Full Text Journal Articles by
Author Jean Soulier

Advertisement

Find full text journal articles






The long non-coding RNA CRNDE regulates growth of multiple myeloma cells via an effect on IL6 signalling.

Antoine David, Simone Zocchi, Alexis Talbot, Caroline Choisy, Ashley Ohnona, Julien Lion, Wendy Cuccuini, Jean Soulier, Bertrand Arnulf, Jean-Christophe Bories, Michele Goodhardt, David Garrick,

Multiple myeloma (MM) is a currently incurable malignancy of antibody-secreting plasma cells. Long non-coding RNAs (lncRNAs) have been recognised as an important class of regulatory molecules which are increasingly implicated in tumorigenesis. While recent studies have demonstrated changes in expression of lncRNAs in MM, the functional significance and molecular pathways ... Read more >>

Leukemia (Leukemia)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Introduction to a review series on secondary leukemia.

Jean Soulier,

Blood (Blood)
[2020, 136(1):1]

Cited: 0 times

View full text PDF listing >>



Advertisement

XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature

Andrey Yurchenko, Ismael Padioleau, Bakhyt Matkarimov, Jean Soulier, Alain Sarasin, Sergey Nikolaev,

ABSTRACT Recent studies demonstrated a dramatically increased risk of leukemia in patients with a rare genetic disorder, Xeroderma Pigmentosum group C (XP-C), characterized by constitutive deficiency of global genome nucleotide excision repair (GG-NER). However, the genetic mechanisms of non-skin cancers in XP-C patients remain unexplored. In this study, we analyzed ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Clonal dominance is an adverse prognostic factor in acute myeloid leukemia treated with intensive chemotherapy.

Marco Cerrano, Matthieu Duchmann, Rathana Kim, Loic Vasseur, Pierre Hirsch, Xavier Thomas, Samuel Quentin, Justine Pasanisi, Marie Passet, Florence Rabian, Ramy Rahmé, Etienne Lengliné, Emmanuel Raffoux, Nathalie Dhédin, Marie Sébert, Odile Maarek, Anna Raimbault, Karine Celli-Lebras, Lionel Adès, Pierre Fenaux, Nicolas Boissel, François Delhommeau, Jean Soulier, Hervé Dombret, Emmanuelle Clappier, Pierre Sujobert, Raphael Itzykson,

Intra-tumor heterogeneity portends poor outcome in many cancers. In AML, a higher number of drivers worsens prognosis. The Shannon Index is a robust metric of clonal heterogeneity that accounts for the number of clones, but also their relative abundance. We show that a Shannon Index can be estimated from bulk ... Read more >>

Leukemia (Leukemia)
[2020, :]

Cited: 0 times

View full text PDF listing >>



A paediatric myelodysplastic syndrome with 5q deletion associated with Fanconi anaemia.

Laure Kornreich, Jean Soulier, Béatrice Grange, Sandrine Girard, Marie Ouchée-Chardin, Antony Ceraulo,

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(7):e28369]

Cited: 0 times

View full text PDF listing >>



Outcome and clinicophenotypical features of acute lymphoblastic leukemia/lymphoblastic lymphoma with cutaneous involvement: A multicenter case series.

Christophe Bontoux, Adèle De Masson, Olivia Boccara, Christine Bodemer, Sylvie Fraitag, Brigitte Balme, Nathalie Franck, Agnès Carlotti, François Comoz, Laurence Verneuil, Jean-François Brasme, Mylène Duplan, Anne Croué, Isabelle Templier, Helmut Beltraminelli, Olivier Dereure, Vanessa Szablewski, Céline Thevenin, Serge Boulinguez, Roland Viraben, Emilie Tournier, Laurence Lamant, Nicolas Ortonne, Saskia Ingen-Housz-Oro, Florence Beckerich, Florent Grange, Anne Durlach, Florent Amatore, Eric Frouin, Elizabeth McIntyre, Vahid Asnafi, Rathana Kim, Emmanuelle Clappier, Jean Soulier, Nicolas Boissel, Hervé Dombret, Martine Bagot, Maxime Battistella, ,

J. Am. Acad. Dermatol. (Journal of the American Academy of Dermatology)
[2020, 83(4):1166-1170]

Cited: 0 times

View full text PDF listing >>



BET inhibitors impair leukemic stem cell function only in defined oncogenic subgroups of acute myeloid leukaemias.

