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Author Jayendra Shukla

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Impact of Different Patterns of Organ Failure on Mortality in Acute Necrotizing Pancreatitis.

Anupam K Singh, Jayanta Samanta, Jayendra Shukla, Chhagan Lal Birda, Jahnvi Dhar, Pankaj Gupta, Praveen Kumar-M, Vikas Gupta, Thakur Deen Yadav, Saroj K Sinha, Rakesh Kochhar,

<h4>Objectives</h4>Organ failure (OF) and infected necrosis (IN) are the most important predictors of mortality in necrotizing acute pancreatitis (AP). We studied the relationship between timing (onset and duration) and patterns of OF with mortality and the impact of IN on mortality.<h4>Methods</h4>Consecutive patients with necrotizing AP between January 2017 and February ... Read more >>

Pancreas (Pancreas)
[2021, 50(7):1030-1036]

Cited: 0 times

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Hepatic tuberculosis: myriad of hues.

Arup Choudhury, Jayendra Shukla, Gaurav Mahajan, Day Krishna Jha, Pankaj Gupta, Vishal Sharma,

<h4>Introduction</h4>Gastrointestinal tuberculosis is an important form of extrapulmonary tuberculosis but liver involvement is uncommon. Hepatic tuberculosis can manifest in variable manners including as a space occupying lesion, diffuse infiltration by granulomas (granulomatous hepatitis) and as liver abscess. Hepatic tuberculosis is usually associated with lesions elsewhere but the diagnosis is often ... Read more >>

Germs (Germs)
[2021, 11(2):310-313]

Cited: 0 times

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Acute severe ulcerative colitis: management advice for internal medicine and emergency physicians-comment.

Jayendra Shukla, Anuraag Jena, Vishal Sharma,

Intern Emerg Med (Internal and emergency medicine)
[2021, 16(8):2323]

Cited: 0 times

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Long Non-Coding RNAs in Insects.

Chhavi Choudhary, Shivasmi Sharma, Keshav Kumar Meghwanshi, Smit Patel, Prachi Mehta, Nidhi Shukla, Duy Ngoc Do, Subhash Rajpurohit, Prashanth Suravajhala, Jayendra Nath Shukla,

Only a small subset of all the transcribed RNAs are used as a template for protein translation, whereas RNA molecules that are not translated play a very important role as regulatory non-coding RNAs (ncRNAs). Besides traditionally known RNAs (ribosomal and transfer RNAs), ncRNAs also include small non-coding RNAs (sncRNAs) and ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2021, 11(4):]

Cited: 1 time

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Genome-editing approaches and applications: a brief review on CRISPR technology and its role in cancer.

Narmadhaa Siva, Sonal Gupta, Ayam Gupta, Jayendra Nath Shukla, Babita Malik, Nidhi Shukla,

The development of genome-editing technologies in 1970s has discerned a new beginning in the field of science. Out of different genome-editing approaches such as Zing-finger nucleases, TALENs, and meganucleases, clustered regularly interspaced short palindromic repeats-CRISPR-associated protein 9 (CRISPR/Cas9) is a recent and versatile technology that has the ability of making ... Read more >>

3 Biotech (3 Biotech)
[2021, 11(3):146]

Cited: 2 times

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Cost concerns, not the guidelines, drive clinical care of IBD during COVID pandemic in a resource limited setting.

Vishal Sharma, Jayendra Shukla, Vikas Suri, Anuraag Jena, Anirudh Mukerjee, Harshal S Mandavdhare, Ashish Bhalla, Usha Dutta,

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2021, 15(4):465-466]

Cited: 0 times

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Mandatory preprocedure testing for SARS-CoV-2 for all-comers may not be required for resuming endoscopic services amidst the ongoing COVID-19 pandemic.

Soumya Jagannath, Ashish Agarwal, Deepak Gunjan, Samir Mohindra, Vishal Sharma, Sudipta Dhar Chowdhury, Sanjeev Sachdeva, Vivek A Saraswat, Rakesh Kochhar, Anoop Saraya, ,

Gut (Gut)
[2021, 70(9):1805-1806]

Cited: 1 time

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Management of gastrointestinal tuberculosis during COVID pandemic: Lessons for posterity.

