Full Text Journal Articles by
Author James S Malter

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Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration.

Zhong-Jian Shen, Jie Hu, Melissa A O'Neal, James S Malter,

Eosinophils become polarized in response to cytokines such IL-5 or eotaxin prior to directional migration. Polarization is preceded by F-actin assembly, but the mechanisms that regulate these events and how the shape change influences cell migration from the peripheral blood into the lung remain unclear. In this study, we show ... Read more >>

Cells (Cells)
[2021, 10(2):]

Cited: 1 time

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Eosinophils, Pin1 and the Response to Respiratory Viral Infection and Allergic Stimuli.

Zhong-Jian Shen, James S Malter,

Eosinophils (Eos) are prominent inflammatory cells found in the sputum, airways, and airway walls during and after exacerbations of allergic asthma. These cells are potent secretors of a wide array of cytotoxic granule proteins, cytokines, and lipid mediators involved in the initiation and maintenance of the Th2-type inflammatory reaction. Even ... Read more >>

Crit Rev Immunol (Critical reviews in immunology)
[2019, 39(2):135-149]

Cited: 0 times

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TLR-7 Stress Signaling in Differentiating and Mature Eosinophils Is Mediated by the Prolyl Isomerase Pin1.

Zhong-Jian Shen, Jie Hu, Venkatesh Kashi, Yury A Bochkov, James E Gern, James S Malter,

The response of eosinophils (Eos) to respiratory virus has emerged as an important link between pulmonary infection and allergic asthmatic exacerbations. Eos activate innate immune responses through TLR signaling. In this study, using mouse and human Eos and mice lacking the prolyl isomerase Pin1 selectively in Eos, we show that ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2018, 201(12):3503-3513]

Cited: 3 times

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Alzheimer's Disease, Dendritic Spines, and Calcineurin Inhibitors: A New Approach?

Melissa A O'Neal, Nancy R Stallings, James S Malter,

Therapeutics to effectively treat Alzheimer's disease (AD) are lacking. In vitro, animal and human studies have implicated the excessive activation of the protein phosphatase calcineurin (CN) as an early step in the pathogenesis of AD. We discuss recent data showing that the prolyl isomerase Pin1 is suppressed by CN-mediated dephosphorylation ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2018, 9(6):1233-1234]

Cited: 5 times

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Aggressive Behavior in Silent Subtype III Pituitary Adenomas May Depend on Suppression of Local Immune Response: A Whole Transcriptome Analysis.

Timothy E Richardson, Zhong-Jian Shen, Mohammed Kanchwala, Chao Xing, Alexander Filatenkov, Ping Shang, Samuel Barnett, Zahidur Abedin, James S Malter, Jack M Raisanen, Dennis K Burns, Charles L White, Kimmo J Hatanpaa,

Silent subtype III pituitary adenomas (SS-3) are clinically nonfunctional adenomas that are more aggressive in terms of invasion and risk of recurrence than their conventional null cell counterparts. We previously showed that these tumors can be distinguished by immunohistochemistry based on the identification of a markedly enlarged and fragmented Golgi ... Read more >>

J Neuropathol Exp Neurol (Journal of neuropathology and experimental neurology)
[2017, 76(10):874-882]

Cited: 10 times

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Erratum: Publisher Correction: Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.

Dinesh Rakheja, Kenneth S Chen, Yangjian Liu, Abhay A Shukla, Vanessa Schmid, Tsung-Cheng Chang, Shama Khokhar, Jonathan E Wickiser, Nitin J Karandikar, James S Malter, Joshua T Mendell, James F Amatruda,

[This corrects the article DOI: 10.1038/ncomms5802.]. ... Read more >>

Nat Commun (Nature communications)
[2017, 8:16177]

Cited: 0 times

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Sampling strategies to capture single-cell heterogeneity.

Satwik Rajaram, Louise E Heinrich, John D Gordan, Jayant Avva, Kathy M Bonness, Agnieszka K Witkiewicz, James S Malter, Chloe E Atreya, Robert S Warren, Lani F Wu, Steven J Altschuler,

Advances in single-cell technologies have highlighted the prevalence and biological significance of cellular heterogeneity. A critical question researchers face is how to design experiments that faithfully capture the true range of heterogeneity from samples of cellular populations. Here we develop a data-driven approach, illustrated in the context of image data, ... Read more >>

Nat Methods (Nature methods)
[2017, 14(10):967-970]

Cited: 5 times

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NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.

