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Author Jayne Ness

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Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis.

Kristen M Krysko, Jennifer S Graves, Mary Rensel, Bianca Weinstock-Guttman, Alice Rutatangwa, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu S Goyal, Yolanda Harris, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To assess real-world effectiveness of initial treatment with newer compared to injectable disease-modifying therapies (DMTs) on disease activity in pediatric multiple sclerosis (MS) and clinically isolated syndrome (CIS). METHODS:This is a cohort study of children with MS/CIS followed at 12 clinics in the US Network of Pediatric MS Centers, who ... Read more >>

Ann. Neurol. (Annals of neurology)
[2020, :]

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Cognitive processing speed in pediatric-onset multiple sclerosis: Baseline characteristics of impairment and prediction of decline.

Asya I Wallach, Michael Waltz, T Charles Casper, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Jennifer Graves, Yolanda Harris, Timothy E Lotze, Soe Mar, Manikum Moodley, Jayne M Ness, Mary Rensel, Moses Rodriguez, John W Rose, Teri Schreiner, Jan-Mendelt Tillema, Emmanuelle Waubant, Bianca Weinstock-Guttman, Leigh E Charvet, Lauren B Krupp,

BACKGROUND:Cognitive impairment occurs in approximately one-third of pediatric-onset multiple sclerosis (POMS) patients. The Symbol Digit Modalities Test (SDMT), a widely used cognitive screen in adults, has yet to be incorporated early into the standard care of POMS. OBJECTIVE:To screen for cognitive impairment early in the course of POMS and analyze ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, :1352458519891984]

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Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.

Emmanuelle Waubant, Brenda Banwell, Evangeline Wassmer, Maria-Pia Sormani, Maria-Pia Amato, Rogier Hintzen, Lauren Krupp, Kevin Rostásy, Silvia Tenembaum, Tanuja Chitnis, ,

OBJECTIVE:The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data for effective therapies for pediatric patients, in a reasonable timeframe, with a key focus on short- and long-term safety. METHODS:The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review ... Read more >>

Neurology (Neurology)
[2019, 92(22):e2538-e2549]

Cited: 1 time

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miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.

Brooke Rhead, Xiaorong Shao, Jennifer S Graves, Tanuja Chitnis, Amy T Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Lauren Krupp, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Moses Rodriguez, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan S Candee, Mark Gorman, Leslie Benson, Soe Mar, Ilana Kahn, John Rose, T Charles Casper, Hong Quach, Diana Quach, Catherine Schaefer, Emmanuelle Waubant, Lisa F Barcellos, ,

Objective:Onset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small noncoding RNAs that affect gene expression by binding target gene mRNAs. Few studies have specifically examined ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(6):1053-1061]

Cited: 1 time

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Vitamin D genes influence MS relapses in children.

Jennifer S Graves, Lisa F Barcellos, Lauren Krupp, Anita Belman, Xiaorong Shao, Hong Quach, Janace Hart, Tanuja Chitnis, Bianca Weinstock-Guttman, Gregory Aaen, Leslie Benson, Mark Gorman, Benjamin Greenberg, Timothy Lotze, Mar Soe, Jayne Ness, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, T Charles Casper, Emmanuelle Waubant,

OBJECTIVE:The aim of this study was to determine whether a vitamin D genetic risk score (vitDGRS) is associated with 25-hydroxyvitamin D (25(OH)D) level and multiple sclerosis (MS) relapses in children. METHODS:DNA samples were typed for single nucleotide polymorphisms (SNPs) from four genes previously identified to be associated with 25(OH)D levels. ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, :1352458519845842]

Cited: 1 time

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Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry.

Calvin Chi, Xiaorong Shao, Brooke Rhead, Edlin Gonzales, Jessica B Smith, Anny H Xiang, Jennifer Graves, Amy Waldman, Timothy Lotze, Teri Schreiner, Bianca Weinstock-Guttman, Gregory Aaen, Jan-Mendelt Tillema, Jayne Ness, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Tanuja Chitnis, Soe Mar, Anita Belman, Theron Charles Casper, John Rose, Manikum Moodley, Mary Rensel, Moses Rodriguez, Benjamin Greenberg, Llana Kahn, Jennifer Rubin, Catherine Schaefer, Emmanuelle Waubant, Annette Langer-Gould, Lisa F Barcellos,

Multiple sclerosis (MS) is an autoimmune disease with high prevalence among populations of northern European ancestry. Past studies have shown that exposure to ultraviolet radiation could explain the difference in MS prevalence across the globe. In this study, we investigate whether the difference in MS prevalence could be explained by ... Read more >>

PLoS Genet. (PLoS genetics)
[2019, 15(1):e1007808]

Cited: 2 times

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Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis.

