Full Text Journal Articles by
Author Jawad Ahmed

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Restless Leg syndrome in patients with liver cirrhosis! Its frequency, severity, and correlation.

Iftikhar Haider Naqvi, Jawad Ahmed, Maliha Salim, Muhammad Ubaid, Farheen Malik, Razna Afzal, Muhammad Moinuddin Ashrafi, Muhammad Arbaz Arshad Khan,

<h4>Background</h4>Restless leg syndrome (RLS) has been recognized as a typical extra appearance among patients with cirrhosis of liver. RLS prevalence in liver cirrhosis further augments the worsening quality of life which has already been compromised with the disease related complications of cirrhosis itself.<h4>Aims</h4>The study was aimed to determine the frequency ... Read more >>

CNS Neurol Disord Drug Targets (CNS & neurological disorders drug targets)
[2020, :]

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Seroprevalence and Risk Factors of SARS CoV-2 in Health Care Workers of Tertiary-Care Hospitals in the Province of Khyber Pakhtunkhwa, Pakistan

Mohsina Haq, Asif Rehman, Muhammad Noor, Jawad Ahmed, Junaid Ahmad, Muhammad irfan, Saeed Anwar, Sajjad Ahmad, Said Amin, Fawad Rahim, Najib Ul Haq,

<h4>Background: </h4> High number of SARS CoV2 infected patients has overburdened healthcare delivery system, particularly in low-income countries. In the recent past many studies from the developed countries have been published on the prevalence of SARS CoV2 antibodies and the risk factors of COVID 19 in healthcare-workers but little is ... Read more >>

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Prophylactic Mesh Placement for the Prevention of Incisional Hernia in High-Risk Patients After Abdominal Surgery: A Systematic Review and Meta-Analysis.

Jawad Ahmed, Nimra Hasnain, Iayla Fatima, Farheen Malik, Muhammad A Chaudhary, Junaid Ahmad, Mehreen Malik, Laraib Malik, Muhammad Osama, Mirza Zain Baig, Faisal Khosa, Faiz Bhora,

Background and objectives In high-risk populations, the efficacy of mesh placement in incisional hernia (IH) prevention after elective abdominal surgeries has been supported by many published studies. This meta-analysis aimed at providing comprehensive and updated clinical implications of prophylactic mesh placement (PMP) for the prevention of IH as compared to ... Read more >>

Cureus (Cureus)
[2020, 12(9):e10491]

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Use of Tocilizumab in COVID-19: A Systematic Review and Meta-Analysis of Current Evidence.

Sohny Kotak, Mahima Khatri, Mehreen Malik, Maria Malik, Warda Hassan, Arooba Amjad, Farheen Malik, Hani Hassan, Jawad Ahmed, Marium Zafar,

Background and objectives A flare-up in coronavirus disease 2019 (COVID-19) cases threatens the health of people, and though there is no proven pharmacological treatment, many analytical studies have suggested that interleukin-6 (IL-6) levels are elevated in cases of severe COVID-19 and that the anti-IL-6 biologic agent tocilizumab may be beneficial. ... Read more >>

Cureus (Cureus)
[2020, 12(10):e10869]

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Giant Leiomyosarcoma Arising in Posterior Thigh: Management of a Rare Case

Alexander Muacevic, John R Adler, Tehlil Rizwan, Jawad Ahmed, Fahad H Shaikh, Farheen Malik, Shuah Ullah,

Leiomyosarcoma, primarily a tumor of smooth muscle origin, frequently originates from the uterus, retroperitoneum, and intra-abdominal region. Rarely, the tumor may arise from the conjunctiva, inferior vena cava, or oral cavity. Here we report a case of a 65-year-old male patient who presented with a swelling in the posterior thigh for ... Read more >>

Cureus (Cureus)
[0, 12(8):]

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Giant Leiomyosarcoma Arising in Posterior Thigh: Management of a Rare Case.

