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Author Jane W Newburger

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Low-Molecular-Weight Heparin vs Warfarin for Thromboprophylaxis in Children with Coronary Artery Aneurysms After Kawasaki Disease: A Pragmatic Registry Trial.

Cedric Manlhiot, Jane W Newburger, Tisiana Low, Nagib Dahdah, Andrew S Mackie, Geetha Raghuveer, Therese M Giglia, Frederic Dallaire, Mathew Mathew, Kyle Runeckles, Elfriede Pahl, Ashraf S Harahsheh, Kambiz Norozi, Sarah D de Ferranti, Kevin Friedman, Anji T Yetman, Shelby Kutty, Tapas Mondal, Brian W McCrindle, ,

The substantial risk of thrombosis in large coronary artery aneurysms (CAAs) (maximum z-score ≥ 10) after Kawasaki disease (KD) mandates effective thromboprophylaxis. We sought to determine the effectiveness of anticoagulation (low-molecular-weight heparin [LMWH] or warfarin) for thromboprophylaxis in large CAAs. Data from 383 patients enrolled in the International KD Registry ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2020, :]

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Multisystem Inflammatory Syndrome in U.S. Children and Adolescents.

Leora R Feldstein, Erica B Rose, Steven M Horwitz, Jennifer P Collins, Margaret M Newhams, Mary Beth F Son, Jane W Newburger, Lawrence C Kleinman, Sabrina M Heidemann, Amarilis A Martin, Aalok R Singh, Simon Li, Keiko M Tarquinio, Preeti Jaggi, Matthew E Oster, Sheemon P Zackai, Jennifer Gillen, Adam J Ratner, Rowan F Walsh, Julie C Fitzgerald, Michael A Keenaghan, Hussam Alharash, Sule Doymaz, Katharine N Clouser, John S Giuliano, Anjali Gupta, Robert M Parker, Aline B Maddux, Vinod Havalad, Stacy Ramsingh, Hulya Bukulmez, Tamara T Bradford, Lincoln S Smith, Mark W Tenforde, Christopher L Carroll, Becky J Riggs, Shira J Gertz, Ariel Daube, Amanda Lansell, Alvaro Coronado Munoz, Charlotte V Hobbs, Kimberly L Marohn, Natasha B Halasa, Manish M Patel, Adrienne G Randolph,

BACKGROUND:Understanding the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) and its temporal association with coronavirus disease 2019 (Covid-19) is important, given the clinical and public health implications of the syndrome. METHODS:We conducted targeted surveillance for MIS-C from March 15 to May 20, 2020, in pediatric health ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2020, :]

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Ashraf S Harahsheh, Nagib Dahdah, Jane W Newburger, Michael A Portman, Robert Tulloh, Brian W McCrindle, Rolando Cimaz, Jane C Burns,

J. Pediatr. (The Journal of pediatrics)
[2020, :]

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Stress ulcer prophylaxis versus placebo-a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD).

Kimberly I Mills, Ben D Albert, Lori J Bechard, Christopher P Duggan, Aditya Kaza, Seth Rakoff-Nahoum, Hera Vlamakis, Lynn A Sleeper, Jane W Newburger, Gregory P Priebe, Nilesh M Mehta,

BACKGROUND:Critically ill infants with congenital heart disease (CHD) are often prescribed stress ulcer prophylaxis (SUP) to prevent upper gastrointestinal bleeding, despite the low incidence of stress ulcers and limited data on the safety and efficacy of SUP in infants. Recently, SUP has been associated with an increased incidence of hospital-acquired ... Read more >>

Trials (Trials)
[2020, 21(1):590]

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Genomic analyses implicate noncoding de novo variants in congenital heart disease.