S M Nashir Udden, Lan Peng, Jia-Liang Gan, John M Shelton, James S Malter, Lora V Hooper, Md Hasan Zaki,

Although NOD2 is the major inflammatory bowel disease susceptibility gene, its role in colorectal tumorigenesis is poorly defined. Here, we show that Nod2-deficient mice are highly susceptible to experimental colorectal tumorigenesis independent of gut microbial dysbiosis. Interestingly, the expression of inflammatory genes and the activation of inflammatory pathways, including NF-κB, ... Read more >>

Cell Rep (Cell reports)
[2017, 19(13):2756-2770]

Cited: 21 times

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Epstein-Barr Virus-induced Gene 2 Mediates Allergen-induced Leukocyte Migration into Airways.

Zhong-Jian Shen, Jie Hu, Venkatesh P Kashi, Elizabeth A Kelly, Loren C Denlinger, Kevan Lutchman, Jeffrey G McDonald, Nizar N Jarjour, James S Malter,

<h4>Rationale</h4>Leukocyte recruitment to sites of allergic inflammation depends on the local production of priming cytokines, chemokines, and potentially other mediators. Previously, we showed that eosinophils (Eos) express numerous orphan G-protein-coupled receptors, including Epstein-Barr virus-induced gene 2 (EBI2). Despite its contribution to inflammatory diseases, the role of EBI2 in pulmonary eosinophilia ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2017, 195(12):1576-1585]

Cited: 7 times

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Protein interacting with NIMA (never in mitosis A)-1 regulates axonal growth cone adhesion and spreading through myristoylated alanine-rich C kinase substrate isomerization.

Lucas J Sosa, James S Malter, Jie Hu, Florentyna Bustos Plonka, Mariana Oksdath, Alvaro F Nieto Guil, Santiago Quiroga, Karl H Pfenninger,

Axonal growth cone motility requires precise regulation of adhesion to navigate the complex environment of the nervous system and reach its target. Myristoylated alanine-rich C kinase substrate (MARCKS) protein is enriched in the developing brain and plays an important, phosphorylation-dependent role in the modulation of axonal growth cone adhesion. The ... Read more >>

J Neurochem (Journal of neurochemistry)
[2016, 137(5):744-755]

Cited: 5 times

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Phosphate-Induced Renal Fibrosis Requires the Prolyl Isomerase Pin1.

Zhong-Jian Shen, Jie Hu, Kazuhiro Shiizaki, Makoto Kuro-o, James S Malter,

Tubulo-interstitial fibrosis is a common, destructive endpoint for a variety of kidney diseases. Fibrosis is well correlated with the loss of kidney function in both humans and rodents. The identification of modulators of fibrosis could provide novel therapeutic approaches to reducing disease progression or severity. Here, we show that the ... Read more >>

PLoS One (PloS one)
[2016, 11(2):e0150093]

Cited: 10 times

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Human eosinophil activin A synthesis and mRNA stabilization are induced by the combination of IL-3 plus TNF.

Elizabeth A Kelly, Stephane Esnault, Sean H Johnson, Lin Ying Liu, James S Malter, Mandy E Burnham, Nizar N Jarjour,

Eosinophils contribute to immune regulation and wound healing/fibrosis in various diseases, including asthma. Growing appreciation for the role of activin A in such processes led us to hypothesize that eosinophils are a source of this transforming growth factor-ß superfamily member. Tumor necrosis factor-α (TNF) induces activin A by other cell ... Read more >>

Immunol Cell Biol (Immunology and cell biology)
[2016, 94(7):701-708]

Cited: 10 times

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The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.

Shuiqing Hu, Lan Peng, Youn-Tae Kwak, Erin McElvania Tekippe, Chandrashekhar Pasare, James S Malter, Lora V Hooper, Md Hasan Zaki,

Microbial pattern molecules in the intestine play immunoregulatory roles via diverse pattern recognition receptors. However, the role of the cytosolic DNA sensor AIM2 in the maintenance of intestinal homeostasis is unknown. Here, we show that Aim2(-/-) mice are highly susceptible to dextran sodium sulfate-induced colitis that is associated with microbial ... Read more >>

Cell Rep (Cell reports)
[2015, 13(9):1922-1936]

Cited: 52 times

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IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils.

