Full Text Journal Articles by
Author Jason Brophy

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Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study.

Carmen Yea, Ari Bitnun, Helen M Branson, Beyza Ciftci-Kavaklioglu, Mubeen F Rafay, Olivier Fortin, Paola Moresoli, Guillaume Sébire, Myriam Srour, Hélène Decaluwe, Louis Marois, Félixe Pelletier, Michelle Barton, Maryam Nabavi Nouri, Jason Brophy, Sunita Venkateswaran, Daniela Pohl, Kathryn Selby, Kevin Jones, Joan Robinson, Aleksandra Mineyko, Christoph Licht, Birgit Ertl-Wagner, E Ann Yeh,

BACKGROUND:Acute flaccid myelitis (AFM) is characterised by rapid onset of limb weakness with spinal cord grey-matter abnormalities on MRI scan. We aimed to assess whether detection of enterovirus in respiratory or other specimens can help predict prognosis in children with AFM. METHODS:In this nationwide, longitudinal study, we evaluated the significance ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):828-836]

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Predictive value of repeated cerebrospinal fluid parameters in the outcomes of bacterial meningitis in infants <90 days of age.

Joseph Y Ting, Ashley Roberts, Sarah Khan, Ari Bitnun, Michael Hawkes, Michelle Barton, Jennifer Bowes, Jason Brophy, Lynda Ouchenir, Christian Renaud, Andrée-Anne Boisvert, Jane McDonald, Joan L Robinson,

BACKGROUND:There are variations in recommendations from different guidelines regarding the indications for repeat lumbar puncture (LP) in young infants with the diagnosis of bacterial meningitis. OBJECTIVE:To evaluate the frequency of repeat LPs and the characteristics of cerebrospinal fluid (CSF) parameters in repeated sampling and their predictive values for adverse outcomes ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0238056]

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Enteroviral and Herpes Simplex Virus  Central Nervous System Infections in Infants <90 Days Old: A Paediatric Investigators’ Collaborative Network on Infections in Canada (PICNIC) Study

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

Abstract Background: The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. Methods: In this cross-sectional retrospective study, seven centers from the Pediatric ... Read more >>

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Assessing Gaps in Comprehensive HIV Care Across Settings of Care for Women Living with HIV in Canada.

Nadia O'Brien, Claire Godard-Sebillotte, Lashanda Skerritt, Janice Dayle, Allison Carter, Susan Law, Joseph Cox, Neil Andersson, Angela Kaida, Mona Loutfy, Alexandra de Pokomandy, ,

Background: Women living with HIV in Canada experience barriers to comprehensive HIV care. We sought to describe care gaps across a typology of care. Methods: We analyzed baseline data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS). A typology of care was characterized by primary HIV ... Read more >>

J Womens Health (Larchmt) (Journal of women's health (2002))
[2020, 29(11):1475-1485]

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Blood mitochondrial DNA levels remain elevated from birth to early life in children HIV-exposed uninfected exposed to combination antiretroviral therapy in utero.

Abhinav Ajaykumar, Mayanne Zhu, Fatima Kakkar, Jason Brophy, Ari Bitnun, Ariane Alimenti, Hugo Soudeyns, Sara Saberi, Arianne Y K Albert, Deborah M Money, Hélène C F CÔtÉ, ,

BACKGROUND:Combination antiretroviral therapy (cART) during pregnancy prevents vertical transmission, but many antiretrovirals cross the placenta and several can affect mitochondria. Exposure to maternal HIV and/or cART could have long-term effects on children HIV-exposed uninfected (CHEU). Our objective was to compare blood mitochondrial DNA (mtDNA) content in CHEU and children HIV-unexposed ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, :]

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Enteroviral and herpes simplex virus central nervous system infections in infants < 90 days old: a Paediatric Investigators' Collaborative Network on Infections in Canada (PICNIC) study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan L Robinson,

BACKGROUND:The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. METHODS:In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):252]

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Challenges to achieving and maintaining viral suppression among children living with HIV.

Fatima Kakkar, Terry Lee, Michael T Hawkes, Jason Brophy, Samson Lindy, Joel Singer, Hinatea Dieumegard, Laura Sauve, Ariane Alimenti, Wendy Vaudry, Sandra Seigel, Ben Tan, Christos Karatzios, Valerie Lamarre, Stanley Read, Hugo Soudeyns, Ari Bitnun, ,

OBJECTIVES:The objective of this study was to determine the time to, and durability of, viral suppression, among Canadian children living with HIV after initiation of combination antiretroviral therapy (cART). DESIGN:Prospective, multicenter Canadian cohort study (Early Pediatric Initiation Canada Child Cure Cohort), using both prospective and retrospectively collected data. METHODS:Kaplan-Meir survival ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(5):687-697]

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Social Determinants of Health and Retention in HIV Care Among Recently Incarcerated Women Living with HIV in Canada.