Aline Massé, Louise Roulin, Justine Pasanisi, Justine Penneroux, Stéphanie Gachet, Marc Delord, Ashfaq Ali, Antonio Alberdi, Jeannig Berrou, Marie Passet, Lucie Hernandez, Samuel Quentin, Claude Gardin, Emmanuel Raffoux, Lionel Adès, Thorsten Braun, Jean Soulier, Emmanuelle Clappier, Hervé Dombret, Alexandre Puissant, Raphael Itzykson,

Bromodomain and Extra-Terminal inhibitors (BETi) such as OTX015 are active in Acute Myeloid Leukaemias (AML). Their activity on Leukemic Stem Cells (LSCs) is less documented. We interrogated the anti-LSC activity of OTX015 in a niche-like long-term culture in 26 primary AML samples and validated our findings in vivo. OTX015 impaired ... Read more >>

Leuk. Res. (Leukemia research)
[2019, 87:106269]

Cited: 0 times

View full text PDF listing >>



ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.

Xi Luo, Simone Feurstein, Shruthi Mohan, Christopher C Porter, Sarah A Jackson, Sioban Keel, Michael Chicka, Anna L Brown, Chimene Kesserwan, Anupriya Agarwal, Minjie Luo, Zejuan Li, Justyne E Ross, Panagiotis Baliakas, Daniel Pineda-Alvarez, Courtney D DiNardo, Alison A Bertuch, Nikita Mehta, Tom Vulliamy, Ying Wang, Kim E Nichols, Luca Malcovati, Michael F Walsh, Lesley H Rawlings, Shannon K McWeeney, Jean Soulier, Anna Raimbault, Mark J Routbort, Liying Zhang, Gabriella Ryan, Nancy A Speck, Sharon E Plon, David Wu, Lucy A Godley,

Standardized variant curation is essential for clinical care recommendations for patients with inherited disorders. Clinical Genome Resource (ClinGen) variant curation expert panels are developing disease-associated gene specifications using the 2015 American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) guidelines to reduce curation discrepancies. The ... Read more >>

Blood Adv (Blood advances)
[2019, 3(20):2962-2979]

Cited: 3 times

View full text PDF listing >>



Efficacy of tyrosine kinase inhibitors in Ph-like acute lymphoblastic leukemia harboring ABL-class rearrangements.

Ilaria Tanasi, Ibrahima Ba, Nicolas Sirvent, Thorsten Braun, Wendy Cuccuini, Paola Ballerini, Nicolas Duployez, Aline Tanguy-Schmidt, Jérôme Tamburini, Sébastien Maury, Eric Doré, Chantal Himberlin, Cédric Duclos, Patrice Chevallier, Philippe Rousselot, Massimiliano Bonifacio, Hélène Cavé, André Baruchel, Hervé Dombret, Jean Soulier, Judith Landman-Parker, Nicolas Boissel, Emmanuelle Clappier,

Blood (Blood)
[2019, 134(16):1351-1355]

Cited: 3 times

View full text PDF listing >>



Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia.

Paula Río, Susana Navarro, Wei Wang, Rebeca Sánchez-Domínguez, Roser M Pujol, José C Segovia, Massimo Bogliolo, Eva Merino, Ning Wu, Rocío Salgado, María L Lamana, Rosa M Yañez, José A Casado, Yari Giménez, Francisco J Román-Rodríguez, Lara Álvarez, Omaira Alberquilla, Anna Raimbault, Guillermo Guenechea, M Luz Lozano, Laura Cerrato, Miriam Hernando, Eva Gálvez, Raquel Hladun, Irina Giralt, Jordi Barquinero, Anne Galy, Nagore García de Andoín, Ricardo López, Albert Catalá, Jonathan D Schwartz, Jordi Surrallés, Jean Soulier, Manfred Schmidt, Cristina Díaz de Heredia, Julián Sevilla, Juan A Bueren,

Fanconi anemia (FA) is a DNA repair syndrome generated by mutations in any of the 22 FA genes discovered to date1,2. Mutations in FANCA account for more than 60% of FA cases worldwide3,4. Clinically, FA is associated with congenital abnormalities and cancer predisposition. However, bone marrow failure is the primary ... Read more >>

Nat Med (Nature medicine)
[2019, 25(9):1396-1401]

Cited: 4 times

View full text PDF listing >>



Germline DDX41 mutations define a significant entity within adult MDS/AML patients.

