Full Text Journal Articles by
Author James Keane

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Gut microbiome patterns depending on children's psychosocial stress: Reports versus biomarkers.

Nathalie Michels, Tom Van de Wiele, Fiona Fouhy, Siobhain O'Mahony, Gerard Clarke, James Keane,

AIM:Chronic stress increases disease vulnerability factors including inflammation, a pathological characteristic potentially regulated by the gut microbiota. We checked the association between the gut microbiome and psychosocial stress in children/adolescents and investigated which stress parameter (negative versus positive emotion, self-report versus parental report, events versus emotions, biomarker cortisol versus parasympathetic ... Read more >>

Brain Behav. Immun. (Brain, behavior, and immunity)
[2019, 80:751-762]

Cited: 0 times

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Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout.

William B White, Kenneth G Saag, Michael A Becker, Jeffrey S Borer, Philip B Gorelick, Andrew Whelton, Barbara Hunt, Majin Castillo, Lhanoo Gunawardhana, ,

BACKGROUND:Cardiovascular risk is increased in patients with gout. We compared cardiovascular outcomes associated with febuxostat, a nonpurine xanthine oxidase inhibitor, with those associated with allopurinol, a purine base analogue xanthine oxidase inhibitor, in patients with gout and cardiovascular disease. METHODS:We conducted a multicenter, double-blind, noninferiority trial involving patients with gout ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2018, 378(13):1200-1210]

Cited: 64 times

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Ring faults and ring dikes around the Orientale basin on the Moon.

Jeffrey C Andrews-Hanna, James W Head, Brandon Johnson, James T Keane, Walter S Kiefer, Patrick J McGovern, Gregory A Neumann, Mark A Wieczorek, Maria T Zuber,

The Orientale basin is the youngest and best-preserved multiring impact basin on the Moon, having experienced only modest modification by subsequent impacts and volcanism. Orientale is often treated as the type example of a multiring basin, with three prominent rings outside of the inner depression: the Inner Rook Montes, the ... Read more >>

Icarus (Icarus)
[2018, 310:1-20]

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Observation of Dog-Ear Regression by Anatomical Location.

Thomas A Jennings, James C Keane, Rajat Varma, Stephanie B Walsh, Conway C Huang,

BACKGROUND:When an excision is performed by a method other than elliptical excision, direct primary wound closure can result in standing cones or "dog-ears." In 2008, Lee and colleagues noted that dog-ears of <8 mm in height have a statistically greater tendency to resolve without further surgical correction than larger dog-ears. ... Read more >>

Dermatol Surg (Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.])
[2017, 43(11):1367-1370]

Cited: 1 time

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Decrease of DHEA-S concentration succeeding a micro-dose thumb exertion: mood-state determinants reflect stress-biomarker responses.

Adam Michael Szlezak, Lotti Tajouri, Siri Lauluten Szlezak, James Keane, Clare Minahan,

The present study examined the effect of a micro-dose of resistance-exercise on serum DHEA-S, IL-6 and mood-state determinants. Potential relationships between mood and the biomarkers were also studied with the aim of directing research on non-invasive exercise-monitoring methods.30 male participants (20 weightlifting-trained; 10 untrained) were separated into 3 groups of ... Read more >>

Springerplus (SpringerPlus)
[2016, 5(1):1446]

Cited: 0 times

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Formation of the Orientale lunar multiring basin.

Brandon C Johnson, David M Blair, Gareth S Collins, H Jay Melosh, Andrew M Freed, G Jeffrey Taylor, James W Head, Mark A Wieczorek, Jeffrey C Andrews-Hanna, Francis Nimmo, James T Keane, Katarina Miljković, Jason M Soderblom, Maria T Zuber,

Multiring basins, large impact craters characterized by multiple concentric topographic rings, dominate the stratigraphy, tectonics, and crustal structure of the Moon. Using a hydrocode, we simulated the formation of the Orientale multiring basin, producing a subsurface structure consistent with high-resolution gravity data from the Gravity Recovery and Interior Laboratory (GRAIL) ... Read more >>

Science (Science (New York, N.Y.))
[2016, 354(6311):441-444]

Cited: 2 times

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Reorientation and faulting of Pluto due to volatile loading within Sputnik Planitia.

James T Keane, Isamu Matsuyama, Shunichi Kamata, Jordan K Steckloff,

Pluto is an astoundingly diverse, geologically dynamic world. The dominant feature is Sputnik Planitia-a tear-drop-shaped topographic depression approximately 1,000 kilometres in diameter possibly representing an ancient impact basin. The interior of Sputnik Planitia is characterized by a smooth, craterless plain three to four kilometres beneath the surrounding rugged uplands, and ... Read more >>

Nature (Nature)
[2016, 540(7631):90-93]

Cited: 2 times

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Gravity field of the Orientale basin from the Gravity Recovery and Interior Laboratory Mission.

