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Author Jason Chiang

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Infratentorial C11orf95-fused gliomas share histologic, immunophenotypic, and molecular characteristics of supratentorial RELA-fused ependymoma.

Camille Keenan, Richard T Graham, Julie H Harreld, John T Lucas, David Finkelstein, David Wheeler, Xiaoyu Li, James Dalton, Santhosh A Upadhyaya, Susana C Raimondi, Frederick A Boop, Michael DeCuypere, Jinghui Zhang, Anna Vinitsky, Lu Wang, Jason Chiang,

Acta Neuropathol (Acta neuropathologica)
[2020, :]

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Case 286.

Jason Chiang, Frank Hebroni, Arash Bedayat, Lila Pourzand,

History A 70-year-old man had a posterior left thigh lesion confirmed to be biopsy-proven melanoma. The patient underwent wide excision and sentinel node biopsy, which showed absence of residual melanoma. Two years later, the patient noticed a subcentimeter subcutaneous lump in his thigh. Repeat excisional biopsy showed involvement of the ... Read more >>

Radiology (Radiology)
[2020, 297(1):237-238]

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Inline balloon-assisted vascular sheath fragment removal.

Neema Jamshidi, Jason Chiang,

BACKGROUND:Unretrievable foreign bodies are associated with high morbidity and mortality. While the majority of reported cases involve the venous circulation, intra-arterial foreign body displacement have the potential to migrate more distally with a higher risk for dissection and hemorrhagic complications during retrieval. As the number of intravascular procedures continues to ... Read more >>

CVIR Endovasc (CVIR endovascular)
[2020, 3(1):53]

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Multimorbidity, glycaemic variability and time in target range in people with type 2 diabetes: A baseline analysis of the GP-OSMOTIC trial.

Jason I Chiang, Jo-Anne Manski-Nankervis, Sharmala Thuraisingam, Alicia Jenkins, David O'Neal, Frances S Mair, Bhautesh Dinesh Jani, Barbara I Nicholl, John Furler,

AIMS:To explore associations between multimorbidity condition counts (total; concordant (diabetes-related); discordant (unrelated to diabetes)) and glycaemia (HbA1c; glycaemic variability (GV); time in range (TIR)) using data from a randomised controlled trial examining effectiveness of continuous glucose monitoring (CGM) in people with type 2 diabetes (T2D). METHODS:Cross-sectional study: 279 people with ... Read more >>

Diabetes Res Clin Pract (Diabetes research and clinical practice)
[2020, 169:108451]

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Use of Contrast-Enhanced Ultrasound in Ablation Therapy of HCC: Planning, Guiding, and Assessing Treatment Response.

Maria Franca Meloni, Giampiero Francica, Jason Chiang, Andrea Coltorti, Roberta Danzi, Paul F Laeseke,

Contrast-enhanced ultrasonography (CEUS) plays an important role in the management of patients treated with ablation therapies, in the diagnostic, therapeutic and monitoring phases. Compared to contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging, CEUS presents several advantages in imaging HCC, including real time imaging capability, high sensitivity for tumor vascularity, ... Read more >>

J Ultrasound Med (Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine)
[2020, :]

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Risk stratification in pediatric low-grade glioma and glioneuronal tumor treated with radiation therapy: an integrated clinicopathologic and molecular analysis.

Sahaja Acharya, Jo-Fen Liu, Ruth G Tatevossian, Jason Chiang, Ibrahim Qaddoumi, Amar Gajjar, David Walker, Julie H Harreld, Thomas E Merchant, David W Ellison,

BACKGROUND:Management of unresectable pediatric low-grade glioma and glioneuronal tumor (LGG/LGGNT) is controversial. There are no validated prognostic features to guide use of radiation therapy (RT). Our study aimed to identify negative prognostic features in patients treated with RT using clinicopathologic and molecular data and validate these findings in an external ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, 22(8):1203-1213]

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Safety and efficacy of brainstem biopsy in children and young adults.

David S Hersh, Rahul Kumar, Kenneth A Moore, Luke G F Smith, Christopher L Tinkle, Jason Chiang, Zoltan Patay, Amar Gajjar, Asim F Choudhri, Jorge A Lee-Diaz, Brandy Vaughn, Paul Klimo,

OBJECTIVE:Biopsies of brainstem lesions are performed to establish a diagnosis in the setting of an atypical clinical or radiological presentation, or to facilitate molecular studies. A better understanding of the safety and diagnostic yield of brainstem biopsies would help guide appropriate patient selection. METHODS:All patients who underwent biopsy of a ... Read more >>

J Neurosurg Pediatr (Journal of neurosurgery. Pediatrics)
[2020, :1-11]

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Focal 18F-NaF PET Prostate Activity in the Setting of Prostate Adenocarcinoma.

