal of neuropsychopharmacology)
[2019, 22(5):329-338]

Cited: 5 times

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Brain serotonin transporter binding, plasma arachidonic acid and depression severity: A positron emission tomography study of major depression.

Manesh Gopaldas, Francesca Zanderigo, Serena Zhan, R Todd Ogden, Jeffrey M Miller, Harry Rubin-Falcone, Thomas B Cooper, Maria A Oquendo, Gregory Sullivan, J John Mann, M Elizabeth Sublette,

<h4>Background</h4>Serotonin transporter (5-HTT) binding and polyunsaturated fatty acids (PUFAs) are implicated in major depressive disorder (MDD). Links between the two systems in animal models have not been investigated in humans.<h4>Methods</h4>Using positron emission tomography (PET) and [<sup>11</sup>C]DASB, we studied relationships between 5-HTT binding potential and plasma levels of PUFAs docosahexaenoic acid ... Read more >>

J Affect Disord (Journal of affective disorders)
[2019, 257:495-503]

Cited: 3 times

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Resting-state amplitude of low-frequency fluctuation is associated with suicidal ideation.

Martin J Lan, Mina M Rizk, Spiro P Pantazatos, Harry Rubin-Falcone, Jeffrey M Miller, M Elizabeth Sublette, Maria A Oquendo, John G Keilp, J John Mann,

BACKGROUND:Identifying brain activity patterns that are associated with suicidal ideation (SI) may help to elucidate its pathogenesis and etiology. Suicide poses a significant public health problem, and SI is a risk factor for suicidal behavior. METHODS:Forty-one unmedicated adult participants in a major depressive episode (MDE), 26 with SI on the ... Read more >>

Depress Anxiety (Depression and anxiety)
[2019, 36(5):433-441]

Cited: 6 times

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Routine Cholesterol Tests and Subsequent Change in BMI Among Overweight and Obese Children.

Emily F Gregory, Jeffrey M Miller, Richard C Wasserman, Roopa Seshadri, David M Rubin, Alexander G Fiks,

<h4>Introduction</h4>In 2011, the National Heart, Lung and Blood Institute and American Academy of Pediatrics concluded that both familial and obesity-associated dyslipidemias increase cardiovascular risk and recommended universal cholesterol testing at ages 9 to 11. It remains unknown whether testing influences body mass index (BMI) trajectory, a key modifiable cardiovascular outcome.<h4>Methods</h4>This ... Read more >>

Acad Pediatr (Academic pediatrics)
[2019, 19(7):773-779]

Cited: 2 times

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Systematic Review of Gut Microbiota and Major Depression.

Stephanie G Cheung, Ariel R Goldenthal, Anne-Catrin Uhlemann, J John Mann, Jeffrey M Miller, M Elizabeth Sublette,

<b>Background:</b> Recently discovered relationships between the gastrointestinal microbiome and the brain have implications for psychiatric disorders, including major depressive disorder (MDD). Bacterial transplantation from MDD patients to rodents produces depression-like behaviors. In humans, case-control studies have examined the gut microbiome in healthy and affected individuals. We systematically reviewed existing studies ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2019, 10:34]

Cited: 75 times

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Neural predictors and effects of cognitive behavioral therapy for depression: the role of emotional reactivity and regulation.

Harry Rubin-Falcone, Jochen Weber, Ronit Kishon, Kevin Ochsner, Lauren Delaparte, Bruce Doré, Sudha Raman, Bryan T Denny, Maria A Oquendo, J John Mann, Jeffrey M Miller,

BACKGROUND:Cognitive behavioral therapy (CBT) is an effective treatment for many patients suffering from major depressive disorder (MDD), but predictors of treatment outcome are lacking, and little is known about its neural mechanisms. We recently identified longitudinal changes in neural correlates of conscious emotion regulation that scaled with clinical responses to ... Read more >>

Psychol Med (Psychological medicine)
[2020, 50(1):146-160]

Cited: 4 times

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Assessing the Safety of Custom Web-Based Clinical Decision Support Systems in Electronic Health Records: A Case Study.

Jeritt G Thayer, Jeffrey M Miller, Alexander G Fiks, Linda Tague, Robert W Grundmeier,

<h4>Background</h4>With the widespread adoption of vendor-supplied electronic health record (EHR) systems, clinical decision support (CDS) customization efforts beyond those anticipated by the vendor may require the use of technologies external to the EHR such as web services. Pursuing such customizations, however, is not without risk. Validating the expected behavior of ... Read more >>

Appl Clin Inform (Applied clinical informatics)
[2019, 10(2):237-246]

Cited: 5 times

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