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Tissue Factor Pathway Inhibitor Levels During Veno-Arterial Extracorporeal Membrane Oxygenation in Adults.

Michael Mazzeffi, Miranda Judd, Joseph Rabin, Ali Tabatabai, Jay Menaker, Ashley Menne, Jonathan Chow, Aakash Shah, Reney Henderson, Daniel Herr, Kenichi Tanaka,

Tissue factor pathway inhibitor (TFPI) has multiple anticoagulant properties. To our knowledge, no studies have measured TFPI levels in adult veno-arterial (VA) extracorporeal membrane oxygenation patients. We hypothesized that adult VA ECMO patients would have increased TFPI levels and slowed tissue factor triggered thrombin generation. Twenty VA ECMO patients had ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(8):878-883]

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A Comparison of Anticoagulation Strategies in Veno-venous Extracorporeal Membrane Oxygenation.

Aakash Shah, Chetan Pasrija, Anthony Kronfli, Eno-Obong Essien, Ya Zhou, Francis Brigante, Gregory Bittle, Jay Menaker, Daniel Herr, Michael A Mazzeffi, Kristopher B Deatrick, Zachary N Kon,

Bleeding remains a major source of morbidity associated with veno-venous extracorporeal membrane oxygenation (VV-ECMO). Moreover, there remains significant controversy, and a paucity of data regarding the ideal anticoagulation strategy for VV-ECMO patients. All patients undergoing isolated, peripheral VV-ECMO between January 2009 and December 2014 at our institution were retrospectively reviewed. ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, :]

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A descriptive evaluation of causes of death in venovenous extracorporeal membrane oxygenation.

Sagar B Dave, Kristopher B Deatrick, Samuel M Galvagno, Michael A Mazzeffi, David J Kaczorowski, Ronson J Madathil, Raymond Rector, Ali Tabatabai, Daniel J Haase, Daniel Herr, Thomas M Scalea, Jay Menaker,

Veno-venous extracorporeal membrane oxygenation (VV ECMO) has become an important support modality for patients with acute respiratory failure refractory to optimal medical therapy, such as low tidal volume mechanical ventilator support, early paralytic infusion, and early prone positioning. The objective of this cohort study was to investigate the causes and ... Read more >>

Perfusion (Perfusion)
[2021, :2676591211035938]

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A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part II: Clinical Management.

Aakash Shah, Sagar Dave, Samuel Galvagno, Kristen George, Ashley R Menne, Daniel J Haase, Brian McCormick, Raymond Rector, Siamak Dahi, Ronson J Madathil, Kristopher B Deatrick, Mehrdad Ghoreishi, James S Gammie, David J Kaczorowski, Thomas M Scalea, Jay Menaker, Daniel Herr, Ali Tabatabai, Eric Krause,

(1) Background: COVID-19 acute respiratory distress syndrome (CARDS) has several distinctions from traditional acute respiratory distress syndrome (ARDS); however, patients with refractory respiratory failure may still benefit from veno-venous extracorporeal membrane oxygenation (VV-ECMO) support. We report our challenges caring for CARDS patients on VV-ECMO and alterations to traditional management strategies. ... Read more >>

Membranes (Basel) (Membranes)
[2021, 11(5):]

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Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019.

Jonathan H Chow, Ashish K Khanna, Shravan Kethireddy, David Yamane, Andrea Levine, Amanda M Jackson, Michael T McCurdy, Ali Tabatabai, Gagan Kumar, Paul Park, Ivy Benjenk, Jay Menaker, Nayab Ahmed, Evan Glidewell, Elizabeth Presutto, Shannon Cain, Naeha Haridasa, Wesley Field, Jacob G Fowler, Duy Trinh, Kathleen N Johnson, Aman Kaur, Amanda Lee, Kyle Sebastian, Allison Ulrich, Salvador Peña, Ross Carpenter, Shruti Sudhakar, Pushpinder Uppal, Benjamin T Fedeles, Aaron Sachs, Layth Dahbour, William Teeter, Kenichi Tanaka, Samuel M Galvagno, Daniel L Herr, Thomas M Scalea, Michael A Mazzeffi,

<h4>Background</h4>Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality.<h4>Methods</h4>A retrospective, observational cohort study of adult patients admitted with ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(4):930-941]

Cited: 83 times

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A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part I: System Planning and Care Teams.