Jayendra Shukla, Anuraag Jena, Harjeet Singh, Harshal S Mandavdhare, Usha Dutta, Vishal Sharma,

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2021, 53(4):394-396]

Cited: 0 times

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Coronavirus Disease (COVID-19) and the Liver: A comprehensive systematic review and meta-analysis

Praveen Kumar-M, Shubhra Mishra, Daya Krishna Jha, Jayendra Shukla, Arup Choudhury, Ritin Mohindra, Harshal Mandavdhare, Usha Dutta, Vishal Sharma,

<h4>Background: </h4> Liver function derangements have been reported in coronavirus disease (COVID-19) but reported rates are variable. <h4>Methods: </h4>: We searched Pubmed and Embase with terms COVID and SARS-COV-2 from December 1, 2019 till April 5, 2020. We estimated overall prevalence, stratified prevalence based on severity, estimated risk ratio (RR) ... Read more >>

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Coronavirus disease (COVID-19) and the liver: a comprehensive systematic review and meta-analysis.

Praveen Kumar-M, Shubhra Mishra, Daya Krishna Jha, Jayendra Shukla, Arup Choudhury, Ritin Mohindra, Harshal S Mandavdhare, Usha Dutta, Vishal Sharma,

<h4>Background</h4>Liver function derangements have been reported in coronavirus disease (COVID-19), but reported rates are variable.<h4>Methods</h4>We searched PubMed and Embase with terms COVID and SARS-COV-2 from December 1, 2019 till April 5, 2020. We estimated overall prevalence, stratified prevalence based on severity, estimated risk ratio (RR), and estimated standardized mean difference ... Read more >>

Hepatol Int (Hepatology international)
[2020, 14(5):711-722]

Cited: 31 times

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Lipids help double-stranded RNA in endosomal escape and improve RNA interference in the fall armyworm, Spodoptera frugiperda.

Dhandapani Gurusamy, Kanakachari Mogilicherla, Jayendra Nath Shukla, Subba Reddy Palli,

RNA interference (RNAi) is a valuable method for understanding the gene function and holds great potential for insect pest management. While RNAi is efficient and systemic in coleopteran insects, RNAi is inefficient in lepidopteran insects. In this study, we explored the possibility of improving RNAi in the fall armyworm (FAW), ... Read more >>

Arch Insect Biochem Physiol (Archives of insect biochemistry and physiology)
[2020, 104(4):e21678]

Cited: 2 times

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Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome.

Kristen A Panfilio, Iris M Vargas Jentzsch, Joshua B Benoit, Deniz Erezyilmaz, Yuichiro Suzuki, Stefano Colella, Hugh M Robertson, Monica F Poelchau, Robert M Waterhouse, Panagiotis Ioannidis, Matthew T Weirauch, Daniel S T Hughes, Shwetha C Murali, John H Werren, Chris G C Jacobs, Elizabeth J Duncan, David Armisén, Barbara M I Vreede, Patrice Baa-Puyoulet, Chloé S Berger, Chun-Che Chang, Hsu Chao, Mei-Ju M Chen, Yen-Ta Chen, Christopher P Childers, Ariel D Chipman, Andrew G Cridge, Antonin J J Crumière, Peter K Dearden, Elise M Didion, Huyen Dinh, Harsha Vardhan Doddapaneni, Amanda Dolan, Shannon Dugan, Cassandra G Extavour, Gérard Febvay, Markus Friedrich, Neta Ginzburg, Yi Han, Peter Heger, Christopher J Holmes, Thorsten Horn, Yi-Min Hsiao, Emily C Jennings, J Spencer Johnston, Tamsin E Jones, Jeffery W Jones, Abderrahman Khila, Stefan Koelzer, Viera Kovacova, Megan Leask, Sandra L Lee, Chien-Yueh Lee, Mackenzie R Lovegrove, Hsiao-Ling Lu, Yong Lu, Patricia J Moore, Monica C Munoz-Torres, Donna M Muzny, Subba R Palli, Nicolas Parisot, Leslie Pick, Megan L Porter, Jiaxin Qu, Peter N Refki, Rose Richter, Rolando Rivera-Pomar, Andrew J Rosendale, Siegfried Roth, Lena Sachs, M Emília Santos, Jan Seibert, Essia Sghaier, Jayendra N Shukla, Richard J Stancliffe, Olivia Tidswell, Lucila Traverso, Maurijn van der Zee, Séverine Viala, Kim C Worley, Evgeny M Zdobnov, Richard A Gibbs, Stephen Richards,

BACKGROUND:The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology and excellent experimental tractability for molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids and blood-feeding bed bugs, we present the genome sequence and comparative analyses centered on ... Read more >>

Genome Biol (Genome biology)
[2019, 20(1):64]

Cited: 26 times

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Comparative analysis of double-stranded RNA degradation and processing in insects.

