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Health of war-affected Karen adults 5 years post-resettlement.

Sarah J Hoffman, Patricia J Shannon, Tonya L Horn, James Letts, Michelle A Mathiason,

<h4>Background</h4>An estimated 140 000 refugees from Burma have resettled to the USA since 2009, comprising 21% of total resettlement in the USA over the last decade. Our objective was to describe patterns of longitudinal health outcomes in a cohort of Karen refugees resettled in the USA for 5 years, and ... Read more >>

Fam Pract (Family practice)
[2021, 38(4):403-409]

Cited: 1 time

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Intensive psychotherapy and case management for Karen refugees with Major Depression in primary care: a pragmatic randomized control trial

Andrea Northwood, Maria Vukovich, Alison Beckman, Jeffrey Walter, Novia Josiah, Leora Hudak, Kathleen O’Donnell Burrows, James Letts, Christine Danner,

<h4>Background: </h4> Despite an unparalleled global refugee crisis, there are almost no studies in primary care addressing real-world conditions and longer courses of treatment that are typical when resettled refugees present to their physician with critical psychosocial needs and complex symptoms. We studied the effects of a year of psychotherapy ... Read more >>

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Intensive psychotherapy and case management for Karen refugees with major depression in primary care: a pragmatic randomized control trial.

Andrea K Northwood, Maria M Vukovich, Alison Beckman, Jeffrey P Walter, Novia Josiah, Leora Hudak, Kathleen O'Donnell Burrows, James P Letts, Christine C Danner,

BACKGROUND:Despite an unparalleled global refugee crisis, there are almost no studies in primary care addressing real-world conditions and longer courses of treatment that are typical when resettled refugees present to their physician with critical psychosocial needs and complex symptoms. We studied the effects of a year of psychotherapy and case ... Read more >>

BMC Fam Pract (BMC family practice)
[2020, 21(1):17]

Cited: 2 times

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Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases.

Susannah M L Gagnon, Max S G Legg, Robert Polakowski, James A Letts, Mattias Persson, Shuangjun Lin, Ruixiang Blake Zheng, Brian Rempel, Brock Schuman, Omid Haji-Ghassemi, Svetlana N Borisova, Monica M Palcic, Stephen V Evans,

Homologous glycosyltransferases GTA and GTB perform the final step in human ABO(H) blood group A and B antigen synthesis by transferring the sugar moiety from donor UDP-GalNAc/UDP-Gal to the terminal H antigen disaccharide acceptor. Like other GT-A fold family 6 glycosyltransferases, GTA and GTB undergo major conformational changes in two ... Read more >>

Glycobiology (Glycobiology)
[2018, 28(8):624-636]

Cited: 2 times

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Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain.

James A Letts, Leonid A Sazanov,

The oxidative phosphorylation electron transport chain (OXPHOS-ETC) of the inner mitochondrial membrane is composed of five large protein complexes, named CI-CV. These complexes convert energy from the food we eat into ATP, a small molecule used to power a multitude of essential reactions throughout the cell. OXPHOS-ETC complexes are organized ... Read more >>

Nat Struct Mol Biol (Nature structural & molecular biology)
[2017, 24(10):800-808]

Cited: 79 times

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High-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release.

Susannah M L Gagnon, Max S G Legg, Nora Sindhuwinata, James A Letts, Asha R Johal, Brock Schuman, Svetlana N Borisova, Monica M Palcic, Thomas Peters, Stephen V Evans,

The human ABO(H) blood group A- and B-synthesizing glycosyltransferases GTA and GTB have been structurally characterized to high resolution in complex with their respective trisaccharide antigen products. These findings are particularly timely and relevant given the dearth of glycosyltransferase structures collected in complex with their saccharide reaction products. GTA and ... Read more >>

Glycobiology (Glycobiology)
[2017, 27(10):966-977]

Cited: 3 times

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Glycosyltransfer in mutants of putative catalytic residue Glu303 of the human ABO(H) A and B blood group glycosyltransferases GTA and GTB proceeds through a labile active site.

