Full Text Journal Articles by
Author Javier S Burgos

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A new portrait by Géricault.

Javier S Burgos,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(2):90-91]

Cited: 0 times

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Association Between Periodontitis and Amyloid β Peptide in Elderly People With and Without Cognitive Impairment.

José Antonio Gil-Montoya, Rocío Barrios, Soraya Santana, Inés Sanchez-Lara, Cristobal Carnero Pardo, Francisco Fornieles-Rubio, Juan Montes, Carlos Ramírez, Miguel Angel González-Moles, Javier S Burgos,

<h4>Background</h4>Evidence that periodontal disease is a possible risk factor for cognitive impairment may be explained by the inflammatory hypothesis. The aim of this study is to determine whether periodontitis is related to the amyloid β (Aβ) load in blood and the role of any such relationship in the association between ... Read more >>

J Periodontol (Journal of periodontology)
[2017, 88(10):1051-1058]

Cited: 7 times

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2-Methyl-6-(phenylethynyl)pyridine Hydrochloride Modulates Metabotropic Glutamate 5 Receptors Endogenously Expressed in Zebrafish Brain.

José Luis Albasanz, Soraya Santana, Fernando Guzman-Sanchez, David León, Javier S Burgos, Mairena Martín,

Due to phylogenetic proximity to the human, zebrafish has been recognized as a reliable model to study Alzheimer's disease (AD) and other central nervous system disorders. Furthermore, metabotropic glutamate receptors have been previously reported to be impaired in brain from AD patients. Metabotropic glutamate 5 (mGlu<sub>5</sub>) receptors are G-protein coupled ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2016, 7(12):1690-1697]

Cited: 1 time

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Can zebrafish be used as animal model to study Alzheimer's disease?

Soraya Santana, Eduardo P Rico, Javier S Burgos,

Zebrafish is rapidly emerging as a promising model organism to study various central nervous system (CNS) disorders, including Alzheimer's disease (AD). AD is the main cause of dementia in the human population and there is an urgency to understand the causes of this neurodegenerative disease. In this respect, the development ... Read more >>

Am J Neurodegener Dis (American journal of neurodegenerative disease)
[2012, 1(1):32-48]

Cited: 17 times

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Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish.

Saleta Sierra, Juan M Alfaro, Sonia Sánchez, Javier S Burgos,

Docosahexaeonic acid (DHA) is the final compound in the omega-3 polyunsaturated fatty acids (PUFA) synthetic pathway and the most abundant PUFA found in the brain. DHA plays an essential role in the development of the brain, and the intakes in pregnancy and early life affect growth and cognitive performance later ... Read more >>

Brain Res Bull (Brain research bulletin)
[2012, 88(5):467-470]

Cited: 8 times

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How statins could be evaluated successfully in clinical trials for Alzheimer's disease?

Javier S Burgos, Jesús Benavides, Patrice Douillet, Javier Velasco, Fernando Valdivieso,

Over the last decade, a large number of experimental observations have suggested a relationship between alterations in cholesterol homeostasis and Alzheimer's disease (AD). Moreover, epidemiological studies have pointed an association between statin treatment and a decrease in the risk of having AD. For these reasons, a large number of clinical ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2012, 27(3):151-153]

Cited: 3 times

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ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage.

Carlos Ramírez, Saleta Sierra, Inmaculada Tercero, Jose Antonio Vázquez, Antonia Pineda, Tatiana Manrique, Javier S Burgos,

Recent clinical findings support the notion that the progressive deterioration of cholesterol homeostasis is a central player in Alzheimer's disease (AD). Epidemiological studies suggest that high midlife plasma total cholesterol levels are associated with an increased risk of AD. This paper reports the plasma cholesterol concentrations, cognitive performance, locomotor activity ... Read more >>

PLoS One (PloS one)
[2011, 6(7):e22712]

Cited: 15 times

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Aging-related neurostructural, neuropathological, and behavioral changes associated with herpes simplex virus type 1 brain infection in mice.

Fernando Guzman-Sanchez, Fernando Valdivieso, Javier S Burgos,

To date, the main advances in understanding Alzheimer's disease (AD) have revolved around the genetic variants associated with the familial form of the disease, yet the majority of cases are sporadic. The main risk factor for AD is aging, followed by production of the E4 isoform of apolipoprotein E (APOE). ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2012, 30(4):779-790]

Cited: 9 times

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Simvastatin modulates the Alzheimer's disease-related gene seladin-1.

Maria C Ramos, Saleta Sierra, Carlos Ramirez, Javier Velasco, Javier S Burgos,

This work describes a novel mechanism of neuroprotection by simvastatin: the modulation of seladin-1, an enzyme involved in Alzheimer's disease. Genomic and proteomic studies in human neuronal cells showed seladin-1 production to be increased in a dose- and time-dependent manner by simvastatin. This was confirmed in mice by immunohistochemical and ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2012, 28(2):297-301]

Cited: 5 times

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Simvastatin is the statin that most efficiently protects against kainate-induced excitotoxicity and memory impairment.

