Full Text Journal Articles by
Author Jasmin Lienau

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Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis.

Holger Müller-Redetzky, Ute Kellermann, Sandra-Maria Wienhold, Birgitt Gutbier, Jasmin Lienau, Katharina Hellwig, Katrin Reppe, Eleftheria Letsiou, Thomas Tschernig, Markus Scholz, Peter Ahnert, Christian Maasch, Kai Hoehlig, Sven Klussmann, Axel Vater, Theresa C Firsching, Judith Hoppe, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory functions and is associated with tissue damage in various inflammatory conditions. The authors hypothesized that C5a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):795-807]

Cited: 0 times

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Cardiovascular sequelae of pneumonia.

Markus C Brack, Jasmin Lienau, Wolfgang M Kuebler, Martin Witzenrath,

PURPOSE OF REVIEW:In this brief review, we discuss the current epidemiological data and latest results from basic research on the cardiovascular sequelae after lower respiratory tract infection. RECENT FINDINGS:Novel epidemiological evidence substantiates the association between pneumonia and subsequent cardiovascular events (CVEs) in the short- and long-term after viral or bacterial ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2019, 25(3):257-262]

Cited: 0 times

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Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia.

Sarah Berger, Cengiz Goekeri, Shishir K Gupta, Julio Vera, Kristina Dietert, Ulrike Behrendt, Jasmin Lienau, Sandra-Maria Wienhold, Achim D Gruber, Norbert Suttorp, Martin Witzenrath, Geraldine Nouailles,

BACKGROUND:Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are still not fully understood. METHODS:To model timely versus delayed antibiotic therapy in patients, mice with pneumococcal pneumonia received ampicillin twice a day starting early (24 h) or late ... Read more >>

Crit Care (Critical care (London, England))
[2018, 22(1):287]

Cited: 0 times

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Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.

Sandra-Maria Wienhold, Mario Macrì, Geraldine Nouailles, Kristina Dietert, Corinne Gurtner, Achim D Gruber, Markus M Heimesaat, Jasmin Lienau, Fabian Schumacher, Burkhard Kleuser, Bastian Opitz, Norbert Suttorp, Martin Witzenrath, Holger C Müller-Redetzky,

BACKGROUND:Antibiotic exposure alters the microbiota, which can impact the inflammatory immune responses. Critically ill patients frequently receive antibiotic treatment and are often subjected to mechanical ventilation, which may induce local and systemic inflammatory responses and development of ventilator-induced lung injury (VILI). The aim of this study was to investigate whether ... Read more >>

Crit Care (Critical care (London, England))
[2018, 22(1):282]

Cited: 1 time

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Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Birgitt Gutbier, Xiaohui Jiang, Kristina Dietert, Carolin Ehrler, Jasmin Lienau, Paul Van Slyke, Harold Kim, Van C Hoang, Jason T Maynes, Daniel J Dumont, Achim D Gruber, Norbert Weissmann, Timothy J Mitchell, Norbert Suttorp, Martin Witzenrath,

<label>BACKGROUND</label>Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality worldwide. Despite effective antimicrobial therapy, CAP can induce pulmonary endothelial hyperpermeability resulting in life-threatening lung failure due to an exaggerated host-pathogen interaction. Treatment of acute lung injury is mainly supportive because key elements of inflammation-induced barrier disruption remain undetermined. ... Read more >>

Crit Care (Critical care (London, England))
[2017, 21(1):274]

Cited: 5 times

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Therapeutic strategies in pneumonia: going beyond antibiotics.

Holger Müller-Redetzky, Jasmin Lienau, Norbert Suttorp, Martin Witzenrath,

Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therapeutic targets have been identified and numerous innovative therapeutic approaches ... Read more >>

Eur Respir Rev (European respiratory review : an official journal of the European Respiratory Society)
[2015, 24(137):516-524]

Cited: 4 times

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One step creation of multifunctional 3D architectured hydrogels inducing bone regeneration.