Tehlil Rizwan, Jawad Ahmed, Fahad H Shaikh, Farheen Malik, Shuah Ullah,

Leiomyosarcoma, primarily a tumor of smooth muscle origin, frequently originates from the uterus, retroperitoneum, and intra-abdominal region. Rarely, the tumor may arise from the conjunctiva, inferior vena cava, or oral cavity. Here we report a case of a 65-year-old male patient who presented with a swelling in the posterior thigh for ... Read more >>

Cureus (Cureus)
[2020, 12(8):e10146]

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Respiratory illness linked with the use of electronic cigarettes: An alarming situation.

Farheen Malik, Jawad Ahmed, Suha Safi Qureshi, Rohan Kumar Ochani,

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2020, 70(9):1676]

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Age-Adjusted Risk Factors Associated with Mortality and Mechanical Ventilation Utilization Amongst COVID-19 Hospitalizations-a Systematic Review and Meta-Analysis.

Urvish Patel, Preeti Malik, Muhammad Shariq Usman, Deep Mehta, Ashish Sharma, Faizan Ahmad Malik, Nashmia Khan, Tariq Jamal Siddiqi, Jawad Ahmed, Achint Patel, Henry Sacks,

The increasing COVID-19 cases in the USA have led to overburdening of healthcare in regard to invasive mechanical ventilation (IMV) utilization as well as mortality. We aim to identify risk factors associated with poor outcomes (IMV and mortality) of COVID-19 hospitalized patients. A meta-analysis of observational studies with epidemiological characteristics ... Read more >>

SN Compr Clin Med (SN comprehensive clinical medicine)
[2020, :1-10]

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Effect of exogenous glucocorticoids on male hypogonadism.

Adel Gassab Mohammed, Abbas Ali Mansour, Jawad Hassan Ahmed,

The aim of the present study was to investigate the effects of exogenous glucocorticoids (GCs), a potent cause of male hypogonadism, on the function of the hypothalamic-pituitary-gonadal axis, and to determine their secondary effects in male patients. The present study was a case-controlled study conducted in Basrah, Iraq. Of the ... Read more >>

Biomed Rep (Biomedical reports)
[2020, 13(3):12]

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De Novo and Bi-allelic Pathogenic Variants in NARS1 Cause Neurodevelopmental Delay Due to Toxic Gain-of-Function and Partial Loss-of-Function Effects.

Andreea Manole, Stephanie Efthymiou, Emer O'Connor, Marisa I Mendes, Matthew Jennings, Reza Maroofian, Indran Davagnanam, Kshitij Mankad, Maria Rodriguez Lopez, Vincenzo Salpietro, Ricardo Harripaul, Lauren Badalato, Jagdeep Walia, Christopher S Francklyn, Alkyoni Athanasiou-Fragkouli, Roisin Sullivan, Sonal Desai, Kristin Baranano, Faisal Zafar, Nuzhat Rana, Muhammed Ilyas, Alejandro Horga, Majdi Kara, Francesca Mattioli, Alice Goldenberg, Helen Griffin, Amelie Piton, Lindsay B Henderson, Benyekhlef Kara, Ayca Dilruba Aslanger, Joost Raaphorst, Rolph Pfundt, Ruben Portier, Marwan Shinawi, Amelia Kirby, Katherine M Christensen, Lu Wang, Rasim O Rosti, Sohail A Paracha, Muhammad T Sarwar, Dagan Jenkins, , Jawad Ahmed, Federico A Santoni, Emmanuelle Ranza, Justyna Iwaszkiewicz, Cheryl Cytrynbaum, Rosanna Weksberg, Ingrid M Wentzensen, Maria J Guillen Sacoto, Yue Si, Aida Telegrafi, Marisa V Andrews, Dustin Baldridge, Heinz Gabriel, Julia Mohr, Barbara Oehl-Jaschkowitz, Sylvain Debard, Bruno Senger, Frédéric Fischer, Conny van Ravenwaaij, Annemarie J M Fock, Servi J C Stevens, Jürg Bähler, Amina Nasar, John F Mantovani, Adnan Manzur, Anna Sarkozy, Desirée E C Smith, Gajja S Salomons, Zubair M Ahmed, Shaikh Riazuddin, Saima Riazuddin, Muhammad A Usmani, Annette Seibt, Muhammad Ansar, Stylianos E Antonarakis, John B Vincent, Muhammad Ayub, Mona Grimmel, Anne Marie Jelsig, Tina Duelund Hjortshøj, Helena Gásdal Karstensen, Marybeth Hummel, Tobias B Haack, Yalda Jamshidi, Felix Distelmaier, Rita Horvath, Joseph G Gleeson, Hubert Becker, Jean-Louis Mandel, David A Koolen, Henry Houlden,

