Full Text Journal Articles by
Author James K Burmester


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Clinical Factors Affecting Bevacizumab Efficacy With and Without Conventional Chemotherapy in Metastatic Colon Cancer.

Rezwan Islam, Rafiullah Khan, Asad Ali, Vidya Kollu, TramAnh Phan, Po-Huang Chyou, James K Burmester, Muhammad G Kibriya,

<h4>Purpose</h4>Bevacizumab (BZ) combined with first line chemotherapy (CC) has shown good clinical outcomes in metastatic colorectal cancer (mCRC). Overall survival (OS) and/or progression free survival in mCRC patients receiving BZ with or without 5FU-based CC is thought to be affected by clinical and morphological factor(s).<h4>Patients and methods</h4>We reviewed retrospective medical ... Read more >>

Am J Ther (American journal of therapeutics)
[2020, 27(5):e500-e506]

Cited: 0 times

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Developing Research Priorities for Prediction and Prevention of Preterm Birth.

William A Agger, Charles W Schauberger, James K Burmester, Sanjay K Shukla,

Clin Med Res (Clinical medicine & research)
[2016, 14(3-4):123-125]

Cited: 1 time

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A SMAD4 mutation indicative of juvenile polyposis syndrome in a family previously diagnosed with Menetrier's disease.

James K Burmester, Lauren N Bell, Deanna Cross, Patrick Meyer, Steven H Yale,

<h4>Background</h4>Menetrier's disease (MD) is a rare disease with unknown aetiology, characterized by hypertrophic folds within the fundus and body of the stomach.<h4>Aims</h4>We investigated mutations of the candidate genes SMAD4, BMPR1A, TGF-α, and PDX1 within a family with MD.<h4>Methods</h4>A large 4-generation family with MD was identified. This family had 5 cases ... Read more >>

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2016, 48(10):1255-1259]

Cited: 2 times

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Genome-wide association study of warfarin maintenance dose in a Brazilian sample.

Esteban J Parra, Mariana R Botton, Jamila A Perini, S Krithika, Stephane Bourgeois, Todd A Johnson, Tatsuhiko Tsunoda, Munir Pirmohamed, Mia Wadelius, Nita A Limdi, Larisa H Cavallari, James K Burmester, Allan E Rettie, Teri E Klein, Julie A Johnson, Mara H Hutz, Guilherme Suarez-Kurtz,

<h4>Aim</h4>Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians.<h4>Methods</h4>Patients receiving low (≤ 20 mg/week; n = 180) or high stable warfarin doses (≥ 42.5 mg/week; n = 187) were genotyped with Affymetrix Axiom(®) Biobank arrays. Imputation ... Read more >>

Pharmacogenomics (Pharmacogenomics)
[2015, 16(11):1253-1263]

Cited: 14 times

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Epidemiologic factors and urogenital infections associated with preterm birth in a midwestern U.S. population.

William A Agger, Danish Siddiqui, Steven D Lovrich, Steven M Callister, Andrew J Borgert, Kenneth W Merkitch, Tina C Mason, Dennis J Baumgardner, James K Burmester, Sanjay K Shukla, Joseph D Welter, Katharina S Stewart, M J Washburn, Howard H Bailey,

<h4>Objective</h4>To correlate epidemiologic factors with urogenital infections associated with preterm birth.<h4>Methods</h4>Pregnant women were sequentially included from four Wisconsin cohorts: large urban, midsize urban, small city, and rural city. Demographic, clinical, and current pregnancy data were collected. Cervical and urine specimens were analyzed by microscopy, culture, and polymerase chain reaction for ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2014, 124(5):969-977]

Cited: 15 times

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Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases.

