Full Text Journal Articles by
Author Janice S Kwon

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Comments on: Peripheral blood BRCA1 methylation profiling to predict familial ovarian cancer.

Janice S Kwon,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e33]

Cited: 0 times

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Evaluating the impact of universal Lynch syndrome screening in a publicly funded healthcare system.

Petra W C Lee, Angela C Bedard, Setareh Samimi, Vivienne K Beard, Quan Hong, James E J Bedard, Blake Gilks, David F Schaeffer, Robert Wolber, Janice S Kwon, Howard J Lim, Sophie Sun, Kasmintan A Schrader,

<h4>Purpose</h4>Referrals for Lynch syndrome (LS) assessment have traditionally been based on personal and family medical history. The introduction of universal screening practices has allowed for referrals based on immunohistochemistry tests for mismatch repair (MMR) protein expression. This study aims to characterize the effect of universal screening in a publicly funded ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(18):6507-6514]

Cited: 2 times

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Evaluating the diagnostic performance of preoperative endometrial biopsies in patients diagnosed with high grade endometrial cancer: A study of the Society of Gynecologic Oncology (GOC) Community of Practice (CoP).

Kizanee Jegatheeswaran, Beatrice Cormier, Samantha Dube, Walter Henri Gotlieb, Limor Helpman, Janice S Kwon, Susie Lau, Sarah Mah, Taymaa May, Dima Saab, Maggie McNeill, Marie Plante, Marie Claude Renaud, Sarah Shamiya, Danielle Vicus, Carlos Parra-Herran, Tomer Feigenberg,

<h4>Background</h4>High grade cancers account for a disproportionate number of recurrences in patients with endometrial cancer. Accurately identifying these cases on endometrial biopsies allows for better surgical planning. This study evaluates the diagnostic accuracy of general pathologists (GP) compared to gynecological pathologists (GYNP) in interpreting preoperative biopsies.<h4>Methods</h4>A retrospective cohort study was ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(1):52-57]

Cited: 0 times

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Mismatch repair deficiency and prognostic significance in patients with low-risk endometrioid endometrial cancers.

Soyoun Rachel Kim, Annick Pina, Arianne Albert, Jessica N McAlpine, Robert Wolber, Blake Gilks, Mark S Carey, Janice S Kwon,

OBJECTIVES:Mismatch repair deficiency is observed in 25%-30% of all endometrial cancers. This can be detected by the absence of mismatch repair protein staining on immunohistochemistry, and is used as a screen for Lynch syndrome. Only 10% of women with mismatch repair deficiency have Lynch syndrome, but mismatch repair deficiency may ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(6):783-788]

Cited: 0 times

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Hormone Therapy Use After Premature Surgical Menopause Based on Prescription Records: A Population-Based Study.

Ji-Hyun Jang, Nimisha Arora, Janice S Kwon, Gillian E Hanley,

<h4>Objective</h4>Premature surgical menopause (PSM) without subsequent hormone replacement therapy (HRT) can lead to morbidity and mortality. Our objective was to describe the use of HRT following PSM and identify variables associated with HRT use based on prescription records from a population-based cohort.<h4>Methods</h4>A population-based retrospective cohort of women in British Columbia, ... Read more >>

J Obstet Gynaecol Can (Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC)
[2020, 42(12):1511-1517]

Cited: 0 times

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Examining indicators of early menopause following opportunistic salpingectomy: a cohort study from British Columbia, Canada.

Gillian E Hanley, Janice S Kwon, Jessica N McAlpine, David G Huntsman, Sarah J Finlayson, Dianne Miller,

BACKGROUND:The fallopian tube may often be the site of origin for the most common and lethal form of ovarian cancer, high-grade serous ovarian cancer. As a result, many colleges of obstetrics and gynecology, which include the American College of Obstetricians and Gynecologists, are recommending surgical removal of the fallopian tube ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2020, 223(2):221.e1-221.e11]

Cited: 0 times

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Low-grade serous carcinoma (LGSC): A Canadian multicenter review of practice patterns and patient outcomes.