Jason Chiang, Jonathan P Gershenson, Michael S Lewis, Kiarash Vahidi, Gholam R Berenji,

A 72-year-old man with a family history of prostate cancer and initial diagnosis of favorable intermediate risk prostate cancer via biopsy in 2017 elected for active surveillance. Two years later, he underwent prostate biopsy showing intermediate-risk cT1c Nx Mx lesion with Gleason score 3 + 4 = 7 (5 core ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2020, 45(7):e334-e335]

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Multimorbidity, mortality, and HbA1c in type 2 diabetes: A cohort study with UK and Taiwanese cohorts.

Jason I Chiang, Peter Hanlon, Tsai-Chung Li, Bhautesh Dinesh Jani, Jo-Anne Manski-Nankervis, John Furler, Cheng-Chieh Lin, Shing-Yu Yang, Barbara I Nicholl, Sharmala Thuraisingam, Frances S Mair,

BACKGROUND:There is emerging interest in multimorbidity in type 2 diabetes (T2D), which can be either concordant (T2D related) or discordant (unrelated), as a way of understanding the burden of disease in T2D. Current diabetes guidelines acknowledge the complex nature of multimorbidity, the management of which should be based on the ... Read more >>

PLoS Med (PLoS medicine)
[2020, 17(5):e1003094]

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Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG.

Jason Chiang, Alexander K Diaz, Lydia Makepeace, Xiaoyu Li, Yuanyuan Han, Yimei Li, Paul Klimo, Frederick A Boop, Suzanne J Baker, Amar Gajjar, Thomas E Merchant, David W Ellison, Alberto Broniscer, Zoltan Patay, Christopher L Tinkle,

Diffuse intrinsic pontine glioma (DIPG) is most commonly diagnosed based on imaging criteria, with biopsy often reserved for pontine tumors with imaging features not typical for DIPG (atypical DIPG, 'aDIPG'). The histopathologic and molecular spectra of the clinical entity aDIPG remain to be studied systematically. In this study, thirty-three patients ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):57]

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Abdominal wall and pelvic hernias: classic and unusual hernias and their mimics.

Arash Bedayat, Cameron Hassani, Jason Chiang, Frank Hebroni, Saeed Ghandili, Hamid Chalian, Pegah Khoshpouri, Hao S Lo, Adib R Karam,

Abdominal and pelvic wall hernias are classically defined as a weakness or opening of the muscular wall through which abdominal or pelvic tissues protrude. The aim of this manuscript is to review the imaging findings of abdominal and pelvic wall hernias and their mimics and to discuss pearls and pitfalls ... Read more >>

Clin Imaging (Clinical imaging)
[2020, 64:57-66]

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4D Flow MR Imaging to Improve Microwave Ablation Prediction Models: A Feasibility Study in an In Vivo Porcine Liver.

Jason Chiang, Michael Loecher, Kevin Moulin, M Franca Meloni, Steven S Raman, Justin P McWilliams, Daniel B Ennis, Edward W Lee,

PURPOSE:To characterize the effect of hepatic vessel flow using 4-dimensional (4D) flow magnetic resonance (MR) imaging and correlate their effect on microwave ablation volumes in an in vivo non-cirrhotic porcine liver model. MATERIALS AND METHODS:Microwave ablation antennas were placed under ultrasound guidance in each liver lobe of swine (n = 3 in ... Read more >>

J Vasc Interv Radiol (Journal of vascular and interventional radiology : JVIR)
[2020, 31(10):1691-1696.e1]

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A 4-Year-Old Girl With a Supratentorial Mass.

Lincy Thomas, Naina Gross, Spencer Thompson, Rene McNall-Knapp, David Ellison, Jason Chiang, Jo Elle Peterson, Kar-Ming Fung, Abhishek Bavle,

Brain Pathol. (Brain pathology (Zurich, Switzerland))
[2020, 30(2):421-422]

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High-grade neuroepithelial tumor with medulloepithelioma-like areas out of the central nervous system in an infant with hemihypertrophy: a unique association.

İbrahim Karnak, Gökhan Gedikoğlu, Berna Oğuz, Figen Söylemezoğlu, Armita Bahrami, Jason Chiang, Tezer Kutluk,

BACKGROUND:High-grade neuroepithelial tumor with areas resembling medulloepithelioma was diagnosed in an infant with coccygeal and inguinal masses. Hemihypertrophy is associated with Wilms tumor, hepatoblastoma and pancreatic tumors in children. CASE:The authors report on the first case of peripheral HNET associated with hemihypertrophy in an infant, with special discussion on histopathological ... Read more >>

Turk J Pediatr (The Turkish journal of pediatrics)
[2020, 62(5):836-842]

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Tectal glioma harbors high rates of KRAS G12R and concomitant KRAS and BRAF alterations.