Felix Richter, Sarah U Morton, Seong Won Kim, Alexander Kitaygorodsky, Lauren K Wasson, Kathleen M Chen, Jian Zhou, Hongjian Qi, Nihir Patel, Steven R DePalma, Michael Parfenov, Jason Homsy, Joshua M Gorham, Kathryn B Manheimer, Matthew Velinder, Andrew Farrell, Gabor Marth, Eric E Schadt, Jonathan R Kaltman, Jane W Newburger, Alessandro Giardini, Elizabeth Goldmuntz, Martina Brueckner, Richard Kim, George A Porter, Daniel Bernstein, Wendy K Chung, Deepak Srivastava, Martin Tristani-Firouzi, Olga G Troyanskaya, Diane E Dickel, Yufeng Shen, Jonathan G Seidman, Christine E Seidman, Bruce D Gelb,

A genetic etiology is identified for one-third of patients with congenital heart disease (CHD), with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution of noncoding DNVs to CHD, we compared genome sequences from 749 CHD probands and their parents with those from 1,611 unaffected ... Read more >>

Nat. Genet. (Nature genetics)
[2020, :]

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Multi-System Inflammatory Syndrome in Children in Association with COVID-19.

John M Simpson, Jane W Newburger,

Circulation (Circulation)
[2020, :]

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High-Throughput Screening of Kawasaki Disease Sera for Antiviral Antibodies.

Daniel Quiat, Tomasz Kula, Chisato Shimizu, John T Kanegaye, Adriana H Tremoulet, Zachary Pitkowsky, MaryBeth Son, Jane W Newburger, Stephen J Elledge, Jane C Burns,

Clinical features of Kawasaki disease (KD) display overlap with common pediatric viral illnesses, leading some to hypothesize that a viral infection is the inciting event for KD. To investigate viral infection history in KD patients, we performed comprehensive serological profiling using a high-throughput phage immunoprecipitation sequencing assay covering the complete ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, :]

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Registry-based trials: a potential model for cost savings?

Brett R Anderson, Evelyn G Gotlieb, Kevin Hill, Kimberly E McHugh, Mark A Scheurer, Carlos M Mery, Glenn J Pelletier, Jonathan R Kaltman, Owen J White, Felicia L Trachtenberg, Danielle Hollenbeck-Pringle, Brian W McCrindle, Donna M Sylvester, Aaron W Eckhauser, Sara K Pasquali, Jeffery B Anderson, Marcus S Schamberger, Subhadra Shashidharan, Jeffrey P Jacobs, Marshall L Jacobs, Marko Boskovski, Jane W Newburger, Meena Nathan, ,

BACKGROUND/AIMS:Registry-based trials have emerged as a potentially cost-saving study methodology. Early estimates of cost savings, however, conflated the benefits associated with registry utilisation and those associated with other aspects of pragmatic trial designs, which might not all be as broadly applicable. In this study, we sought to build a practical ... Read more >>

Cardiol Young (Cardiology in the young)
[2020, 30(6):807-817]

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Missed or delayed diagnosis of Kawasaki disease during the 2019 novel coronavirus disease (COVID-19) pandemic.

Ashraf S Harahsheh, Nagib Dahdah, Jane W Newburger, Michael A Portman, Maryam Piram, Robert Tulloh, Brian W McCrindle, Sarah D de Ferranti, Rolando Cimaz, Dongngan T Truong, Jane C Burns,

J. Pediatr. (The Journal of pediatrics)
[2020, 222:261-262]

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Prevalence and Prognostic Association of a Clinical Diagnosis of Depression in Adult Congenital Heart Disease: Results of the Boston Adult Congenital Heart Disease Biobank.

Matthew R Carazo, Meghan S Kolodziej, Elizabeth S DeWitt, Nadine A Kasparian, Jane W Newburger, Valeria E Duarte, Michael N Singh, Alexander R Opotowsky,

Background In adults with acquired heart disease, depression is common and associated with adverse outcomes. Depression may also be important in adults with congenital heart disease (CHD). Methods and Results We conducted a cohort study of outpatients with CHD, aged ≥18 years, enrolled in a prospective biobank between 2012 and 2017. ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(9):e014820]

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EM-mosaic detects mosaic point mutations that contribute to congenital heart disease.