Ryan J Blackler, Susannah M L Gagnon, Robert Polakowski, Natisha L Rose, Ruixiang B Zheng, James A Letts, Asha R Johal, Brock Schuman, Svetlana N Borisova, Monica M Palcic, Stephen V Evans,

The homologous glycosyltransferases α-1,3-N-acetylgalactosaminyltransferase (GTA) and α-1,3-galactosyltransferase (GTB) carry out the final synthetic step of the closely related human ABO(H) blood group A and B antigens. The catalytic mechanism of these model retaining enzymes remains under debate, where Glu303 has been suggested to act as a putative nucleophile in a ... Read more >>

Glycobiology (Glycobiology)
[2017, 27(4):370-380]

Cited: 4 times

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The architecture of respiratory supercomplexes.

James A Letts, Karol Fiedorczuk, Leonid A Sazanov,

Mitochondrial electron transport chain complexes are organized into supercomplexes responsible for carrying out cellular respiration. Here we present three architectures of mammalian (ovine) supercomplexes determined by cryo-electron microscopy. We identify two distinct arrangements of supercomplex CICIII<sub>2</sub>CIV (the respirasome)-a major 'tight' form and a minor 'loose' form (resolved at the resolution ... Read more >>

Nature (Nature)
[2016, 537(7622):644-648]

Cited: 175 times

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Gaining mass: the structure of respiratory complex I-from bacterial towards mitochondrial versions.

James A Letts, Leonid A Sazanov,

The 1MDa, 45-subunit proton-pumping NADH-ubiquinone oxidoreductase (complex I) is the largest complex of the mitochondrial electron transport chain. The molecular mechanism of complex I is central to the metabolism of cells, but has yet to be fully characterized. The last two years have seen steady progress towards this goal with ... Read more >>

Curr Opin Struct Biol (Current opinion in structural biology)
[2015, 33:135-145]

Cited: 15 times

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War trauma and torture experiences reported during public health screening of newly resettled Karen refugees: a qualitative study.

Tonya L Cook, Patricia J Shannon, Gregory A Vinson, James P Letts, Ehtaw Dwee,

<h4>Background</h4>Karen refugees have suffered traumatic experiences that affect their physical and mental health in resettlement. The United States Centers for Disease Control and Prevention recommends assessing traumatic histories and mental health symptoms during initial public health screening. This article reports the traumatic experiences that Karen refugees were able to describe ... Read more >>

BMC Int Health Hum Rights (BMC international health and human rights)
[2015, 15:8]

Cited: 4 times

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The antigen-binding site of an N-propionylated polysialic acid-specific antibody protective against group B meningococci is consistent with extended epitopes.

Asha R Johal, Harold C Jarrell, James A Letts, Nam Huan Khieu, Roxanne C Landry, Wojciech Jachymek, Qingling Yang, Harold J Jennings, Jean-Robert Brisson, Stephen V Evans,

Monoclonal antibodies 13D9 and 6B9 are both specific for N-propionylated polysialic acid (NPrPSA); however, while 13D9 is protective against meningitis caused by group B meningococci and Escherichia coli capsular type K1 infection, 6B9 is not. The crystal structures of the Fabs from the two antibodies determined at 2.06 and 2.45 ... Read more >>

Glycobiology (Glycobiology)
[2013, 23(8):946-954]

Cited: 4 times

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Caring for the Karen. A newly arrived refugee group.

David V Power, Emily Moody, Kristi Trussell, Ann O'Fallon, Sara Chute, Merdin Kyaw, James Letts, Blain Mamo,

Since 2004, Minnesota has seen an influx of refugees from Burma. Many of these newcomers came from the Karen state and spent time in refugee camps in Thailand before resettling in the United States. To better understand the health needs of this population, the authors of this article conducted chart ... Read more >>

Minn Med (Minnesota medicine)
[2010, 93(4):49-53]

Cited: 2 times

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Magnetic resonance imaging of partial segmental priapism (segmental thrombosis of corpus cavernosum).

Sean D Galvin, James A Letts, Narayanan R Sampangi,

Partial segment priapism or segmental thrombosis of the corpus cavernosum is a rare urologic condition reported 23 times in the world literature. We present the clinical and radiologic findings of a 22-year-old man who presented 7 days after the onset of symptoms in whom the diagnosis was confirmed with magnetic ... Read more >>

Urology (Urology)
[2009, 73(2):275-276]

Cited: 7 times

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Functional reconstitution of purified human Hv1 H+ channels.