Jason Chiang, Xiaoyu Li, Anthony P Y Liu, Ibrahim Qaddoumi, Sahaja Acharya, David W Ellison,

Acta Neuropathol. (Acta neuropathologica)
[2020, 139(3):601-602]

Cited: 1 time

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Use of professional-mode flash glucose monitoring, at 3-month intervals, in adults with type 2 diabetes in general practice (GP-OSMOTIC): a pragmatic, open-label, 12-month, randomised controlled trial.

John Furler, David O'Neal, Jane Speight, Irene Blackberry, Jo-Anne Manski-Nankervis, Sharmala Thuraisingam, Katie de La Rue, Louise Ginnivan, Rebecca Doyle, Elizabeth Holmes-Truscott, Kamlesh Khunti, Kim Dalziel, Jason Chiang, Ralph Audehm, Mark Kennedy, Malcolm Clark, Alicia Jenkins, Amelia J Lake, Andrzej S Januszewski, Max Catchpool, Danny Liew, Philip Clarke, James Best,

BACKGROUND:Continuous glucose monitoring, either real-time (personal) or retrospective (professional mode), can identify day-to-day glucose profiles to guide management decisions for people with type 2 diabetes. We aimed to examine the effects of professional-mode flash glucose monitoring, done at 3-month intervals, in adults with type 2 diabetes in general practice. METHODS:We ... Read more >>

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2020, 8(1):17-26]

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Clinicopathologic and molecular features of intracranial desmoplastic small round cell tumors.

Julieann C Lee, Javier E Villanueva-Meyer, Sean P Ferris, Elaine M Cham, Jacob Zucker, Tabitha Cooney, Ahmed Gilani, Bette K Kleinschmidt-DeMasters, Dimitri Trembath, Manuela Mafra, Jason Chiang, David W Ellison, Soo-Jin Cho, Andrew E Horvai, Jessica Van Ziffle, Courtney Onodera, Patrick Devine, James P Grenert, Carmen M A de Voijs, W T Marja van Blokland, Wendy W J de Leng, Marieke J Ploegmakers, Uta Flucke, Melike Pekmezci, Andrew W Bollen, Tarik Tihan, Christian Koelsche, Andreas von Deimling, Pieter Wesseling, David A Solomon, Arie Perry,

Desmoplastic small round cell tumors (DSRCTs) are highly aggressive sarcomas that most commonly occur intra-abdominally, and are defined by EWSR1-WT1 gene fusion. Intracranial DSRCTs are exceptionally rare with only seven previously reported fusion-positive cases. Herein, we evaluate the clinical, morphologic, immunohistochemical and molecular features of five additional examples. All patients ... Read more >>

Brain Pathol (Brain pathology (Zurich, Switzerland))
[2020, 30(2):213-225]

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YAP1-fusions in pediatric NF2-wildtype meningioma.

Philipp Sievers, Jason Chiang, Daniel Schrimpf, Damian Stichel, Nagarajan Paramasivam, Martin Sill, Tenzin Gayden, Belen Casalini, David E Reuss, James Dalton, Kristian W Pajtler, Daniel Hänggi, Christel Herold-Mende, Elisabeth Rushing, Andrey Korshunov, Christian Mawrin, Michael Weller, Matthias Schlesner, Wolfgang Wick, Nada Jabado, David T W Jones, Stefan M Pfister, Andreas von Deimling, David W Ellison, Felix Sahm,

Acta Neuropathol. (Acta neuropathologica)
[2020, 139(1):215-218]

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Defining Optimal Target Volumes of Conformal Radiation Therapy for Diffuse Intrinsic Pontine Glioma.

Christopher L Tinkle, Brittany Simone, Jason Chiang, Xiaoyu Li, Kristen Campbell, Yuanyuan Han, Yimei Li, Laura D Hover, Jason K Molitoris, Jared Becksfort, John T Lucas, Zoltan Patay, Suzanne J Baker, Alberto Broniscer, Thomas E Merchant,

PURPOSE:Optimal radiation therapy (RT) target margins for diffuse intrinsic pontine glioma (DIPG) are unknown. We sought to define disease progression patterns in a contemporary cohort treated with conformal RT using different clinical target volume (CTV) margins. METHODS AND MATERIALS:We reviewed 105 patients with newly diagnosed DIPG treated with conformal conventionally ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2020, 106(4):838-847]

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Evaluating pediatric spinal low-grade gliomas: a 30-year retrospective analysis.