Robert L Davis, Mia A Gallagher, Maryam M Asgari, Melody J Eide, David J Margolis, Eric Macy, James K Burmester, Nandini Selvam, Joseph A Boscarino, Lee F Cromwell, Heather S Feigelson, Jennifer L Kuntz, Pamala A Pawloski, Robert B Penfold, Marsha A Raebel, Gayathri Sridhar, Ann Wu, Lois A La Grenade, Michael A Pacanowski, Simone P Pinheiro,

<h4>Background</h4>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) carry a high mortality risk. While identifying clinical and genetic risk factors for these conditions has been hindered by their rarity, large electronic health databases hold promise for identifying large numbers of cases for study, especially with the introduction in 2008 of ... Read more >>

Pharmacoepidemiol Drug Saf (Pharmacoepidemiology and drug safety)
[2015, 24(7):684-692]

Cited: 17 times

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Factors that affect rate of INR decline after warfarin discontinuation.

James K Burmester, Richard L Berg, John R Schmelzer, Joseph J Mazza, Steven H Yale,

<h4>Background</h4>Despite vast literature on warfarin, optimal strategies for temporarily discontinuing and restarting warfarin have not been established. To improve warfarin discontinuation processes, we investigated known medical and genetic factors that influence stable warfarin dose to determine how well they predict the time until patients become subtherapeutic after discontinuing warfarin.<h4>Methods</h4>This was ... Read more >>

WMJ (WMJ : official publication of the State Medical Society of Wisconsin)
[2015, 114(1):16-20]

Cited: 4 times

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Reinitiating warfarin: relationships between dose and selected patient, clinical and hospital measures.

Lucas G Leonhard, Richard L Berg, James K Burmester, Joseph J Mazza, John R Schmelzer, Steven H Yale,

<h4>Background</h4>Warfarin is an oral anticoagulant used in the long-term treatment/prevention of venothromboembolic disease. Patients undergoing elective surgical and non-surgical procedures may require temporary warfarin discontinuation followed by reinitiation after their procedure. Because little information is available regarding best methods for warfarin reinitiation, we investigated current practices to inform management decisions.<h4>Methods</h4>Subjects ... Read more >>

Clin Med Res (Clinical medicine & research)
[2015, 13(1):1-6]

Cited: 1 time

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A pharmacogenetic versus a clinical algorithm for warfarin dosing.

Stephen E Kimmel, Benjamin French, Scott E Kasner, Julie A Johnson, Jeffrey L Anderson, Brian F Gage, Yves D Rosenberg, Charles S Eby, Rosemary A Madigan, Robert B McBane, Sherif Z Abdel-Rahman, Scott M Stevens, Steven Yale, Emile R Mohler, Margaret C Fang, Vinay Shah, Richard B Horenstein, Nita A Limdi, James A S Muldowney, Jaspal Gujral, Patrice Delafontaine, Robert J Desnick, Thomas L Ortel, Henny H Billett, Robert C Pendleton, Nancy L Geller, Jonathan L Halperin, Samuel Z Goldhaber, Michael D Caldwell, Robert M Califf, Jonas H Ellenberg, ,

<h4>Background</h4>The clinical utility of genotype-guided (pharmacogenetically based) dosing of warfarin has been tested only in small clinical trials or observational studies, with equivocal results.<h4>Methods</h4>We randomly assigned 1015 patients to receive doses of warfarin during the first 5 days of therapy that were determined according to a dosing algorithm that included ... Read more >>

N Engl J Med (The New England journal of medicine)
[2013, 369(24):2283-2293]

Cited: 390 times

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Modeling efficacy of bevacizumab treatment for metastatic colon cancer.

Rezwan Islam, Po-Huang Chyou, James K Burmester,

<h4>Purpose</h4>Bevacizumab, an FDA-approved adjuvant treatment for metastatic colon cancer, has extended survival for many patients. However, factors predicting response to treatment remain undefined.<h4>Patients and methods</h4>Relevant clinical and environmental data were abstracted from medical records of 149 evaluable patients treated with bevacizumab for metastatic colon cancer at a multi-specialty clinic. Tumor ... Read more >>

J Cancer (Journal of Cancer)
[2013, 4(4):330-335]

Cited: 5 times

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SNPs previously associated with Dupuytren's disease replicated in a North American cohort.