Seok-Yong Lee, James A Letts, Roderick MacKinnon,

Voltage-dependent H(+) (Hv) channels mediate proton conduction into and out of cells under the control of membrane voltage. Hv channels are unusual compared to voltage-dependent K(+), Na(+), and Ca(2+) channels in that Hv channel genes encode a voltage sensor domain (VSD) without a pore domain. The H(+) currents observed when ... Read more >>

J Mol Biol (Journal of molecular biology)
[2009, 387(5):1055-1060]

Cited: 69 times

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Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1.

Seok-Yong Lee, James A Letts, Roderick Mackinnon,

In voltage-gated Na(+), K(+), and Ca(2+) channels, four voltage-sensor domains operate on a central pore domain in response to membrane voltage. In contrast, the voltage-gated proton channel (Hv) contains only a voltage-sensor domain, lacking a separate pore domain. The subunit stoichiometry and organization of Hv has been unknown. Here, we ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2008, 105(22):7692-7695]

Cited: 120 times

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Structural basis for red cell phenotypic changes in newly identified, naturally occurring subgroup mutants of the human blood group B glycosyltransferase.

Bahram Hosseini-Maaf, James A Letts, Mattias Persson, Elizabeth Smart, Pierre-Yves LePennec, Hein Hustinx, Zhihon Zhao, Monica M Palcic, Stephen V Evans, M Alan Chester, Martin L Olsson,

<h4>Background</h4>Four amino-acid-changing polymorphisms differentiate the blood group A and B alleles. Multiple missense mutations are associated with weak expression of A and B antigens but the structural changes causing subgroups have not been studied.<h4>Study design and methods</h4>Individuals or families having serologically weak B antigen on their red cells were studied. ... Read more >>

Transfusion (Transfusion)
[2007, 47(5):864-875]

Cited: 16 times

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ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes.

Javier A Alfaro, Ruixiang Blake Zheng, Mattias Persson, James A Letts, Robert Polakowski, Yu Bai, Svetlana N Borisova, Nina O L Seto, Todd L Lowary, Monica M Palcic, Stephen V Evans,

The final step in the enzymatic synthesis of the ABO(H) blood group A and B antigens is catalyzed by two closely related glycosyltransferases, an alpha-(1-->3)-N-acetylgalactosaminyltransferase (GTA) and an alpha-(1-->3)-galactosyltransferase (GTB). Of their 354 amino acid residues, GTA and GTB differ by only four "critical" residues. High resolution structures for GTB ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2008, 283(15):10097-10108]

Cited: 51 times

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Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif.

Mattias Persson, James A Letts, Bahram Hosseini-Maaf, Svetlana N Borisova, Monica M Palcic, Stephen V Evans, Martin L Olsson,

Human blood group A and B antigens are produced by two closely related glycosyltransferase enzymes. An N-acetylgalactosaminyltransferase (GTA) utilizes UDP-GalNAc to extend H antigen acceptors (Fuc alpha(1-2)Gal beta-OR) producing A antigens, whereas a galactosyltransferase (GTB) utilizes UDP-Gal as a donor to extend H structures producing B antigens. GTA and GTB ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2007, 282(13):9564-9570]

Cited: 12 times

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The effect of heavy atoms on the conformation of the active-site polypeptide loop in human ABO(H) blood-group glycosyltransferase B.

James A Letts, Mattias Persson, Brock Schuman, Svetlana N Borisova, Monica M Palcic, Stephen V Evans,

The human ABO(H) blood-group antigens are oligosaccharide structures that are expressed on erythrocyte and other cell surfaces. The terminal carbohydrate residue differs between the blood types and determines the immune reactivity of this antigen. Individuals with blood type A have a terminal N-acetylgalactosamine residue and those with blood type B ... Read more >>

Acta Crystallogr D Biol Crystallogr (Acta crystallographica. Section D, Biological crystallography)
[2007, 63(Pt 8):860-865]

Cited: 8 times

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Differential recognition of the type I and II H antigen acceptors by the human ABO(H) blood group A and B glycosyltransferases.

James A Letts, Natisha L Rose, Ying R Fang, Christopher H Barry, Svetlana N Borisova, Nina O L Seto, Monica M Palcic, Stephen V Evans,

The human ABO(H) blood group A and B antigens are generated by the homologous glycosyltransferases A (GTA) and B (GTB), which add the monosaccharides GalNAc and Gal, respectively, to the cell-surface H antigens. In the first comprehensive structural study of the recognition by a glycosyltransferase of a panel of substrates ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2006, 281(6):3625-3632]

Cited: 28 times

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