Carlos Ramirez, Inmaculada Tercero, Antonia Pineda, Javier S Burgos,

Statins have recently been shown to act as protectants against several neuropathological conditions. They have received special attention in the field of Alzheimer's disease (AD), where epidemiological studies indicating a lower prevalence of AD/dementia in statin-prescribed populations. Excitotoxicity, which derives from the overstimulation of glutamate receptors, is a major cause ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2011, 24(1):161-174]

Cited: 36 times

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Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death.

Saleta Sierra, Maria C Ramos, Pilar Molina, Cynthia Esteo, Jose Antonio Vázquez, Javier S Burgos,

There is growing evidence to support the hypothesis that statins may act as neuroprotectants in several neuropathological conditions, including Alzheimer's disease. The mechanisms for neuroprotection are only partially understood, however, and pleiotropic phenomena could be involved. We have made a comparative study of 9 statins (lovastatin, mevastatin, pravastatin, simvastatin, cerivastatin, ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2011, 23(2):307-318]

Cited: 83 times

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Kainate administered to adult zebrafish causes seizures similar to those in rodent models.

Juan M Alfaro, Jorge Ripoll-Gómez, Javier S Burgos,

Glutamate is the major excitatory neurotransmitter of the central nervous system in vertebrates. Excitotoxicity, caused by over-stimulation of the glutamate receptors, is a major cause of neuron death in several brain diseases, including epilepsy. We describe here how behavioural seizures can be triggered in adult zebrafish by the administration of ... Read more >>

Eur J Neurosci (The European journal of neuroscience)
[2011, 33(7):1252-1255]

Cited: 23 times

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Semisynthesis of novel monacolin J derivatives: hypocholesterolemic and neuroprotective activities.

Sonia Campoy, Saleta Sierra, Beatriz Suarez, Maria C Ramos, Javier Velasco, Javier S Burgos, Jose L Adrio,

A fungal strain able to naturally accumulate large amounts of monacolin J was improved by N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis and genetic disruption of the lovF gene. Semisynthesis was then used to produce novel statins by attaching different side chains at the C8 hydroxyl residue. In vitro hypocholesterolemic and neuroprotection assays showed that ... Read more >>

J Antibiot (Tokyo) (The Journal of antibiotics)
[2010, 63(8):499-505]

Cited: 1 time

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Biomedical properties of a series of ruthenium-N-heterocyclic carbene complexes based on oxidant activity in vitro and assessment in vivo of biosafety in zebrafish embryos.

Juan M Alfaro, Amparo Prades, María del Carmen Ramos, Eduardo Peris, Jorge Ripoll-Gómez, Macarena Poyatos, Javier S Burgos,

N-Heterocyclic carbene (NHC) ligands have attracted great interest over the last decade for their use in the design of homogenous catalysts. NHC-based metal complexes have interesting potential biomedical applications, such as in antimicrobial and cancer therapy, which are beginning to be explored more fully. We have studied here the oxidant ... Read more >>

Zebrafish (Zebrafish)
[2010, 7(1):13-21]

Cited: 9 times

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Zebrafish as a new model for herpes simplex virus type 1 infection.

Javier S Burgos, Jorge Ripoll-Gomez, Juan M Alfaro, Isabel Sastre, Fernando Valdivieso,

The zebrafish (Danio rerio) is rapidly gaining ground as a disease model. However, until now, the use of this species with human pathogens has been restricted to just three bacteria; no studies involving viruses that infect humans are recorded. In this study, the zebrafish was used as a model of ... Read more >>

Zebrafish (Zebrafish)
[2008, 5(4):323-333]

Cited: 35 times

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Noninvasive bioluminescent imaging of infections.

Javier S Burgos,

Traditional studies of viral and bacterial infection and pathogenesis have generally relied on animal models that require the sacrifice of infected animals to determine viral or bacterial distributions and titers. The recent application of the in vivo bioluminescence imaging (BLI) to monitor the replication and tropism of pathogens expressing the ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2009, 574:115-124]

Cited: 1 time

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Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner.

Javier S Burgos, Carlos Ramirez, Isabel Sastre, Fernando Valdivieso,

There is growing evidence that herpes simplex virus type 1 (HSV-1), together with the apolipoprotein E 4 (APOE4) allele, contribute to the pathogenesis of Alzheimer's disease (AD), although the mechanism of their interaction remains uncertain. Here we show that the combination of inherited APOE genotype and vertical transmission of HSV-1 ... Read more >>

Aging Cell (Aging cell)
[2007, 6(6):841-842]

Cited: 8 times

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Changes in immunoglobulin levels related to herpes simplex virus type 1 brain infection in pregnant mice.

