Full Text Journal Articles by
Author Jean Paul Brouillet


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Relevance of total PSA and free PSA prescriptions.

Pierre-Jean Lamy, Jean-Paul Brouillet, Laurent Bermont, Guy Fouillet, Sylvain Loric,

The total PSA testing has been frequently criticized for its effectiveness in the early detection of prostate cancer. These widely resumed in and out of the medical community have led to a decrease in prescriptions. Recommendations against the use of PSA for screening have been issued in France and in ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2018, 76(6):659-663]

Cited: 0 times

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Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability.

Litaty Céphanoée Mbatchi, Jean-Paul Brouillet, Alexandre Evrard,

NR1I2 (PXR) and NR1I3 (CAR) are nuclear receptors that are classified as xenoreceptors. Upon activation by various xenobiotics, including marketed drugs, they regulate the transcription level of major drug-metabolizing enzymes and transporters and facilitate the elimination of xenobiotics from the body. The modulation of the activity of these two xenoreceptors ... Read more >>

Pharmacogenomics (Pharmacogenomics)
[2018, 19(1):61-77]

Cited: 3 times

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Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination.

Litaty Céphanoée Mbatchi, Antonin Schmitt, Fabienne Thomas, Yoann Cazaubon, Jacques Robert, Serge Lumbroso, Jean-Paul Brouillet, Philippe Pourquier, Etienne Chatelut, Jean-Christophe Boyer, Alexandre Evrard,

The goal of our study was to assess the impact of patients' genetic background on their sensitivity to carboplatin/paclitaxel hematotoxicity.Parameters describing sensitivity to neutropenia and to thrombocytopenia of 201 patients were extracted from a previous pharmacokinetic/pharmacodynamics analysis, in order to assess their association with 52 candidates SNPs in 18 genes.Carriers ... Read more >>

Pharmacogenomics (Pharmacogenomics)
[2015, 16(13):1439-1450]

Cited: 8 times

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A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia.

Kevin Mouzat, Eric Mercier, Anne Polge, Alexandre Evrard, Silvère Baron, Jean-Pierre Balducchi, Jean-Paul Brouillet, Serge Lumbroso, Jean-Christophe Gris,

Preeclampsia is a frequent complication of pregnancy and a leading cause of perinatal mortality. Both genetic and environmental risk factors have been identified. Lipid metabolism, particularly cholesterol metabolism, is associated with this disease. Liver X receptors alpha (NR1H3, also known as LXRalpha) and beta (NR1H2, also known as LXRbeta) play ... Read more >>

BMC Med. Genet. (BMC medical genetics)
[2011, 12:145]

Cited: 12 times

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Gene expression profiling in head and neck squamous cell carcinoma: Clinical perspectives.

Benjamin Lallemant, Alexandre Evrard, Guillaume Chambon, Omar Sabra, Sophie Kacha, Jean-Gabriel Lallemant, Serge Lumbroso, Jean-Paul Brouillet,

BACKGROUND: To date, more than 60 gene expression profiling (GEP) studies have been published in the field of head and neck squamous cell carcinoma (HNSCC) with variable objectives, methods, and results. METHODS: The purpose of this study was to present a state-of-the-art review of GEP in HNSCC focusing on the ... Read more >>

Head Neck (Head & neck)
[2010, 32(12):1712-1719]

Cited: 19 times

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Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse.

Benjamin Lallemant, Alexandre Evrard, Christophe Combescure, Heliette Chapuis, Guillaume Chambon, Caroline Raynal, Christophe Reynaud, Omar Sabra, Dominique Joubert, Frédéric Hollande, Jean-Gabriel Lallemant, Serge Lumbroso, Jean-Paul Brouillet,

BACKGROUND: Analysis of 23 published transcriptome studies allowed us to identify nine genes displaying frequent alterations in HNSCC (FN1, MMP1, PLAU, SPARC, IL1RN, KRT4, KRT13, MAL, and TGM3). We aimed to independently confirm these dysregulations and to identify potential relationships with clinical data for diagnostic, staging and prognostic purposes either ... Read more >>

BMC Cancer (BMC cancer)
[2009, 9:370]

Cited: 21 times

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Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

Caroline Raynal, Jean-Marc Pascussi, Géraldine Leguelinel, Cyril Breuker, Jovana Kantar, Benjamin Lallemant, Sylvain Poujol, Caroline Bonnans, Dominique Joubert, Frédéric Hollande, Serge Lumbroso, Jean-Paul Brouillet, Alexandre Evrard,

Clinical efficacy of chemotherapy in colorectal cancer is subjected to broad inter-individual variations leading to the inability to predict outcome and toxicity. The topoisomerase I inhibitor irinotecan (CPT-11) is worldwide approved for the treatment of metastatic colorectal cancer and undergoes extensive peripheral and tumoral metabolism. PXR is a xenoreceptor activated ... Read more >>

Mol. Cancer (Molecular cancer)
[2010, 9:46]

Cited: 44 times

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High-resolution melting analysis of sequence variations in the cytidine deaminase gene (CDA) in patients with cancer treated with gemcitabine.

