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Transitions of Care After Critical Illness-Challenges to Recovery and Adaptive Problem Solving.

Kimberley J Haines, Elizabeth Hibbert, Nina Leggett, Leanne M Boehm, Tarli Hall, Rita N Bakhru, Anthony J Bastin, Brad W Butcher, Tammy L Eaton, Wendy Harris, Aluko A Hope, James Jackson, Annie Johnson, Janet A Kloos, Karen A Korzick, Pamela Mactavish, Joel Meyer, Ashley Montgomery-Yates, Tara Quasim, Andrew Slack, Dorothy Wade, Mary Still, Giora Netzer, Ramona O Hopkins, Theodore J Iwashyna, Mark E Mikkelsen, Joanne McPeake, Carla M Sevin, ,

<h4>Objectives</h4>Investigate the challenges experienced by survivors of critical illness and their caregivers across the transitions of care from intensive care to community, and the potential problem-solving strategies used to navigate these challenges.<h4>Design</h4>Qualitative design-data generation via interviews and data analysis via the framework analysis method.<h4>Setting</h4>Patients and caregivers from three continents, identified ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1923-1931]

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Mouse model and human patient data suggest critical roles for Pten and p53 in suppressing POLE mutant tumor development

Vivian Park, Meijuan J.S. Sun, Wesley Frey, Leonard Williams, Karl Hodel, Juliet Strauss, Sydney Wellens, James Jackson, Zachary Pursell,

<h4>ABSTRACT</h4> Mutations in the exonuclease domain of POLE are associated with tumors harboring very high mutation burdens. The mechanisms linking this significant mutation accumulation and tumor development remain poorly understood. Pole +/P286R ; Trp53 +/− mice showed accelerated cancer mortality compared to Pole +/P286R ; Trp53 +/+ mice. Cells from ... Read more >>

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The Molecular Subtyping Resource (MouSR): a user-friendly tool for rapid biological discovery from human or mouse transcriptional data

Baharak Ahmaderaghi, Raheleh Amirkhah, James Jackson, Tamsin RM Lannagan, Kathryn Gilroy, Sudhir Malla, Keara Redmond, Tim Maughan, Simon Leedham, Andrew Campbell, Owen Sansom, Mark Lawler, Philip Dunne, ,

<h4>ABSTRACT</h4> Generation of transcriptional data has dramatically increased in the last decade, driving the development of analytical algorithms that enable interrogation of the biology underpinning the profiled samples. However, these resources require users to have expertise in data wrangling and analytics, reducing opportunities for biological discovery by “wet-lab” users with ... Read more >>

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ICU Survivorship-The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness.

Matthew F Mart, Brenda T Pun, Pratik Pandharipande, James C Jackson, E Wesley Ely,

The advent of modern critical care medicine has revolutionized care of the critically ill patient in the last 50 years. The Society of Critical Care Medicine (was formed in recognition of the challenges and need for specialized treatment for these fragile patients. As the specialty has grown, it has achieved ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(8):1227-1240]

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Positive Effects of Religion and Social Ties on the Health of Former NFL Athletes.

Tim Cupery, Evelyn Bush, Robert W Turner, Amanda Sonnega, Teri Rosales, Kalpana Vissa, Keith E Whitfield, James S Jackson, David Weir,

This study explores the relationship between religious service attendance, social ties, and health among former NFL players, a population with relatively high levels of religious attendance who endure physically demanding occupations. Research shows that frequent religious service attenders tend to have better health, partly because of social connections formed through ... Read more >>

J Relig Health (Journal of religion and health)
[2021, :]

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Burden and Quality of Life Among Female and Male Patients with Heart Failure in Europe: A Real-World Cross-Sectional Study.

