Full Text Journal Articles by
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Medical planning for disaster response: Identifying risk factors for developing adult respiratory distress syndrome among trauma patients.

Ryan J Keneally, Mark C Hubbard, Katrina Hawkins, Danielle Davison, Jeffrey S Berger,

<h4>Introduction</h4>Adult respiratory distress syndrome (ARDS) is a well-described complication of critical illness. We hy-pothesized that rates of comorbid diseases in a population may influence the risk for developing ARDS in trauma pa-tients. This can help plan medical responses.<h4>Methods</h4>Patients from the 2017 National Trauma Databank were analyzed. Inclusion criteria were an ... Read more >>

Am J Disaster Med (American journal of disaster medicine)
[2021, 16(1):43-48]

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Outcomes of Participants with Diabetes in the ISCHEMIA Trials.

Jonathan D Newman, Rebecca Anthopolos, G B John Mancini, Sripal Bangalore, Harmony R Reynolds, Dennis F Kunichoff, Roxy Senior, Jesus Peteiro, Balram Bhargava, Pallav Garg, Jorge Escobedo, Rolf Doerr, Tomasz Mazurek, Jose Gonzalez-Juanatey, Grzegorz Gajos, Carlo Briguori, Hong Cheng, Andras Vertes, Sandeep Mahajan, Luis A Guzman, Matyas Keltai, Aldo P Maggioni, Gregg W Stone, Jeffrey S Berger, Yves D Rosenberg, William E Boden, Bernard R Chaitman, Jerome L Fleg, Judith S Hochman, David J Maron,

<b>Background:</b> Among patients with diabetes mellitus (diabetes) and chronic coronary disease (CCD), it is unclear if invasive management improves outcomes when added to medical therapy. <b>Methods:</b> The ISCHEMIA Trials (ISCHEMIA and ISCHEMIA CKD) randomized CCD patients to an invasive (medical therapy + angiography and revascularization if feasible) or a conservative ... Read more >>

Circulation (Circulation)
[2021, :]

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World regional differences in outcomes for patients with peripheral artery disease: Insights from the EUCLID trial.

Lars Norgren, Rebecca North, Iris Baumgartner, Jeffrey S Berger, Juuso I Blomster, William R Hiatt, W Schuyler Jones, Brian G Katona, Kenneth W Mahaffey, Hillary Mulder, Manesh R Patel, Frank W Rockhold, F Gerry R Fowkes,

Regional variations exist in the epidemiology of peripheral artery disease (PAD), in comorbidities, use of secondary prevention, and outcomes. Large studies of these variations in worldwide populations are rare. The EUCLID (Examining Use of tiCagreLor In peripheral artery Disease) trial included 13,885 patients with PAD from four geographical regions (Central/South ... Read more >>

Vasc Med (Vascular medicine (London, England))
[2021, :1358863X211038620]

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Outcomes of cesarean delivery in obstetric patients with SARS-CoV-2 infection.

Allison Lankford, Jeffrey Berger, Ivy Benjenk, Amanda Jackson, Homa Ahmadzia, Michael Mazzeffi,

The impact of SARS-CoV-2's infection on cesarean delivery (CD) outcomes is not well described in the current literature. The present study's objective was to explore outcomes in SARS-CoV-2 infected CD patients using a statewide administrative database in Maryland, USA. ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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Chronic stress primes innate immune responses in mice and humans.

Tessa J Barrett, Emma M Corr, Coen van Solingen, Florencia Schlamp, Emily J Brown, Graeme J Koelwyn, Angela H Lee, Lianne C Shanley, Tanya M Spruill, Fazli Bozal, Annika de Jong, Alexandra A C Newman, Kamelia Drenkova, Michele Silvestro, Bhama Ramkhelawon, Harmony R Reynolds, Judith S Hochman, Matthias Nahrendorf, Filip K Swirski, Edward A Fisher, Jeffrey S Berger, Kathryn J Moore,

Psychological stress (PS) is associated with systemic inflammation and accelerates inflammatory disease progression (e.g., atherosclerosis). The mechanisms underlying stress-mediated inflammation and future health risk are poorly understood. Monocytes are key in sustaining systemic inflammation, and recent studies demonstrate that they maintain the memory of inflammatory insults, leading to a heightened ... Read more >>

Cell Rep (Cell reports)
[2021, 36(10):109595]

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Platelets amplify endotheliopathy in COVID-19.