Gregory Aaen, Michael Waltz, Wendy Vargas, Naila Makhani, Jayne Ness, Yolanda Harris, T Charles Casper, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Jennifer Graves, Benjamin Greenberg, Timothy Lotze, Soe Mar, Jan-Mendelt Tillema, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Amy Waldman, Bianca Weinstock-Guttman, Anita Belman, Emmanuelle Waubant, Lauren Krupp,

Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisition of 2-word phrases. A total of 467 (308 female) cases and 428 (209 female) controls were enrolled. Pediatric ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2019, 34(3):148-152]

Cited: 0 times

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Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US.

Kristen M Krysko, Jennifer Graves, Mary Rensel, Bianca Weinstock-Guttman, Gregory Aaen, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu Goyal, Lauren Krupp, Timothy Lotze, Soe Mar, Moses Rodriguez, John Rose, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To characterize the use and safety of newer disease-modifying therapies (DMTs) in children with multiple sclerosis (MS) and clinically isolated syndrome (CIS) treated under 18 years of age. METHODS:This is a cohort study including children with MS or CIS followed at 12 outpatient practices participating in the US Network of ... Read more >>

Neurology (Neurology)
[2018, 91(19):e1778-e1787]

Cited: 3 times

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Several household chemical exposures are associated with pediatric-onset multiple sclerosis.

Soe Mar, Shannon Liang, Michael Waltz, T Charles Casper, Manu Goyal, Benjamin Greenberg, Bianca Weinstock-Guttman, Moses Rodriguez, Gregory Aaen, Anita Belman, Lisa F Barcellos, John Rose, Mark Gorman, Leslie Benson, Meghan Candee, Tanjua Chitnis, Yolanda Harris, Ilana Kahn, Shelly Roalsted, Janace Hart, Timothy Lotze, Manikum Moodley, Jayne Ness, Mary Rensel, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Lauren Krupp, Jennifer S Graves, Emmanuelle Waubant, ,

Background:There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods:We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(12):1513-1521]

Cited: 1 time

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Heterogeneity in association of remote herpesvirus infections and pediatric MS.

Bardia Nourbakhsh, Alice Rutatangwa, Michael Waltz, Mary Rensel, Manikum Moodley, Jennifer Graves, Theron Charles Casper, Amy Waldman, Anita Belman, Benjamin Greenberg, Manu Goyal, Yolanda Harris, Ilana Kahn, Timothy Lotze, Soe Mar, Teri Schreiner, Gregory Aaen, Janace Hart, Jayne Ness, Jennifer Rubin, Jan-Mendelt Tillema, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, John Rose, Meghan Candee, Bianca Weinstock-Guttman, Xiaorong Shao, Lisa Barcellos, Judith James, Emmanuelle Waubant, ,

Objective:While prior Epstein-Barr virus (EBV) infection has been consistently associated with subsequent risk of developing multiple sclerosis (MS), the association with other common herpesviruses has been more controversial. Our objectives were to determine whether remote infection with EBV and other common herpesviruses affect the susceptibility to pediatric MS and if ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(10):1222-1228]

Cited: 2 times

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Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis.

Tanuja Chitnis, Douglas L Arnold, Brenda Banwell, Wolfgang Brück, Angelo Ghezzi, Gavin Giovannoni, Benjamin Greenberg, Lauren Krupp, Kevin Rostásy, Marc Tardieu, Emmanuelle Waubant, Jerry S Wolinsky, Amit Bar-Or, Tracy Stites, Yu Chen, Norman Putzki, Martin Merschhemke, Jutta Gärtner, ,

Treatment of patients younger than 18 years of age with multiple sclerosis has not been adequately examined in randomized trials. We compared fingolimod with interferon beta-1a in this population.In this phase 3 trial, we randomly assigned patients 10 to 17 years of age with relapsing multiple sclerosis in a 1:1 ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2018, 379(11):1017-1027]

Cited: 13 times

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Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis.

Leena Suleiman, Emmanuelle Waubant, Gregory Aaen, Anita Belman, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Manu Goyal, Benjamin Greenberg, Yolanda Harris, Janace Hart, Ilana Kahn, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Bardia Nourbakhsh, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, T Charles Casper, Michael Waltz, Jennifer S Graves, ,

OBJECTIVE:We sought to determine if early infectious exposures such as daycare, early use of antibiotics, vaccinations and other germ exposures including pacifier use and playing on grass are associated with multiple sclerosis (MS) risk in children. METHODS:This was a case-control study of children with MS or clinically isolated syndrome (CIS) ... Read more >>

Mult Scler Relat Disord (Multiple Sclerosis and Related Disorders)
[2018, 22:103-107]

Cited: 0 times

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Pediatric multiple sclerosis: current perspectives on health behaviors.