Aminoacyl-tRNA synthetases (ARSs) are ubiquitous, ancient enzymes that charge amino acids to cognate tRNA molecules, the essential first step of protein translation. Here, we describe 32 individuals from 21 families, presenting with microcephaly, neurodevelopmental delay, seizures, peripheral neuropathy, and ataxia, with de novo heterozygous and bi-allelic mutations in asparaginyl-tRNA synthetase ... Read more >>

Am J Hum Genet (American journal of human genetics)
[2020, 107(2):311-324]

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Is there a smoker's paradox in COVID-19?

Muhammad Shariq Usman, Tariq Jamal Siddiqi, Muhammad Shahzeb Khan, Urvish K Patel, Izza Shahid, Jawad Ahmed, Ankur Kalra, Erin D Michos,

Although it is well established that cigarette smoking is associated with morbidity and mortality in several respiratory infections, data from recent studies suggest that active smokers are underrepresented among patients with COVID-19. This has led to claims that a 'smoker's paradox' may exist in COVID-19, wherein smokers are protected from ... Read more >>

BMJ Evid Based Med (BMJ evidence-based medicine)
[2020, :]

Cited: 1 time

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COVID-19 and Liver Injury: A Systematic Review and Meta-Analysis.

Jawad Ahmed, Tehlil Rizwan, Farheen Malik, Raniyah Akhter, Mehreen Malik, Junaid Ahmad, Abdul Wasay Khan, Muhammad A Chaudhary, Muhammad Shariq Usman,

Background and Aims The prevalence and extent of liver damage in coronavirus disease 2019 (COVID-19) patients remain poorly understood, primarily due to small-sized epidemiological studies with varying definitions of "liver injury". We conducted a meta-analysis to derive generalizable, well-powered estimates of liver injury prevalence in COVID-19 patients. We also aimed ... Read more >>

Cureus (Cureus)
[2020, 12(7):e9424]

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Left Ventricular Thrombus Formation in Acute Anterior Wall Myocardial Infarction: A Comparison Between Thrombolyzed and Non-Thrombolyzed Patients.

Kashif A Hashmi, Hadi Y Saeed, Jawad Ahmed, Javeria Najam, Muhammad Irfan, Atif A Hashmi,

Introduction Left ventricular thrombus (LVT) formation is a prominent complication of acute myocardial infarction (AMI). Accurate and prompt detection of the condition is important as it poses a high risk for thromboembolic events that can be arrested by systemic anticoagulation. The purpose of our study was to evaluate the frequency ... Read more >>

Cureus (Cureus)
[2020, 12(7):e9090]

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Epidemiological and Clinical Features of SARS-CoV-2: A Retrospective Study from East Karachi, Pakistan.

Shumaila Tahir, Syeda Anjala Tahir, Taha Bin Arif, Bushra Majid, Zainab Majid, Farheen Malik, Ashfaque Ahmed, Arslan Memon, Jawad Ahmed,

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to almost every country on the globe, and each country is reporting the symptomatic presentation of their patients to give better insight into the various clinical presentations of SARS-CoV-2. However, the epidemiological literature from Pakistan is scanty. Methods We retrospectively ... Read more >>

Cureus (Cureus)
[2020, 12(6):e8679]

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Availability of Personal Protective Equipment (PPE) Among US and Pakistani Doctors in COVID-19 Pandemic.

