Full Text Journal Articles by
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Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis.

Marta Celorrio, Miguel A Abellanas, James Rhodes, Victoria Goodwin, Jennie Moritz, Sangeetha Vadivelu, Leran Wang, Rachel Rodgers, Sophia Xiao, Ilakkia Anabayan, Camryn Payne, Alexandra M Perry, Megan T Baldridge, Maria S Aymerich, Ashley Steed, Stuart H Friess,

The influence of the gut microbiota on traumatic brain injury (TBI) is presently unknown. This knowledge gap is of paramount clinical significance as TBI patients are highly susceptible to alterations in the gut microbiota by antibiotic exposure. Antibiotic-induced gut microbial dysbiosis established prior to TBI significantly worsened neuronal loss and ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2021, 9(1):40]

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Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD.

Benjamin Watkins, Muna Qayed, Courtney McCracken, Brandi Bratrude, Kayla Betz, Yvonne Suessmuth, Alison Yu, Shauna Sinclair, Scott Furlan, Steven Bosinger, Victor Tkachev, James Rhodes, Audrey Grizzle Tumlin, Alexandria Narayan, Kayla Cribbin, Scott Gillespie, Ted A Gooley, Marcelo C Pasquini, Kyle Hebert, Urvi Kapoor, Andre Rogatko, Mourad Tighiouart, Sungjin Kim, Catherine Bresee, Sung W Choi, Jeffrey Davis, Christine Duncan, Roger Giller, Michael Grimley, Andrew C Harris, David Jacobsohn, Nahal Lalefar, Maxim Norkin, Nosha Farhadfar, Michael A Pulsipher, Shalini Shenoy, Aleksandra Petrovic, Kirk R Schultz, Gregory A Yanik, Edmund K Waller, John E Levine, James L Ferrara, Bruce R Blazar, Amelia Langston, John T Horan, Leslie S Kean,

<h4>Purpose</h4>Severe (grade 3-4) acute graft-versus-host disease (AGVHD) is a major cause of death after unrelated-donor (URD) hematopoietic cell transplant (HCT), resulting in particularly high mortality after HLA-mismatched transplantation. There are no approved agents for AGVHD prevention, underscoring the critical unmet need for novel therapeutics. ABA2 was a phase II trial ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, :JCO2001086]

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N-acetylcysteine reduces brain injury after delayed hypoxemia following traumatic brain injury.

Marta Celorrio, James Rhodes, Sangeetha Vadivelu, McKenzie Davies, Stuart H Friess,

Preclinical investigations into neuroprotective agents for traumatic brain injury (TBI) have shown promise when administered before or very early after experimental TBI. However clinical trials of therapeutics demonstrating preclinical efficacy for TBI have failed to replicate these results in humans, a lost in translation phenomenon. N-acetylcysteine (NAC) is a potent ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 335:113507]

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Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA.

Ke Zhang, Dan-Ya Wu, Hui Zheng, Yao Wang, Qiao-Ran Sun, Xin Liu, Li-Yan Wang, Wen-Jing Xiong, Qiujun Wang, James D P Rhodes, Kai Xu, Lijia Li, Zili Lin, Guang Yu, Weikun Xia, Bo Huang, Zhenhai Du, Yao Yao, Kim A Nasmyth, Robert J Klose, Yi-Liang Miao, Wei Xie,

Somatic cell nuclear transfer (SCNT) can reprogram a somatic nucleus to a totipotent state. However, the re-organization of 3D chromatin structure in this process remains poorly understood. Using low-input Hi-C, we revealed that, during SCNT, the transferred nucleus first enters a mitotic-like state (premature chromatin condensation). Unlike fertilized embryos, SCNT ... Read more >>

Mol Cell (Molecular cell)
[2020, 79(2):234-250.e9]

Cited: 2 times

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Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells.