Stephanie A Scott, Marta Llaurado Fernandez, Hannah Kim, Laurie Elit, Melica Nourmoussavi, Sarah Glaze, Lesley Roberts, Saul L Offman, Kurosh Rahimi, Alice Lytwyn, Monalisa Sur, C Blake Gilks, Kara Matheson, Martin Köbel, Amy Dawson, Anna V Tinker, Janice S Kwon, Paul Hoskins, Jennifer L Santos, Andrea Cheung, Diane Provencher, Mark S Carey, ,

OBJECTIVE:Patients with advanced low-grade serous carcinoma (LGSC) have poor long-term survival rates. As a rare histotype, there are uncertainties regarding the use of current therapies. Thus, we studied practice patterns and treatment outcomes as part of a national initiative to better understand and improve the care of women with advanced ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 157(1):36-45]

Cited: 0 times

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Preoperative CA-125 in low-grade endometrial cancer: risk stratification and implications for treatment.

Janice S Kwon,

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(5):e92]

Cited: 1 time

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Mismatch repair deficiency as a predictive marker for response to adjuvant radiotherapy in endometrial cancer.

Casper Reijnen, Heidi V N Küsters-Vandevelde, Clemens F Prinsen, Leon F A G Massuger, Marc P M L Snijders, Stefan Kommoss, Sara Y Brucker, Janice S Kwon, Jessica N McAlpine, Johanna M A Pijnenborg,

<h4>Background</h4>Mismatch repair (MMR) deficiency is found in 20 to 40% of endometrial cancers (ECs) and was recently identified as a discerning feature of one of the four prognostic subgroups identified by The Cancer Genome Atlas. There is accumulating evidence that MMR proteins are involved in the DNA repair processes following ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 154(1):124-130]

Cited: 6 times

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BRCA mutation testing for first-degree relatives of women with high-grade serous ovarian cancer.

Janice S Kwon, Anna V Tinker, Gillian E Hanley, Gary Pansegrau, Sophie Sun, Mark S Carey, Intan Schrader,

<h4>Background</h4>Women with high-grade serous ovarian cancer (HGSC) have a 20% chance of carrying a BRCA1 or 2 mutation. Not all undergo genetic testing, and there is a large legacy group of untested patients. Their female first-degree relatives (FDR) may not qualify for testing unless they have specific ethnicity, or personal/family ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 152(3):459-464]

Cited: 2 times

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Does MMR status in endometrial cancer influence response to adjuvant therapy?

Soyoun Rachel Kim, Annick Pina, Arianne Albert, Jessica McAlpine, Robert Wolber, C Blake Gilks, Janice S Kwon,

<h4>Objective</h4>Mismatch repair (MMR) deficiency occurs in 20-40% of endometrial cancers but its therapeutic implication remains uncertain. Our objective was to compare clinical outcomes after adjuvant therapy between MMR deficient and proficient endometrial cancers from a population-based study.<h4>Methods</h4>This was a retrospective population-based cohort study of all endometrial cancers from the Vancouver ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2018, 151(1):76-81]

Cited: 4 times

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Endometrial Cancer Presentation and Outcomes Based on Mismatch Repair Protein Expression From a Population-Based Study.

Annick Pina, Robert Wolber, Jessica N McAlpine, Blake Gilks, Janice S Kwon,

<h4>Objective</h4>There is uncertainty about the prognostic significance of mismatch repair (MMR) deficiency in endometrial cancer. The objective was to evaluate clinical characteristics and outcomes of endometrial cancers based on MMR status within a population-based study.<h4>Methods</h4>This was a retrospective population-based cohort study of all endometrial cancer cases from the Vancouver Coastal ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2018, 28(8):1624-1630]

Cited: 0 times

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Extending the safety evidence for opportunistic salpingectomy in prevention of ovarian cancer: a cohort study from British Columbia, Canada.

Gillian E Hanley, Janice S Kwon, Sarah J Finlayson, David G Huntsman, Dianne Miller, Jessica N McAlpine,

BACKGROUND:Recent evidence has suggested that the fallopian tube may often be the site of origin for the most common and lethal form of ovarian cancer. As a result, many Colleges of Obstetrics and Gynecology, including the American College of Obstetricians and Gynecology, are recommending surgical removal of the fallopian tube ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2018, 219(2):172.e1-172.e8]

Cited: 3 times

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The role of adjuvant therapy in stage IA serous and clear cell uterine cancer: A multi-institutional pooled analysis.