Sagar Dave, Aakash Shah, Samuel Galvagno, Kristen George, Ashley R Menne, Daniel J Haase, Brian McCormick, Raymond Rector, Siamak Dahi, Ronson J Madathil, Kristopher B Deatrick, Mehrdad Ghoreishi, James S Gammie, David J Kaczorowski, Thomas M Scalea, Jay Menaker, Daniel Herr, Eric Krause, Ali Tabatabai,

<h4>Background</h4>The most critically ill patients with coronavirus disease 2019 (COVID-19) may require advanced support modalities, such as veno-venous extracorporeal membrane oxygenation (VV-ECMO). A systematic, methodical approach to a respiratory pandemic on a state and institutional level is critical.<h4>Methods</h4>We conducted retrospective review of our institutional response to the COVID-19 pandemic, focusing ... Read more >>

Membranes (Basel) (Membranes)
[2021, 11(4):]

Cited: 1 time

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Neurological complications during veno-venous extracorporeal membrane oxygenation: Does the configuration matter? A retrospective analysis of the ELSO database.

Roberto Lorusso, Mirko Belliato, Michael Mazzeffi, Michele Di Mauro, Fabio Silvio Taccone, Orlando Parise, Ayat Albanawi, Veena Nandwani, Paul McCarthy, Zachary Kon, Jay Menaker, Daniel M Johnson, Sandro Gelsomino, Daniel Herr,

<h4>Background</h4>Single- (SL) and double-lumen (DL) catheters are used in clinical practice for veno-venous extracorporeal membrane oxygenation (V-V ECMO) therapy. However, information is lacking regarding the effects of the cannulation on neurological complications.<h4>Methods</h4>A retrospective observational study based on data from the Extracorporeal Life Support Organization (ELSO) registry. All adult patients included ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):107]

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Clinical Outcomes of Pregnant and Postpartum Extracorporeal Membrane Oxygenation Patients.

Allison S Lankford, Jonathan H Chow, Amanda M Jackson, Marianne Wallis, Samuel M Galvagno, Andrew M Malinow, Ozhan M Turan, Jay A Menaker, Sarah D Crimmins, Raymond Rector, David Kaczorowski, Bartley Griffith, Zachary Kon, Daniel Herr, Michael A Mazzeffi,

<h4>Background</h4>The use of extracorporeal membrane oxygenation (ECMO) as a rescue therapy for cardiopulmonary failure is expanding in critical care medicine. In this case series, we describe the clinical outcomes of 21 consecutive pregnant or postpartum patients that required venovenous (VV) or venoarterial (VA) ECMO. Our objective was to characterize maternal ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(3):777-787]

Cited: 1 time

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Breathing Life Back Into the Kidney-Continuous Renal Replacement Therapy and Veno-Venous Extracorporeal Membrane Oxygenation.

Kristopher B Deatrick, Michael A Mazzeffi, Samuel M Galvagno, Kimberly Boswell, David J Kaczoroswki, Ronald P Rabinowitz, Ronson J Madathil, Christopher R Cornachione, Daniel L Herr, Thomas M Scalea, Jay Menaker,

The purpose of this study was to evaluate the incidence of continuous renal replacement therapy (CRRT) in patients supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Secondary outcomes included mortality and the need for hemodialysis on hospital discharge. We performed a retrospective cohort study of all patients admitted to a ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(2):208-212]

Cited: 4 times

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The Age Barrier for VV ECMO-Where Should It Be?