Rebecca Gormley, Sally Y Lin, Allison Carter, Valerie Nicholson, Kath Webster, Ruth Elwood Martin, M-J Milloy, Neora Pick, Terry Howard, Lu Wang, Alexandra de Pokomandy, Mona Loutfy, Angela Kaida, ,

Women living with HIV (WLWH) are over-represented in corrections in Canada, yet little is known about women's experiences post-release. We used CHIWOS cross-sectional data from WLWH to estimate associations between social determinants of health and HIV-related care outcomes among WLWH with recent (within past year) or ever (before past year) ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, 24(4):1212-1225]

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Impact of quadrivalent HPV vaccine dose spacing on immunologic response in women living with HIV.

Elisabeth McClymont, Gina Ogilvie, Arianne Albert, Angela Johnston, Janet Raboud, Sharon Walmsley, Nancy Lipsky, Mona Loutfy, Sylvie Trottier, Fiona Smaill, Mark H Yudin, Marina B Klein, Marianne Harris, Wendy Wobeser, Ari Bitnun, Fatima Kakkar, Lindy Samson, Jason Brophy, Christos Karatzios, Deborah Money, ,

HPV vaccination schedules have changed as evidence has supported reduced dosing and extended intervals. Women living with HIV (WLWH) represent an important population with no data on alternative dosing. Girls and WLWH received quadrivalent HPV (qHPV) vaccine in a pan-Canadian study of immunogenicity and efficacy. Serology was performed at months ... Read more >>

Vaccine (Vaccine)
[2020, 38(15):3073-3078]

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Assessing adolescent immunization options for pertussis in Canada: A cost-utility analysis.

Kika Anyiwe, Marina Richardson, Jason Brophy, Beate Sander,

BACKGROUND:Adolescent tetanus, diphtheria and pertussis (Tdap) immunization helps prevent pertussis infection. Timing of Tdap receipt represents an important facet of successful adolescent pertussis immunization. Potential strategies for timing of vaccine administration are each associated with different benefits - including disease prevention - and costs. The objective of this study was ... Read more >>

Vaccine (Vaccine)
[2020, 38(7):1825-1833]

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Transition from Pediatric to Adult HIV Care for Young Women Living with HIV.

Victoria Logan Kennedy, Kaitlyn Luisa Mellor, Jason Brophy, Ari Bitnun, Ariane Alimenti, Fatima Kakkar, Carmen Helen Logie, Kath Webster, Karène Proulx-Boucher, Erin Ding, Shahab Jabbari, Angela Kaida, Alexandra de Pokomandy, Mona Loutfy, ,

Transitioning from pediatric to adult care is a complicated process for youth with chronic illnesses. This study elucidates the unique factors affecting transition preparedness and perception of adult HIV care among a cohort of young women with HIV. Between 2013 and 2015, 48 women with HIV, who had experience with ... Read more >>

J Int Assoc Provid AIDS Care (Journal of the International Association of Providers of AIDS Care)
[2020, 19:2325958220903574]

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A Latent Class Analysis of the Social Determinants of Health Impacting Heavy Alcohol Consumption Among Women Living with HIV in Canada: The Canadian HIV Women's Sexual and Reproductive Health Cohort Study.

Mostafa Shokoohi, Greta R Bauer, Angela Kaida, Carmen H Logie, Allison Carter, Ashley Lacombe-Duncan, Mona Loutfy, ,

We used longitudinal data from the 2013-2017 Canadian HIV Women's Sexual and Reproductive Health Cohort Study (N = 1422) to assess the clustered impact of social determinants of health (SDoH) on hazardous drinking. Two measures of alcohol use were defined: (i) weekly alcohol use, with > 7 drinks/week as heavy drinking, and (ii) monthly ... Read more >>

AIDS Behav (AIDS and behavior)
[2019, 23(12):3226-3236]

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Hiring, training, and supporting Peer Research Associates: Operationalizing community-based research principles within epidemiological studies by, with, and for women living with HIV.

Angela Kaida, Allison Carter, Valerie Nicholson, Jo Lemay, Nadia O'Brien, Saara Greene, Wangari Tharao, Karène Proulx-Boucher, Rebecca Gormley, Anita Benoit, Mélina Bernier, Jamie Thomas-Pavanel, Johanna Lewis, Alexandra de Pokomandy, Mona Loutfy, ,

BACKGROUND:A community-based research (CBR) approach is critical to redressing the exclusion of women-particularly, traditionally marginalized women including those who use substances-from HIV research participation and benefit. However, few studies have articulated their process of involving and engaging peers, particularly within large-scale cohort studies of women living with HIV where gender, ... Read more >>

Harm Reduct J (Harm reduction journal)
[2019, 16(1):47]

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A longitudinal study of associations between HIV-related stigma, recent violence and depression among women living with HIV in a Canadian cohort study.

