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Author James S Meabon

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Oxidative Stress Signaling in Blast TBI-Induced Tau Phosphorylation.

Chunyu Wang, Changjuan Shao, Li Zhang, Sandra L Siedlak, James S Meabon, Elaine R Peskind, Yubing Lu, Wenzhang Wang, George Perry, David G Cook, Xiongwei Zhu,

Traumatic brain injury caused by blast is associated with long-term neuropathological changes including tau phosphorylation and pathology. In this study, we aimed to determine changes in initial tau phosphorylation after exposure to a single mild blast and the potential contribution of oxidative stress response pathways. C57BL/6 mice were exposed to ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(6):]

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Repetitive Blast Promotes Chronic Aversion to Neutral Cues Encountered in the Peri-Blast Environment.

Abigail G Schindler, Garth E Terry, Tami Wolden-Hanson, Marcella Cline, Michael Park, Janet Lee, Mayumi Yagi, James S Meabon, Elaine R Peskind, Murray M Raskind, Paul E M Phillips, David G Cook,

Repetitive mild traumatic brain injury (mTBI) has been called the "signature injury" of military service members in the Iraq and Afghanistan wars and is highly comorbid with post-traumatic stress disorder (PTSD). Correct attribution of adverse blast-induced mTBI and/or PTSD remains challenging. Pre-clinical research using animal models can provide important insight ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(7):940-948]

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Effect of blast-related mTBI on the working memory system: a resting state fMRI study.

Kathleen F Pagulayan, Eric C Petrie, David G Cook, Rebecca C Hendrickson, Holly Rau, Melissa Reilly, Cindy Mayer, James S Meabon, Murray A Raskind, Elaine R Peskind, Natalia Kleinhans,

Reduced working memory is frequently reported by Veterans with a history of blast-related mild traumatic brain injury (mTBI), but can be difficult to quantify on neuropsychological measures. This study aimed to improve our understanding of the impact of blast-related mTBI on the working memory system by using resting state functional ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2020, 14(4):949-960]

Cited: 2 times

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Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure.

James S Meabon, David G Cook, Mayumi Yagi, Garth E Terry, Donna J Cross, Mark Muzi, Kathleen F Pagulayan, Aric F Logsdon, Abigail G Schindler, Vikas Ghai, Kai Wang, Shannon Fallen, Yong Zhou, Taek-Kyun Kim, Inyoul Lee, William A Banks, Erik S Carlson, Cynthia Mayer, Rebecca C Hendrickson, Murray A Raskind, Desiree A Marshall, Daniel P Perl, C Dirk Keene, Elaine R Peskind,

Mounting evidence points to the significance of neurovascular-related dysfunction in veterans with blast-related mTBI, which is also associated with reduced [<sup>18</sup>F]-fluorodeoxyglucose (FDG) uptake. The goal of this study was to determine whether plasma VEGF-A is altered in veterans with blast-related mTBI and address whether VEGF-A levels correlate with FDG uptake ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2020, 417:117049]

Cited: 0 times

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Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury.

Aric F Logsdon, Abigail G Schindler, James S Meabon, Mayumi Yagi, Melanie J Herbert, William A Banks, Murray A Raskind, Desiree A Marshall, C Dirk Keene, Daniel P Perl, Elaine R Peskind, David G Cook,

We investigated the role of nitric oxide synthase (NOS) in mediating blood-brain barrier (BBB) disruption and peripheral immune cell infiltration in the cerebellum following blast exposure. Repetitive, but not single blast exposure, induced delayed-onset BBB disruption (72 hours post-blast) in cerebellum. The NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) administered after blast ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9420]

Cited: 4 times

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Alterations in Plasma microRNA and Protein Levels in War Veterans with Chronic Mild Traumatic Brain Injury.

Vikas Ghai, Shannon Fallen, David Baxter, Kelsey Scherler, Taek-Kyun Kim, Yong Zhou, James S Meabon, Aric F Logsdon, William A Banks, Abigail G Schindler, David G Cook, Elaine R Peskind, Inyoul Lee, Kai Wang,

Blast-related mild traumatic brain injury (mTBI) is considered the "signature" injury of the wars in Iraq and Afghanistan. Identifying biomarkers that could aid in diagnosis and assessment of chronic mTBI are urgently needed, as little progress has been made toward identifying blood-based biomarkers of repetitive mTBI in the chronic state. ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, 37(12):1418-1430]

Cited: 4 times

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Heterozygous STUB1 missense variants cause ataxia, cognitive decline, and STUB1 mislocalization.