Samuel M Galvagno, Michael A Mazzeffi, K Barry Deatrick, Jay Menaker,

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(1):e56]

Cited: 0 times

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Mortality Risk Assessment in COVID-19 Venovenous Extracorporeal Membrane Oxygenation.

Ali Tabatabai, Mira H Ghneim, David J Kaczorowski, Aakash Shah, Sagar Dave, Daniel J Haase, Roumen Vesselinov, Kristopher B Deatrick, Joseph Rabin, Ronald P Rabinowitz, Samuel Galvagno, James V O'Connor, Jay Menaker, Daniel L Herr, James S Gammie, Thomas M Scalea, Ronson J Madathil,

<h4>Background</h4>A life-threatening complication of coronavirus disease 2019 (COVID-19) is acute respiratory distress syndrome (ARDS) refractory to conventional management. Venovenous (VV) extracorporeal membrane oxygenation (ECMO) (VV-ECMO) is used to support patients with ARDS in whom conventional management fails. Scoring systems to predict mortality in VV-ECMO remain unvalidated in COVID-19 ARDS. This ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 112(6):1983-1989]

Cited: 1 time

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Transfer of Patients with Spontaneous Intracranial Hemorrhage who Need External Ventricular Drain: Does Admission Location Matter?

Quincy K. Tran, Sagar Dave, Daniel J. Haase, Laura Tiffany, Shannon Gaasch, Wan-tsu W. Chang, Kevin Jones, Matthew J. Kole, Aaron Wessell, Gary Schwartzbauer, Thomas M. Scalea, Jay Menaker,

<h4>Introduction</h4> Patients with spontaneous intracranial hemorrhage (sICH) are associated with high mortality and require early neurosurgical interventions. At our academic referral center, the neurocritical care unit (NCCU) receives patients directly from referring facilities. However, when no NCCU bed is immediately available, patients are initially admitted to the critical care resuscitation ... Read more >>

West J Emerg Med (The western journal of emergency medicine)
[2021, 22(2):379-388]

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Transfer of Patients with Spontaneous Intracranial Hemorrhage who Need External Ventricular Drain: Does Admission Location Matter?

Quincy K Tran, Sagar Dave, Daniel J Haase, Laura Tiffany, Shannon Gaasch, Wan-Tsu W Chang, Kevin Jones, Matthew J Kole, Aaron Wessell, Gary Schwartzbauer, Thomas M Scalea, Jay Menaker,

<h4>Introduction</h4>Patients with spontaneous intracranial hemorrhage (sICH) are associated with high mortality and require early neurosurgical interventions. At our academic referral center, the neurocritical care unit (NCCU) receives patients directly from referring facilities. However, when no NCCU bed is immediately available, patients are initially admitted to the critical care resuscitation unit ... Read more >>

West J Emerg Med (The western journal of emergency medicine)
[2021, 22(2):379-388]

Cited: 0 times

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Single Center Experience With Veno-Venous Extracorporeal Membrane Oxygenation in Patients With Traumatic Brain Injury.

Brandon M Parker, Jay Menaker, Cherisse D Berry, Ronald B Tesoreiero, James V O'Connor, Deborah M Stein, Thomas M Scalea,

<h4>Methods</h4>We retrospectively reviewed TBI patients ≥ 18 years of age treated with VV-ECMO. The primary outcome was survival to discharge. Secondary outcomes included progression of intracranial hemorrhage, bleeding complications, and episodes of oxygenator thrombosis requiring exchange. Medians and interquartile ranges were reported where appropriate.<h4>Results</h4>13 TBI patients received VV-ECMO support during the ... Read more >>

Am Surg (The American surgeon)
[2021, 87(6):949-953]

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Tracheostomy in Patients on Venovenous Extracorporeal Membrane Oxygenation: Is It Safe?