James D P Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M Brown, Nadezda A Fursova, Neil P Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K Huseyin, Aleksander Szczurek, Kai Kruse, Kim A Nasmyth, Veronica J Buckle, Juan M Vaquerizas, Robert J Klose,

How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression. Here, we examine chromosome conformation in embryonic stem cells lacking cohesin and find, as in other cell types, that ... Read more >>

Cell Rep (Cell reports)
[2020, 30(3):820-835.e10]

Cited: 18 times

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Photovoice as a promising public engagement approach: capturing and communicating ethnic minority people's lived experiences of severe mental illness and its treatment.

Kristoffer Halvorsrud, James Rhodes, Georgia Mae Webster, Joy Francis, Maria Haarmans, Natalia Dawkins, James Nazroo, Kamaldeep Bhui, ,

BMJ Open Qual (BMJ open quality)
[2019, 8(4):e000665]

Cited: 1 time

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Identifying evidence of effectiveness in the co-creation of research: a systematic review and meta-analysis of the international healthcare literature.

Kristoffer Halvorsrud, Justyna Kucharska, Katherine Adlington, Katja Rüdell, Eva Brown Hajdukova, James Nazroo, Maria Haarmans, James Rhodes, Kamaldeep Bhui,

<h4>Background</h4>To investigate and address the evidence gap on the effectiveness of co-creation/production in international health research.<h4>Methods</h4>An initial systematic search of previous reviews published by 22 July 2017 in Medline, Embase, PsycINFO, Scopus and Web of Science. We extracted reported aims, elements and outcomes of co-creation/production from 50 reviews; however, reviews ... Read more >>

J Public Health (Oxf) (Journal of public health (Oxford, England))
[2019, :]

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Readiness and the drivers of sustainable implementation of clinical pharmacy services.

James A M Rhodes, Bryan C McCarthy,

Am J Health Syst Pharm (American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists)
[2019, 76(21):1716-1717]

Cited: 0 times

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Organization of Chromosomal DNA by SMC Complexes.

Stanislau Yatskevich, James Rhodes, Kim Nasmyth,

Structural maintenance of chromosomes (SMC) complexes are key organizers of chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such as chromosome segregation, chromosome maintenance, sister chromatid cohesion, and mitotic chromosome compaction, it appears that these complexes function via highly conserved mechanisms and that they represent a novel ... Read more >>

Annu Rev Genet (Annual review of genetics)
[2019, 53:445-482]

Cited: 23 times

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Where next for understanding race/ethnic inequalities in severe mental illness? Structural, interpersonal and institutional racism.

James Y Nazroo, Kamaldeep S Bhui, James Rhodes,

In this article we use the example of race/ethnic inequalities in severe mental illness to demonstrate the utility of a novel integrative approach to theorising the role of racism in generating inequality. Ethnic minority people in the UK are at much greater risk than White British people of being diagnosed ... Read more >>

Sociol Health Illn (Sociology of health & illness)
[2020, 42(2):262-276]

Cited: 3 times

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Automated dispensing cabinet technology limitations compromise patient safety.

James A M Rhodes, Bryan C McCarthy,

Am J Health Syst Pharm (American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists)
[2019, 76(18):1372-1373]

Cited: 0 times

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Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

Gabrielle Olley, Morad Ansari, Hemant Bengani, Graeme R Grimes, James Rhodes, Alex von Kriegsheim, Ana Blatnik, Fiona J Stewart, Emma Wakeling, Nicola Carroll, Alison Ross, Soo-Mi Park, , Wendy A Bickmore, Madapura M Pradeepa, David R FitzPatrick,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Genet (Nature genetics)
[2019, 51(7):1192]

Cited: 1 time

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Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin

Ezequiel Miron, Roel Oldenkamp, Jill Brown, David Pinto, Shan Xu, Ana Faria, Haitham Shaban, Haitham Shaban, James Rhodes, Cassandravictoria Innocent, Sara de Ornellas, Harald Hess, Veronica Buckle, Lothar Schermelleh,

<h4>ABSTRACT</h4> Three-dimensional (3D) chromatin organization plays a key role in regulating mammalian genome function, however many of its physical features at the single-cell level remain underexplored. Here we use 3D super-resolution and scanning electron microscopy to analyze structural and functional nuclear organization in somatic cells. We identify linked chromatin domains ... Read more >>

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Use of Medicare Claims Data for the Identification of Myocardial Infarction: The Reasons for Geographic And Racial Differences in Stroke Study.