Stephane Esnault, Elizabeth A B Kelly, Zhong-Jian Shen, Mats W Johansson, James S Malter, Nizar N Jarjour,

IL-5 is a major therapeutic target to reduce eosinophilia. However, all of the eosinophil-activating cytokines, such as IL-5, IL-3, and GM-CSF, are typically present in atopic diseases, including allergic asthma. As a result of the functional redundancy of these three cytokines on eosinophils and the loss of IL-5R on airway ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2015, 195(6):2529-2539]

Cited: 23 times

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XBP1, a determinant of the eosinophil lineage.

Zhong-Jian Shen, James S Malter,

Nat Immunol (Nature immunology)
[2015, 16(8):793-794]

Cited: 0 times

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RNA Seq profiling reveals a novel expression pattern of TGF-β target genes in human blood eosinophils.

Zhong-Jian Shen, Jie Hu, Stephane Esnault, Igor Dozmorov, James S Malter,

Despite major advances in our understanding of TGF-β signaling in multiple cell types, little is known about the direct target genes of this pathway in human eosinophils. These cells constitute the major inflammatory component present in the sputum and lung of active asthmatics and their numbers correlate well with disease ... Read more >>

Immunol Lett (Immunology letters)
[2015, 167(1):1-10]

Cited: 20 times

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Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours.

Dinesh Rakheja, Kenneth S Chen, Yangjian Liu, Abhay A Shukla, Vanessa Schmid, Tsung-Cheng Chang, Shama Khokhar, Jonathan E Wickiser, Nitin J Karandikar, James S Malter, Joshua T Mendell, James F Amatruda,

Wilms tumour is the most common childhood kidney cancer. Here we report the whole-exome sequencing of 44 Wilms tumours, identifying missense mutations in the microRNA (miRNA)-processing enzymes DROSHA and DICER1, and novel mutations in MYCN, SMARCA4 and ARID1A. Examination of tumour miRNA expression, in vitro processing assays and genomic editing ... Read more >>

Nat Commun (Nature communications)
[2014, 2:4802]

Cited: 101 times

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Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines.

Stephane Esnault, Elizabeth A Kelly, Mats W Johansson, Lin Ying Liu, Shih-Tsung Han, Moneeb Akhtar, Nathan Sandbo, Deane F Mosher, Loren C Denlinger, Sameer K Mathur, James S Malter, Nizar N Jarjour,

Semaphorin 7A (sema7a) plays a major role in TGF-β1-induced lung fibrosis. Based on the accumulating evidence that eosinophils contribute to fibrosis/remodeling in the airway, we hypothesized that airway eosinophils may be a significant source of sema7a. In vivo, sema7a was expressed on the surface of circulating eosinophils and upregulated on ... Read more >>

Clin Immunol (Clinical immunology (Orlando, Fla.))
[2014, 150(1):90-100]

Cited: 29 times

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Pin1 null mice exhibit low bone mass and attenuation of BMP signaling.

Zhong-Jian Shen, Jie Hu, Aktar Ali, Johanne Pastor, Kazuhiro Shiizaki, Robert D Blank, Makoto Kuro-o, James S Malter,

Bone is constantly formed and resorbed throughout life by coordinated actions of osteoblasts and osteoclasts. However, the molecular mechanisms involved in osteoblast function remain incompletely understood. Here we show, for the first time, that the peptidyl-prolyl isomerase PIN1 controls the osteogenic activity of osteoblasts. Pin1 null mice exhibited an age-dependent ... Read more >>

PLoS One (PloS one)
[2013, 8(5):e63565]

Cited: 17 times

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Identification of genes expressed by human airway eosinophils after an in vivo allergen challenge.