Indrakant K Singh, Satnam Singh, Kanakachari Mogilicherla, Jayendra Nath Shukla, Subba Reddy Palli,

RNA interference (RNAi) based methods are being developed for pest management. A few products for control of coleopteran pests are expected to be commercialized soon. However, variability in RNAi efficiency among insects is preventing the widespread use of this technology. In this study, we conducted research to identify reasons for ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):17059]

Cited: 33 times

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Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome

Kristen Panfilio, Iris Vargas Jentzsch, Joshua Benoit, Deniz Erezyilmaz, Yuichiro Suzuki, Stefano Colella, Hugh Robertson, Monica Poelchau, Robert Waterhouse, Panagiotis Ioannidis, Matthew Weirauch, Daniel S.T. Hughes, Shwetha Murali, John Werren, Chris G.C. Jacobs, Elizabeth Duncan, David Armisén, Barbara M.I. Vreede, Patrice Baa-Puyoulet, Chloé Berger, Chun-che Chang, Hsu Chao, Mei-Ju Chen, Yen-Ta Chen, Christopher Childers, Ariel Chipman, Andrew Cridge, Antonin J.J. Crumière, Peter Dearden, Elise Didion, Huyen Dinh, HarshaVardhan Doddapaneni, Amanda Dolan, Shannon Dugan, Cassandra Extavour, Gérard Febvay, Markus Friedrich, Neta Ginzburg, Yi Han, Peter Heger, Christopher Holmes, Thorsten Horn, Yi-min Hsiao, Emily Jennings, Spencer Johnston, Tamsin Jones, Jeffery Jones, Abderrahman Khila, Stefan Koelzer, Viera Kovacova, Megan Leask, Sandra Lee, Chien-Yueh Lee, Mackenzie Lovegrove, Hsiao-ling Lu, Yong Lu, Patricia Moore, Monica Munoz-Torres, Donna Muzny, Subba Palli, Nicolas Parisot, Leslie Pick, Megan Porter, Jiaxin Qu, Peter Refki, Rose Richter, Rolando Rivera Pomar, Andrew Rosendale, Siegfried Roth, Lena Sachs, Emília Santos, Jan Seibert, Essia Sghaier, Jayendra Shukla, Richard Stancliffe, Olivia Tidswell, Lucila Traverso, Maurijn van der Zee, Séverine Viala, Kim Worley, Evgeny Zdobnov, Richard Gibbs, Stephen Richards,

<h4>Background</h4> The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology and excellent experimental tractability for molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids and blood-feeding bed bugs, we present the genome sequence and comparative analyses centered ... Read more >>

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Cited: 3 times

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RNA interference in the Colorado potato beetle, Leptinotarsa decemlineata: Identification of key contributors.

June-Sun Yoon, Jayendra Nath Shukla, Zhong Jun Gong, Kanakachari Mogilicherla, Subba Reddy Palli,

RNA interference (RNAi) is a useful reverse genetics tool for investigation of gene function as well as for practical applications in many fields including medicine and agriculture. RNAi works very well in coleopteran insects including the Colorado potato beetle (CPB), Leptinotarsa decemlineata. We used a cell line (Lepd-SL1) developed from ... Read more >>

Insect Biochem Mol Biol (Insect biochemistry and molecular biology)
[2016, 78:78-88]

Cited: 24 times

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Reduced stability and intracellular transport of dsRNA contribute to poor RNAi response in lepidopteran insects.

Jayendra Nath Shukla, Megha Kalsi, Amit Sethi, Kenneth E Narva, Elane Fishilevich, Satnam Singh, Kanakachari Mogilicherla, Subba Reddy Palli,

RNA interference (RNAi) has become a widely used reverse genetic tool to study gene function in eukaryotic organisms and is being developed as a technology for insect pest management. The efficiency of RNAi varies among organisms. Insects from different orders also display differential efficiency of RNAi, ranging from highly efficient ... Read more >>

RNA Biol (RNA biology)
[2016, 13(7):656-669]

Cited: 52 times

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Unique features of a global human ectoparasite identified through sequencing of the bed bug genome.

