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Author Jan Godzinski

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The European Paediatric Rare Tumours Network - European Registry (PARTNER) project for very rare tumors in children.

Daniel Orbach, Andrea Ferrari, Dominik T Schneider, Yves Reguerre, Jan Godzinski, Ewa Bien, Teresa Stachowicz-Stencel, Aurore Surun, Ricardo Lopez Almaraz, Monica Dragomir, Dragana Jani, Tal Ben Ami, Jelena Roganovic, Ines B Brecht, Ruth Ladenstein, Gianni Bisogno,

The PARTNER project (Paediatric Rare Tumours Network - European Registry) was launched in 2016. PARTNER aims to create a European Registry dedicated to children and adolescents with very rare tumors (VRT). It links existing national registries and provides a registry for those countries in which a VRT registry has not ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, :e29072]

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Thymoma and thymic carcinoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations.

Teresa Stachowicz-Stencel, Anna Synakiewicz, Marianna Cornet, Andrea Ferrari, Marina Garassino, Jordi Remon Masip, Rod Julien, Calogero Virgone, Dominik T Schneider, Ines B Brecht, Tal Ben-Ami, Ewa Bien, Yves Reguerre, Jan Godzinski, Gianni Bisogno, Daniel Orbach, Sabine Sarnacki,

Thymic tumors are epithelial tumors arising from the anterior mediastinum and constitute 0.2-1.5% of all adult malignancies but are exceptional in pediatric population. Thymic epithelial tumors (TETs) encompass a variety of histologic subtypes associated with different clinical outcomes. Due to its rarity in children, TETs' management requires a multidisciplinary approach. ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, :e29042]

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Pleuropulmonary blastoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations.

Gianni Bisogno, Sabine Sarnacki, Teresa Stachowicz-Stencel, V Minard Colin, Andrea Ferrari, Jan Godzinski, Marion Gauthier Villars, Ewa Bien, Frederic Hameury, Sylvie Helfre, Dominik T Schneider, Yves Reguerre, Ricardo Lopez Almaraz, Dragana Janic, Maja Cesen, Alexandra Kolenova, Jelena Rascon, Kata Martinova, Rodica Cosnarovici, Apostolos Pourtsidis, Tal Ben Ami, Jelena Roganovic, Ewa Koscielniak, Kris Ann P Schultz, Ines B Brecht, Daniel Orbach,

Pleuropulmonary blastoma (PPB) is a rare cancer occurring mainly during early childhood and often associated with germline DICER1 mutations. It is classified by the macroscopic appearance into three interrelated clinico-pathologic entities on a developmental continuum. Complete tumor resection is a main prognostic factor and can be performed at diagnosis or ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, :e29045]

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Consensus recommendations from the EXPeRT/PARTNER groups for the diagnosis and therapy of sex cord stromal tumors in children and adolescents.

Dominik T Schneider, Daniel Orbach, Tal Ben-Ami, Ewa Bien, Gianni Bisogno, Ines B Brecht, Giovanni Cecchetto, Andrea Ferrari, Jan Godzinski, Dragana Janic, Ricardo Lopez Almaraz, Apostolos Pourtsidis, Jelena Roganovic, Kris Ann P Schultz, Teresa Stachowicz-Stencel, Brice Fresneau,

As part of the European Union-funded project designated Paediatric Rare Tumours Network - European Registry (PARTNER), the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) is continuously developing consensus recommendations in order to harmonize standard care for very rare solid tumors of children and adolescents. This paper presents the ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, :e29017]

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Characteristics and outcome of pediatric renal cell carcinoma patients registered in the International Society of Pediatric Oncology (SIOP) 93-01, 2001 and UK-IMPORT database: A report of the SIOP-Renal Tumor Study Group.