Axel T Neffe, Benjamin F Pierce, Giuseppe Tronci, Nan Ma, Erik Pittermann, Tim Gebauer, Oliver Frank, Michael Schossig, Xun Xu, Bettina M Willie, Michèle Forner, Agnes Ellinghaus, Jasmin Lienau, Georg N Duda, Andreas Lendlein,

Structured hydrogels showing form stability and elastic properties individually tailorable on different length scales are accessible in a one-step process. They support cell adhesion and differentiation and display growing pore size during degradation. In vivo experiments demonstrate their efficacy in biomaterial-induced bone regeneration, not requiring addition of cells or growth ... Read more >>

Adv. Mater. Weinheim (Advanced materials (Deerfield Beach, Fla.))
[2015, 27(10):1738-1744]

Cited: 14 times

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Improved bone defect healing by a superagonistic GDF5 variant derived from a patient with multiple synostoses syndrome.

Elisa Degenkolbe, Carolin Schwarz, Claus-Eric Ott, Jana König, Katharina Schmidt-Bleek, Agnes Ellinghaus, Tanja Schmidt, Jasmin Lienau, Frank Plöger, Stefan Mundlos, Georg N Duda, Bettina M Willie, Petra Seemann,

Multiple synostoses syndrome 2 (SYNS2) is a rare genetic disease characterized by multiple fusions of the joints of the extremities, like phalangeal joints, carpal and tarsal joints or the knee and elbows. SYNS2 is caused by point mutations in the Growth and Differentiation Factor 5 (GDF5), which plays an essential ... Read more >>

Bone (Bone)
[2015, 73:111-119]

Cited: 5 times

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Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.

Christoph Tabeling, Heide Scheer, Stefanie M Schönrock, Franziska Runge, Birgitt Gutbier, Jasmin Lienau, Eckard Hamelmann, Bastian Opitz, Norbert Suttorp, Konstantin Mayer, Georg M Behrens, Thomas Tschernig, Martin Witzenrath,

The cytosolic nucleotide oligomerization domain (NOD)-like receptors NOD1 and NOD2 are important contributors to the intracellular recognition of pathogens including Chlamydophila pneumoniae, but little is known about their influence on allergen-induced airway inflammation. In BALB/c mice, we observed that infection with C. pneumoniae before systemic sensitization with ovalbumin (OVA) and ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2014, 50(5):903-911]

Cited: 5 times

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In vivo tracking of segmental bone defect healing reveals that callus patterning is related to early mechanical stimuli.

Manav Mehta, Sara Checa, Jasmin Lienau, Dietmar Hutmacher, Georg N Duda,

This study addresses the hypothesis that callus formation, patterning, and mineralisation are impaired during the early phase of critical sized bone defect healing, and may relate to inter-fragmentary tissue strains within the bone defect area. Twenty four 12 week old Sprague Dawley rats were used for this study. They were ... Read more >>

Eur Cell Mater (European cells & materials)
[2012, 24:358-71; discussion 371]

Cited: 7 times

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Mechanical load modulates the stimulatory effect of BMP2 in a rat nonunion model.

Carolin Schwarz, Dag Wulsten, Agnes Ellinghaus, Jasmin Lienau, Bettina M Willie, Georg N Duda,

INTRODUCTION: Local application of bone morphogenetic proteins (BMPs) at the fracture site is known to stimulate bone regeneration. However, recent studies illustrate that the BMP-initiated mineralization may be enhanced by additional mechanical stimulation. Therefore, bone healing was monitored in vivo in order to investigate the effect of mechanical loading on ... Read more >>

Tissue Eng Part A (Tissue engineering. Part A)
[2013, 19(1-2):247-254]

Cited: 25 times

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Initial immune reaction and angiogenesis in bone healing.

Katharina Schmidt-Bleek, Hanna Schell, Jasmin Lienau, Norma Schulz, Paula Hoff, Michael Pfaff, Gregor Schmidt, Claudia Martin, Carsten Perka, Frank Buttgereit, Hans-Dieter Volk, Georg Duda,

During hematoma formation following injury, an inflammatory reaction ensues as an initial step in the healing process. As granulation tissue matures, revascularization is a prerequisite for successful healing. The hypothesis of this study was that scarless tissue reconstitution in the regenerative bone healing process is dependent on a balanced immune ... Read more >>

J Tissue Eng Regen Med (Journal of tissue engineering and regenerative medicine)
[2014, 8(2):120-130]

Cited: 30 times

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Inflammatory phase of bone healing initiates the regenerative healing cascade.