Marie Sébert, Marie Passet, Anna Raimbault, Ramy Rahmé, Emmanuel Raffoux, Flore Sicre de Fontbrune, Marco Cerrano, Samuel Quentin, Nadia Vasquez, Mélanie Da Costa, Nicolas Boissel, Hervé Dombret, Régis Peffault de Latour, Gérard Socié, Raphaël Itzykson, Pierre Fenaux, Jean Soulier, Lionel Adès, Emmanuelle Clappier,

Germline DDX41 mutations are involved in familial myelodysplastic syndromes (MDSs) and acute myeloid leukemias (AMLs). We analyzed the prevalence and characteristics of DDX41-related myeloid malignancies in an unselected cohort of 1385 patients with MDS or AML. Using targeted next-generation sequencing, we identified 28 different germline DDX41 variants in 43 unrelated ... Read more >>

Blood (Blood)
[2019, 134(17):1441-1444]

Cited: 3 times

View full text PDF listing >>



Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.

Daphna Nachmani, Anne H Bothmer, Silvia Grisendi, Aldo Mele, Dietmar Bothmer, Jonathan D Lee, Emanuele Monteleone, Ke Cheng, Yang Zhang, Assaf C Bester, Alison Guzzetti, Caitlin A Mitchell, Lourdes M Mendez, Olga Pozdnyakova, Paolo Sportoletti, Maria-Paola Martelli, Tom J Vulliamy, Modi Safra, Schraga Schwartz, Lucio Luzzatto, Olivier Bluteau, Jean Soulier, Robert B Darnell, Brunangelo Falini, Inderjeet Dokal, Keisuke Ito, John G Clohessy, Pier Paolo Pandolfi,

RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2'-O-methylation (2'-O-Me) to the etiology of dyskeratosis congenita. We identify nucleophosmin (NPM1) as an essential regulator of 2'-O-Me on rRNA by directly binding ... Read more >>

Nat Genet (Nature genetics)
[2019, 51(10):1518-1529]

Cited: 4 times

View full text PDF listing >>



A comprehensive dataset of TLX1 positive ALL-SIL lymphoblasts and primary T-cell acute lymphoblastic leukemias

Karen Verboom, Wouter Van Loocke, Emmanuelle Clappier, Jean Soulier, Jo Vandesompele, Frank Speleman, Kaat Durinck,

Abstract Most currently available transcriptome data of T-cell acute lymphoblastic leukemia (T-ALL) are based on polyA[+] RNA sequencing methods thus lacking non-polyadenylated transcripts. Here, we present the data of polyA[+] and total RNA sequencing in the context of in vitro TLX1 knockdown in ALL-SIL cells and a primary T-ALL cohort. ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Familial predisposition to TP53/complex karyotype MDS and leukemia in DNA repair-deficient xeroderma pigmentosum.

Alain Sarasin, Samuel Quentin, Nathalie Droin, Mourad Sahbatou, Véronique Saada, Nathalie Auger, Yannick Boursin, Philippe Dessen, Anna Raimbault, Vahid Asnafi, Jean-Luc Schmutz, Alain Taïeb, Carlos F M Menck, Filippo Rosselli, Laurianne Drieu La Rochelle, Caroline Robert, Flore Sicre de Fontbrune, Marie Sébert, Thierry Leblanc, Patricia Kannouche, Stéphane De Botton, Eric Solary, Jean Soulier,

Blood (Blood)
[2019, 133(25):2718-2724]

Cited: 2 times

View full text PDF listing >>



PAX5 P80R mutation identifies a novel subtype of B-cell precursor acute lymphoblastic leukemia with favorable outcome.