Javier S Burgos, Carlos Ramirez, Anna Brachet, Juan M Alfaro, Isabel Sastre, Fernando Valdivieso,

Disseminated herpes simplex virus type 1 (HSV-1) infection during pregnancy is poorly described even though it is associated with high maternal and fetal morbidity and neonatal mortality in humans. In a previous paper using mice as a model, the authors demonstrated that HSV-1 is transmitted hematogenously from mother to offspring, ... Read more >>

J Neurovirol (Journal of neurovirology)
[2007, 13(3):233-241]

Cited: 2 times

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Non-invasive bioluminescence imaging for monitoring herpes simplex virus type 1 hematogenous infection.

Javier S Burgos, Fernando Guzman-Sanchez, Isabel Sastre, Cristina Fillat, Fernando Valdivieso,

Traditional studies on viral neuroinvasiveness and pathogenesis have generally relied on murine models that require the sacrifice of infected animals to determine viral distributions and titers. The present paper reports the use of in vivo bioluminescence imaging to monitor the replication and tropism of KOS strain HSV-1 viruses expressing the ... Read more >>

Microbes Infect (Microbes and infection)
[2006, 8(5):1330-1338]

Cited: 14 times

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Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA.

Javier S Burgos, Carlos Ramirez, Isabel Sastre, Fernando Valdivieso,

Herpes simplex virus type 1 (HSV-1) is neurotropic and enters a latent state lasting the lifetime of the host. This pathogen has recently been proposed as a risk factor for Alzheimer's disease (AD) in conjunction with apolipoprotein E4 (ApoE4). In a murine acute infection model, we showed that viral neuroinvasiveness ... Read more >>

J Virol (Journal of virology)
[2006, 80(11):5383-5387]

Cited: 47 times

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Hematogenous vertical transmission of herpes simplex virus type 1 in mice.

Javier S Burgos, Carlos Ramirez, Fernando Guzman-Sanchez, Juan M Alfaro, Isabel Sastre, Fernando Valdivieso,

Herpes simplex virus type 1 (HSV-1) is a neurotropic virus that causes severe disease and death in newborn humans but, to date, it remains unclear how neonatal infection occurs. We show here that the vertical transmission of HSV-1 in mice is mainly hematogenous and involves the colonization of the neonate ... Read more >>

J Virol (Journal of virology)
[2006, 80(6):2823-2831]

Cited: 10 times

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Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis.

Javier S Burgos,

The aim of this study was to discuss the relevance of the Epstein-Barr virus (EBV) in the nasopharyngeal carcinoma (NPC), analyzing the variations of several molecules potentially involved in the pathogenesis of this cancer. EBV was detected in all the NPC samples by several techniques including PCR, in situ hybridization, ... Read more >>

Med Oncol (Medical oncology (Northwood, London, England))
[2005, 22(2):113-121]

Cited: 38 times

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Herpes simplex virus type 1 infection via the bloodstream with apolipoprotein E dependence in the gonads is influenced by gender.

Javier S Burgos, Carlos Ramirez, Isabel Sastre, Juan M Alfaro, Fernando Valdivieso,

Herpes simplex virus type 1 (HSV-1) causes disease in humans and animals. Infection usually occurs via the neural route and possibly occurs via the hematogenous route. The latter, however, is the main route by which immunosuppressed individuals and neonates are infected. Gender-dependent differences in the incidence and severity of some ... Read more >>

J Virol (Journal of virology)
[2005, 79(3):1605-1612]

Cited: 20 times

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ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1.

Javier S Burgos, Carlos Ramirez, Isabel Sastre, Maria J Bullido, Fernando Valdivieso,

Apolipoprotein E (ApoE) plays a relevant role in herpes simplex type 1 (HSV-1) infection of the CNS; after infection by the hematogenous route, the viral neuroinvasiveness directly depends on the APOE gene dose. To analyze the effect of ApoE isoforms on the HSV-1 infectivity to the brain, we have used ... Read more >>

Neuroreport (Neuroreport)
[2003, 14(14):1825-1827]

Cited: 46 times

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Kainate-triggered currents in Xenopus oocytes injected with chick retinal membrane fragments: effect of guanine nucleotides.

Javier S Burgos, Jordi Aleu, Ana Barat, Carles Solsona, Jordi Marsal, Galo Ramírez,

PURPOSE:To electrophysiologically characterize alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)/kainate receptors in chick retinal membrane fragments, incorporated into Xenopus oocytes by direct microinjection. METHODS:A 6-day retinal membrane suspension was injected into Xenopus oocytes by use of an electronic nanoliter injector. Fifteen to 40 hours after injection, the oocytes were assayed for kainate-elicited inward currents, under ... Read more >>

Invest Ophthalmol Vis Sci (Investigative ophthalmology & visual science)
[2003, 44(7):3124-3129]

Cited: 4 times

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