Stephane Esnault, Elizabeth A Kelly, Elizabeth A Schwantes, Lin Ying Liu, Larissa P DeLain, Jami A Hauer, Yury A Bochkov, Loren C Denlinger, James S Malter, Sameer K Mathur, Nizar N Jarjour,

<h4>Background</h4>The mechanism for the contribution of eosinophils (EOS) to asthma pathophysiology is not fully understood. Genome-wide expression analysis of airway EOS by microarrays has been limited by the ability to generate high quality RNA from sufficient numbers of airway EOS.<h4>Objective</h4>To identify, by genome-wide expression analyses, a compendium of expressed genes ... Read more >>

PLoS One (PloS one)
[2013, 8(7):e67560]

Cited: 32 times

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Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function.

Velusamy Rangasamy, Rajakishore Mishra, Gautam Sondarva, Subhasis Das, Tae Ho Lee, Joanna C Bakowska, Guri Tzivion, James S Malter, Basabi Rana, Kun Ping Lu, Anumantha Kanthasamy, Ajay Rana,

Nuclear protein peptidyl-prolyl isomerase Pin1-mediated prolyl isomerization is an essential and novel regulatory mechanism for protein phosphorylation. Therefore, tight regulation of Pin1 localization and catalytic activity is crucial for its normal nuclear functions. Pin1 is commonly dysregulated during oncogenesis and likely contributes to these pathologies; however, the mechanism(s) by which ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2012, 109(21):8149-8154]

Cited: 37 times

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Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.

Zhong-Jian Shen, Ruedi K Braun, Jie Hu, Qifa Xie, Haiyan Chu, Robert B Love, Levi A Stodola, Louis A Rosenthal, Renee J Szakaly, Ronald L Sorkness, James S Malter,

Interstitial pulmonary fibrosis is caused by the excess production of extracellular matrix (ECM) by Fb in response to TGF-β1. Here, we show that the peptidyl-prolyl isomerase Pin1 modulates the production of many pro- and antifibrogenic cytokines and ECM. After acute, bleomycin injury, Pin1(-/-) mice showed reduced, pulmonary expression of collagens, ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2012, 287(28):23294-23305]

Cited: 27 times

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Effect of Anticoagulants on Amyloid β-Protein Precursor and Amyloid Beta Levels in Plasma.

Cara J Westmark, Crystal M Hervey, Elizabeth M Berry-Kravis, James S Malter,

Altered levels of amyloid β-protein precursor (AβPP) and/or amyloid beta (Aβ) are characteristic of several neurological disorders including Alzheimer's disease (AD), Down syndrome (DS), Fragile X syndrome (FXS), Parkinson's disease (PD), autism and epilepsy. Thus, these proteins could serve as valuable blood-based biomarkers for assessing disease severity and pharmacological efficacy. ... Read more >>

J Alzheimers Dis Parkinsonism (Journal of Alzheimer's disease & Parkinsonism)
[2011, 1:101]

Cited: 4 times

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Transforming Growth Factor-β1 Antagonizes Interleukin-5 Pro-Survival Signaling by Activating Calpain-1 in Primary Human Eosinophils.

Qifa Xie, Zhong-Jian Shen, Jiyoung Oh, Haiyan Chu, James S Malter,

<h4>Background</h4>Eosinophils rapidly undergo apoptosis unless exposed to prosurvival cytokines such as interleukin 5 (IL-5) or granulocyte-macrophage colony stimulating factor (GM-CSF). <i>In vivo,</i> eosinophils are exposed to TGF-β 1 which can induce apoptosis suggesting it may function to counteract the effects of IL-5 or GM-CSF and limit, <i>in vivo</i> tissue eosinophilia.<h4>Objective</h4>The ... Read more >>

J Clin Cell Immunol (Journal of clinical & cellular immunology)
[2011, Suppl 1:]

Cited: 1 time

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Preparation of synaptoneurosomes from mouse cortex using a discontinuous percoll-sucrose density gradient.

Pamela R Westmark, Cara J Westmark, Athavi Jeevananthan, James S Malter,

Synaptoneurosomes (SNs) are obtained after homogenization and fractionation of mouse brain cortex. They are resealed vesicles or isolated terminals that break away from axon terminals when the cortical tissue is homogenized. The SNs retain pre- and postsynaptic characteristics, which makes them useful in the study of synaptic transmission. They retain ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2011, (55):]

Cited: 11 times

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