Joshua B Benoit, Zach N Adelman, Klaus Reinhardt, Amanda Dolan, Monica Poelchau, Emily C Jennings, Elise M Szuter, Richard W Hagan, Hemant Gujar, Jayendra Nath Shukla, Fang Zhu, M Mohan, David R Nelson, Andrew J Rosendale, Christian Derst, Valentina Resnik, Sebastian Wernig, Pamela Menegazzi, Christian Wegener, Nicolai Peschel, Jacob M Hendershot, Wolfgang Blenau, Reinhard Predel, Paul R Johnston, Panagiotis Ioannidis, Robert M Waterhouse, Ralf Nauen, Corinna Schorn, Mark-Christoph Ott, Frank Maiwald, J Spencer Johnston, Ameya D Gondhalekar, Michael E Scharf, Brittany F Peterson, Kapil R Raje, Benjamin A Hottel, David Armisén, Antonin Jean Johan Crumière, Peter Nagui Refki, Maria Emilia Santos, Essia Sghaier, Sèverine Viala, Abderrahman Khila, Seung-Joon Ahn, Christopher Childers, Chien-Yueh Lee, Han Lin, Daniel S T Hughes, Elizabeth J Duncan, Shwetha C Murali, Jiaxin Qu, Shannon Dugan, Sandra L Lee, Hsu Chao, Huyen Dinh, Yi Han, Harshavardhan Doddapaneni, Kim C Worley, Donna M Muzny, David Wheeler, Kristen A Panfilio, Iris M Vargas Jentzsch, Edward L Vargo, Warren Booth, Markus Friedrich, Matthew T Weirauch, Michelle A E Anderson, Jeffery W Jones, Omprakash Mittapalli, Chaoyang Zhao, Jing-Jiang Zhou, Jay D Evans, Geoffrey M Attardo, Hugh M Robertson, Evgeny M Zdobnov, Jose M C Ribeiro, Richard A Gibbs, John H Werren, Subba R Palli, Coby Schal, Stephen Richards,

The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and ... Read more >>

Nat Commun (Nature communications)
[2016, 7:10165]

Cited: 65 times

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Production of all female progeny: evidence for the presence of the male sex determination factor on the Y chromosome.

Jayendra Nath Shukla, Subba Reddy Palli,

The red flour beetle, Tribolium castaneum, follows an XX (female) and XY (male) sex determination system. Maternal supply of the protein Transformer (Tra) is required for XX insects to follow the female pathway. The nature and source of the signal that regulates male sex determination in XY beetles are not ... Read more >>

J Exp Biol (The Journal of experimental biology)
[2014, 217(Pt 10):1653-1655]

Cited: 5 times

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Tribolium castaneum Transformer-2 regulates sex determination and development in both males and females.

Jayendra Nath Shukla, Subba Reddy Palli,

Tribolium castaneum Transformer (TcTra) is essential for female sex determination and maintenance through the regulation of sex-specific splicing of doublesex (dsx) pre-mRNA. In females, TcTra also regulates the sex-specific splicing of its own pre-mRNA to ensure continuous production of functional Tra protein. Transformer protein is absent in males and hence ... Read more >>

Insect Biochem Mol Biol (Insect biochemistry and molecular biology)
[2013, 43(12):1125-1132]

Cited: 15 times

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Doublesex target genes in the red flour beetle, Tribolium castaneum.

Jayendra Nath Shukla, Subba Reddy Palli,

Sex determination cascade in insects terminates with the production of sex-specific protein, Doublesex (Dsx). We identified the dsx homolog (Tcdsx) in Tribolium castaneum. The pre-mRNA of Tcdsx is sex-specifically spliced into three female (Tcdsxf1, Tcdsxf2 and Tcdsxf3) and one male-specific (Tcdsxm) isoforms. Cis-regulatory elements potentially involved in sex-specific splicing of ... Read more >>

Sci Rep (Scientific reports)
[2012, 2:948]

Cited: 23 times

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Sex determination in beetles: production of all male progeny by parental RNAi knockdown of transformer.

Jayendra Nath Shukla, Subba Reddy Palli,

Sex in insects is determined by a cascade of regulators ultimately controlling sex-specific splicing of a transcription factor, Doublesex (Dsx). We recently identified homolog of dsx in the red flour beetle, Tribolium castaneum (Tcdsx). Here, we report on the identification and characterization of a regulator of Tcdsx splicing in T. ... Read more >>

Sci Rep (Scientific reports)
[2012, 2:602]

Cited: 31 times

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Novel female-specific splice form of dsx in the silkworm, Bombyx mori.

Jayendra Nath Shukla, Santosh Jadhav, Javaregowda Nagaraju,

The Bombyx mori doublesex (Bmdsx), a homologue of doublesex of Drosophila, is the bottom most gene of the sex determination cascade. Bmdsx plays a very crucial role in somatic sexual development. Its pre-mRNA sex-specifically splices to generate two splice variants; one encodes female-specific and the other encodes male-specific polypeptides which ... Read more >>

Genetica (Genetica)
[2011, 139(1):23-31]

Cited: 11 times

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