Justine N van der Beek, Janna A Hol, Aurore Coulomb-l'Hermine, Norbert Graf, Harm van Tinteren, Kathy Pritchard-Jones, Maite E Houwing, Ronald R de Krijger, Gordan M Vujanic, Kristina Dzhuma, Jens-Peter Schenk, Annemieke S Littooij, Gema L Ramírez-Villar, Dermot Murphy, Satyajit Ray, Reem Al-Saadi, Manfred Gessler, Jan Godzinski, Christian Ruebe, Paola Collini, Arnaud C Verschuur, Tony Frisk, Christian Vokuhl, Christina A Hulsbergen-van de Kaa, Beatriz de Camargo, Bengt Sandstedt, Barbara Selle, Godelieve A M Tytgat, Marry M van den Heuvel-Eibrink,

In children, renal cell carcinoma (RCC) is rare. This study is the first report of pediatric patients with RCC registered by the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG). Pediatric patients with histologically confirmed RCC, registered in SIOP 93-01, 2001 and UK-IMPORT databases, were included. Event-free survival (EFS) ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 148(11):2724-2735]

Cited: 1 time

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Bilateral Nephroblastoma with Dilated Cardiomyopathy as an Indication for Off-Protocol Treatment: A Case Report.

Patrycja Sosnowska-Sienkiewicz, Ewelina Gowin, Katarzyna Jończyk-Potoczna, Przemysław Mańkowski, Jan Godziński, Danuta Januszkiewicz-Lewandowska,

Patients with a Wilms tumor are often admitted to the hospital accidentally, with an abdominal mass causing asymmetry of the abdominal wall. Hypertension accompanying a Wilms tumor occurs in about 10-27% of children, but cardiomyopathy associated with a Wilms tumor is very rarely described. This publication presents a case of ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(24):]

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The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.

Geert O Janssens, Patrick Melchior, Joeri Mul, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Line Claude, Kristin Gurtner, Kees P van de Ven, Martine van Grotel, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Xavier Muracciole, Tom Boterberg, Henry Mandeville, Jan Godzinski, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe,

For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are implementing advanced radiotherapy techniques that spare healthy tissue. To decrease the radiotherapy dose to healthy structures while preserving oncological efficacy, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):846-852]

Cited: 1 time

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Surgical management of extremity rhabdomyosarcoma: A consensus opinion from the Children's Oncology Group, the European Pediatric Soft-Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe.

Carol D Morris, Per-Ulf Tunn, David A Rodeberg, Sheila Terwisscha van Scheltinga, Odion Binitie, Jan Godzinski, Patrizia Dall'Igna, Lynn Million, Douglas S Hawkins, Ewa Koscielniak, Gianni Bisogno, Timothy N Rogers,

The treatment of extremity rhabdomyosarcoma remains a challenge due to several adverse prognostic factors frequently associated with this tumor site. The International Soft-Tissue Sarcoma Database Consortium (INSTRuCT) is a collaboration of the Children's Oncology Group Soft-Tissue Sarcoma Committee, the European Pediatric Soft-Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe. ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, :e28608]

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Influence of Surgical Excision on the Survival of Patients With Stage 4 High-Risk Neuroblastoma: A Report From the HR-NBL1/SIOPEN Study.

Keith Holmes, Ulrike Pötschger, Andrew D J Pearson, Sabine Sarnacki, Giovanni Cecchetto, Javier Gomez-Chacon, Roly Squire, Enrique Freud, Adam Bysiek, Lucas E Matthyssens, Martin Metzelder, Tom Monclair, Jakob Stenman, Michal Rygl, Lars Rasmussen, Jean-Marc Joseph, Sabine Irtan, Stefano Avanzini, Jan Godzinski, Kristin Björnland, Martin Elliott, Roberto Luksch, Victoria Castel, Shifra Ash, Walentyna Balwierz, Geneviève Laureys, Ellen Ruud, Vassilios Papadakis, Josef Malis, Cormac Owens, Henrik Schroeder, Maja Beck-Popovic, Toby Trahair, Ana Forjaz de Lacerda, Peter F Ambros, Mark N Gaze, Kieran McHugh, Dominique Valteau-Couanet, Ruth Lydia Ladenstein, ,

<h4>Purpose</h4>To evaluate the impact of surgeon-assessed extent of primary tumor resection on local progression and survival in patients in the International Society of Pediatric Oncology Europe Neuroblastoma Group High-Risk Neuroblastoma 1 trial.<h4>Patients and methods</h4>Patients recruited between 2002 and 2015 with stage 4 disease > 1 year or stage 4/4S with ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(25):2902-2915]

Cited: 2 times

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ESGO-SIOPE guidelines for the management of adolescents and young adults with non-epithelial ovarian cancers.