Lisandro D Colantonio, Emily B Levitan, Huifeng Yun, Meredith L Kilgore, James D Rhodes, George Howard, Monika M Safford, Paul Muntner,

<h4>Objectives</h4>Assess the validity of Medicare claims for identifying myocardial infarction (MI).<h4>Methods</h4>We used data from 9951 Medicare beneficiaries 65 years and above in the Reasons for Geographic And Racial Differences in Stroke study. Between 2003 and 2012, 669 participants had an MI identified and adjudicated through study procedures (ie, the gold ... Read more >>

Med Care (Medical care)
[2018, 56(12):1051-1059]

Cited: 7 times

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Altering the Speed Profiles of Wheelchair Rugby Players With Game-Simulation Drill Design.

James M Rhodes, Barry S Mason, Thomas A W Paulson, Victoria L Goosey-Tolfrey,

<h4>Purpose</h4>To examine the speed profiles of elite wheelchair rugby (WCR) players during game-simulation training drills of differing player number and shot-clock regulations. A secondary aim was to determine whether the profiles were further influenced by player classification.<h4>Methods</h4>Eight elite WCR players (low-point n = 3, high-point n = 5) were monitored using a radio-frequency-based indoor ... Read more >>

Int J Sports Physiol Perform (International journal of sports physiology and performance)
[2018, 13(1):37-43]

Cited: 1 time

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Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

Gabrielle Olley, Morad Ansari, Hemant Bengani, Graeme R Grimes, James Rhodes, Alex von Kriegsheim, Ana Blatnik, Fiona J Stewart, Emma Wakeling, Nicola Carroll, Alison Ross, Soo-Mi Park, Wendy A Bickmore, Madapura M Pradeepa, David R FitzPatrick, ,

In the version of this article initially published, Wendy Bickmore and Madapura Pradeepa were incorrectly not indicated as corresponding authors. The error has been corrected in the HTML and PDF versions of the paper. ... Read more >>

Nat Genet (Nature genetics)
[2018, 50(5):767]

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BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

Gabrielle Olley, Morad Ansari, Hemant Bengani, Graeme R Grimes, James Rhodes, Alex von Kriegsheim, Ana Blatnik, Fiona J Stewart, Emma Wakeling, Nicola Carroll, Alison Ross, Soo-Mi Park, , Wendy A Bickmore, Madapura M Pradeepa, David R FitzPatrick,

We found that the clinical phenotype associated with BRD4 haploinsufficiency overlapped with that of Cornelia de Lange syndrome (CdLS), which is most often caused by mutation of NIPBL. More typical CdLS was observed with a de novo BRD4 missense variant, which retained the ability to coimmunoprecipitate with NIPBL, but bound ... Read more >>

Nat Genet (Nature genetics)
[2018, 50(3):329-332]

Cited: 17 times

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Scc2/Nipbl hops between chromosomal cohesin rings after loading

James D.P. Rhodes, Davide Mazza, Kim Nasmyth, Stephan Uphoff,

The cohesin complex mediates DNA-DNA interactions both between (sister chromatid cohesion) and within chromosomes (DNA looping) via a process thought to involve entrapment of DNAs within its tripartite ring. It has been suggested that intra- chromosome loops are generated through processive extrusion of DNAs through the lumen of cohesin’s ring. ... Read more >>

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Cohesin can remain associated with chromosomes during DNA replication

James Rhodes, Judith Haarhuis, Jonathan Grimm, Benjamin Rowland, Luke Lavis, Kim Nasmyth,

<h4>Summary</h4> To ensure disjunction to opposite poles during anaphase, sister chromatids must be held together following DNA replication. This is mediated by cohesin, which is thought to entrap sister DNAs inside a tripartite ring composed of its Smc and kleisin (Scc1) subunits. How such structures are created during S phase ... Read more >>

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Large-Vessel Vasculopathy in Children With Sickle Cell Disease: A Magnetic Resonance Imaging Study of Infarct Topography and Focal Atrophy.