Ana Filipa Fonseca, Raquel Lahoz, Clare Proudfoot, Stefano Corda, Emil Loefroth, James Jackson, Sarah Cotton, Rachel Studer,

<h4>Purpose</h4>To characterize symptoms, clinical burden, and health-related quality of life (HRQoL) among women and men with heart failure (HF) with a left ventricular ejection fraction (LVEF) of ≤60% in Europe.<h4>Patients and methods</h4>A real-world cross-sectional study was conducted in France, Germany, Italy, Spain, and United Kingdom from June to November 2019. ... Read more >>

Patient Prefer Adherence (Patient preference and adherence)
[2021, 15:1693-1706]

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Patient-Reported Outcomes for Migraine in the US and Europe: Burden Associated with Multiple Preventive Treatment Failures.

Janet Ford, Russell M Nichols, Wenyu Ye, Antje Tockhorn-Heidenreich, Sarah Cotton, James Jackson,

<h4>Purpose</h4>To evaluate patient-reported outcomes (PROs) among patients with migraine, including those who were preventive-naïve and preventive-treated.<h4>Methods</h4>This was a point-in-time, real-world study of patients with migraine in the US and EU5 (France, Germany, Spain, Italy, and UK) and their physicians using data from the Adelphi Migraine Disease Specific Programme (DSP™). Physicians ... Read more >>

Clinicoecon Outcomes Res (ClinicoEconomics and outcomes research : CEOR)
[2021, 13:647-660]

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Femtosecond dynamics and coherence of ionic retro-Diels-Alder reactions.

Shuai Li, Bethany Jochim, James E Jackson, Marcos Dantus,

Ultrafast tunnel ionization enables femtosecond time-resolved dynamic measurements of the retro-Diels-Alder reactions of positively charged cyclohexene, norbornene, and dicyclopentadiene. Unlike the reaction times of 500-600 ps that are observed following UV excitation of neutral species, on the ionic potential energy surfaces, these reactions occur on a single picosecond timescale and, in ... Read more >>

J Chem Phys (The Journal of chemical physics)
[2021, 155(4):044303]

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Concern about addiction is associated with lower quality of life in patients with osteoarthritis: an exploratory, real-world data analysis.

Louis P Garrison, Patricia Schepman, Andrew G Bushmakin, Rebecca L Robinson, Leslie Tive, Jerry Hall, Mendwas Dzingina, James Jackson, Mia Berry, Joseph C Cappelleri, Stuart Silverman,

<h4>Purpose</h4>To evaluate the relationship between self-reported concerns about becoming addicted to a medication and health-related quality of life (HRQoL) in patients with osteoarthritis (OA).<h4>Methods</h4>This real-world study used patient-level cross-sectional survey data collected from the US Adelphi Disease Specific Programme (DSP). The DSP for OA selected 153 physicians who collected de-identified ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2021, :]

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Six-month and 12-month patient outcomes based on inflammatory subphenotypes in sepsis-associated ARDS: secondary analysis of SAILS-ALTOS trial.

Mohamed D Hashem, Ramona O Hopkins, Elizabeth Colantuoni, Victor D Dinglas, Pratik Sinha, Lisa Aronson Friedman, Peter E Morris, James C Jackson, Catherine L Hough, Carolyn S Calfee, Dale M Needham,

<h4>Background</h4>Prior acute respiratory distress syndrome (ARDS) trials have identified hypoinflammatory and hyperinflammatory subphenotypes, with distinct differences in short-term outcomes. It is unknown if such differences extend beyond 90 days or are associated with physical, mental health or cognitive outcomes.<h4>Methods</h4>568 patients in the multicentre Statins for Acutely Injured Lungs from Sepsis ... Read more >>

Thorax (Thorax)
[2021, :]

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Randomized Trial of Radiation Therapy With Weekly Cisplatin or Cetuximab in Low-Risk HPV-Associated Oropharyngeal Cancer (TROG 12.01) - A Trans-Tasman Radiation Oncology Group Study.