Cristiana Sessa, Dominik T Schneider, François Planchamp, Katja Baust, Elena Ioana Braicu, Nicole Concin, Jan Godzinski, W Glenn McCluggage, Daniel Orbach, Patricia Pautier, Fedro A Peccatori, Philippe Morice, Gabriele Calaminus,

The European Society of Gynaecological Oncology and the European Society for Paediatric Oncology jointly developed clinically relevant and evidence-based guidelines for the management of adolescents and young adults aged 15 to 25 years with non-epithelial ovarian cancers, including malignant ovarian germ cell tumours, sex cord-stromal tumours, and small cell carcinoma ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2020, 21(7):e360-e368]

Cited: 1 time

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Outcome of patients with stage IV high-risk Wilms tumour treated according to the SIOP2001 protocol: A report of the SIOP Renal Tumour Study Group.

Claudia Pasqualini, Rhoikos Furtwängler, Harm van Tinteren, Roberto A P Teixeira, Tomas Acha, Lisa Howell, Gordan Vujanic, Jan Godzinski, Patrick Melchior, Anne M Smets, Aurore Coulomb-L'Hermine, Hervé Brisse, Kathy Pritchard-Jones, Christophe Bergeron, Beatriz de Camargo, Marry M van den Heuvel-Eibrink, Norbert Graf, Arnauld C Verschuur,

INTRODUCTION:High-risk (HR) metastatic (stage IV) Wilms tumours (WTs) have a particular poor outcome. METHODS:Here, we report the results of HR (diffuse anaplastic [DA] or blastemal type [BT]) stage IV WT treated patients according to the HR arm in the SIOP2001 prospective study. RESULTS:From January 2002 to August 2014, 3559 patients ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 128:38-46]

Cited: 1 time

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Optimal neoadjuvant chemotherapy duration in Wilms tumour with intravascular thrombus: A literature review and evidence from SIOP WT 2001 trial.

Louise Morris, Roly Squire, Beata Sznajder, Harm van Tinteren, Jan Godzinski, Mark Powis,

<h4>Introduction</h4>Preoperative chemotherapy is recommended for children with Wilms tumour with intravascular extension. Extended chemotherapy may improve resectability, but increase tumour adherence to vascular endothelium, precluding complete resection. To evaluate the optimal length of preoperative treatment, we report a two-part review comprising systematic review of the literature and investigation of patients ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(11):e27930]

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Evaluation of needle biopsy as a potential risk factor for local recurrence of Wilms tumour in the SIOP WT 2001 trial.

Sabine Irtan, Harm Van Tinteren, Norbert Graf, Marry M van den Heuvel-Eibrink, Hugo Heij, Christophe Bergeron, Beatriz de Camargo, Tomas Acha, Filippo Spreafico, Gordan Vujanic, Mark Powis, Bruce Okoye, Jim Wilde, Jan Godzinski, Kathy Pritchard-Jones,

<h4>Rationale</h4>The impact of biopsying Wilms tumour (WT) at diagnosis on assigning the tumour stage and recommended treatment remains controversial. To address this important question, we analysed the potential association of all types of biopsy with local recurrence in patients treated in the SIOP WT 2001 trial, where needle biopsy was ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2019, 116:13-20]

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Defining and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors.

Andrea Ferrari, Ines B Brecht, Gemma Gatta, Dominik T Schneider, Daniel Orbach, Giovanni Cecchetto, Jan Godzinski, Yves Reguerre, Ewa Bien, Teresa Stachowicz-Stencel, Michael Ost, Chiara Magni, Pamela Kearns, Gilles Vassal, Maura Massimino, Andrea Biondi, Gianni Bisogno, Annalisa Trama,

Although all tumours are rare in childhood, there are some particularly rare paediatric cancers which have not benefited from advances made by the international paediatric oncology network. To establish a shared definition and produce a list of these entities, the European Union Joint Action on Rare Cancers (JARC) promoted a ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2019, 110:120-126]

Cited: 3 times

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Position paper: Rationale for the treatment of children with CCSK in the UMBRELLA SIOP-RTSG 2016 protocol.