Alexander Hsieh, Sarah U Morton, Jon A L Willcox, Joshua M Gorham, Angela C Tai, Hongjian Qi, Steven DePalma, David McKean, Emily Griffin, Kathryn B Manheimer, Daniel Bernstein, Richard W Kim, Jane W Newburger, George A Porter, Deepak Srivastava, Martin Tristani-Firouzi, Martina Brueckner, Richard P Lifton, Elizabeth Goldmuntz, Bruce D Gelb, Wendy K Chung, Christine E Seidman, J G Seidman, Yufeng Shen,

BACKGROUND:The contribution of somatic mosaicism, or genetic mutations arising after oocyte fertilization, to congenital heart disease (CHD) is not well understood. Further, the relationship between mosaicism in blood and cardiovascular tissue has not been determined. METHODS:We developed a new computational method, EM-mosaic (Expectation-Maximization-based detection of mosaicism), to analyze mosaicism in ... Read more >>

Genome Med (Genome medicine)
[2020, 12(1):42]

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Management of Myocardial Infarction in Children with Giant Coronary Artery Aneurysms after Kawasaki Disease.

Jane C Burns, Howaida El-Said, Adriana H Tremoulet, Kevin Friedman, John B Gordon, Jane W Newburger,

J. Pediatr. (The Journal of Pediatrics)
[2020, 221:230-234]

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Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome: A Decision Analysis.

Sarah S Pickard, John B Wong, Emily M Bucholz, Jane W Newburger, Wayne Tworetzky, Terra Lafranchi, Carol B Benson, Louise E Wilkins-Haug, Diego Porras, Ryan Callahan, Kevin G Friedman,

BACKGROUND:Fetal aortic valvuloplasty (FAV) may prevent progression of midgestation aortic stenosis to hypoplastic left heart syndrome. However, FAV has well-established risks, and its survival benefit remains unknown. Our primary aim was to determine whether FAV for midgestation aortic stenosis increases survival from fetal diagnosis to age 6 years. METHODS AND ... Read more >>

Circ Cardiovasc Qual Outcomes (Circulation. Cardiovascular quality and outcomes)
[2020, 13(4):e006127]

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Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects.

Jonathan J Edwards, Andrew D Rouillard, Nicolas F Fernandez, Zichen Wang, Alexander Lachmann, Sunita S Shankaran, Brent W Bisgrove, Bradley Demarest, Nahid Turan, Deepak Srivastava, Daniel Bernstein, John Deanfield, Alessandro Giardini, George Porter, Richard Kim, Amy E Roberts, Jane W Newburger, Elizabeth Goldmuntz, Martina Brueckner, Richard P Lifton, Christine E Seidman, Wendy K Chung, Martin Tristani-Firouzi, H Joseph Yost, Avi Ma'ayan, Bruce D Gelb,

Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited. To identify causal CHD genes that are associated with specific molecular functions, the study used prior knowledge to filter de novo variants from 2,881 probands with sporadic severe CHD. ... Read more >>

JACC Basic Transl Sci (JACC. Basic to translational science)
[2020, 5(4):376-386]

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Health-Related Quality of Life in Children, Adolescents, and Adults With a Fontan Circulation: A Meta-Analysis.

Kate H Marshall, Yves D'Udekem, Gary F Sholler, Alexander R Opotowsky, Daniel S J Costa, Louise Sharpe, David S Celermajer, David S Winlaw, Jane W Newburger, Nadine A Kasparian,

Background People with a Fontan circulation experience a range of physical, psychosocial and neurodevelopmental challenges alongside, or caused by, their cardiac condition, with significant consequences for health-related quality of life (HRQOL). We meta-analyzed HRQOL outcomes reported by people with a Fontan circulation or their proxies and evaluated predictors of poorer ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(6):e014172]

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Multicentre validation of a computer-based tool for differentiation of acute Kawasaki disease from clinically similar febrile illnesses.