Eric R Anderson, Zhan Ye, Michael D Caldwell, James K Burmester,

<h4>Objective</h4>Dupuytren's disease is a progressive fibrosis of the hand that often results in debilitating flexion contractures. Its etiology is not completely understood but likely involves both genetic and environmental factors. A recent study performed in Europe identified DNA variants that associate with Dupuytren's disease. Given the likelihood for genetic variation ... Read more >>

Clin Med Res (Clinical medicine & research)
[2014, 12(3-4):133-137]

Cited: 3 times

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Does CALU SNP rs1043550 contribute variability to therapeutic warfarin dosing requirements?

Ingrid Glurich, Richard L Berg, James K Burmester,

<h4>Objectives</h4>Calumenin, a molecular chaperone, exerts a regulatory effect on the vitamin K-dependent γ-carboxylation redox cycle that inhibits transfer of the reduced vitamin K from VKORC1, the pharmacological target of warfarin, to the γ-carboxylase. Because of its polymorphic structure and central role in the warfarin metabolic pathway, a contributory role for ... Read more >>

Clin Med Res (Clinical medicine & research)
[2013, 11(2):73-79]

Cited: 6 times

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Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.

Minoli A Perera, Larisa H Cavallari, Nita A Limdi, Eric R Gamazon, Anuar Konkashbaev, Roxana Daneshjou, Anna Pluzhnikov, Dana C Crawford, Jelai Wang, Nianjun Liu, Nicholas Tatonetti, Stephane Bourgeois, Harumi Takahashi, Yukiko Bradford, Benjamin M Burkley, Robert J Desnick, Jonathan L Halperin, Sherief I Khalifa, Taimour Y Langaee, Steven A Lubitz, Edith A Nutescu, Matthew Oetjens, Mohamed H Shahin, Shitalben R Patel, Hersh Sagreiya, Matthew Tector, Karen E Weck, Mark J Rieder, Stuart A Scott, Alan H B Wu, James K Burmester, Mia Wadelius, Panos Deloukas, Michael J Wagner, Taisei Mushiroda, Michiaki Kubo, Dan M Roden, Nancy J Cox, Russ B Altman, Teri E Klein, Yusuke Nakamura, Julie A Johnson,

<h4>Background</h4>VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans.<h4>Methods</h4>We did a genome-wide association study of discovery and replication ... Read more >>

Lancet (Lancet (London, England))
[2013, 382(9894):790-796]

Cited: 129 times

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Pathway analysis of genome-wide data improves warfarin dose prediction.

Roxana Daneshjou, Nicholas P Tatonetti, Konrad J Karczewski, Hersh Sagreiya, Stephane Bourgeois, Katarzyna Drozda, James K Burmester, Tatsuhiko Tsunoda, Yusuke Nakamura, Michiaki Kubo, Matthew Tector, Nita A Limdi, Larisa H Cavallari, Minoli Perera, Julie A Johnson, Teri E Klein, Russ B Altman,

<h4>Background</h4>Many genome-wide association studies focus on associating single loci with target phenotypes. However, in the setting of rare variation, accumulating sufficient samples to assess these associations can be difficult. Moreover, multiple variations in a gene or a set of genes within a pathway may all contribute to the phenotype, suggesting ... Read more >>

BMC Genomics (BMC genomics)
[2013, 14 Suppl 3:S11]

Cited: 8 times

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Anti-phospholipid antibodies in patients undergoing total joint replacement surgery.

Melissa Simpson, Michael J Sanfelippo, Adedayo A Onitilo, James K Burmester, William Hocking, Steven H Yale, Joseph J Mazza,

Background. Patients undergoing joint replacement remain at increased risk for venous thromboembolism (VTE) compared to other types of surgery, regardless of thromboprophylactic regimen. The pathophysiologic processes rendering this group of patients at risk for VTE are multifactorial. Procedure-specific and patient-specific exposures play a role in the postoperative development of VTE, ... Read more >>

Thrombosis (Thrombosis)
[2012, 2012:142615]

Cited: 1 time

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Evaluation of a mitochondrial DNA mutation in maternally inherited and sporadic cases of Dupuytren disease.