Saskia L Gooskens, Norbert Graf, Rhoikos Furtwängler, Filippo Spreafico, Christophe Bergeron, Gema L Ramírez-Villar, Jan Godzinski, Christian Rübe, Geert O Janssens, Gordan M Vujanic, Ivo Leuschner, Aurore Coulomb-L'Hermine, Anne M Smets, Beatriz de Camargo, Sara Stoneham, Harm van Tinteren, Kathy Pritchard-Jones, Marry M van den Heuvel-Eibrink, ,

The International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG) has developed a new protocol for the diagnosis, treatment, and follow-up monitoring of childhood renal tumours - the UMBRELLA SIOP-RTSG 2016 protocol (the UMBRELLA protocol). This protocol has been designed to continue international collaboration in the treatment of childhood renal ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2018, 15(5):309-319]

Cited: 3 times

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Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol.

Marry M van den Heuvel-Eibrink, Janna A Hol, Kathy Pritchard-Jones, Harm van Tinteren, Rhoikos Furtwängler, Arnauld C Verschuur, Gordan M Vujanic, Ivo Leuschner, Jesper Brok, Christian Rübe, Anne M Smets, Geert O Janssens, Jan Godzinski, Gema L Ramírez-Villar, Beatriz de Camargo, Heidi Segers, Paola Collini, Manfred Gessler, Christophe Bergeron, Filippo Spreafico, Norbert Graf, ,

The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2017, 14(12):743-752]

Cited: 33 times

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Pediatric patients with cutaneous melanoma: A European study.

Ines B Brecht, Angela De Paoli, Gianni Bisogno, Daniel Orbach, Dominik T Schneider, Ulrike Leiter, Sonja Offenmueller, Giovanni Cecchetto, Jan Godzinski, Ewa Bien, Teresa Stachowicz-Stencel, Tal Ben-Ami, Stefano Chiaravalli, Andrea Maurichi, Gian Luca De Salvo, Silvia Sorbara, Christine Bodemer, Claus Garbe, Yves Reguerre, Andrea Ferrari,

INTRODUCTION:Cutaneous melanoma is rare in childhood and published studies have mainly been retrospective single-institution series or small case series. Given the absence of clinical protocols dedicated to pediatric melanoma, the treatment approach is generally extrapolated from the ones applied to adults. METHODS:Coordinated by the European Cooperative Study Group for Pediatric ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2018, 65(6):e26974]

Cited: 5 times

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Outcome and prognostic factors in high-risk childhood adrenocortical carcinomas: A report from the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT).

Giovanni Cecchetto, Alba Ganarin, Ewa Bien, Peter Vorwerk, Gianni Bisogno, Jan Godzinski, Patrizia Dall'Igna, Yves Reguerre, Dominik Schneider, Laurence Brugières, Pierre Leblond, Andrea Ferrari, Ines Brecht, Angela De Paoli, Daniel Orbach,

<h4>Objectives</h4>The aim of this retrospective international analysis was to evaluate the role of risk factors in pediatric patients with adrenocortical carcinoma (ACC) observed in European countries (2000-2013) in an attempt to identify factors associated with poor prognosis.<h4>Procedures</h4>Data were retrieved from databases of Germany, France, Poland, and Italy, which form the ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2017, 64(6):]

Cited: 7 times

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Paediatric renal tumours: perspectives from the SIOP-RTSG.

,

The >90% rates of overall survival for children with Wilms tumour are remarkable and have been achieved at the same time as reducing treatment for most patients. However, beneath this headline figure, 20% of patients still relapse after first-line therapy and up to 25% of survivors report severe late effects. ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2017, 14(1):3-4]

Cited: 6 times

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Improvements in the Treatment of Patients Suffering from Bladder-Prostate Rhabdomyosarcoma: A Report from the CWS-2002P Trial.