Jawad Ahmed, Farheen Malik, Taha Bin Arif, Zainab Majid, Muhammad A Chaudhary, Junaid Ahmad, Mehreen Malik, Taj M Khan, Muhammad Khalid,

Background The coronavirus disease (COVID-19) pandemic has put an excessive strain on healthcare systems across the globe, causing a shortage of personal protective equipment (PPE). PPE is a precious commodity for health personnel to protect them against infections. We investigated the availability of PPE among doctors in the United States ... Read more >>

Cureus (Cureus)
[2020, 12(6):e8550]

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Anti-tuberculous Effects of Statin Therapy: A Review of Literature.

Faryal Tahir, Taha Bin Arif, Jawad Ahmed, Syed Raza Shah, Muhammad Khalid,

Tuberculosis (TB) is a chronic infection caused by <i>Mycobacterium tuberculosis</i> (M. TB). It is transmitted through respiratory droplets. Increased cholesterol level is a predisposing factor for TB. M. TB uses cholesterol in the host macrophage membranes to bind and enter the macrophages. Statins are the drugs that are prescribed to ... Read more >>

Cureus (Cureus)
[2020, 12(3):e7404]

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Ivabradine in Postural Orthostatic Tachycardia Syndrome: A Review of the Literature.

Faryal Tahir, Taha Bin Arif, Zainab Majid, Jawad Ahmed, Muhammad Khalid,

Postural orthostatic tachycardia syndrome (POTS) is an autonomic disorder characterized by symptoms such as palpitations, dyspnea, chest discomfort, and lightheadedness affecting various systems. The pathophysiology of POTS is not completely understood due to a variety of symptoms showing that the disease is multifactorial. There is no approved uniform management strategy ... Read more >>

Cureus (Cureus)
[2020, 12(4):e7868]

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Biallelic variants in PSMB1 encoding the proteasome subunit β6 cause impairment of proteasome function, microcephaly, intellectual disability, developmental delay and short stature.

Muhammad Ansar, Frédéric Ebstein, Hayriye Özkoç, Sohail A Paracha, Justyna Iwaszkiewicz, Matthias Gesemann, Vincent Zoete, Emmanuelle Ranza, Federico A Santoni, Muhammad T Sarwar, Jawad Ahmed, Elke Krüger, Ruxandra Bachmann-Gagescu, Stylianos E Antonarakis,

The molecular cause of the majority of rare autosomal recessive disorders remains unknown. Consanguinity due to extensive homozygosity unravels many recessive phenotypes and facilitates the detection of novel gene-disease links. Here, we report two siblings with phenotypic signs, including intellectual disability (ID), developmental delay and microcephaly from a Pakistani consanguineous ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2020, 29(7):1132-1143]

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Accuracy of Pediatric Risk of Mortality (PRISM) III Score in Predicting Mortality Outcomes in a Pediatric Intensive Care Unit in Karachi.

Sadiq Mirza, Laraib Malik, Jawad Ahmed, Farheen Malik, Hassaan Sadiq, Sanower Ali, Sina Aziz,

Background With the advancements in medicine and increasing access to modern technology, pediatric intensive care units (PICU) are becoming a vital part of any health care setting. PICUs play a key role in saving the life of young patients. Various scales have been designed by researchers to aid in predicting the ... Read more >>

Cureus (Cureus)
[2020, 12(3):e7489]

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Protein C Deficiency as a Risk Factor for Stroke in Young Adults: A Review.