Shiying Hao, Xuefeng B Ling, John T Kanegaye, Emelia Bainto, Samuel R Dominguez, Heather Heizer, Pei-Ni Jone, Marsha S Anderson, Preeti Jaggi, Annette Baker, Mary Beth Son, Jane W Newburger, Negar Ashouri, Doff B McElhinney, Jane C Burns, John C Whitin, Harvey J Cohen, Adriana H Tremoulet, ,

BACKGROUND:The clinical features of Kawasaki disease (KD) overlap with those of other paediatric febrile illnesses. A missed or delayed diagnosis increases the risk of coronary artery damage. Our computer algorithm for KD and febrile illness differentiation had a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2020, :]

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Abnormal Left-Hemispheric Sulcal Patterns Correlate with Neurodevelopmental Outcomes in Subjects with Single Ventricular Congenital Heart Disease.

Sarah U Morton, Lara Maleyeff, David Wypij, Hyuk Jin Yun, Jane W Newburger, David C Bellinger, Amy E Roberts, Michael J Rivkin, J G Seidman, Christine E Seidman, P Ellen Grant, Kiho Im,

Neurodevelopmental abnormalities are the most common noncardiac complications in patients with congenital heart disease (CHD). Prenatal brain abnormalities may be due to reduced oxygenation, genetic factors, or less commonly, teratogens. Understanding the contribution of these factors is essential to improve outcomes. Because primary sulcal patterns are prenatally determined and under ... Read more >>

Cereb. Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, 30(2):476-487]

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Development and Utility of Quality Metrics for Ambulatory Pediatric Cardiology in Kawasaki Disease.

David F Teitel, Jane W Newburger, Nicole Sutton, Lloyd Y Tani, Ashraf S Harahsheh, Pei-Ni Jone, Deborah J Mensch, Timothy Cotts, Alex Davidson, Nagib Dahdah, Walter H Johnson, Michael A Portman,

The Adult Congenital and Pediatric Cardiology (ACPC) Section of the American College of Cardiology sought to develop quality indicators/metrics for ambulatory pediatric cardiology practice. The objective of this study was to report the creation of metrics for patients with Kawasaki disease. Over a period of 5 months, 12 pediatric cardiologists ... Read more >>

Clin Pediatr (Phila) (Clinical pediatrics)
[2020, 59(3):245-251]

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Variation in care for children undergoing the Fontan operation for hypoplastic left heart syndrome.

Aaron W Eckhauser, Maria I Van Rompay, Chitra Ravishankar, Jane W Newburger, S Ram Kumar, Christian Pizarro, Nancy Ghanayem, Felicia L Trachtenberg, Kristin M Burns, Garick D Hill, Andrew M Atz, Michelle S Hamstra, Mjaye Mazwi, Patsy Park, Marc E Richmond, Michael Wolf, Jeffrey D Zampi, Jeffrey P Jacobs, L LuAnn Minich, ,

BACKGROUND:The Single Ventricle Reconstruction Trial randomised neonates with hypoplastic left heart syndrome to a shunt strategy but otherwise retained standard of care. We aimed to describe centre-level practice variation at Fontan completion. METHODS:Centre-level data are reported as median or median frequency across all centres and range of medians or frequencies ... Read more >>

Cardiol Young (Cardiology in the young)
[2019, 29(12):1510-1516]

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Anti-thrombosis management of patients with Kawasaki disease: Results from an international survey.

Audrey Dionne, Nagib Dahdah, Davinder Singh-Grewal, David P Burgner, Jane W Newburger, Sarah D de Ferranti,

BACKGROUND:Patients with coronary artery aneurysms (CAA) after Kawasaki disease (KD) are at risk of thrombosis, which can lead to myocardial infarction or sudden death. Clinical practice guidelines recommend anticoagulation for high-risk patients. METHODS:Web-based worldwide survey of physicians completed between 2016 and 2017 investigating anti-thrombotic management after KD. We compared management ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2020, 307:154-158]

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The Pediatric Heart Network Residual Lesion Score Study: Design and objectives.