Carmen H Logie, Natania Marcus, Ying Wang, Angela Kaida, Patricia O'Campo, Uzma Ahmed, Nadia O'Brien, Valerie Nicholson, Tracey Conway, Alexandra de Pokomandy, Mylène Fernet, Mona Loutfy, ,

INTRODUCTION:Women living with HIV (WLHIV) experience stigma and elevated exposure to violence in comparison with HIV-negative women. We examined the mediating role of experiencing recent violence in the relationship between stigma and depression among WLHIV in Canada. METHODS:We conducted a cohort study with WLHIV in three Canadian provinces. Recent violence ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2019, 22(7):e25341]

Cited: 3 times

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45 The Rise of Lyme Disease in Eastern Ontario.

Stephanie Zahradnik, Jacqueline Willmore, Dara Spatz-Friedman, Cameron McDermaid, Anne Pham-Huy, Jason Brophy,

AbstractBackgroundLyme disease is a multi-system illness with a broad spectrum of clinical manifestations. Infection is caused by the tick-borne bacterium Borrelia burgdorferi. Over the past ten years, the incidence of Lyme disease has increased in Canada due to the spread of its vector, the blacklegged tick, most recently into the ... Read more >>

(Paediatrics & child health)
[2019, 24(Suppl 2):e18-e19]

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44 Viral Central Nervous System Infections in Canadian Infants <90 Days Old: Encephalitis as a Predictor of Neurodevelopmental Morbidity.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

AbstractBackgroundHerpes simplex virus (HSV) and enterovirus (EV) are important causes of central nervous system (CNS) infections in young infants. Though long-term morbidity has been linked to HSV, there is still limited data on outcomes of other viral CNS infections in young infants.Objectives1) Conduct a descriptive analysis of viral CNS infections ... Read more >>

(Paediatrics & child health)
[2019, 24(Suppl 2):e18-e18]

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Identification of rare HIV-1-infected patients with extreme CD4+ T cell decline despite ART-mediated viral suppression.

Andrea Lisco, Chun-Shu Wong, Silvia Lucena Lage, Itzchak Levy, Jason Brophy, Jeffrey Lennox, Maura Manion, Megan V Anderson, Yolanda Mejia, Christopher Grivas, Harry Mystakelis, Peter D Burbelo, Ainhoa Perez-Diez, Adam Rupert, Craig A Martens, Sarah L Anzick, Caryn Morse, Shanna Chan, Claire Deleage, Irini Sereti,

BACKGROUND:The goal of antiretroviral therapy (ART) is to suppress HIV-1 replication and reconstitute CD4+ T cells. Here, we report on HIV-infected individuals who had a paradoxical decline in CD4+ T cells despite ART-mediated suppression of plasma HIV-1 load (pVL). We defined such an immunological outcome as extreme immune decline (EXID). ... Read more >>

JCI Insight (JCI insight)
[2019, 4(8):]

Cited: 2 times

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Love with HIV: A Latent Class Analysis of Sexual and Intimate Relationship Experiences Among Women Living with HIV in Canada.

Allison Carter, Saara Greene, Deborah Money, Margarite Sanchez, Kath Webster, Valerie Nicholson, Lori A Brotto, Catherine Hankins, Mary Kestler, Neora Pick, Kate Salters, Karène Proulx-Boucher, Nadia O'Brien, Sophie Patterson, Alexandra de Pokomandy, Mona Loutfy, Angela Kaida, ,

Love remains hidden in HIV research in favor of a focus on risk. Among 1424 women living with HIV in Canada, we explored (1) whether eight facets of sex and intimacy (marital status, sexual activity, physical intimacy, emotional closeness, power equity, sexual exclusivity, relationship duration, and couple HIV serostatus) may ... Read more >>

Arch Sex Behav (Archives of sexual behavior)
[2019, 48(4):1015-1040]

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Brief Report: Higher Levels of Angiopoietin-1 Are Associated With Early and Sustained Viral Suppression in Children Living With Vertically Acquired HIV.

Vishrut Gulhati, Jeremy Soo, Doris G Ransy, Jason Brophy, Fatima Kakkar, Ari Bitnun, Lindy Samson, Stanley Read, Hugo Soudeyns, Michael T Hawkes, ,

BACKGROUND:Systemic inflammation, platelet dysfunction, and endothelial activation persist in people living with HIV despite sustained virologic suppression (SVS) with combined antiretroviral therapy (cART) and may lead to complications such as atherosclerosis and cardiovascular disease. Angiopoietin-1 (Ang-1) is a key regulator of angiogenesis and endothelial activation and has been studied as ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 80(5):590-595]

Cited: 1 time

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Assessing the adoption of lopinavir/ritonavir oral pellets for HIV-positive children in Zimbabwe.