Guido Seitz, Jörg Fuchs, Monika Sparber-Sauer, Ivo Leuschner, Jan Godzinski, Thomas Klingebiel, Andreas Schuck, Peter Martus, Tobias M Dantonello, Ewa Koscielniak,

<h4>Purpose</h4>Modern treatment concepts for bladder/prostate rhabdomyosarcoma (BPRMS) are designed to improve survival, to reduce therapy intensity, and to increase bladder preservation rates. Nevertheless, treatment is not optimal. The purpose of this study was to analyze BPRMS patients treated within the CWS-2002P trial regarding outcome, treatment modalities, complications, and to compare ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2016, 23(12):4067-4072]

Cited: 1 time

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Omission of doxorubicin from the treatment of stage II-III, intermediate-risk Wilms' tumour (SIOP WT 2001): an open-label, non-inferiority, randomised controlled trial.

Kathy Pritchard-Jones, Christophe Bergeron, Beatriz de Camargo, Marry M van den Heuvel-Eibrink, Tomas Acha, Jan Godzinski, Foppe Oldenburger, Liliane Boccon-Gibod, Ivo Leuschner, Gordan Vujanic, Bengt Sandstedt, Jan de Kraker, Harm van Tinteren, Norbert Graf, ,

<h4>Background</h4>Before this study started, the standard postoperative chemotherapy regimen for stage II-III Wilms' tumour pretreated with chemotherapy was to include doxorubicin. However, avoidance of doxorubicin-related cardiotoxicity effects is important to improve long-term outcomes for childhood cancers that have excellent prognosis. We aimed to assess whether doxorubicin can be omitted safely ... Read more >>

Lancet (Lancet (London, England))
[2015, 386(9999):1156-1164]

Cited: 49 times

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Reply to comment on: Nephron-sparing surgery (NSS) for unilateral Wilms tumor (UWT): The SIOP 2001 experience.

Jim C H Wilde, Jan Godzinski, Hugo Heij, Daniel C Aronson,

Pediatr Blood Cancer (Pediatric blood & cancer)
[2015, 62(8):1490]

Cited: 0 times

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Ovarian Sertoli Leydig cell tumours in children and adolescents: an analysis of the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT).

Dominik T Schneider, Daniel Orbach, Giovanni Cecchetto, Teresa Stachowicz-Stencel, Bastian Brummel, Ines B Brecht, Gianni Bisogno, Andrea Ferrari, Yves Reguerre, Jan Godzinski, Ewa Bien, Gabriele Calaminus, Ulrich Göbel, Catherine Patte,

<h4>Objective</h4>To analyse ovarian Sertoli-Leydig cell tumours (SLCTs) for potential prognostic markers and their use for treatment stratification.<h4>Patients</h4>Forty-four patients were included. Patients were prospectively reported to the German MAKEI (Maligne Keimzelltumoren) studies (n=23), French TGM protocols (n=10), Italian Rare Tumour Project (TREP) registry (n=6), and the Polish Pediatric Rare Tumour Study ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2015, 51(4):543-550]

Cited: 14 times

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The current status of treatment of Wilms' tumor as per the SIOP trials.

Jan Godzinski,

This paper attempts to briefly describe the International Society of Paediatric Oncology (SIOP) policy of treatment of nephroblastoma since first study (SIOP 1) launched in 1971 until today. It focuses on the advantages of the preoperative chemotherapy and the stratification of patients induced this way. Marked efficacy of the pretreatment ... Read more >>

J Indian Assoc Pediatr Surg (Journal of Indian Association of Pediatric Surgeons)
[2015, 20(1):16-20]

Cited: 9 times

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Current concepts in surgery for Wilms tumor--the risk and function-adapted strategy.

Jan Godzinski, Norbert Graf, Georges Audry,

This article describes the current status of surgical approach to Wilms tumor. Combined multimodal treatment including classical open nephrectomy is still the most recommended and offers excellent survivals. Patients suffering from Wilms tumor as potentially very long-term survivors also need great care of quality of their further life. Nephron-sparing surgery ... Read more >>

Eur J Pediatr Surg (European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie)
[2014, 24(6):457-460]

Cited: 12 times

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