Meena Nathan, Felicia L Trachtenberg, Maria I Van Rompay, William Gaynor, Kirk Kanter, Richard Ohye, Emile A Bacha, James Tweddell, Steven M Schwartz, L LuAnn Minich, Carlos M Mery, Steven D Colan, Jami Levine, Linda M Lambert, Jane W Newburger, ,

OBJECTIVES:The Residual Lesion Score (RLS) was developed as a novel tool for assessing residual lesions after congenital heart operations based on widely available clinical and echocardiographic characteristics. The RLS ranks postoperative findings as follows: Class 1 (no/trivial residua), Class 2 (minor residua), or Class 3 (major residua or reintervention before ... Read more >>

J. Thorac. Cardiovasc. Surg. (The Journal of thoracic and cardiovascular surgery)
[2020, 160(1):218-223.e1]

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Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis.

Pui Y Lee, Grant S Schulert, Scott W Canna, Yuelong Huang, Jacob Sundel, Ying Li, Kacie J Hoyt, Rachel B Blaustein, Alexandra Wactor, Thuy Do, Olha Halyabar, Margaret H Chang, Fatma Dedeoglu, Siobhan M Case, Esra Meidan, Mindy S Lo, Robert P Sundel, Edward T Richardson, Jane W Newburger, Michael S Hershfield, Mary Beth Son, Lauren A Henderson, Peter A Nigrovic,

OBJECTIVE:Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile idiopathic arthritis (sJIA) characterised by a vicious cycle of immune amplification that can culminate in overwhelming inflammation and multiorgan failure. The clinical features of MAS overlap with those of active sJIA, complicating early diagnosis and treatment. We evaluated adenosine ... Read more >>

Ann. Rheum. Dis. (Annals of the rheumatic diseases)
[2020, 79(2):225-231]

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De novo and recessive forms of congenital heart disease have distinct genetic and phenotypic landscapes.

W Scott Watkins, E Javier Hernandez, Sergiusz Wesolowski, Brent W Bisgrove, Ryan T Sunderland, Edwin Lin, Gordon Lemmon, Bradley L Demarest, Thomas A Miller, Daniel Bernstein, Martina Brueckner, Wendy K Chung, Bruce D Gelb, Elizabeth Goldmuntz, Jane W Newburger, Christine E Seidman, Yufeng Shen, H Joseph Yost, Mark Yandell, Martin Tristani-Firouzi,

The genetic architecture of sporadic congenital heart disease (CHD) is characterized by enrichment in damaging de novo variants in chromatin-modifying genes. To test the hypothesis that gene pathways contributing to de novo forms of CHD are distinct from those for recessive forms, we analyze 2391 whole-exome trios from the Pediatric ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):4722]

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Behavior and Quality of Life at 6 Years for Children With Hypoplastic Left Heart Syndrome.

Caren S Goldberg, Chenwei Hu, Cheryl Brosig, J William Gaynor, William T Mahle, Thomas Miller, Kathleen A Mussatto, Renee Sananes, Karen Uzark, Felicia Trachtenberg, Christian Pizarro, Victoria L Pemberton, Alan B Lewis, Jennifer S Li, Jeffrey P Jacobs, James Cnota, Andrew M Atz, Wyman W Lai, David Bellinger, Jane W Newburger, ,

OBJECTIVES:We measured behavioral, quality of life (QoL), and functional status outcomes for 6-year-old children with hypoplastic left heart syndrome enrolled in the Single Ventricle Reconstruction Trial. We sought to compare these outcomes with those in the normative population and to analyze risk factors for worse outcomes within the single-ventricle group. ... Read more >>

Pediatrics (Pediatrics)
[2019, 144(5):]

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Introduction to the Mini-Symposium: Ethical Dilemmas in Caring for the Hearts of Children.

Pirooz Eghtesady, Catherine D Krawczeski, Jane W Newburger,

Ann. Thorac. Surg. (The Annals of thoracic surgery)
[2019, 108(5):1277]

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