Maria T Zuber, David E Smith, Gregory A Neumann, Sander Goossens, Jeffrey C Andrews-Hanna, James W Head, Walter S Kiefer, Sami W Asmar, Alexander S Konopliv, Frank G Lemoine, Isamu Matsuyama, H Jay Melosh, Patrick J McGovern, Francis Nimmo, Roger J Phillips, Sean C Solomon, G Jeffrey Taylor, Michael M Watkins, Mark A Wieczorek, James G Williams, Johanna C Jansen, Brandon C Johnson, James T Keane, Erwan Mazarico, Katarina Miljković, Ryan S Park, Jason M Soderblom, Dah-Ning Yuan,

The Orientale basin is the youngest and best-preserved major impact structure on the Moon. We used the Gravity Recovery and Interior Laboratory (GRAIL) spacecraft to investigate the gravitational field of Orientale at 3- to 5-kilometer (km) horizontal resolution. A volume of at least (3.4 ± 0.2) × 106 km3 of ... Read more >>

Science (Science (New York, N.Y.))
[2016, 354(6311):438-441]

Cited: 3 times

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Establishing a dose-response relationship between acute resistance-exercise and the immune system: Protocol for a systematic review.

Adam Michael Szlezak, Siri Lauluten Szlezak, James Keane, Lotti Tajouri, Clare Minahan,

Exercise immunology research has traditionally focussed on aerobic-exercise, however it has become apparent in more recent years that resistance-exercise can also considerably affect host immunobiology. To date however, no systematic process has been used to establish a dose-response relationship between resistance-exercise and the immune system. The present systematic review was ... Read more >>

Immunol. Lett. (Immunology letters)
[2016, 180:54-65]

Cited: 2 times

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Recombinant human growth hormone and insulin-like growth factor-1 do not affect mitochondrial derived highly reactive oxygen species production in peripheral blood mononuclear cells under conditions of substrate saturation in-vitro.

James Keane, Lotti Tajouri, Bon Gray,

The purpose of this study was to investigate the mitochondrial effects exerted by physiological and supra-physiological concentrations of recombinant human growth hormone (rhGH) and recombinant insulin-like growth factor-1 (rIGF-1) under conditions of substrate saturation in peripheral blood mononuclear cells (PBMCs).PBMCs from healthy male subjects were treated with either rhGH, at ... Read more >>

Nutr Metab (Lond) (Nutrition & metabolism)
[2016, 13:45]

Cited: 2 times

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Utility of Wood's light in margin determination of melanoma in situ after excisional biopsy.

Stephanie B Walsh, Rajat Varma, David Raimer, James Cooper Keane, Alan Cantor, Amy Theos, Marian Northington, Conway C Huang,

BACKGROUND: Margin evaluation of melanoma in situ (MIS) is difficult because of its ill-defined clinical borders. Wood's light examination is commonly used to help delineate MIS margin before excision. OBJECTIVE: To prospectively study the accuracy of preoperative Wood's light examination for margin assessment of MIS. MATERIALS AND METHODS: The authors ... Read more >>

Dermatol Surg (Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.])
[2015, 41(5):572-578]

Cited: 2 times

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The effect of recombinant human growth hormone and insulin-like growth factor-1 on the mitochondrial function and viability of peripheral blood mononuclear cells in vitro.

James Keane, Lotti Tajouri, Bon Gray,

This study investigated whether the putative physiological benefits induced by growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are countered at supra-physiological concentrations because of an augmentation in the production of mitochondrial-derived free radicals with a subsequent increase in oxidative damage, compromising mitochondrial function. To test this hypothesis, peripheral blood ... Read more >>

Appl Physiol Nutr Metab (Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme)
[2015, 40(2):105-115]

Cited: 4 times

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Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Ekua W Brenu, Mieke L van Driel, Don R Staines, Kevin J Ashton, Sandra B Ramos, James Keane, Nancy G Klimas, Sonya M Marshall-Gradisnik,

BACKGROUND: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is characterised by severe prolonged fatigue, and decreases in cognition and other physiological functions, resulting in severe loss of quality of life, difficult clinical management and high costs to the health care system. To date there is no proven pathomechanism to satisfactorily explain this ... Read more >>

J Transl Med (Journal of translational medicine)
[2011, 9:81]

Cited: 100 times

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Assessment of oxidant susceptibility of red blood cells in various species based on cell deformability.

Michael J Simmonds, Herbert J Meiselman, Sonya M Marshall-Gradisnik, Michael Pyne, Michael Kakanis, James Keane, Ekua Brenu, Rhys Christy, Oguz K Baskurt,

The present study was designed to investigate the oxidant susceptibility of red blood cells (RBC) from four species (echidna, human, koala, Tasmanian devil) based on changes in cellular deformability. These species were specifically chosen based on differences in lifestyle and/or biology associated with varied levels of oxidative stress. The major ... Read more >>

Biorheology (Biorheology)
[2011, 48(5):293-304]

Cited: 8 times

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Third nerve palsy: analysis of 1400 personally-examined inpatients.

