Full Text Journal Articles by
Author Jane Norman

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FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm.

Jane Norman, Andrew Shennan, Bo Jacobsson, Sarah J Stock, ,

For women with a singleton or a multiple pregnancy in situations where active neonatal care is appropriate, and for whom preterm birth is anticipated between 24 and 34 weeks of gestation, one course of prenatal corticosteroids should ideally be offered 18 to 72 h before preterm birth is expected to improve outcomes ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):26-30]

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FIGO good practice recommendations on the importance of registry data for monitoring rates and health systems performance in prevention and management of preterm birth.

J Frederik Frøen, Ana Bianchi, Ann-Beth Moller, Bo Jacobsson, ,

FIGO calls for strengthening of health information systems for reproductive, maternal, newborn, and child health services, co-designed with users, to ensure the timely accessibility of actionable high-quality data for all stakeholders engaged in preventing and managing preterm birth consequences. FIGO calls for strengthening of investments and capacity for implementing digital ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):5-7]

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FIGO good practice recommendations on reduction of preterm birth in pregnancies conceived by assisted reproductive technologies.

Ben W Mol, Bo Jacobsson, William A Grobman, Kelle Moley, ,

FIGO (the International Federation of Gynecology and Obstetrics) supports assisted reproductive technologies (ART) to achieve pregnancy and supports their availability in all nations. However, the increased frequency of preterm birth must be taken into account. Therefore, before in vitro fertilization (IVF) is started, other approaches, including expectant management, should be ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):13-15]

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FIGO good practice recommendations for reducing preterm birth and improving child outcomes.

Bo Jacobsson, Joe Leigh Simpson, ,

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):1-4]

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FIGO good practice recommendations on cervical cerclage for prevention of preterm birth.

Andrew Shennan, Lisa Story, Bo Jacobsson, William A Grobman, ,

Cervical cerclage is an intervention which when given to the right women can prevent preterm birth and second-trimester fetal losses. A history-indicated cerclage should be offered to women who have had three or more preterm deliveries and/or mid-trimester losses. An ultrasound-indicated cerclage should be offered to women with a cervical ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):19-22]

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FIGO good practice recommendations on delayed umbilical cord clamping.

Ana Bianchi, Bo Jacobsson, Ben W Mol, ,

Delayed cord clamping in the first minute in preterm infants born before 34 weeks of gestation improves neonatal hematologic measures and may reduce mortality without increasing any other morbidity. In term-born babies, it also seems to improve both the short- and long-term outcomes and shows favorable scores in fine motor and ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):34-36]

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FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth.

Catalina M Valencia, Ben W Mol, Bo Jacobsson, ,

Iatrogenic preterm birth is a planned delivery that occurs before 37 weeks of gestation due to maternal and/or fetal causes. However, in some cases, such deliveries also occur with no apparent medical indication. The increasing numbers of iatrogenic preterm deliveries worldwide have led researchers to identify modifiable causes that allow the ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):8-12]

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FIGO good practice recommendations on progestogens for prevention of preterm delivery.

Andrew Shennan, Natalie Suff, Joe Leigh Simpson, Bo Jacobsson, Ben W Mol, William A Grobman, ,

Women at high risk of preterm birth (either a previous spontaneous preterm birth and/or sonographic short cervix) with a singleton gestation should be offered daily vaginal progesterone or weekly 17-OHPC treatment to prevent preterm birth. Benefit is most significant in those with prior history of preterm birth and a short ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):16-18]

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FIGO good practice recommendations on the use of pessary for reducing the frequency and improving outcomes of preterm birth.

William A Grobman, Jane Norman, Bo Jacobsson, ,

A pessary is a device made of synthetic material that is placed in the vagina and has been used for prevention of preterm birth. It has been suggested that a potential mechanism of the pessary is alteration of the cervico-uterine angle to a more posterior position, which reduces cervical compression ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):23-25]

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A prognostic model, including quantitative fetal fibronectin, to predict preterm labour: the QUIDS meta-analysis and prospective cohort study.

Sarah J Stock, Margaret Horne, Merel Bruijn, Helen White, Robert Heggie, Lisa Wotherspoon, Kathleen Boyd, Lorna Aucott, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna David, Asma Khalil, Andrew Shennan, Gert-Jan van Baaren, Victoria Hodgetts-Morton, Tina Lavender, Ewoud Schuit, Susan Harper-Clarke, Ben Mol, Richard D Riley, Jane Norman, John Norrie,

<h4>Background</h4>The diagnosis of preterm labour is challenging. False-positive diagnoses are common and result in unnecessary, potentially harmful treatments (e.g. tocolytics, antenatal corticosteroids and magnesium sulphate) and costly hospital admissions. Measurement of fetal fibronectin in vaginal fluid is a biochemical test that can indicate impending preterm birth.<h4>Objectives</h4>To develop an externally validated ... Read more >>

Health Technol Assess (Health technology assessment (Winchester, England))
[2021, 25(52):1-168]

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External validation of prognostic models to predict stillbirth using the International Prediction of Pregnancy Complications (IPPIC) Network database: an individual participant data meta-analysis.