Caroline Raynal, Joseph Ciccolini, Cédric Mercier, Jean-Christophe Boyer, Anne Polge, Benjamin Lallemant, Kévin Mouzat, Serge Lumbroso, Jean-Paul Brouillet, Alexandre Evrard,

Gemcitabine (2',2'-difluorodeoxycytidine) is a major antimetabolite cytotoxic drug with a wide spectrum of activity against solid tumors. Hepatic elimination of gemcitabine depends on a catabolic pathway through a deamination step driven by the enzyme cytidine deaminase (CDA). Severe hematologic toxicity to gemcitabine was reported in patients harboring genetic polymorphisms in ... Read more >>

Ther Drug Monit (Therapeutic drug monitoring)
[2010, 32(1):53-60]

Cited: 13 times

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Reference gene selection for head and neck squamous cell carcinoma gene expression studies.

Benjamin Lallemant, Alexandre Evrard, Christophe Combescure, Heliette Chapuis, Guillaume Chambon, Caroline Raynal, Christophe Reynaud, Omar Sabra, Dominique Joubert, Frédéric Hollande, Jean-Gabriel Lallemant, Serge Lumbroso, Jean-Paul Brouillet,

BACKGROUND: It is no longer adequate to choose reference genes blindly. We present the first study that defines the suitability of 12 reference genes commonly used in cancer studies (ACT, ALAS, B2M, GAPDH, HMBS, HPRT, KALPHA, RPS18, RPL27, RPS29, SHAD and TBP) for the normalization of quantitative expression data in ... Read more >>

BMC Mol. Biol. (BMC molecular biology)
[2009, 10:78]

Cited: 29 times

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Detection of circulating prostate-specific antigen-secreting cells in prostate cancer patients.

Catherine Alix-Panabières, Xavier Rebillard, Jean-Paul Brouillet, Eric Barbotte, François Iborra, Bruno Segui, Thierry Maudelonde, Colette Jolivet-Reynaud, Jean-Pierre Vendrell,

Clin. Chem. (Clinical chemistry)
[2005, 51(8):1538-1541]

Cited: 31 times

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Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients.

Catherine Alix-Panabières, Jean-Paul Brouillet, Michel Fabbro, Hans Yssel, Thérèse Rousset, Thierry Maudelonde, Genevieve Choquet-Kastylevsky, Jean-Pierre Vendrell,

In the process of metastasis, malignant cells are released from the primary tumor and migrate to specific organs via the lymphatic and blood circulation systems. These circulating tumor cells have been characterized by immunochemistry, the reverse transcription-polymerase chain reaction, and flow cytometry. Using the MCF-7 breast cancer cell line, we ... Read more >>

J. Immunol. Methods (Journal of immunological methods)
[2005, 299(1-2):177-188]

Cited: 39 times

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Six novel heterozygous MLH1, MSH2, and MSH6 and one homozygous MLH1 germline mutations in hereditary nonpolyposis colorectal cancer.

Jean-Marc Rey, Mehrdad Noruzinia, Jean-Paul Brouillet, Pierre Sarda, Thierry Maudelonde, Pascal Pujol,

Most hereditary nonpolyposis colorectal cancer (HNPCC) cases are caused by germline mutations of mismatch repair (MMR) genes (i.e., MLH1, MSH2, or MSH6). Here we describe six novel mutations in patients referred for genetic assessment. All of these mutations lead to premature translation termination. Five single base pair deletions lead to ... Read more >>

Cancer Genet. Cytogenet. (Cancer genetics and cytogenetics)
[2004, 155(2):149-151]

Cited: 20 times

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Assessment of RNA quality extracted from laser-captured tissues using miniaturized capillary electrophoresis.

Virginie Copois, Caroline Bret, Frédéric Bibeau, Jean-Paul Brouillet, Maguy Del Rio, Marie-Laurence Berthe, Thierry Maudelonde, Nathalie Boulle,

Lab. Invest. (Laboratory investigation; a journal of technical methods and pathology)
[2003, 83(4):599-602]

Cited: 9 times

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Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis.

Guy Berchem, Murielle Glondu, Michel Gleizes, Jean-Paul Brouillet, Françoise Vignon, Marcel Garcia, Emmanuelle Liaudet-Coopman,

Cathepsin-D is an independent marker of poor prognosis in human breast cancer. We previously showed that human wild-type cathepsin-D, as well as its mutated form devoid of proteolytic activity stably transfected in 3Y1-Ad12 cancer cells, stimulated tumor growth. To investigate the mechanisms by which human cathepsin-D and its catalytically-inactive counterpart ... Read more >>

Oncogene (Oncogene)
[2002, 21(38):5951-5955]

Cited: 113 times

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[Genetic alterations of transcription cofactors in solid tumors].

Jean-François Rouayrenc, Audrey Castet, Jean-Marc Rey, Jean-Paul Brouillet, Pascal Pujol, Françoise Vignon, Thierry Maudelonde, Vincent Cavaillès,

Many hormones exert their effects through specific nuclear receptors which belong to a superfamily of ligand-activated transcription factors. These receptors control target gene expression through the recruitment of different cofactors acting as transcription activation or repression mediators, generally as parts of multiprotein complexes. The importance and the role in physiopathology ... Read more >>

Bull Cancer (Bulletin du cancer)
[2002, 89(4):357-364]

Cited: 0 times

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