Marie Passet, Nicolas Boissel, François Sigaux, Colombe Saillard, Mario Bargetzi, Ibrahima Ba, Xavier Thomas, Carlos Graux, Yves Chalandon, Thibaut Leguay, Etienne Lengliné, Johanna Konopacki, Samuel Quentin, Eric Delabesse, Marina Lafage-Pochitaloff, Cédric Pastoret, Nathalie Grardel, Vahid Asnafi, Véronique Lhéritier, Jean Soulier, Hervé Dombret, Emmanuelle Clappier, ,

Blood (Blood)
[2019, 133(3):280-284]

Cited: 2 times

View full text PDF listing >>



Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.

Carine Domenech, Loïc Maillard, Alix Rousseau, Fabien Guidez, Laurence Petit, Marika Pla, Denis Clay, Fabien Guimiot, Sandra Sanfilippo, Sebastien Jacques, Pierre de la Grange, Noémie Robil, Jean Soulier, Michèle Souyri,

Fanconi anemia (FA) causes bone marrow failure early during childhood, and recent studies indicate that a hematopoietic defect could begin in utero. We performed a unique kinetics study of hematopoiesis in Fancg-/- mouse embryos, between the early embryonic day 11.5 (E11.5) to E12.5 developmental window (when the highest level of ... Read more >>

Stem Cell Reports (Stem cell reports)
[2018, 11(5):1075-1091]

Cited: 2 times

View full text PDF listing >>



T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development.

Charles E de Bock, Michelle Down, Kinsha Baidya, Bram Sweron, Andrew W Boyd, Mark Fiers, Gordon F Burns, Timothy J Molloy, Richard B Lock, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jan Cools, Jeff Holst, Rick F Thorne,

Haematologica (Haematologica)
[2019, 104(5):e204-e207]

Cited: 0 times

View full text PDF listing >>



Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML.

Lina Benajiba, Gabriela Alexe, Angela Su, Emmanuel Raffoux, Jean Soulier, Michael T Hemann, Olivier Hermine, Raphael Itzykson, Kimberly Stegmaier, Alexandre Puissant,

Leukemia (Leukemia)
[2019, 33(3):800-804]

Cited: 1 time

View full text PDF listing >>



A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing.

Karen Verboom, Wouter Van Loocke, Pieter-Jan Volders, Bieke Decaesteker, Francisco Avila Cobos, Simon Bornschein, Charles E de Bock, Zeynep Kalender Atak, Emmanuelle Clappier, Stein Aerts, Jan Cools, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jo Vandesompele, Frank Speleman, Kaat Durinck,

Haematologica (Haematologica)
[2018, 103(12):e585-e589]

Cited: 0 times

View full text PDF listing >>



Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia.

Ashfaq Ali, Justine Penneroux, Reinaldo Dal Bello, Aline Massé, Samuel Quentin, Ashwin Unnikrishnan, Lucie Hernandez, Emmanuel Raffoux, Raouf Ben Abdelali, Aline Renneville, Claude Preudhomme, John Pimanda, Hervé Dombret, Jean Soulier, Pierre Fenaux, Emmanuelle Clappier, Lionel Adès, Alexandre Puissant, Raphael Itzykson,

Leukemia (Leukemia)
[2018, 32(8):1856-1860]

Cited: 0 times

View full text PDF listing >>



HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development.

Charles E de Bock, Sofie Demeyer, Sandrine Degryse, Delphine Verbeke, Bram Sweron, Olga Gielen, Roel Vandepoel, Carmen Vicente, Marlies Vanden Bempt, Antonis Dagklis, Ellen Geerdens, Simon Bornschein, Rik Gijsbers, Jean Soulier, Jules P Meijerink, Merja Heinäniemi, Susanna Teppo, Maria Bouvy-Liivrand, Olli Lohi, Enrico Radaelli, Jan Cools,

Leukemia is caused by the accumulation of multiple genomic lesions in hematopoietic precursor cells. However, how these events cooperate during oncogenic transformation remains poorly understood. We studied the cooperation between activated JAK3/STAT5 signaling and HOXA9 overexpression, two events identified as significantly co-occurring in T-cell acute lymphoblastic leukemia. Expression of mutant ... Read more >>

Cancer Discov (Cancer discovery)
[2018, 8(5):616-631]

Cited: 11 times

View full text PDF listing >>



Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL.