Dong-Hui Chen, Caitlin Latimer, Mayumi Yagi, Mesaki Kenneth Ndugga-Kabuye, Elyana Heigham, Suman Jayadev, James S Meabon, Christopher M Gomez, C Dirk Keene, David G Cook, Wendy H Raskind, Thomas D Bird,

<h4>Objective</h4>To identify the genetic cause of autosomal dominant ataxia complicated by behavioral abnormalities, cognitive decline, and autism in 2 families and to characterize brain neuropathologic signatures of dominant <i>STUB1</i>-related ataxia and investigate the effects of pathogenic variants on <i>STUB1</i> localization.<h4>Methods</h4>Clinical and research-based exome sequencing was used to identify the causative ... Read more >>

Neurol Genet (Neurology. Genetics)
[2020, 6(2):1-13]

Cited: 5 times

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Paclitaxel Reduces Brain Injury from Repeated Head Trauma in Mice.

Donna J Cross, James S Meabon, Marcella M Cline, Todd L Richards, Amanda J Stump, Chloe G Cross, Satoshi Minoshima, William A Banks, David G Cook,

Repetitive mild traumatic brain injury (rmTBI) is known to disturb axonal integrity and may play an important role in the pathogenic cascades leading to neurodegeneration. One critical approach to reduce the future onset of neurodegeneration is to intervene in this process at an early stage following a brain injury. Previously ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2019, 67(3):859-874]

Cited: 2 times

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Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes.

Aric F Logsdon, James S Meabon, Marcella M Cline, Kristin M Bullock, Murray A Raskind, Elaine R Peskind, William A Banks, David G Cook,

Mild blast-induced traumatic brain injury (TBI) is associated with blood-brain barrier (BBB) disruption. However, the mechanisms whereby blast disrupts BBB integrity are not well understood. To address this issue BBB permeability to peripherally injected <sup>14</sup>C-sucrose and <sup>99m</sup>Tc-albumin was quantified in ten brain regions at time points ranging from 0.25 to ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):11344]

Cited: 12 times

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Retrospective and Prospective Memory Among OEF/OIF/OND Veterans With a Self-Reported History of Blast-Related mTBI.

Kathleen F Pagulayan, Holly Rau, Renee Madathil, Madeleine Werhane, Steven P Millard, Eric C Petrie, Brett Parmenter, Sarah Peterson, Scott Sorg, Rebecca Hendrickson, Cindy Mayer, James S Meabon, Bertrand R Huber, Murray Raskind, David G Cook, Elaine R Peskind,

OBJECTIVES:To evaluate prospective and retrospective memory abilities in Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans with and without a self-reported history of blast-related mild traumatic brain injury (mTBI). METHODS:Sixty-one OEF/OIF/OND Veterans, including Veterans with a self-reported history of blast-related mTBI (mTBI group; n=42) ... Read more >>

J Int Neuropsychol Soc (Journal of the International Neuropsychological Society : JINS)
[2018, 24(4):324-334]

Cited: 7 times

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ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury.

Jiqing Cao, Farida El Gaamouch, James S Meabon, Kole D Meeker, Li Zhu, Margaret B Zhong, John Bendik, Gregory Elder, Ping Jing, Jiahong Xia, Wenjie Luo, David G Cook, Dongming Cai,

The apolipoprotein E4 (ApoE4) genotype combines with traumatic brain injury (TBI) to increase the risk of developing Alzheimer's Disease (AD). However, the underlying mechanism(s) is not well-understood. We found that after exposure to repetitive blast-induced TBI, phosphoinositol biphosphate (PIP<sub>2</sub>) levels in hippocampal regions of young ApoE3 mice were elevated and ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):11372]

Cited: 24 times

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Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction.