Katharina Schmidt-Bleek, Hanna Schell, Norma Schulz, Paula Hoff, Carsten Perka, Frank Buttgereit, Hans-Dieter Volk, Jasmin Lienau, Georg N Duda,

Bone healing commences with an inflammatory reaction which initiates the regenerative healing process leading in the end to reconstitution of bone. An unbalanced immune reaction during this early bone healing phase is hypothesized to disturb the healing cascade in a way that delays bone healing and jeopardizes the successful healing ... Read more >>

Cell Tissue Res. (Cell and tissue research)
[2012, 347(3):567-573]

Cited: 76 times

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Composite transcriptome assembly of RNA-seq data in a sheep model for delayed bone healing.

Marten Jäger, Claus-Eric Ott, Johannes Grünhagen, Jochen Hecht, Hanna Schell, Stefan Mundlos, Georg N Duda, Peter N Robinson, Jasmin Lienau,

BACKGROUND: The sheep is an important model organism for many types of medically relevant research, but molecular genetic experiments in the sheep have been limited by the lack of knowledge about ovine gene sequences. RESULTS: Prior to our study, mRNA sequences for only 1,556 partial or complete ovine genes were ... Read more >>

BMC Genomics (BMC genomics)
[2011, 12:158]

Cited: 39 times

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The pin-bone interface in external fixator: a standardized analysis in a sheep osteotomy model.

Hanna Schell, Theresa Reuther, Georg N Duda, Jasmin Lienau,

OBJECTIVES: The hypothesis of the study was that the incidence of pin loosening and pin infection would increase, whereas the general stability of the pin-bone interface would decrease with ongoing implantation time. The aim of this study was to analyze the biologic reactions of the bone tissue adjacent to the ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2011, 25(7):438-445]

Cited: 1 time

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Fracture healing is accelerated in the absence of the adaptive immune system.

Daniel Toben, Ireen Schroeder, Thaqif El Khassawna, Manav Mehta, Jan-Erik Hoffmann, Jan-Tilmann Frisch, Hanna Schell, Jasmin Lienau, Alessandro Serra, Andreas Radbruch, Georg N Duda,

Fracture healing is a unique biologic process starting with an initial inflammatory response. As in other regenerative processes, bone and the immune system interact closely during fracture healing. This project was aimed at further elucidating how the host immune system participates in fracture healing. A standard closed femoral fracture was ... Read more >>

J. Bone Miner. Res. (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2011, 26(1):113-124]

Cited: 79 times

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Standard bone healing stages occur during delayed bone healing, albeit with a different temporal onset and spatial distribution of callus tissues.

Anja Peters, Hanna Schell, Hermann J Bail, Marion Hannemann, Tanja Schumann, Georg N Duda, Jasmin Lienau,

Bone healing is considered as a recapitulation of a developmental program initiated at the time of injury. This study tested the hypothesis that in delayed bone healing the regular cascade of healing events, including remodeling of woven to lamellar bone, would be similar compared to standard healing, although the temporal ... Read more >>

Histol. Histopathol. (Histology and histopathology)
[2010, 25(9):1149-1162]

Cited: 10 times

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A 5-mm femoral defect in female but not in male rats leads to a reproducible atrophic non-union.

Manav Mehta, Hanna Schell, Carolin Schwarz, Anja Peters, Katharina Schmidt-Bleek, Agnes Ellinghaus, Hermann J Bail, Georg N Duda, Jasmin Lienau,

INTRODUCTION: The objectives of this study were to (1) establish a reproducible atrophic non-union model in rats by creation of a segmental femoral bone defect that allows, (2) in-depth characterization of impaired healing, and (3) contrast its healing patterns to the normal course. Hypothesis was that a 5-mm bone defect ... Read more >>

Arch Orthop Trauma Surg (Archives of orthopaedic and trauma surgery)
[2011, 131(1):121-129]

Cited: 24 times

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Custom-made composite scaffolds for segmental defect repair in long bones.

Johannes C Reichert, Martin E Wullschleger, Amaia Cipitria, Jasmin Lienau, Tan K Cheng, Michael A Schütz, Georg N Duda, Ulrich Nöth, Jochen Eulert, Dietmar W Hutmacher,

Current approaches for segmental bone defect reconstruction are restricted to autografts and allografts which possess osteoconductive, osteoinductive and osteogenic properties, but face significant disadvantages. The objective of this study was to compare the regenerative potential of scaffolds with different material composition but similar mechanical properties to autologous bone graft from ... Read more >>

Int Orthop (International orthopaedics)
[2011, 35(8):1229-1236]

Cited: 35 times

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Insight into the molecular pathophysiology of delayed bone healing in a sheep model.