Tessa J Barrett, MacIntosh Cornwell, Khrystyna Myndzar, Christina C Rolling, Yuhe Xia, Kamelia Drenkova, Antoine Biebuyck, Alexander T Fields, Michael Tawil, Elliot Luttrell-Williams, Eugene Yuriditsky, Grace Smith, Paolo Cotzia, Matthew D Neal, Lucy Z Kornblith, Stefania Pittaluga, Amy V Rapkiewicz, Hannah M Burgess, Ian Mohr, Kenneth A Stapleford, Deepak Voora, Kelly Ruggles, Judith Hochman, Jeffrey S Berger,

[Figure: see text]. ... Read more >>

Sci Adv (Science advances)
[2021, 7(37):eabh2434]

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Psoriasis and Cardiovascular Disease: Novel Mechanisms and Evolving Therapeutics.

Brittany Weber, Joseph F Merola, M Elaine Husni, Marcelo Di Carli, Jeffrey S Berger, Michael S Garshick,

<h4>Purpose of review</h4>Psoriasis is a chronic inflammatory skin condition that is associated with increased cardiovascular risk compared to those without psoriasis. This review will cover emerging mechanisms of cardiovascular risk, key pathways targeted with biologic therapies, and the current evidence on therapies to modulate this risk in patients with psoriasis.<h4>Recent ... Read more >>

Curr Atheroscler Rep (Current atherosclerosis reports)
[2021, 23(11):67]

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Comparison of Days Alive Out of Hospital With Initial Invasive vs Conservative Management: A Prespecified Analysis of the ISCHEMIA Trial.

Harvey D White, Sean M O'Brien, Karen P Alexander, William E Boden, Sripal Bangalore, Jianghao Li, Cholenahally N Manjunath, Jose Luis Lopez-Sendon, Jesus Peteiro, Gilbert Gosselin, Jeffrey S Berger, Aldo Pietro Maggioni, Harmony R Reynolds, Judith S Hochman, David J Maron,

<h4>Importance</h4>Traditional time-to-event analyses rate events occurring early as more important than later events, even if later events are more severe, eg, death. Days alive out of hospital (DAOH) adds a patient-focused perspective beyond trial end points.<h4>Objective</h4>To compare DAOH between invasive management and conservative management, including invasive protocol-assigned stays, in the ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2021, 6(9):1023-1031]

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To Deprescribe or Not to Deprescribe Aspirin-A Clear Indication Is the Challenge.

Tania Ahuja, Arun Manmadhan, Jeffrey S Berger,

JAMA Intern Med (JAMA internal medicine)
[2021, :]

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Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

, , , Patrick R Lawler, Ewan C Goligher, Jeffrey S Berger, Matthew D Neal, Bryan J McVerry, Jose C Nicolau, Michelle N Gong, Marc Carrier, Robert S Rosenson, Harmony R Reynolds, Alexis F Turgeon, Jorge Escobedo, David T Huang, Charlotte A Bradbury, Brett L Houston, Lucy Z Kornblith, Anand Kumar, Susan R Kahn, Mary Cushman, Zoe McQuilten, Arthur S Slutsky, Keri S Kim, Anthony C Gordon, Bridget-Anne Kirwan, Maria M Brooks, Alisa M Higgins, Roger J Lewis, Elizabeth Lorenzi, Scott M Berry, Lindsay R Berry, Aaron W Aday, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Todd W Costantini, Sophie de Brouwer, Lennie P G Derde, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Sebastian García-Madrona, Timothy D Girard, Lucas C Godoy, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Naomi M Hamburg, Rashan Haniffa, George Hanna, Nicholas Hanna, Sheila M Hegde, Carolyn M Hendrickson, R Duncan Hite, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Vivek N Iyer, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei L Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Vidya Krishnan, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Jose L Lopez-Sendon Moreno, Sylvain A Lother, Saurabh Malhotra, Miguel Marcos, Andréa Saud Marinez, John C Marshall, Nicole Marten, Michael A Matthay, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Steven C Moore, Raquel Morillo Guerrero, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Brenda Nunez-Garcia, Ambarish Pandey, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Yessica S Pérez González, Mauricio Pompilio, Matthew E Prekker, John G Quigley, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler Olombrada Santos, Lewis Satterwhite, Christina T Saunders, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Manu Shankar-Hari, John P Sheehan, Aneesh B Singhal, Dayna Solvason, Simon J Stanworth, Tobias Tritschler, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, Bryan J Wells, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Fernando G Zampieri, Derek C Angus, Colin J McArthur, Steven A Webb, Michael E Farkouh, Judith S Hochman, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.<h4>Methods</h4>In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):790-802]

Cited: 3 times

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Economic burden of rivaroxaban and warfarin among nonvalvular atrial fibrillation patients with obesity and polypharmacy.