Elizabeth Morghen Sikes, Robert W Motl, Jayne M Ness,

Pediatric-onset multiple sclerosis (POMS) accounts for ~5% of all multiple sclerosis cases, and has a prevalence of ~10,000 children in the USA. POMS is associated with a higher relapse rate, and results in irreversible disability on average 10 years earlier than adult-onset multiple sclerosis. Other manifestations of POMS include mental ... Read more >>

Pediatric Health Med Ther (Pediatric health, medicine and therapeutics)
[2018, 9:17-25]

Cited: 1 time

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Correction to: Impact of an electronic monitoring device and behavioural feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.

E Ann Yeh, Stephanie A Grover, Victoria E Powell, Gulay Alper, Brenda L Banwell, Kim Edwards, Mark Gorman, Jennifer Graves, Timothy E Lotze, Jean K Mah, Lauren Mednick, Jayne Ness, Maya Obadia, Ruth Slater, Amy Waldman, Emmanuelle Waubant, Carolyn E Schwartz, ,

The clinicaltrials.gov identifying number for the article titled "Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial" is NCT02234713 (https://clinicaltrials.gov/ct2/show/NCT02234713). ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2018, 27(4):1117]

Cited: 0 times

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Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis.

Saeedeh Azary, Teri Schreiner, Jennifer Graves, Amy Waldman, Anita Belman, Bianca Weinstock Guttman, Gregory Aaen, Jan-Mendelt Tillema, Soe Mar, Janace Hart, Jayne Ness, Yolanda Harris, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, John Rose, Lisa F Barcellos, Tim Lotze, Suzan L Carmichael, Shelly Roalstad, Charles T Casper, Emmanuelle Waubant,

OBJECTIVE:The role of diet in multiple sclerosis (MS) course remains largely unknown. Children with MS have a higher relapse rate compared with MS in adults. Thus, studying the effect of diet on relapse rate in this age group is likely to provide more robust answers. METHODS:This is a multicentre study ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2018, 89(1):28-33]

Cited: 13 times

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Genetic risk factors for pediatric-onset multiple sclerosis.

Milena A Gianfrancesco, Pernilla Stridh, Xiaorong Shao, Brooke Rhead, Jennifer S Graves, Tanuja Chitnis, Amy Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Benjamin Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Soe Mar, Ilana Kahn, John Rose, Shelly Roalstad, T Charles Casper, Ling Shen, Hong Quach, Diana Quach, Jan Hillert, Anna Hedstrom, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Catherine Schaefer, Lisa F Barcellos, Emmanuelle Waubant, ,

BACKGROUND:Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. OBJECTIVE:We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS. METHODS:Cases with onset <18 years (n = 569) and controls (n = 16,251) were included from ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(14):1825-1834]

Cited: 4 times

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Dietary factors and pediatric multiple sclerosis: A case-control study.

Julia Pakpoor, Brandon Seminatore, Jennifer S Graves, Teri Schreiner, Amy T Waldman, Timothy E Lotze, Anita Belman, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan-Mendelt Tillema, Jamie C McDonald, Janace Hart, Jayne M Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, Soe Mar, Ilana Kahn, John Rose, Suzan L Carmichael, Shelly Roalstad, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

BACKGROUND:The role of diet in multiple sclerosis (MS) is largely uncharacterized, particularly as it pertains to pediatric-onset disease. OBJECTIVE:To determine the association between dietary factors and MS in children. METHODS:Pediatric MS patients and controls were recruited from 16 US centers (MS or clinically isolated syndrome onset before age 18, <4 years ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(8):1067-1076]

Cited: 6 times

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Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.

Milena A Gianfrancesco, Pernilla Stridh, Brooke Rhead, Xiaorong Shao, Edison Xu, Jennifer S Graves, Tanuja Chitnis, Amy Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Benjamin Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Soe Mar, Ilana Kahn, John Rose, Shelly Roalstad, T Charles Casper, Ling Shen, Hong Quach, Diana Quach, Jan Hillert, Maria Bäärnhielm, Anna Hedstrom, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Catherine Metayer, Catherine Schaefer, Lisa F Barcellos, Emmanuelle Waubant, ,

To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS).We constructed an instrumental variable for vitamin D (vitD GRS) by computing a GRS for 3 genetic variants associated with levels ... Read more >>

Neurology (Neurology)
[2017, 88(17):1623-1629]

Cited: 25 times

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Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.

E Ann Yeh, Stephanie A Grover, Victoria E Powell, Gulay Alper, Brenda L Banwell, Kim Edwards, Mark Gorman, Jennifer Graves, Timothy E Lotze, Jean K Mah, Lauren Mednick, Jayne Ness, Maya Obadia, Ruth Slater, Amy Waldman, Emmanuelle Waubant, Carolyn E Schwartz, ,

To report the results of a randomized controlled trial using an electronic monitoring device (EM) plus a motivational interviewing (MI) intervention to enhance adherence to disease-modifying therapies (DMT) in pediatric MS.Fifty-two youth with MS (16.03 ± 2.2 years) were randomized to receive either MI (n = 25) (target intervention) or a MS medication video (n = 27) ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2017, 26(9):2333-2349]

Cited: 4 times

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Distinct effects of obesity and puberty on risk and age at onset of pediatric MS.