J Allotey, R Whittle, K I E Snell, M Smuk, R Townsend, P von Dadelszen, A E P Heazell, L Magee, G C S Smith, J Sandall, B Thilaganathan, J Zamora, R D Riley, A Khalil, S Thangaratinam, ,

<h4>Objective</h4>Stillbirth is a potentially preventable complication of pregnancy. Identifying women at risk can guide decisions on closer surveillance or timing of birth to prevent fetal death. Prognostic models have been developed to predict the risk of stillbirth, but none have yet been externally validated. We externally validated published prediction models ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2021, :]

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C-STICH2: emergency cervical cerclage to prevent miscarriage and preterm birth-study protocol for a randomised controlled trial.

Victoria Hodgetts-Morton, Catherine A Hewitt, Laura Jones, Lisa Leighton, Nicole Pilarski, Eleanor Molloy, Kim Hinshaw, Jane Norman, Jason Waugh, Sarah Stock, Jim Thornton, Philip Toozs-Hobson, Tracey Johnston, Arri Coomarasamy, Shakila Thangaratinam, Ben Mol, Eva Pajkrt, Neil Marlow, Tracy Roberts, Lee Middleton, Peter Brocklehurst, Katie Morris,

<h4>Background</h4>Cervical cerclage is a recognised treatment to prevent late miscarriage and pre-term birth (PTB). Emergency cervical cerclage (ECC) for cervical dilatation with exposed unruptured membranes is less common and the potential benefits of cerclage are less certain. A randomised control trial is needed to accurately assess the effectiveness of ECC ... Read more >>

Trials (Trials)
[2021, 22(1):529]

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The Arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: the STOPPIT 2 RCT.

Jane E Norman, John Norrie, Graeme MacLennan, David Cooper, Sonia Whyte, Sushila Chowdhry, Sarah Cunningham-Burley, Aileen R Neilson, Xue W Mei, Joel Be Smith, Andrew Shennan, Stephen C Robson, Steven Thornton, Mark D Kilby, Neil Marlow, Sarah J Stock, Philip R Bennett, Jane Denton,

<h4>Background</h4>Preterm birth is common in twins and accounts for significant mortality and morbidity. There are no effective preventative treatments. Some studies have suggested that, in twin pregnancy complicated by a short cervix, the Arabin pessary, which fits around the cervix and can be inserted as an outpatient procedure, reduces preterm ... Read more >>

Health Technol Assess (Health technology assessment (Winchester, England))
[2021, 25(44):1-66]

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C-STICH2: Emergency Cervical Cerclage To Prevent Miscarriage And Preterm Birth: Study Protocol For A Randomised Controlled Trial

Victoria Ann Hodgetts Morton, Catherine Hewitt, Laura Jones, Lisa Leighton, Nicole Pilarski, Eleanor Molloy, Kim Hinshaw, Jane Norman, Jason Waugh, Sarah Stock, Jim Thornton, Philip Toozs-Hobson, Tracey Johnston, Andrew Ewer, Arri Coomarasamy, Shakila Thangaratinam, Ben Mol, Eva Pajkrt, Neil Marlow, Tracy Roberts, Lee Middleton, Peter Brocklehurst, Katie Morris,

<h4>Background: </h4> Cervical cerclage is a recognised treatment to prevent late miscarriage and pre-term birth (PTB). Emergency cervical cerclage (ECC) for cervical dilatation with exposed unruptured membranes is less common and the potential benefits of cerclage are less certain. A randomised control trial is needed to accurately assess the effectiveness ... Read more >>

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Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participant data meta-analysis.

Sarah J Stock, Margaret Horne, Merel Bruijn, Helen White, Kathleen A Boyd, Robert Heggie, Lisa Wotherspoon, Lorna Aucott, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Gert-Jan van Baaren, Victoria Hodgetts-Morton, Tina Lavender, Ewoud Schuit, Susan Harper-Clarke, Ben W Mol, Richard D Riley, Jane E Norman, John Norrie,

<h4>Background</h4>Timely interventions in women presenting with preterm labour can substantially improve health outcomes for preterm babies. However, establishing such a diagnosis is very challenging, as signs and symptoms of preterm labour are common and can be nonspecific. We aimed to develop and externally validate a risk prediction model using concentration ... Read more >>

PLoS Med (PLoS medicine)
[2021, 18(7):e1003686]

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Metformin in obese pregnancy has no adverse effects on cardiovascular risk in early childhood.