James S Meabon, Bertrand R Huber, Donna J Cross, Todd L Richards, Satoshi Minoshima, Kathleen F Pagulayan, Ge Li, Kole D Meeker, Brian C Kraemer, Eric C Petrie, Murray A Raskind, Elaine R Peskind, David G Cook,

Blast exposure can cause mild traumatic brain injury (TBI) in mice and other mammals. However, there are important gaps in our understanding of the neuropathology underlying repetitive blast exposure in animal models compared to the neuroimaging abnormalities observed in blast-exposed veterans. Moreover, how an increase in the number of blast ... Read more >>

Sci Transl Med (Science translational medicine)
[2016, 8(321):321ra6]

Cited: 52 times

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Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit.

William A Banks, Alicia M Gray, Michelle A Erickson, Therese S Salameh, Mamatha Damodarasamy, Nader Sheibani, James S Meabon, Emily E Wing, Yoichi Morofuji, David G Cook, May J Reed,

<h4>Background</h4>Disruption of the blood-brain barrier (BBB) occurs in many diseases and is often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well established as a cause of BBB disruption, but many mechanistic questions remain.<h4>Methods</h4>We used lipopolysaccharide (LPS) to induce inflammation and BBB disruption in mice. BBB disruption was measured using ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2015, 12:223]

Cited: 142 times

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Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.

James S Meabon, Rian de Laat, Katsuaki Ieguchi, Dmitry Serbzhinsky, Mark P Hudson, B Russel Huber, Jesse C Wiley, Mark Bothwell,

Neurotrophins, essential regulators of many aspects of neuronal differentiation and function, signal via four receptors, p75, TrkA, TrkB and TrkC. The three Trk paralogs are members of the LIG superfamily of membrane proteins, which share extracellular domains consisting of leucine-rich repeat and C2 Ig domains. Another LIG protein, LINGO-1 has ... Read more >>

Mol Cell Neurosci (Molecular and cellular neurosciences)
[2016, 70:1-10]

Cited: 8 times

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LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor.

Rian de Laat, James S Meabon, Jesse C Wiley, Mark P Hudson, Thomas J Montine, Mark Bothwell,

Sequential proteolytic cleavages of amyloid-β protein precursor (AβPP) by β-secretase and γ-secretase generate amyloid β (Aβ) peptides, which are thought to contribute to Alzheimer's disease (AD). Much of this processing occurs in endosomes following endocytosis of AβPP from the plasma membrane. However, this pathogenic mode of processing AβPP may occur ... Read more >>

Pathobiol Aging Age Relat Dis (Pathobiology of aging & age related diseases)
[2015, 5:25796]

Cited: 3 times

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LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments.

James S Meabon, Rian De Laat, Katsuaki Ieguchi, Jesse C Wiley, Mark P Hudson, Mark Bothwell,

Axon outgrowth inhibition in response to trauma is thought to be mediated via the binding of myelin-associated inhibitory factors (e.g. Nogo-66, myelin-associated glycoprotein, oligodendrocyte myelin glycoprotein, and myelin basic protein) to a putative tripartite LINGO-1·p75(NTR)·Nogo-66 receptor (NgR) complex at the cell surface. We found that endogenous LINGO-1 expression in neurons ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2015, 290(15):9511-9520]

Cited: 12 times

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Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer's Disease.

Kole D Meeker, James S Meabon, David G Cook,

The glutamate transporter GLT-1 (also called EAAT2 in humans) plays a critical role in regulating extracellular glutamate levels in the central nervous system (CNS). In Alzheimer's disease (AD), EAAT2 loss is associated with neuropathology and cognitive impairment. In keeping with this, we have reported that partial GLT-1 loss (GLT-1+/-) causes ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2015, 45(2):509-520]

Cited: 11 times

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Amyloid-β1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1.

Annalisa Scimemi, James S Meabon, Randall L Woltjer, Jane M Sullivan, Jeffrey S Diamond, David G Cook,

GLT-1, the major glutamate transporter in the adult brain, is abundantly expressed in astrocytic processes enveloping synapses. By limiting glutamate escape into the surrounding neuropil, GLT-1 preserves the spatial specificity of synaptic signaling. Here we show that the amyloid-β peptide Aβ1-42 markedly prolongs the extracellular lifetime of synaptically released glutamate ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2013, 33(12):5312-5318]

Cited: 70 times

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Blast exposure causes early and persistent aberrant phospho- and cleaved-tau expression in a murine model of mild blast-induced traumatic brain injury.