Danny Rischin, Madeleine King, Lizbeth Kenny, Sandro Porceddu, Christopher Wratten, Andrew Macann, James E Jackson, Mathias Bressel, Alan Herschtal, Richard Fisher, Tsien Fua, Charles Lin, Chen Liu, Brett G M Hughes, Margaret McGrath, Lachlan McDowell, June Corry,

<h4>Purpose</h4>The excellent prognosis of patients with low-risk human papillomavirus (HPV)- associated oropharyngeal squamous cell carcinoma has led to concerns about overtreatment and excessive toxicity with radiation therapy and cisplatin, leading to interest in de-intensification trials. We investigated whether cetuximab, an epidermal growth factor receptor targeting antibody, when combined with radiation ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2021, 111(4):876-886]

Cited: 2 times

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Optimizing Critical Illness Recovery: Perspectives and Solutions From the Caregivers of ICU Survivors.

Carla M Sevin, Leanne M Boehm, Elizabeth Hibbert, Anthony J Bastin, James C Jackson, Joel Meyer, Tara Quasim, Rita N Bakhru, Ashley Montgomery-Yates, Andrew Slack, Mary Still, Giora Netzer, Mark E Mikkelsen, Theodore J Iwashyna, Kimberley J Haines, Joanne McPeake,

<h4>Objectives</h4>To understand the unmet needs of caregivers of ICU survivors, how they accessed support post ICU, and the key components of beneficial ICU recovery support systems as identified from a caregiver perspective.<h4>Design</h4>International, qualitative study.<h4>Subjects</h4>We conducted 20 semistructured interviews with a diverse group of caregivers in the United States, the United ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(5):e0420]

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High-Throughput Detection of Autoantigen-Specific B Cells Among Distinct Functional Subsets in Autoimmune Donors.

Bryan A Joosse, James H Jackson, Alberto Cisneros, Austin B Santhin, Scott A Smith, Daniel J Moore, Leslie J Crofford, Erin M Wilfong, Rachel H Bonami,

Antigen-specific B cells (ASBCs) can drive autoimmune disease by presenting autoantigen to cognate T cells to drive their activation, proliferation, and effector cell differentiation and/or by differentiating into autoantibody-secreting cells. Autoantibodies are frequently used to predict risk and diagnose several autoimmune diseases. ASBCs can drive type 1 diabetes even when ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:685718]

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Caregivers of Patients with Heart Failure: Burden and the Determinants of Health-Related Quality of Life.

Raquel Lahoz, Clare Proudfoot, Ana Filipa Fonseca, Emil Loefroth, Stefano Corda, James Jackson, Sarah Cotton, Rachel Studer,

<h4>Purpose</h4>To assess the burden among caregivers of patients with heart failure (HF) with left ventricular ejection fraction (LVEF) ≤60%. The burden by New York Heart Association (NYHA) functional class was also characterized.<h4>Patients and methods</h4>A cross-sectional study was conducted in France, Germany, Italy, Spain, and UK from June to November 2019. ... Read more >>

Patient Prefer Adherence (Patient preference and adherence)
[2021, 15:1153-1164]

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Health-related quality of life and lifestyle changes in patients with chronic kidney disease and hyperkalaemia: Real-world data from the US, five European countries and China.

Susan Grandy, James Jackson, Rebecca Moon, Daniel Bluff, Eirini Palaka,

<h4>Background</h4>Chronic kidney disease patients have impaired health-related quality of life and an increased risk of hyperkalaemia.<h4>Aims</h4>The objective was to evaluate the impact of hyperkalaemia on health-related quality of life, and investigate lifestyle change recommendations, in these patients.<h4>Methods</h4>The Adelphi Real World Chronic Kidney Disease Specific Programme™ was used. Data were collected ... Read more >>

Int J Clin Pract (International journal of clinical practice)
[2021, 75(8):e14326]

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Association of Delirium during Critical Illness With Mortality: Multicenter Prospective Cohort Study.