Tanuja Chitnis, Jennifer Graves, Bianca Weinstock-Guttman, Anita Belman, Cody Olsen, Madhusmita Misra, Gregory Aaen, Leslie Benson, Meghan Candee, Mark Gorman, Benjamin Greenberg, Lauren Krupp, Timothy Lotze, Soe Mar, Jayne Ness, John Rose, Jennifer Rubin, Teri Schreiner, Jan Tillema, Amy Waldman, Moses Rodriguez, Charlie Casper, Emmanuelle Waubant, ,

The aim of this study was to examine the relative contributions of body mass index (BMI) and pubertal measures for risk and age of onset of pediatric MS.Case-control study of 254 (63% female) MS cases (onset<18 years of age) and 420 (49% female) controls conducted at 14 U.S. Pediatric MS ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2016, 3(12):897-907]

Cited: 19 times

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Pediatric multiple sclerosis: Clinical features and outcome.

Amy Waldman, Jayne Ness, Daniela Pohl, Isabella Laura Simone, Banu Anlar, Maria Pia Amato, Angelo Ghezzi,

Multiple sclerosis (MS) in children manifests with a relapsing-remitting MS (RRMS) disease course. Acute relapses consist of new neurologic deficits persisting greater than 24 hours, in the absence of intercurrent illness, and occur with a higher frequency early in the disease as compared to adult-onset RRMS. Most pediatric patients with ... Read more >>

Neurology (Neurology)
[2016, 87(9 Suppl 2):S74-81]

Cited: 14 times

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Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls.

Helen Tremlett, Douglas W Fadrosh, Ali A Faruqi, Janace Hart, Shelly Roalstad, Jennifer Graves, Collin M Spencer, Susan V Lynch, Scott S Zamvil, Emmanuelle Waubant, ,

As little is known of association(s) between gut microbiota profiles and host immunological markers, we explored these in children with and without multiple sclerosis (MS).Children ≤18 years provided stool and blood. MS cases were within 2-years of onset. Fecal 16S rRNA gene profiles were generated on an Illumina Miseq platform. Peripheral ... Read more >>

BMC Neurol (BMC neurology)
[2016, 16(1):182]

Cited: 24 times

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Characteristics of Children and Adolescents With Multiple Sclerosis.

Anita L Belman, Lauren B Krupp, Cody S Olsen, John W Rose, Greg Aaen, Leslie Benson, Tanuja Chitnis, Mark Gorman, Jennifer Graves, Yolander Harris, Tim Lotze, Jayne Ness, Moses Rodriguez, Jan-Mendelt Tillema, Emmanuelle Waubant, Bianca Weinstock-Guttman, T Charles Casper, ,

To describe the demographic and clinical characteristics of pediatric multiple sclerosis (MS) in the United States.This prospective observational study included children and adolescents with MS. Cases were evaluated across 9 geographically diverse sites as part of the US Network of Pediatric MS Centers.A total of 490 children and adolescents (324 ... Read more >>

Pediatrics (Pediatrics)
[2016, 138(1):]

Cited: 16 times

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Dietary salt intake and time to relapse in paediatric multiple sclerosis.

Bardia Nourbakhsh, Jennifer Graves, T Charles Casper, Sabeen Lulu, Amy Waldman, Anita Belman, Benjamin Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan-Mendelt Tillema, Janace Hart, Jayne Ness, Jennifer Rubin, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, John Rose, Lisa Barcellos, Emmanuelle Waubant, ,

Salt intake was reported to be associated with increased clinical and MRI activity in adult patients with relapsing-remitting multiple sclerosis (MS).To determine if salt intake is associated with time to relapse in patients with paediatric-onset MS.Paediatric-onset MS and patients with clinically isolated syndrome (CIS) within 4 years of disease onset were ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2016, 87(12):1350-1353]

Cited: 17 times

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T cell cytokine signatures: Biomarkers in pediatric multiple sclerosis.

Cather M Cala, Carson E Moseley, Chad Steele, Sarah M Dowdy, Gary R Cutter, Jayne M Ness, Tara M DeSilva,

Although multiple sclerosis is predominantly regarded as a disease of young adulthood, up to 5% of MS patients are diagnosed prior to age eighteen. The predominant form of MS is relapsing-remitting characterized by exacerbations of symptoms followed by periods of remission. The majority of disease modifying drugs target T cell ... Read more >>

J. Neuroimmunol. (Journal of neuroimmunology)
[2016, 297:1-8]

Cited: 6 times

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