Liu Yang, Lauren Lacey, Sonia Whyte, Siobhan Quenby, Fiona C Denison, Neeraj Dhaun, Jane E Norman, Amanda J Drake, Rebecca M Reynolds,

Metformin is widely used in pregnancy, despite lack of long-term safety for children. We hypothesised that metformin exposure in utero is associated with increased cardiovascular risk. We tested this hypothesis in a follow-up study of children born to obese mothers who had participated in a randomised controlled trial of metformin versus ... Read more >>

J Dev Orig Health Dis (Journal of developmental origins of health and disease)
[2021, :1-5]

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Options in Pregnancy to Increase ActiveLy Sitting (OPALS) Feasibility Study.

Caterina Fazzi, Fiona C Denison, David H Saunders, Jane E Norman, Rebecca M Reynolds,

<h4>Background</h4>A negative association between obesity and pregnancy outcomes has been described, as well as between time sedentary and pregnancy outcomes. Most interventions based on physical activity involving obese pregnant women have failed in improving pregnancy outcomes. Exchanging time spent in sedentary activities with time spent in light-intensity activities, performed in ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(11):]

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Full title: My Baby’s Movements: a stepped-wedge cluster-randomised controlled trial of a fetal movement awareness intervention to reduce stillbirths

Vicki Flenady, Glen Gardener, David Ellwood, Michael Coory, Megan Weller, Kara Warrilow, Philippa Middleton, Aleena Wojcieszek, Katie Groom, Fran Boyle, Christine East, Harriet Lawford, Emily Callander, Joanne Said, Susan Walker, Kassam Mahomed, Christine Andrews, Adrienne Gordon, Jane Norman, Caroline Crowther,

<h4>Objective: </h4> The My Baby’s Movements (MBM) trial aimed to evaluate the impact on stillbirth rates of a multifaceted awareness package (MBM intervention). Design Stepped-wedge cluster-randomised controlled trial. Setting Twenty-seven maternity hospitals in Australia and New Zealand. Population Women with a singleton pregnancy without major fetal anomaly ≥28 weeks’ gestation ... Read more >>

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Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated meta-analysis.

Jane E Norman, John Norrie, Graeme MacLennan, David Cooper, Sonia Whyte, Sue Chowdhry, Sarah Cunningham-Burley, Xue W Mei, Joel B E Smith, Andrew Shennan, Stephen C Robson, Steven Thornton, Mark D Kilby, Neil Marlow, Sarah J Stock, Phillip R Bennett, Jane Denton, ,

<h4>Background</h4>Preterm-labour-associated preterm birth is a common cause of perinatal mortality and morbidity in twin pregnancy. We aimed to test the hypothesis that the Arabin pessary would reduce preterm-labour-associated preterm birth by 40% or greater in women with a twin pregnancy and a short cervix.<h4>Methods and findings</h4>We conducted an open-label randomised ... Read more >>

PLoS Med (PLoS medicine)
[2021, 18(3):e1003506]

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C-STICH: Cerclage Suture Type for an Insufficient Cervix and its Effect on Health Outcomes. A Multicentre Randomised Controlled Trial.

Fidan Israfil-Bayli, Victoria Ann Hodgetts Morton, Catherine Hewitt, Andrew Ewer, Jim Grey, Jane Norman, Christoph Lees, Nigel Simpson, Andrew Shennan, Max Hughes, Jane Daniels, Peter Brocklehurst, R.Katie Morris, Lee Middleton, Philip Toozs-Hobson,

<h4>Background: </h4> Preterm birth is associated with significant mortality and morbidity for mothers and babies. Women are identified as high risk for preterm birth based on either previous medical/pregnancy history or on ultrasound assessment of the cervix. Women identified as high risk can be offered a cervical cerclage (a purse ... Read more >>

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Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials.

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<h4>Background</h4>Preterm birth is a global health priority. Using a progestogen during high-risk pregnancy could reduce preterm birth and adverse neonatal outcomes.<h4>Methods</h4>We did a systematic review of randomised trials comparing vaginal progesterone, intramuscular 17-hydroxyprogesterone caproate (17-OHPC), or oral progesterone with control, or with each other, in asymptomatic women at risk of ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10280):1183-1194]

Cited: 2 times

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Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis.