Christopher G Hughes, Christina J Hayhurst, Pratik P Pandharipande, Matthew S Shotwell, Xiaoke Feng, Jo Ellen Wilson, Nathan E Brummel, Timothy D Girard, James C Jackson, E Wesley Ely, Mayur B Patel,

<h4>Background</h4>The temporal association of delirium during critical illness with mortality is unclear, along with the associations of hypoactive and hyperactive motoric subtypes of delirium with mortality. We aimed to evaluate the relationship of delirium during critical illness, including hypoactive and hyperactive motoric subtypes, with mortality in the hospital and after ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, :]

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Trajectories of depression in sepsis survivors: an observational cohort study.

Monique Boede, Jochen S Gensichen, James C Jackson, Fiene Eißler, Thomas Lehmann, Sven Schulz, Juliana J Petersen, Florian P Wolf, Tobias Dreischulte, Konrad F R Schmidt,

<h4>Background</h4>Advances in critical care medicine have led to a growing number of critical illness survivors. A considerable part of them suffers from long-term sequelae, also known as post-intensive care syndrome. Among these, depressive symptoms are frequently observed. Depressive symptom trajectories and associated factors of critical illness survivors have rarely been ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):161]

Cited: 1 time

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Motoric Subtypes of Delirium and Long-Term Functional and Mental Health Outcomes in Adults After Critical Illness.

Kimberly F Rengel, Christina J Hayhurst, James C Jackson, Christina S Boncyk, Mayur B Patel, Nathan E Brummel, Yaping Shi, Matthew S Shotwell, E Wesley Ely, Pratik P Pandharipande, Christopher G Hughes,

<h4>Objectives</h4>Adult ICU survivors that experience delirium are at high risk for developing new functional disabilities and mental health disorders. We sought to determine if individual motoric subtypes of delirium are associated with worse disability, depression, and/or post-traumatic stress disorder in ICU survivors.<h4>Design</h4>Secondary analysis of a prospective multicenter cohort study.<h4>Setting</h4>Academic, community, ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(5):e521-e532]

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Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults.

Jin H Han, Adit A Ginde, Samuel M Brown, Adrienne Baughman, Erin M Collar, E Wesley Ely, Michelle N Gong, Aluko A Hope, Peter C Hou, Catherine L Hough, Theodore J Iwashyna, James C Jackson, Akram Khan, Onur M Orun, Mayur B Patel, Rameela Raman, Todd W Rice, Nancy Ringwood, Matthew W Semler, Nathan I Shapiro, Daniel S Talmor, Wesley H Self, ,

<h4>Background</h4>Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term cognition.<h4>Research question</h4>Does a single high-dose (540,000 International Units) enteral treatment of vitamin D3 given shortly after hospital admission in critically ill patients who are vitamin D deficient improve long-term global cognition or executive function?<h4>Study design ... Read more >>

Chest (Chest)
[2021, 160(3):909-918]

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Benefits of Peer Support for Intensive Care Unit Survivors: Sharing Experiences, Care Debriefing, and Altruism.

Joanne McPeake, Theodore J Iwashyna, Leanne M Boehm, Elizabeth Hibbert, Rita N Bakhru, Anthony J Bastin, Brad W Butcher, Tammy L Eaton, Wendy Harris, Aluko A Hope, James Jackson, Annie Johnson, Janet A Kloos, Karen A Korzick, Joel Meyer, Ashley Montgomery-Yates, Mark E Mikkelsen, Andrew Slack, Dorothy Wade, Mary Still, Giora Netzer, Ramona O Hopkins, Tara Quasim, Carla M Sevin, Kimberley J Haines,

<h4>Background</h4>After critical illness, patients are often left with impairments in physical, social, emotional, and cognitive functioning. Peer support interventions have been implemented internationally to ameliorate these issues.<h4>Objective</h4>To explore what patients believed to be the key mechanisms of effectiveness of peer support programs implemented during critical care recovery.<h4>Methods</h4>In a secondary analysis ... Read more >>

Am J Crit Care (American journal of critical care : an official publication, American Association of Critical-Care Nurses)
[2021, 30(2):145-149]

Cited: 2 times

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Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis.