James R Keane,

BACKGROUND:Most studies of third nerve palsy (TNP) antedate computerized imaging and focus primarily on chart review of referral outpatients. METHODS:To compare a large contrasting population, I reviewed 1400 personally-examined municipal hospital inpatients with TNPs seen over 37 years. RESULTS:TNPs were bilateral in 11%, complete in 33%, without other neurological signs ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2010, 37(5):662-670]

Cited: 28 times

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Hiccups due to central nervous system disease: analysis of 71 inpatients.

James R Keane,

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2010, 37(6):870-872]

Cited: 3 times

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Piecing together a picture of trisomy 8 mosaicism syndrome.

Nathan Edward Hale, James F Keane,

Relatively few cases of trisomy 8 mosaicism syndrome (T8mS) are documented in the medical literature. It is a rare genetic condition characterized by extreme phenotypic variability--ranging from severe congenital malformations to minute dysmorphic changes. The authors describe a case of T8mS in a man aged 33 years who presented with ... Read more >>

J Am Osteopath Assoc (The Journal of the American Osteopathic Association)
[2010, 110(1):21-23]

Cited: 6 times

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Bilateral ocular paralysis: analysis of 31 inpatients.

James R Keane,

To my knowledge, no general study of complete ophthalmoplegia is available. This study was performed to determine the seats and causes of bilateral ocular paralysis. The personal records of 13 440 neurology and neurosurgery inpatients were reviewed. Eighteen (58%) of 31 patients had Fisher syndrome (13 cases) or Guillain-Barré syndrome ... Read more >>

Arch. Neurol. (Archives of neurology)
[2007, 64(2):178-180]

Cited: 14 times

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Triplopia: thirteen patients from a neurology inpatient service.

James R Keane,

BACKGROUND: Seeing triple is a rare complaint, so anatomically unlikely that it is often considered a diagnostic symptom of hysteria. OBJECTIVE: To evaluate the complaint of triple vision among a large group of neurological inpatients. DESIGN: Personal case series during a 34-year period. SETTING: Neurology and neurosurgery wards of the ... Read more >>

Arch. Neurol. (Archives of neurology)
[2006, 63(3):388-389]

Cited: 0 times

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Multiple cranial nerve palsies: analysis of 979 cases.

James R Keane,

BACKGROUND: To my knowledge, no large series of multiple cranial neuropathies is available. OBJECTIVES: To examine the seats and causes of multiple cranial neuropathies in a large group of inpatients. DESIGN: Personal case series. SETTING: Wards of a large municipal hospital and affiliated rehabilitation hospital. PATIENTS: A consecutive series of ... Read more >>

Arch. Neurol. (Archives of neurology)
[2005, 62(11):1714-1717]

Cited: 36 times

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Internuclear ophthalmoplegia: unusual causes in 114 of 410 patients.

James R Keane,

Internuclear ophthalmoplegia (INO) is a sign of exquisite localizing value, often due to either multiple sclerosis or infarction. To demonstrate that unusual causes of INO are more common than the 11% reported in previous series, this review considers a case series of 410 inpatients whom I personally examined during a ... Read more >>

Arch. Neurol. (Archives of neurology)
[2005, 62(5):714-717]

Cited: 35 times

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Bilateral involvement of a single cranial nerve: analysis of 578 cases.

James R Keane,

The author reviewed 34 years of personal experience with inpatients in a large municipal hospital to analyze the seats and causes of involvement of single pairs of cranial nerves. Among 578 cases, the sixth (n = 234) and second (211) nerves predominated, followed by the fourth (48), seventh (30), third ... Read more >>

Neurology (Neurology)
[2005, 65(6):950-952]

Cited: 5 times

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Fixed eyelid due to metastatic breast cancer.

James R Keane,

Arch. Neurol. (Archives of neurology)
[2005, 62(2):327]

Cited: 0 times

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Right ventricle-sparing heart transplantation effective against iatrogenic pulmonary hypertension.

Constantinos Lovoulos, Shawn Tittle, Lee Goldstein, David J Austin, Simran Singh, Edward Rocco, James Keane, Ping Tang, Gary S Kopf, John A Elefteriades,

BACKGROUND: Right heart failure is the predominant cause of death following heart transplantation, occurring with disturbingly high frequency in patients with severe antecedent pulmonary hypertension. We have recently reported a novel technique of heart transplantation that spares the recipient right ventricle, excising only the recipient left ventricle. The resulting model ... Read more >>

J. Heart Lung Transplant. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2004, 23(2):236-241]

Cited: 4 times

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Tectal fourth nerve palsy due to infarction.

James R Keane,

Arch. Neurol. (Archives of neurology)
[2004, 61(2):280]

Cited: 4 times

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