John Allotey, Kym Ie Snell, Melanie Smuk, Richard Hooper, Claire L Chan, Asif Ahmed, Lucy C Chappell, Peter von Dadelszen, Julie Dodds, Marcus Green, Louise Kenny, Asma Khalil, Khalid S Khan, Ben W Mol, Jenny Myers, Lucilla Poston, Basky Thilaganathan, Anne C Staff, Gordon Cs Smith, Wessel Ganzevoort, Hannele Laivuori, Anthony O Odibo, Javier A Ramírez, John Kingdom, George Daskalakis, Diane Farrar, Ahmet A Baschat, Paul T Seed, Federico Prefumo, Fabricio da Silva Costa, Henk Groen, Francois Audibert, Jacques Masse, Ragnhild B Skråstad, Kjell Å Salvesen, Camilla Haavaldsen, Chie Nagata, Alice R Rumbold, Seppo Heinonen, Lisa M Askie, Luc Jm Smits, Christina A Vinter, Per M Magnus, Kajantie Eero, Pia M Villa, Anne K Jenum, Louise B Andersen, Jane E Norman, Akihide Ohkuchi, Anne Eskild, Sohinee Bhattacharya, Fionnuala M McAuliffe, Alberto Galindo, Ignacio Herraiz, Lionel Carbillon, Kerstin Klipstein-Grobusch, SeonAe Yeo, Helena J Teede, Joyce L Browne, Karel Gm Moons, Richard D Riley, Shakila Thangaratinam,

<h4>Background</h4>Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk is needed to plan management.<h4>Objectives</h4>To assess the performance of existing pre-eclampsia prediction models and to develop and validate models for pre-eclampsia using individual participant data meta-analysis. We also estimated the prognostic value ... Read more >>

Health Technol Assess (Health technology assessment (Winchester, England))
[2020, 24(72):1-252]

Cited: 1 time

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Informing prevention of stillbirth and preterm birth in Malawi: development of a minimum dataset for health facilities participating in the DIPLOMATIC collaboration.

Beatrix von Wissmann, Elizabeth Wastnedge, Donald Waters, Luis A Gadama, Queen Dube, Clemens Masesa, Elizabeth Chodzaza, Sarah Jane Stock, Rebecca M Reynolds, John Norrie, Enita Makwakwa, Bridget Freyne, Harry Campbell, Jane E Norman, Rachael Wood, ,

<h4>Objective</h4>The global research group, DIPLOMATIC (Using eviDence, Implementation science, and a clinical trial PLatform to Optimise MATernal and newborn health in low Income Countries), aims to reduce stillbirths and preterm births and optimise outcomes for babies born preterm. Minimum datasets for routine data collection in healthcare facilities participating in DIPLOMATIC ... Read more >>

BMJ Open (BMJ open)
[2020, 10(11):e038859]

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External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis.

Kym I E Snell, John Allotey, Melanie Smuk, Richard Hooper, Claire Chan, Asif Ahmed, Lucy C Chappell, Peter Von Dadelszen, Marcus Green, Louise Kenny, Asma Khalil, Khalid S Khan, Ben W Mol, Jenny Myers, Lucilla Poston, Basky Thilaganathan, Anne C Staff, Gordon C S Smith, Wessel Ganzevoort, Hannele Laivuori, Anthony O Odibo, Javier Arenas Ramírez, John Kingdom, George Daskalakis, Diane Farrar, Ahmet A Baschat, Paul T Seed, Federico Prefumo, Fabricio da Silva Costa, Henk Groen, Francois Audibert, Jacques Masse, Ragnhild B Skråstad, Kjell Å Salvesen, Camilla Haavaldsen, Chie Nagata, Alice R Rumbold, Seppo Heinonen, Lisa M Askie, Luc J M Smits, Christina A Vinter, Per Magnus, Kajantie Eero, Pia M Villa, Anne K Jenum, Louise B Andersen, Jane E Norman, Akihide Ohkuchi, Anne Eskild, Sohinee Bhattacharya, Fionnuala M McAuliffe, Alberto Galindo, Ignacio Herraiz, Lionel Carbillon, Kerstin Klipstein-Grobusch, Seon Ae Yeo, Joyce L Browne, Karel G M Moons, Richard D Riley, Shakila Thangaratinam, ,

<h4>Background</h4>Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk during pregnancy is required to plan management. Although there are many published prediction models for pre-eclampsia, few have been validated in external data. Our objective was to externally validate published prediction models ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):302]

Cited: 1 time

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Postal recruitment for genetic studies of preterm birth: A feasibility study.

Oonagh E Keag, Lee Murphy, Aoibheann Bradley, Naomi Deakin, Sonia Whyte, Jane E Norman, Sarah J Stock,

<b>Background:</b> Preterm birth (PTB) represents the leading cause of neonatal death. Large-scale genetic studies are necessary to determine genetic influences on PTB risk, but prospective cohort studies are expensive and time-consuming. We investigated the feasibility of retrospective recruitment of post-partum women for efficient collection of genetic samples, with self-collected saliva ... Read more >>

Wellcome Open Res (Wellcome open research)
[2020, 5:26]

Cited: 1 time

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