Zainab Majid, Faryal Tahir, Jawad Ahmed, Taha Bin Arif, Anwarul Haq,

Protein C (PC) is a 62-kD vitamin K dependent glycoprotein produced by the liver as a zymogen and is activated by binding to the thrombin-thrombomodulin complex, with protein S (PS) acting as a cofactor. Among its various functions, PC acts as a naturally occurring anticoagulant and its deficiency, either homozygous ... Read more >>

Cureus (Cureus)
[2020, 12(3):e7472]

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Neonatal Nonketotic Hyperglycinemia: A Rare Case from Pakistan.

Taha Bin Arif, Jawad Ahmed, Farheen Malik, Sharmeen Nasir, Taj M Khan,

Nonketotic hyperglycinemia (NKH) is an autosomal recessive disorder caused by a defect in glycine cleavage enzyme. It leads to the accumulation of glycine in the body tissues, blood, and cerebrospinal fluid (CSF). Most NKH cases are diagnosed during the natal period of life and are fatal if not promptly diagnosed and ... Read more >>

Cureus (Cureus)
[2020, 12(3):e7235]

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Adult-onset Primary Hemophagocytic Lymphohistiocytosis: Reporting a Rare Case with Review of Literature.

Fatima Memon, Jawad Ahmed, Farheen Malik, Junaid Ahmad, Danish Ahmed Memon,

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon, aggressive hematological syndrome. It is caused by an increased and unchecked proliferation of T lymphocytes and histiocytes. These cells secrete a large number of inflammatory cytokines and infiltrate various tissues causing multi-organ system failure. HLH may be primary or associated with different types of ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6723]

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Chronic Non-cirrhotic Portal Vein Thrombosis with Cavernous Transformation Secondary to Protein C and S Deficiency.

Zainab Majid, Faryal Tahir, Taha Bin Arif, Jawad Ahmed,

Hereditary thrombophilia (HT), including the mutation of factor V gene and the deficiency of proteins C, protein S, or antithrombin, is a risk factor for portal vein thrombosis (PVT). PVT in acute cases is usually asymptomatic, whereas chronic cases mostly present as variceal bleeding and splenomegaly. However, cavernous transformation of ... Read more >>

Cureus (Cureus)
[2020, 12(2):e7142]

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Compliance and Knowledge of Healthcare Workers Regarding Hand Hygiene and Use of Disinfectants: A Study Based in Karachi.

Jawad Ahmed, Farheen Malik, Zahid Ali Memon, Taha Bin Arif, Aiman Ali, Sundus Nasim, Junaid Ahmad, Muhammad A Khan,

Background Hand hygiene is the cardinal step in combating various healthcare-associated infections. These infections are a cause of 37,000 deaths in Europe and 100,000 deaths in the United States annually. Thus, prevention of their spread is of utmost importance today. A study conducted in a tertiary care center in Karachi ... Read more >>

Cureus (Cureus)
[2020, 12(2):e7036]

Cited: 2 times

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Taurine treatment of retinal degeneration and cardiomyopathy in a consanguineous family with SLC6A6 taurine transporter deficiency.

Muhammad Ansar, Emmanuelle Ranza, Madhur Shetty, Sohail A Paracha, Maleeha Azam, Ilse Kern, Justyna Iwaszkiewicz, Omer Farooq, Constantin J Pournaras, Ariane Malcles, Mateusz Kecik, Carlo Rivolta, Waqar Muzaffar, Aziz Qurban, Liaqat Ali, Yacine Aggoun, Federico A Santoni, Periklis Makrythanasis, Jawad Ahmed, Raheel Qamar, Muhammad T Sarwar, L Keith Henry, Stylianos E Antonarakis,

In a consanguineous Pakistani family with two affected individuals, a homozygous variant Gly399Val in the eighth transmembrane domain of the taurine transporter SLC6A6 was identified resulting in a hypomorph transporting capacity of ~15% compared with normal. Three-dimensional modeling of this variant has indicated that it likely causes displacement of the ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2020, 29(4):618-623]

Cited: 0 times

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