François Laliberté, Veronica Ashton, Akshay Kharat, Dominique Lejeune, Kenneth Todd Moore, Young Jung, Patrick Lefebvre, Jeffrey S Berger,

<b>Aim:</b> Evaluate healthcare resource utilization (HRU) and costs associated with rivaroxaban and warfarin among nonvalvular atrial fibrillation (NVAF) patients with obesity and polypharmacy. <b>Materials & methods:</b> IQVIA PharMetrics<sup>®</sup> Plus (January 2010-September 2019) data were used to identify NVAF patients with obesity (BMI ≥30 kg/m<sup>2</sup>) and polypharmacy (≥5 medications) initiated on rivaroxaban or warfarin. ... Read more >>

J Comp Eff Res (Journal of comparative effectiveness research)
[2021, :]

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Microvascular endothelial glycocalyx thickness is associated with brachial artery flow-mediated dilation.

Nathaniel R Smilowitz, Elliot Luttrell-Williams, Michael Golpanian, Alexis Engel, Jill P Buyon, Stuart D Katz, Jeffrey S Berger,

Vasc Med (Vascular medicine (London, England))
[2021, :1358863X211026765]

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Summoning STRENGTH to Question the Placebo in REDUCE-IT.

John A Bostrom, Joshua A Beckman, Jeffrey S Berger,

Circulation (Circulation)
[2021, 144(6):407-409]

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Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.

, , , Ewan C Goligher, Charlotte A Bradbury, Bryan J McVerry, Patrick R Lawler, Jeffrey S Berger, Michelle N Gong, Marc Carrier, Harmony R Reynolds, Anand Kumar, Alexis F Turgeon, Lucy Z Kornblith, Susan R Kahn, John C Marshall, Keri S Kim, Brett L Houston, Lennie P G Derde, Mary Cushman, Tobias Tritschler, Derek C Angus, Lucas C Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E Farkouh, Maria M Brooks, Roger J Lewis, Lindsay R Berry, Elizabeth Lorenzi, Anthony C Gordon, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W Costantini, Sophie de Brouwer, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Heather F Eng, Jorge Escobedo, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Joshua D Froess, Zhuxuan Fu, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Timothy D Girard, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Rashan Haniffa, Sheila M Hegde, Carolyn M Hendrickson, Alisa M Higgins, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, David T Huang, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A Lother, Nicole Marten, Andréa Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Jose C Nicolau, Brenda Nunez-Garcia, John J Park, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Mauricio Pompilio, John G Quigley, Robert S Rosenson, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler O Santos, Lewis Satterwhite, Christina T Saunders, Jake Schreiber, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Aneesh B Singhal, Arthur S Slutsky, Dayna Solvason, Simon J Stanworth, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Yongqi Zhong, Scott M Berry, Colin J McArthur, Matthew D Neal, Judith S Hochman, Steven A Webb, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.<h4>Methods</h4>In an open-label, adaptive, multiplatform, randomized clinical trial, critically ill patients with severe Covid-19 were randomly assigned to a pragmatically defined ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):777-789]

Cited: 9 times

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Ankle-Brachial Index for Risk Stratification in Patients With Symptomatic Peripheral Artery Disease With and Without Prior Lower Extremity Revascularization: Observations From the EUCLID Trial.

William R Hiatt, Connie N Hess, Marc P Bonaca, Sarah Kavanagh, Manesh R Patel, Iris Baumgartner, Jeffrey S Berger, Juuso I Blomster, W Schuyler Jones, Brian G Katona, Kenneth W Mahaffey, Lars Norgren, Frank W Rockhold, F Gerry R Fowkes,

[Figure: see text]. ... Read more >>

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2021, 14(7):e009871]

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Data from emergency medicine palliative care access (EMPallA): a randomized controlled trial comparing the effectiveness of specialty outpatient versus telephonic palliative care of older adults with advanced illness presenting to the emergency department.

Abigail M Schmucker, Mara Flannery, Jeanne Cho, Keith S Goldfeld, Corita Grudzen, ,

<h4>Background</h4>The Emergency Medicine Palliative Care Access (EMPallA) trial is a large, multicenter, parallel, two-arm randomized controlled trial in emergency department (ED) patients comparing two models of palliative care: nurse-led telephonic case management and specialty, outpatient palliative care. This report aims to: 1) report baseline demographic and quality of life (QOL) ... Read more >>

BMC Emerg Med (BMC emergency medicine)
[2021, 21(1):83]

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Ticagrelor added to methotrexate improves rheumatoid arthritis disease severity.