Eric R Anderson, James K Burmester, Michael D Caldwell,

<h4>Objective</h4>The purpose was to test the hypothesis that Dupuytren disease (DD) is associated with a previously reported mutation in mitochondrial DNA at position 2839.<h4>Methods</h4>Two hundred sixty-nine cases of DD and an equal number of matched controls were identified in Marshfield Clinic's Personalized Medicine Research Project (PMRP). Clinical data used to ... Read more >>

Clin Med Res (Clinical medicine & research)
[2012, 10(3):122-126]

Cited: 6 times

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Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy.

Benjamin D Horne, Petra A Lenzini, Mia Wadelius, Andrea L Jorgensen, Stephen E Kimmel, Paul M Ridker, Niclas Eriksson, Jeffrey L Anderson, Munir Pirmohamed, Nita A Limdi, Robert C Pendleton, Gwendolyn A McMillin, James K Burmester, Daniel Kurnik, C Michael Stein, Michael D Caldwell, Charles S Eby, Anders Rane, Jonatan D Lindh, Jae-Gook Shin, Ho-Sook Kim, Pantep Angchaisuksiri, Robert J Glynn, Kathryn E Kronquist, John F Carlquist, Gloria R Grice, Robert L Barrack, Juan Li, Brian F Gage,

By guiding initial warfarin dose, pharmacogenetic (PGx) algorithms may improve the safety of warfarin initiation. However, once international normalised ratio (INR) response is known, the contribution of PGx to dose refinements is uncertain. This study sought to develop and validate clinical and PGx dosing algorithms for warfarin dose refinement on ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2012, 107(2):232-240]

Cited: 44 times

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A randomized controlled trial of genotype-based Coumadin initiation.

James K Burmester, Richard L Berg, Steven H Yale, Carla M Rottscheit, Ingrid E Glurich, John R Schmelzer, Michael D Caldwell,

<h4>Purpose</h4>A randomized controlled trial was conducted in patients initiating warfarin to determine whether algorithms that incorporate genotypes affecting warfarin metabolism and function, and Vitamin K metabolism improve prediction of therapeutic warfarin dose and anticoagulation management.<h4>Methods</h4>A total of 230 patients were randomized to either a clinical arm where dosing algorithms considered ... Read more >>

Genet Med (Genetics in medicine : official journal of the American College of Medical Genetics)
[2011, 13(6):509-518]

Cited: 71 times

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Absence of novel CYP4F2 and VKORC1 coding region DNA variants in patients requiring high warfarin doses.

James K Burmester, Richard L Berg, Ingrid Glurich, Steven H Yale, John R Schmelzer, Michael D Caldwell,

<h4>Objective</h4>Warfarin is an FDA-approved oral anticoagulant for long-term prevention of thromboembolism. Substantial inter-individual variation in dosing requirements and the narrow therapeutic index of this widely-prescribed drug make safe initiation and dose stabilization challenging. Single nucleotide polymorphisms (SNPs) occurring in CYP2C9, VKORC1, and CYP4F2 genes are known to impact dose, and ... Read more >>

Clin Med Res (Clinical medicine & research)
[2011, 9(3-4):119-124]

Cited: 8 times

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Alcohol, genetics and risk of breast cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.

Catherine A McCarty, Douglas J Reding, John Commins, Craig Williams, Meredith Yeager, James K Burmester, Catherine Schairer, Regina G Ziegler,

We tested the hypothesis that genes involved in the alcohol oxidation pathway modify the association between alcohol intake and breast cancer. Subjects were women aged 55-74 at baseline from the screening arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Incident breast cancers were identified through annual ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2012, 133(2):785-792]

Cited: 13 times

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The differential diagnosis of pulmonary blastomycosis using case vignettes: a Wisconsin Network for Health Research (WiNHR) study.