Bertrand R Huber, James S Meabon, Tobin J Martin, Pierre D Mourad, Raymond Bennett, Brian C Kraemer, Ibolja Cernak, Eric C Petrie, Michael J Emery, Erik R Swenson, Cynthia Mayer, Edin Mehic, Elaine R Peskind, David G Cook,

Mild traumatic brain injury (mTBI) is considered the 'signature injury' of combat veterans that have served during the wars in Iraq and Afghanistan. This prevalence of mTBI is due in part to the common exposure to high explosive blasts in combat zones. In addition to the threats of blunt impact ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2013, 37(2):309-323]

Cited: 73 times

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Differential expression of the glutamate transporter GLT-1 in pancreas.

James S Meabon, Aven Lee, Kole D Meeker, Lynn M Bekris, Robert K Fujimura, Chang-En Yu, G Stennis Watson, David V Pow, Ian R Sweet, David G Cook,

The glutamate uptake transporter GLT-1 is best understood for its critical role in preventing brain seizures. Increasing evidence argues that GLT-1 also modulates, and is modulated by, metabolic processes that influence glucose homeostasis. To investigate further the potential role of GLT-1 in these regards, the authors examined GLT-1 expression in ... Read more >>

J Histochem Cytochem (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society)
[2012, 60(2):139-151]

Cited: 8 times

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Localisation of novel forms of glutamate transporters and the cystine-glutamate antiporter in the choroid plexus: Implications for CSF glutamate homeostasis.

Aven Lee, Ashley R Anderson, Andrew J Rayfield, Melissa G Stevens, Philip Poronnik, James S Meabon, David G Cook, David V Pow,

The choroid plexus is a structure within each ventricle of the brain that is composed of fenestrated vessels surrounded by secretory epithelial cells. The epithelial cells are linked by tight junctions to create a permeability barrier. The epithelial cells are derived from neuroectoderm, and are thus defined by some authors ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2012, 43(1):64-75]

Cited: 7 times

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GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model.

Paramita Mookherjee, Pattie S Green, G Stennis Watson, Marcos A Marques, Kohichi Tanaka, Kole D Meeker, James S Meabon, Ning Li, Ping Zhu, Valerie G Olson, David G Cook,

Glutamate transporters regulate normal synaptic network interactions and prevent neurotoxicity by rapidly clearing extracellular glutamate. GLT-1, the dominant glutamate transporter in the cerebral cortex and hippocampus, is significantly reduced in Alzheimer's disease (AD). However, the role GLT-1 loss plays in the cognitive dysfunction and pathology of AD is unknown. To ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2011, 26(3):447-455]

Cited: 53 times

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Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells.

Jesse C Wiley, James S Meabon, Harald Frankowski, Elise A Smith, Leslayann C Schecterson, Mark Bothwell, Warren C Ladiges,

<h4>Background</h4>The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological similarity suggests that epigenetic processes may phenocopy the Familial Alzheimer's disease (FAD) mutations within sporadic AD. Numerous groups have demonstrated that FAD mutations in presenilin ... Read more >>

PLoS One (PloS one)
[2010, 5(2):e9135]

Cited: 40 times

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LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.

Kenji Mandai, Ting Guo, Coryse St Hillaire, James S Meabon, Kevin C Kanning, Mark Bothwell, David D Ginty,

Genome-wide screens were performed to identify transmembrane proteins that mediate axonal growth, guidance and target field innervation of somatosensory neurons. One gene, Linx (alias Islr2), encoding a leucine-rich repeat and immunoglobulin (LIG) family protein, is expressed in a subset of developing sensory and motor neurons. Domain and genomic structures of ... Read more >>

Neuron (Neuron)
[2009, 63(5):614-627]

Cited: 49 times

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Mechanisms underlying variations in excitation-contraction coupling across the mouse left ventricular free wall.

Keith W Dilly, Charles F Rossow, V Scott Votaw, James S Meabon, Jennifer L Cabarrus, Luis F Santana,

Ca(2+) release during excitation-contraction (EC) coupling varies across the left ventricular free wall. Here, we investigated the mechanisms underlying EC coupling differences between mouse left ventricular epicardial (Epi) and endocardial (Endo) myocytes. We found that diastolic and systolic [Ca(2+)](i) was higher in paced Endo than in Epi myocytes. Our data ... Read more >>

J Physiol (The Journal of physiology)
[2006, 572(Pt 1):227-241]

Cited: 40 times

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