Sandrine Degryse, Simon Bornschein, Charles E de Bock, Emilie Leroy, Marlies Vanden Bempt, Sofie Demeyer, Kris Jacobs, Ellen Geerdens, Olga Gielen, Jean Soulier, Christine J Harrison, Stefan N Constantinescu, Jan Cools,

The Janus kinase 3 (JAK3) tyrosine kinase is mutated in 10% to 16% of T-cell acute lymphoblastic leukemia (T-ALL) cases. JAK3 mutants induce constitutive JAK/STAT signaling and cause leukemia when expressed in the bone marrow cells of mice. Surprisingly, we observed that one third of JAK3-mutant T-ALL cases harbor 2 ... Read more >>

Blood (Blood)
[2018, 131(4):421-425]

Cited: 5 times

View full text PDF listing >>



Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia.

Emilie Lesport, Alina Ferster, Armand Biver, Benoit Roch, Nadia Vasquez, Nada Jabado, Francina Langa Vives, Patrick Revy, Jean Soulier, Jean-Pierre de Villartay,

The Fanconi anemia (FA) pathway is implicated in the repair of DNA interstrand crosslinks (ICL). In this process, it has been shown that FA factors regulate the choice for DNA double strand break repair towards homologous recombination (HR). As this mechanism is impaired in FA deficient cells exposed to crosslinking ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(3):3779-3793]

Cited: 0 times

View full text PDF listing >>



A landscape of germ line mutations in a cohort of inherited bone marrow failure patients.

Olivier Bluteau, Marie Sebert, Thierry Leblanc, Régis Peffault de Latour, Samuel Quentin, Elodie Lainey, Lucie Hernandez, Jean-Hugues Dalle, Flore Sicre de Fontbrune, Etienne Lengline, Raphael Itzykson, Emmanuelle Clappier, Nicolas Boissel, Nadia Vasquez, Mélanie Da Costa, Julien Masliah-Planchon, Wendy Cuccuini, Anna Raimbault, Louis De Jaegere, Lionel Adès, Pierre Fenaux, Sébastien Maury, Claudine Schmitt, Marc Muller, Carine Domenech, Nicolas Blin, Bénédicte Bruno, Isabelle Pellier, Mathilde Hunault, Stéphane Blanche, Arnaud Petit, Guy Leverger, Gérard Michel, Yves Bertrand, André Baruchel, Gérard Socié, Jean Soulier,

Bone marrow (BM) failure (BMF) in children and young adults is often suspected to be inherited, but in many cases diagnosis remains uncertain. We studied a cohort of 179 patients (from 173 families) with BMF of suspected inherited origin but unresolved diagnosis after medical evaluation and Fanconi anemia exclusion. All ... Read more >>

Blood (Blood)
[2018, 131(7):717-732]

Cited: 35 times

View full text PDF listing >>



Oncogenetic mutations combined with MRD improve outcome prediction in pediatric T-cell acute lymphoblastic leukemia.

Arnaud Petit, Amélie Trinquand, Sylvie Chevret, Paola Ballerini, Jean-Michel Cayuela, Nathalie Grardel, Aurore Touzart, Benoit Brethon, Hélène Lapillonne, Claudine Schmitt, Sandrine Thouvenin, Gerard Michel, Claude Preudhomme, Jean Soulier, Judith Landman-Parker, Guy Leverger, Elizabeth Macintyre, André Baruchel, Vahid Asnafi, ,

Risk stratification in childhood T-cell acute lymphoblastic leukemia (T-ALL) is mainly based on minimal residual disease (MRD) quantification. Whether oncogenetic mutation profiles can improve the discrimination of MRD-defined risk categories was unknown. Two hundred and twenty FRALLE2000T-treated patients were tested retrospectively for NOTCH1/FBXW7/RAS and PTEN alterations. Patients with NOTCH1/FBXW7 (N/F) ... Read more >>

Blood (Blood)
[2018, 131(3):289-300]

Cited: 15 times

View full text PDF listing >>



Advertisement

Disclaimer
1.2451 s