Jasmin Lienau, Katharina Schmidt-Bleek, Anja Peters, Hauke Weber, Hermann J Bail, Georg N Duda, Carsten Perka, Hanna Schell,

Delayed and nonunions are still challenging problems. In this study, we examined the endogenous mRNA expression of genes regulating cartilage formation, bone formation, endochondral ossification, and bone remodeling during mechanically induced delayed bone healing in a large animal model. A tibial osteotomy was performed in two groups of sheep and ... Read more >>

Tissue Eng Part A (Tissue engineering. Part A)
[2010, 16(1):191-199]

Cited: 24 times

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Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies.

Johannes C Reichert, Devakara R Epari, Martin E Wullschleger, Siamak Saifzadeh, Roland Steck, Jasmin Lienau, Scott Sommerville, Ian C Dickinson, Michael A Schütz, Georg N Duda, Dietmar W Hutmacher,

Currently, well-established clinical therapeutic approaches for bone reconstruction are restricted to the transplantation of autografts and allografts, and the implantation of metal devices or ceramic-based implants to assist bone regeneration. Bone grafts possess osteoconductive and osteoinductive properties; however, they are limited in access and availability and associated with donor-site morbidity, ... Read more >>

Tissue Eng Part B Rev (Tissue engineering. Part B, Reviews)
[2010, 16(1):93-104]

Cited: 27 times

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Differential regulation of blood vessel formation between standard and delayed bone healing.

Jasmin Lienau, Katharina Schmidt-Bleek, Anja Peters, Franek Haschke, Georg N Duda, Carsten Perka, Hermann J Bail, Norbert Schütze, Franz Jakob, Hanna Schell,

Blood vessel formation is a prerequisite for bone healing. In this study, we tested the hypothesis that a delay in bone healing is associated with an altered regulation of blood vessel formation. A tibial osteotomy was performed in two groups of sheep and stabilized with either a rigid external fixator ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2009, 27(9):1133-1140]

Cited: 56 times

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Cellular composition of the initial fracture hematoma compared to a muscle hematoma: a study in sheep.

Katharina Schmidt-Bleek, Hanna Schell, Paula Kolar, Michael Pfaff, Carsten Perka, Frank Buttgereit, Georg Duda, Jasmin Lienau,

Bone fracture leads to a cycle of inflammation, cellular migration, and proliferation to restore tissue integrity. Immune cells at the site of injury are involved especially in the early phase of the healing process, but little is known about the cells present in the initial fracture hematoma. The hypothesis of ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2009, 27(9):1147-1151]

Cited: 29 times

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Locally applied osteogenic predifferentiated progenitor cells are more effective than undifferentiated mesenchymal stem cells in the treatment of delayed bone healing.

Anja Peters, Daniel Toben, Jasmin Lienau, Hanna Schell, Hermann J Bail, Georg Matziolis, Georg N Duda, Katharina Kaspar,

Mesenchymal stem cells (MSCs) and osteogenic predifferentiated cells (OPCs) have been shown to promote healing of critical-sized bone defects. This study investigated the regenerative capacity of autologous MSCs versus OPCs after local injection into a compromised bone healing situation. We hypothesized that treatment with MSCs and OPCs would enhance the ... Read more >>

Tissue Eng Part A (Tissue engineering. Part A)
[2009, 15(10):2947-2954]

Cited: 21 times

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FGF23 is a putative marker for bone healing and regeneration.

Sascha Goebel, Jasmin Lienau, Ulrich Rammoser, Lothar Seefried, Karl Florian Wintgens, Jochen Seufert, Georg Duda, Franz Jakob, Regina Ebert,

Besides numerous other factors, fibroblast growth factor receptor (FGFR) signaling is involved in fracture healing and bone remodeling. FGF23 is a phosphatonin produced by osteoblastic cells, which signals via FGFR1, thereby exerting effects in bone and kidney. We analyzed if serum FGF23 levels might be an indicator to predict fracture ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2009, 27(9):1141-1146]

Cited: 23 times

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