Steven S Carey, Zsila Sadighi, Shengjie Wu, Jason Chiang, Giles W Robinson, Yahya Ghazwani, Anthony P Y Liu, Sahaja Acharya, Thomas E Merchant, Frederick A Boop, Amar Gajjar, Ibrahim Qaddoumi,

PURPOSE:Most pediatric spinal tumors are low-grade gliomas (LGGs). Characterization of these tumors has been difficult given their heterogeneity and rare incidence. The objective was to characterize such tumors diagnosed at our institution. METHODS:Spinal tumors diagnosed in our pediatric patients between 1984 and 2014 were reviewed retrospectively. Demographics, presentation, pathology, imaging, ... Read more >>

J. Neurooncol. (Journal of neuro-oncology)
[2019, 145(3):519-529]

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A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration.

Jason Chiang, Julie H Harreld, Christopher L Tinkle, Daniel C Moreira, Xiaoyu Li, Sahaja Acharya, Ibrahim Qaddoumi, David W Ellison,

Acta Neuropathol (Acta neuropathologica)
[2019, 138(6):1091-1092]

Cited: 2 times

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Long-term visual acuity outcomes after radiation therapy for sporadic optic pathway glioma.

Sahaja Acharya, Sophia Quesada, Kenneth Coca, Cody Richardson, Mary E Hoehn, Jason Chiang, Ibrahim Qaddoumi, Frederick A Boop, Amar Gajjar, Thomas E Merchant,

PURPOSE:Children with sporadic optic pathway glioma (OPG) commonly experience a decline in visual acuity (VA). This study aimed to quantify long-term VA outcomes after definitive radiation therapy (RT). METHODS:From 1997 to 2017, 41 patients underwent RT for OPG and had baseline VA testing. All patients underwent serial VA testing every ... Read more >>

J. Neurooncol. (Journal of neuro-oncology)
[2019, 144(3):603-610]

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Global Prevalence of Colorectal Neoplasia: A Systematic Review and Meta-Analysis.

Martin C S Wong, Junjie Huang, Jason L W Huang, Tiffany W Y Pang, Peter Choi, Jingxuan Wang, Jason I Chiang, Johnny Yu Jiang,

BACKGROUND & AIMS:Most colorectal cancers (CRC) arise from colorectal adenomas, yet there is not enough information on global prevalence to inform health care policy. We examined the prevalence of any type of adenomas, advanced adenomas (AADs), and CRC according to age, sex, ethnicity, geographic regions, and anatomic location (proximal vs ... Read more >>

Clin. Gastroenterol. Hepatol. (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, 18(3):553-561.e10]

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Reviewing the Demographic, Prognostic, and Treatment Factors of Primary Adenocarcinoma of the Bladder: A SEER Population-based Study.

Caleb Natale, Gabriel Z Leinwand, Jason Chiang, Jonathan L Silberstein, L Spencer Krane,

INTRODUCTION:The objective of this study was to characterize the demographic, prognostic, and treatment factors for patients with primary adenocarcinoma of the bladder by analyzing the impact of histologic subtype in a large sample size and interpreting newly released Surveillance, Epidemiology, and End Results (SEER) chemotherapy data. MATERIALS AND METHODS:The SEER ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2019, 17(5):380-388]

Cited: 1 time

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Septal dysembryoplastic neuroepithelial tumor: a comprehensive clinical, imaging, histopathologic, and molecular analysis.

Jason C H Chiang, Julie H Harreld, Ryuma Tanaka, Xiaoyu Li, Ji Wen, Chenran Zhang, Daniel R Boué, Tracy M Rauch, J Todd Boyd, Jie Chen, Joseph C Corbo, Thomas W Bouldin, Scott W Elton, Le-Wen L Liu, Deborah Schofield, Sunhee C Lee, John-Paul Bouffard, Maria-Magdalena Georgescu, Rimal H Dossani, Maria A Aguiar, Richard A Sances, Ali G Saad, Frederick A Boop, Ibrahim Qaddoumi, David W Ellison,

BACKGROUND:Dysembryoplastic neuroepithelial tumors (DNETs) are uncommon neural tumors presenting most often in children and young adults and associated with intractable seizures. Rare midline neoplasms with similar histological features to those found in DNETs have been described near the septum pellucidum and termed "DNET-like neoplasms of the septum pellucidum." Due to ... Read more >>

Neuro-oncology (Neuro-oncology)
[2019, 21(6):800-808]

Cited: 1 time

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