X Melody Qu, Vikram M Velker, Eric Leung, Janice S Kwon, Mohamed A Elshaikh, Iwa Kong, Natalie A Logie, Lucas C Mendez, Louis J van der Putten, Elysia K Donovan, Adnan R Munkarah, Ericka M Wiebe, Carlos Parra-Herran, Andrew Warner, Alexander V Louie, David P D'Souza,

As the optimal adjuvant management of stage IA serous or clear cell endometrial cancer is controversial, a multi-institutional review was conducted with the objective of evaluating the appropriateness of various strategies including observation.Retrospective chart reviews for 414 consecutive patients who underwent hysterectomy for FIGO stage IA endometrial cancer with serous, ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2018, 149(2):283-290]

Cited: 4 times

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Cost-effectiveness of Ovarian Cancer Prevention Strategies.

Janice S Kwon,

Ovarian cancer remains to be the most lethal of all gynecologic malignancies. There is no effective screening test proven to reduce the mortality associated with this disease. Costs of treating ovarian cancer are substantial and among the highest of all cancer types. Therefore, it is essential to pursue strategies to ... Read more >>

Clin Obstet Gynecol (Clinical obstetrics and gynecology)
[2017, 60(4):780-788]

Cited: 0 times

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Fertility-Sparing Management Using Progestin for Young Women with Endometrial Cancer From a Population-Based Study.

Soyoun Rachel Kim, Carlijn van der Zanden, Habibe Ikiz, Boris Kuzelijevic, Jon Havelock, Janice S Kwon,

<h4>Objective</h4>For young women with complex atypical endometrial hyperplasia (CAH) and endometrial cancer (EC) who choose to preserve fertility, progestin therapy is the mainstay of treatment. The objective of this study was to evaluate oncologic and reproductive outcomes associated with progestin therapy among these women from a population-based cancer registry.<h4>Methods</h4>This was ... Read more >>

J Obstet Gynaecol Can (Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC)
[2018, 40(3):328-333]

Cited: 5 times

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Costs and Benefits of Extended Endocrine Strategies for Premenopausal Breast Cancer.

Janice S Kwon, Gary Pansegrau, Melica Nourmoussavi, Geoffrey L Hammond, Mark S Carey,

<b>Background:</b> After completing 5 years of adjuvant tamoxifen, women with estrogen receptor (ER)-positive breast cancer benefit from 5 more years of endocrine therapy, either with tamoxifen or an aromatase inhibitor (AI). For premenopausal women, ovarian ablation (OA) would be required before starting an AI (OA/AI). According to the SOFT/TEXT studies, ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2017, 15(8):1015-1021]

Cited: 3 times

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Diabetic Pharmacotherapy and Endometrial Cancer Risk Within a Publicly Funded Health Care System.

Janice S Kwon, Arianne Y K Albert, Sabrina Gill, Jennifer A Hutcheon,

<h4>Objective</h4>There is conflicting evidence regarding the association between metformin and endometrial cancer risk. The objective of this study was to evaluate the association between type of diabetic pharmacotherapy and endometrial cancer risk within a population-based study. The hypothesis was that metformin was associated with the lowest risk.<h4>Methods</h4>This was a nested ... Read more >>

J Obstet Gynaecol Can (Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC)
[2017, 39(1):42-48]

Cited: 0 times

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Improved Outcome of High-Grade, Early 1-Stage Endometrioid Endometrial Carcinoma With Adjuvant Chemotherapy and Radiotherapy: Comparison of 2 Treatment Strategies.

Eline Aem Reynaers, Leah Jutzi, Nicole P M Ezendam, Janice S Kwon, Johanna M A Pijnenborg,

<h4>Objective</h4>Patients with high-grade endometrioid endometrial carcinoma have a high risk of recurrence, even in early stage. To determine the benefit of a more aggressive adjuvant treatment approach, different treatment strategies of 2 referral centers were compared.<h4>Materials and methods</h4>Outcome of all patients with International Federation of Gynecology and Obstetrics IB and ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2017, 27(3):467-472]

Cited: 1 time

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Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach.