Dennis J Baumgardner, Jonathan L Temte, Erin Gutowski, William A Agger, Howard Bailey, James K Burmester, Indrani Banerjee,

<h4>Purpose</h4>Pulmonary blastomycosis is an uncommon but serious fungal infection endemic in Wisconsin. Clinician awareness of the protean presentations of this disease may reduce diagnostic delay. This study addressed the diagnostic accuracy of physicians responding to case vignettes of pulmonary blastomycosis and the primary care differential diagnosis of this disease.<h4>Methods</h4>Eight pulmonary ... Read more >>

WMJ (WMJ : official publication of the State Medical Society of Wisconsin)
[2011, 110(2):68-73]

Cited: 3 times

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Lack of association between polymorphisms in the prostaglandin F2α receptor and solute carrier organic anion transporter family 2A1 genes and intraocular pressure response to prostaglandin analogs.

Catherine A McCarty, Richard Berg, Richard Patchett, Russell A Wilke, James K Burmester,

<h4>Purpose</h4>To evaluate the association between variants in the prostaglandin F(α) receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and intraocular pressure (IOP) response to prostaglandin analogs.<h4>Methods</h4>The medical records of subjects with previously diagnosed open angle glaucoma or ocular hypertension were searched for intraocular pressure measurements before ... Read more >>

Ophthalmic Genet (Ophthalmic genetics)
[2012, 33(2):74-76]

Cited: 5 times

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Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups.

Nita A Limdi, Mia Wadelius, Larisa Cavallari, Niclas Eriksson, Dana C Crawford, Ming-Ta M Lee, Chien-Hsiun Chen, Alison Motsinger-Reif, Hersh Sagreiya, Nianjun Liu, Alan H B Wu, Brian F Gage, Andrea Jorgensen, Munir Pirmohamed, Jae-Gook Shin, Guilherme Suarez-Kurtz, Stephen E Kimmel, Julie A Johnson, Teri E Klein, Michael J Wagner, ,

Warfarin-dosing algorithms incorporating CYP2C9 and VKORC1 -1639G>A improve dose prediction compared with algorithms based solely on clinical and demographic factors. However, these algorithms better capture dose variability among whites than Asians or blacks. Herein, we evaluate whether other VKORC1 polymorphisms and haplotypes explain additional variation in warfarin dose beyond that ... Read more >>

Blood (Blood)
[2010, 115(18):3827-3834]

Cited: 222 times

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Perioperative genomic profiles using structure-specific oligonucleotide probes.

Kirk J Hogan, James K Burmester, Michael D Caldwell, Quinn H Hogan, Douglas B Coursin, Dawn N Green, Rebecca M R Selzer, Thomas P Broderick, Deborah A Rusy, Mark Poroli, Anna L Lutz, Allison M Sanders, Mary C Oldenburg, James A Koelbl, Monika de Arruda-Indig, Jennifer L Halsey, Stephen P Day, Michael J Domanico,

<h4>Objectives</h4>Many complications in the perioperative interval are associated with genetic susceptibilities that may be unknown in advance of surgery and anesthesia, including drug toxicity and inefficacy, thrombosis, prolonged neuromuscular blockade, organ failure and sepsis. The aims of this study were to design and validate the first genetic testing platform and ... Read more >>

Clin Med Res (Clinical medicine & research)
[2009, 7(3):69-84]

Cited: 3 times

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The Wisconsin Network for Health Research (WiNHR): a statewide, collaborative, multi-disciplinary, research group.

Howard Bailey, William Agger, Dennis Baumgardner, James K Burmester, Ron A Cisler, Jennifer Evertsen, Ingrid Glurich, David Hartman, Steven H Yale, David DeMets,

In response to the goals of the Wisconsin Partnership Program and the National Institutes of Health (NIH) Initiatives to Improve Healthcare, the Wisconsin Network for Health Research (WiNHR) was formed. As a collaborative, multi-disciplinary statewide research network, WiNHR encourages and fosters the discovery and application of scientific knowledge for researchers ... Read more >>

WMJ (WMJ : official publication of the State Medical Society of Wisconsin)
[2009, 108(9):453-458]

Cited: 2 times

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