Michael S Garshick, Pamela B Rosenthal, Elliot Luttrell-Williams, Bruce N Cronstein, Jeffrey S Berger,

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, :]

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Perioperative cardiovascular outcomes among older adults undergoing in-hospital noncardiac surgery.

Darcy Banco, John A Dodson, Jeffrey S Berger, Nathaniel R Smilowitz,

<h4>Background</h4>Older adults undergoing noncardiac surgery have a high risk of major adverse cardiovascular events (MACE). This study aims to estimate the magnitude of increased perioperative risk, and examine national trends in perioperative MACE following in-hospital noncardiac surgery in older adults compared to middle-aged adults.<h4>Design</h4>Time-series analysis of retrospective longitudinal data.<h4>Setting</h4>The United ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2021, :]

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The Role of Medical Schools in Propagating Physician Bias.

Dana Ribeiro Miller, Jeffrey T Berger,

N Engl J Med (The New England journal of medicine)
[2021, 384(24):e97]

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C-reactive protein and clinical outcomes in patients with COVID-19.

Nathaniel R Smilowitz, Dennis Kunichoff, Michael Garshick, Binita Shah, Michael Pillinger, Judith S Hochman, Jeffrey S Berger,

<h4>Background</h4>A systemic inflammatory response is observed in coronavirus disease 2019 (COVID-19). Elevated serum levels of C-reactive protein (CRP), a marker of systemic inflammation, are associated with severe disease in bacterial or viral infections. We aimed to explore associations between CRP concentration at initial hospital presentation and clinical outcomes in patients ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(23):2270-2279]

Cited: 12 times

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Anticoagulation in COVID-19: reaction to the ACTION trial.

Jeffrey S Berger, Jean Marie Connors,

Lancet (Lancet (London, England))
[2021, 397(10291):2226-2228]

Cited: 2 times

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Impact of chronic kidney disease on hemoglobin among patients with peripheral artery disease treated with P2Y12 inhibitors: Insights from the EUCLID trial.

Judith Hsia, Sarah T Kavanagh, Charles W Hopley, Iris Baumgartner, Jeffrey S Berger, Gerry R Fowkes, W Schuyler Jones, Kenneth W Mahaffey, Lars Norgren, Manesh R Patel, Frank Rockhold, Juuso Blomster, Brian G Katona, William R Hiatt, Marc P Bonaca,

Patients with chronic kidney disease may develop new or more severe anemia when treated with antiplatelet agents due to blood loss in conjunction with impaired erythropoiesis. Because anemia independently predicts limb amputation and mortality among patients with peripheral artery disease (PAD), we evaluated the relationship between estimated glomerular filtration rate ... Read more >>

Vasc Med (Vascular medicine (London, England))
[2021, :1358863X211017641]

Cited: 0 times

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Health Disparities, Systemic Racism, and Failures of Cultural Competence.

Jeffrey T Berger, Dana Ribeiro Miller,

Health disparities are primarily driven by structural inequality including systemic racism. Medical educators, led by the AAMC, have tended to minimize these core drivers of health disparities. Instead, it has adopted a culture-based agenda through the framework of cultural competence to address disparities despite a paucity of supporting data. Cultural ... Read more >>

Am J Bioeth (The American journal of bioethics : AJOB)
[2021, 21(9):4-10]

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Association of Heart Failure With Outcomes Among Patients With Peripheral Artery Disease: Insights From EUCLID.

Marc D Samsky, Anne Hellkamp, William R Hiatt, F Gerry R Fowkes, Iris Baumgartner, Jeffrey S Berger, Brian G Katona, Kenneth W Mahaffey, Lars Norgren, Juuso I Blomster, Frank W Rockhold, Adam D DeVore, Manesh R Patel, W Schuyler Jones,

Background Peripheral artery disease (PAD) and heart failure (HF) are each independently associated with poor outcomes. Risk factors associated with new-onset HF in patients with primary PAD are unknown. Furthermore, how the presence of HF is associated with outcomes in patients with PAD is unknown. Methods and Results This analysis ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(12):e018684]

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Ethics and Society: Physician Assisted Suicide and White Ethnocentrism.

Dana Ribeiro Miller, Jeffrey T Berger,

J Pain Symptom Manage (Journal of pain and symptom management)
[2021, 62(3):e1-e2]

Cited: 0 times

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