Goli Samimi, Marcus Q Bernardini, Lawrence C Brody, Charlisse F Caga-Anan, Ian G Campbell, Georgia Chenevix-Trench, Fergus J Couch, Michael Dean, Joanne A de Hullu, Susan M Domchek, Ronny Drapkin, Heather Spencer Feigelson, Michael Friedlander, Mia M Gaudet, Marline G Harmsen, Karen Hurley, Paul A James, Janice S Kwon, Felicitas Lacbawan, Stephanie Lheureux, Phuong L Mai, Leah E Mechanic, Lori M Minasian, Evan R Myers, Mark E Robson, Susan J Ramus, Lisa F Rezende, Patricia A Shaw, Thomas P Slavin, Elizabeth M Swisher, Masataka Takenaka, David D Bowtell, Mark E Sherman,

In May 2016, the Division of Cancer Prevention and the Division of Cancer Control and Population Sciences, National Cancer Institute, convened a workshop to discuss a conceptual framework for identifying and genetically testing previously diagnosed but unreferred patients with ovarian cancer and other unrecognized BRCA1 or BRCA2 mutation carriers to ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2017, 35(20):2329-2337]

Cited: 20 times

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Ovarian ablation for premenopausal breast cancer: A review of treatment considerations and the impact of premature menopause.

Melica Nourmoussavi, Gary Pansegrau, Jason Popesku, Geoffrey L Hammond, Janice S Kwon, Mark S Carey,

Historically, ovarian ablation (OA) was used as therapy for women with recurrent hormone-receptor-positive (HRP) premenopausal breast cancer. With the publication of the SOFT (Suppression of Ovarian Function Trial) and TEXT (Tamoxifen and Exemestane Trial) randomized trials, there is considerable interest in OA as an adjuvant treatment, either in combination with ... Read more >>

Cancer Treat Rev (Cancer treatment reviews)
[2017, 55:26-35]

Cited: 5 times

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Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer.

Aline Talhouk, Melissa K McConechy, Samuel Leung, Winnie Yang, Amy Lum, Janine Senz, Niki Boyd, Judith Pike, Michael Anglesio, Janice S Kwon, Anthony N Karnezis, David G Huntsman, C Blake Gilks, Jessica N McAlpine,

<h4>Background</h4>Classification of endometrial carcinomas (ECs) by morphologic features is irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE), a molecular classification system based on The Cancer Genome Atlas genomic subgroups, and sought to confirm both feasibility and prognostic ability in a ... Read more >>

Cancer (Cancer)
[2017, 123(5):802-813]

Cited: 76 times

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Rationale for Developing a Specimen Bank to Study the Pathogenesis of High-Grade Serous Carcinoma: A Review of the Evidence.

Mark E Sherman, Ronny I Drapkin, Neil S Horowitz, Christopher P Crum, Sue Friedman, Janice S Kwon, Douglas A Levine, Ie-Ming Shih, Donna Shoupe, Elizabeth M Swisher, Joan Walker, Britton Trabert, Mark H Greene, Goli Samimi, Sarah M Temkin, Lori M Minasian,

Women with clinically detected high-grade serous carcinomas (HGSC) generally present with advanced-stage disease, which portends a poor prognosis, despite extensive surgery and intensive chemotherapy. Historically, HGSCs were presumed to arise from the ovarian surface epithelium (OSE), but the inability to identify early-stage HGSCs and their putative precursors in the ovary ... Read more >>

Cancer Prev Res (Phila) (Cancer prevention research (Philadelphia, Pa.))
[2016, 9(9):713-720]

Cited: 6 times

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BAF250a Expression in Atypical Endometriosis and Endometriosis-Associated Ovarian Cancer.

John P Stamp, C Blake Gilks, Martine Wesseling, Sima Eshragh, Kathy Ceballos, Michael S Anglesio, Janice S Kwon, Alicia Tone, David G Huntsman, Mark S Carey,

<h4>Background and objective</h4>Atypical endometriosis (AE) is thought to be a precursor lesion to the ovarian cancer subtypes associated with endometriosis, namely, endometrioid and clear cell carcinomas. ARID1A encodes a nuclear protein (BAF250a) governing chromatin remodeling, and mutations in ARID1A have been found in 30% to 50% of clear cell and ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2016, 26(5):825-832]

Cited: 13 times

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Long-term consequences of ovarian ablation for premenopausal breast cancer.

Janice S Kwon, Gary Pansegrau, Melica Nourmoussavi, Geoffrey Hammond, Mark S Carey,

The TEXT and SOFT trials concluded that an aromatase inhibitor (AI) with ovarian ablation (OA) yields a higher 5-year disease-free survival than tamoxifen alone in premenopausal ER+ high-risk early breast cancer. However, the long-term health consequences and costs of OA, either by GnRH agonist or oophorectomy, have not been evaluated. ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2016, 157(3):565-573]

Cited: 2 times

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