Kristin P Guilliams, Melanie E Fields, Dustin K Ragan, Yasheng Chen, Cihat Eldeniz, Monica L Hulbert, Michael M Binkley, James N Rhodes, Joshua S Shimony, Robert C McKinstry, Katie D Vo, Hongyu An, Jin-Moo Lee, Andria L Ford,

<h4>Background</h4>Large-vessel vasculopathy (LVV) increases stroke risk in pediatric sickle cell disease beyond the baseline elevated stroke risk in this vulnerable population. The mechanisms underlying this added risk and its unique impact on the developing brain are not established.<h4>Methods</h4>We analyzed magnetic resonance imaging and angiography scans of 66 children with sickle ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2017, 69:49-57]

Cited: 13 times

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A Comparison of Speed Profiles During Training and Competition in Elite Wheelchair Rugby Players.

James M Rhodes, Barry S Mason, Thomas A W Paulson, Victoria L Goosey-Tolfrey,

<h4>Purpose</h4>To investigate the speed profiles of individual training modes in comparison with wheelchair rugby (WCR) competition across player classifications.<h4>Methods</h4>Speed profiles of 15 international WCR players were determined using a radio-frequency-based indoor tracking system. Mean and peak speed (m/s), work:rest ratios, and the relative time spent in (%) and number of ... Read more >>

Int J Sports Physiol Perform (International journal of sports physiology and performance)
[2017, 12(6):777-782]

Cited: 2 times

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Copovidone-related Cutaneous Response in the Dog.

Sherry J Morgan, Lauren M Besenhofer, Wayne Buck, Helga Lorenz, James W Rhodes, Yi Yang,

A cutaneous response (localized swelling and/or erythema of the skin) has been noted in dog toxicology studies in which multiple, unrelated compounds were administered orally with copovidone as a vehicle. The response has been noted in studies with 6 different test items that are structurally unrelated and span several different ... Read more >>

Toxicol Pathol (Toxicologic pathology)
[2017, 45(1):84-89]

Cited: 0 times

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Medicare claims indicators of healthcare utilization differences after hospitalization for ischemic stroke: Race, gender, and caregiving effects.

David L Roth, Orla C Sheehan, Jin Huang, James D Rhodes, Suzanne E Judd, Meredith Kilgore, Brett Kissela, Janet Prvu Bettger, William E Haley,

Background Differences in healthcare utilization after stroke may partly explain race or gender differences in stroke outcomes and identify factors that might reduce post-acute stroke care costs. Aim To examine systematic differences in Medicare claims for healthcare utilization after hospitalization for ischemic stroke in a US population-based sample. Methods Claims ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2016, 11(8):928-934]

Cited: 13 times

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Individualized Internal and External Training Load Relationships in Elite Wheelchair Rugby Players.

Thomas A W Paulson, Barry Mason, James Rhodes, Victoria L Goosey-Tolfrey,

<h4>Aim</h4>The quantification and longitudinal monitoring of athlete training load (TL) provides a scientific explanation for changes in performance and helps manage injury/illness risk. Therefore, accurate and reliable monitoring tools are essential for the optimization of athletic performance. The aim of the present study was to establish the relationship between measures ... Read more >>

Front Physiol (Frontiers in physiology)
[2015, 6:388]

Cited: 8 times

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Effect of team rank and player classification on activity profiles of elite wheelchair rugby players.

James M Rhodes, Barry S Mason, Laurie A Malone, Victoria L Goosey-Tolfrey,

The aim of the current study was to establish which indicators of mobility are associated with successful wheelchair rugby performance and determine whether these indicators differed across classification. Data were collected from 11 international teams during 30 matches (353 match observations) using a radio-frequency-based, indoor tracking system across two tournaments. ... Read more >>

J Sports Sci (Journal of sports sciences)
[2015, 33(19):2070-2078]

Cited: 9 times

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