Katherine M Kelley, Samuel M Galvagno, Marianne Wallis, Michael A Mazzeffi, Kristopher Deatrick, Richard Betzold, Thomas Scalea, Jay Menaker,

<h4>Background</h4>The anticoagulation and coagulopathy associated with venovenous extracorporeal membrane oxygenation (VV-ECMO) lead to concern for increased risks of tracheostomy. The purpose of this study is to evaluate the safety of tracheostomy in patients on VV-ECMO.<h4>Methods</h4>Patients admitted between November 2015 and January 2019 to a dedicated intensive care unit for VV-ECMO ... Read more >>

Am Surg (The American surgeon)
[2021, 87(8):1292-1298]

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Complete percutaneous decannulation from femoral venoarterial extracorporeal membrane oxygenation.

Aakash Shah, Mehrdad Ghoreishi, Bradley S Taylor, Shahab Toursavadkohi, David J Kaczorowski, ,

<h4>Objectives</h4>To evaluate the clinical outcomes and perioperative complications associated with complete percutaneous decannulation of femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) with the MANTA closure device.<h4>Methods</h4>This is a retrospective analysis of a single surgeon consecutive series of 14 patients at a single center who underwent decannulation from VA-ECMO, 10 of whom ... Read more >>

JTCVS Tech (JTCVS techniques)
[2021, 6:75-81]

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Platelet factor-4 concentration in adult veno-arterial ECMO patients.

Michael Mazzeffi, Madeline Clark, Alison Grazioli, Colleen Dugan, Raymond Rector, Heidi Dalton, Ronson Madathil, Jay Menaker, Daniel Herr, Kenichi Tanaka,

<h4>Background</h4>Heparin induced thrombocytopenia (HIT) is reported at a variable rate in extracorporeal membrane oxygenation (ECMO) patients. A critical factor impacting platelet factor-4 (PF4)-heparin antibody formation is plasma PF4 concentration. We hypothesized that PF4 concentration would be increased during veno-arterial (VA) ECMO.<h4>Methods</h4>Plasma PF4 concentration was measured during the first 5 ECMO ... Read more >>

Perfusion (Perfusion)
[2021, 36(7):688-693]

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Intoxication and overdose should not preclude veno-venous extracorporeal membrane oxygenation.

Jason S Radowsky, Michael M Mazzeffi, K Barry Deatrick, Samuel M Galvagno, Brandon M Parker, Ali Tabatabai, Ronson J Madathil, David J Kaczorowski, Ronald P Rabinowitz, Daniel L Herr, Thomas Scalea, Jay Menaker,

<h4>Introduction</h4>Acute intoxication (AI) related morbidity and mortality are increasing in the United States. For patients with severe respiratory failure in the setting of an acute ingestion, veno-venous extracorporeal membrane oxygenation (VV ECMO) can provide salvage therapy. The purpose of this study was to evaluate outcomes in patients with overdose-related need ... Read more >>

Perfusion (Perfusion)
[2021, 36(8):839-844]

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Cannulation for Venovenous Extracorporeal Membrane Oxygenation After Ligation of the Inferior Vena Cava in a Blunt Trauma Patient.

Katherine M Kelley, Gregory Bittle, Thomas M Scalea, David Kaczorowski, Samuel Galvagno, Jay Menaker, Margaret Lauerman,

Am Surg (The American surgeon)
[2020, 86(11):1582-1583]

Cited: 0 times

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Does Weight Matter? Outcomes in Adult Patients on Venovenous Extracorporeal Membrane Oxygenation When Stratified by Obesity Class.

Samuel M Galvagno, Stacy Pelekhaty, Christopher R Cornachione, Kristopher B Deatrick, Michael A Mazzeffi, Thomas M Scalea, Jay Menaker,

<h4>Background</h4>Many believe obesity is associated with higher rates of mortality in the critically ill. The purpose of this retrospective observational study is to evaluate the association between body mass index (BMI) and survival in patients receiving venovenous (VV) extracorporeal membrane oxygenation (ECMO) for acute hypoxic or hypercarbic respiratory failure.<h4>Methods</h4>All of ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 131(3):754-761]

Cited: 8 times

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Care Intensity During Transport to the Critical Care Resuscitation Unit: Transport Clinician's Role.