Briony Pasipanodya, Rudo Kuwengwa, Margaret L Prust, Bethany Stewart, Christine Chakanyuka, Tonderayi Murimwa, Jason Brophy, Olawale Salami, Angela Mushavi, Tsitsi Apollo,

INTRODUCTION:Heat-stable lopinavir/ritonavir (LPV/r) oral pellets were developed to overcome challenges with administration and storage experienced with previously available tablet and syrup forms of LPV/r prescribed to paediatric HIV patients. We report on the adoption of LPV/r pellets for infants living with HIV in the public sector antiretroviral therapy (ART) programme ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2018, 21(12):e25214]

Cited: 1 time

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2342. Treatment Implications of Herpes Simplex Virus Central Nervous System Infection in Canadian Infants <90 Days Old: A Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) Study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason C Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane Mcdonald, André-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

AbstractBackgroundIn the pre-acyclovir era, HSV CNS infection was associated with very high morbidity and mortality. Since antiviral drugs recommended for therapy and long-term prophylaxis improve outcomes, clinicians need to be able to clinically detect young infants most likely to have HSV to facilitate early initiation of therapy. Limited data exist ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S696-S696]

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Immunogenicity and Safety of the Quadrivalent Human Papillomavirus Vaccine in Girls Living With HIV.

Jason Brophy, Ari Bitnun, Ariane Alimenti, Normand Lapointe, Lindy Samson, Stanley Read, Christos Karatzios, Simon Dobson, Erin Moses, Sandra Blitz, Nancy-Grace Lipsky, Gina Ogilvie, Sharon Walmsley, Janet Raboud, Deborah Money, ,

We evaluated quadrivalent human papillomavirus vaccine seroresponses among 35 girls living with HIV (9-13 years of ages) and compared with data on girls without HIV, as part of a subgroup analysis. The quadrivalent human papillomavirus vaccine was safe and well tolerated. However, antibody response was significantly lower in girls living ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2018, 37(6):595-597]

Cited: 1 time

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A RANDOMIZED CONTROLLED TRIAL: SUPRAPUBIC ASPIRATION VERSUS URINARY CATHETERIZATION IN THE NEONATAL INTENSIVE CARE UNIT.

Gregory Moore, Franco Momoli, Amisha Agarwal, Rula Agarushi, Jason Brophy, Erika Bariciak,

AbstractBACKGROUNDUrinary tract infection (UTI) is common in infants (10%). Urinary catheterization (UC) and supra-pubic aspiration (SPA) allow for sterile collection of urine. Some studies suggest SPA has a lower contamination rate than UC, however the optimal method of urine collection for culture remains unclear.OBJECTIVESTo determine if there is: 1) a ... Read more >>

(Paediatrics & child health)
[2018, 23(Suppl 1):e20-e20]

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Missed opportunities for prevention of vertical HIV transmission in Canada, 1997-2016: a surveillance study.

Ari Bitnun, Terry Lee, Jason Brophy, Lindy M Samson, Fatima Kakkar, Wendy Vaudry, Ben Tan, Deborah M Money, Joel Singer, Laura J Sauvé, Ariane Alimenti, ,

BACKGROUND:Vertical HIV transmission has declined in Canada, but missed opportunities for prevention continue to occur. We sought to determine the adequacy, and changes over time in adequacy, of uptake of maternal and neonatal antiretroviral therapy for the prevention of vertical HIV transmission, and to determine the vertical transmission rate over ... Read more >>

CMAJ Open (CMAJ open)
[2018, 6(2):E202-E210]

Cited: 1 time

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Leukocyte Telomere Length at Birth and During the Early Life of Children Exposed to but Uninfected With HIV After In Utero Exposure to Antiretrovirals.

Abhinav Ajaykumar, Hugo Soudeyns, Fatima Kakkar, Jason Brophy, Ari Bitnun, Ariane Alimenti, Arianne Y K Albert, Deborah M Money, Hélène C F Côté, , ,

Background:Maternal combination antiretroviral therapy (cART) during pregnancy could impact the health of human immunodeficiency virus (HIV)-exposed, HIV-uninfected (HEU) children, because some antiretrovirals cross the placenta and can inhibit telomerase. Our objective was to compare leukocyte telomere length (LTL) in HEU children and HIV-unexposed, HIV-uninfected (HUU) children at birth and in ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2018, 217(5):710-720]

Cited: 2 times

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