Quincy K Tran, Olufisola Famuyiwa, Daniel J Haase, Kaitlynn Holland, Benjamin Lawner, Samuel Matta, Leigha McGuin, Jay Menaker, Ashley Menne, Edgard E Ngono, Erin Niles, James O'Connor, Thomas Scalea, Samuel Galvagno,

<h4>Objective</h4>Patients are often transferred between hospitals for a higher level of care. Critically ill patients require high-intensity care after transfer, but their care intensity during transport is unknown. We studied transport clinicians' management for patients who had time-sensitive or critical illnesses and were transferred to a critical care resuscitation unit ... Read more >>

Air Med J (Air medical journal)
[2020, 39(6):473-478]

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Outcomes of Venovenous Extracorporeal Membrane Oxygenation When Stratified by Age: How Old Is Too Old?

Kristopher B Deatrick, Michael A Mazzeffi, Samuel M Galvagno, Ronald B Tesoriero, David J Kaczoroswki, Daniel L Herr, Katelyn Dolly, Ronald P Rabinowitz, Thomas M Scalea, Jay Menaker,

The purpose of this study was to evaluate survival to hospital discharge for patients on venovenous extracorporeal membrane oxygenation (VV ECMO) when stratified by age. We performed a retrospective study at single, academic, tertiary care center intensive care unit for VV ECMO. All patients, older than 17 years of age, ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2020, 66(8):946-951]

Cited: 4 times

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Extracorporeal Membrane Oxygenation for COVID-19.

Zachary Sanford, Ronson J Madathil, Kristopher B Deatrick, Ali Tabatabai, Jay Menaker, Samuel M Galvagno, Michael A Mazzeffi, Joseph Rabin, Mehrdad Ghoreishi, Raymond Rector, Daniel L Herr, David J Kaczorowski,

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2020, 15(4):306-313]

Cited: 0 times

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Von Willebrand Factor Concentrate Administration for Acquired Von Willebrand Syndrome- Related Bleeding During Adult Extracorporeal Membrane Oxygenation.

Michael Mazzeffi, Allison Bathula, Ali Tabatabai, Jay Menaker, David Kaczorowski, Ronson Madathil, Samuel Galvagno, Chetan Pasrija, Raymond Rector, Kenichi Tanaka, Daniel Herr,

<h4>Objective</h4>To review the use of Von Willebrand Factor (VWF) concentrate for treatment of acquired Von Willebrand syndrome (VWS)-related bleeding in adult extracorporeal membrane oxygenation (ECMO) patients and determine if it was associated with improved VWF laboratory parameters.<h4>Design</h4>Retrospective observational cohort study.<h4>Setting</h4>Tertiary care academic medical center.<h4>Participants</h4>Adult ECMO patients who received VWF concentrate ... Read more >>

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2021, 35(3):882-887]

Cited: 1 time

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Comparison of Outcomes After Treatment of Large Vessel Occlusion in a Critical Care Resuscitation Unit or a Neurocritical Care Unit.

Quincy K Tran, Karen L Yarbrough, Paul Capobianco, Wan-Tsu W Chang, Gaurav Jindal, Amir Medic, Jay Menaker, Mehboob A Rehan, Isabella Swafford, Timothy Traynor, Michael S Phipps,

<h4>Background</h4>Mechanical thrombectomy (MT) has become first-line treatment for patients with acute ischemic stroke caused by large vessel occlusion (AIS-LVO). Delay in the interhospital transfer (IHT) of patients from referral hospitals to a comprehensive stroke center is associated with worse outcomes. At our academic tertiary care facility in an urban setting, ... Read more >>

Neurocrit Care (Neurocritical care)
[2020, 32(3):725-733]

Cited: 0 times

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