Thomas Bieber, Eric L Simpson, Jonathan I Silverberg, Diamant Thaçi, Carle Paul, Andrew E Pink, Yoko Kataoka, Chia-Yu Chu, Marco DiBonaventura, Ricardo Rojo, Jeremias Antinew, Ileana Ionita, Rodney Sinclair, Seth Forman, Jacek Zdybski, Pinaki Biswas, Bimal Malhotra, Fan Zhang, Hernan Valdez, ,

<h4>Background</h4>The oral Janus kinase 1 (JAK1) inhibitor abrocitinib, which reduces interleukin-4 and interleukin-13 signaling, is being investigated for the treatment of atopic dermatitis. Data from trials comparing JAK1 inhibitors with monoclonal antibodies, such as dupilumab, that block interleukin-4 receptors are limited.<h4>Methods</h4>In a phase 3, double-blind trial, we randomly assigned patients ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(12):1101-1112]

Cited: 8 times

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Inflammation and Coagulation during Critical Illness and Long-Term Cognitive Impairment and Disability.

Nathan E Brummel, Christopher G Hughes, Jennifer L Thompson, James C Jackson, Pratik Pandharipande, J Brennan McNeil, Rameela Raman, Onur M Orun, Lorraine B Ware, Gordon R Bernard, E Wesley Ely, Timothy D Girard,

<b>Rationale:</b> The biological mechanisms of long-term cognitive impairment and disability after critical illness are unclear.<b>Objectives:</b> To test the hypothesis that markers of acute inflammation and coagulation are associated with subsequent long-term cognitive impairment and disability.<b>Methods:</b> We obtained plasma samples from adults with respiratory failure or shock on Study Days 1, ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(6):699-706]

Cited: 2 times

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Establishing a Peer Support Program for Survivors of COVID-19: A Report From the Critical and Acute Illness Recovery Organization.

Aluko A Hope, Andrea Annie Johnson, Joanne McPeake, Hali Felt, Carla M Sevin, Mark E Mikkelsen, Theodore J Iwashyna, Caroline Lassen-Greene, Kimberley J Haines, Sachin Agarwal, Rita N Bakhru, Leanne M Boehm, Brad W Butcher, Kelly Drumright, Tammy L Eaton, Elizabeth Hibbert, Karen Sara Hoehn, David Hornstein, Heather Imperato-Shedden, James C Jackson, Janet A Kloos, Anna Lewis, Joel Meyer, Ashley Montgomery-Yates, Veronica Rojas, Christa Schorr, Dorothy Wade, Cydni Williams,

Am J Crit Care (American journal of critical care : an official publication, American Association of Critical-Care Nurses)
[2021, :e1-e5]

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Characterizing the role of, and physical and emotional burden on caregivers of patients with heart failure: Results from a cross-sectional survey in Japan.

Erika Hayashi, Hironobu Mitani, Hiroki Murayama, Toshihisa Anzai, Rachel Studer, Sarah Cotton, James Jackson, Hollie Bailey, Hiroshi Kitagawa, Naotsugu Oyama,

The aim of this cross-sectional survey was to characterize the role of and burden on caregivers of heart failure (HF) patients in Japan, since such data are limited at present. Data from 126 caregivers whose average age was 63.5 years were analyzed. Helping to prepare meals/cooking was the most frequently ... Read more >>

Geriatr Nurs (Geriatric nursing (New York, N.Y.))
[2021, 42(2):379-385]

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Maternal temperature in emergency caesarean section (MATES): an observational multicentre study.

P T Thorburn, R Monteiro, A Chakladar, A Cochrane, J Roberts, , C Mark Harper,

<h4>Background</h4>Temperature regulation in women undergoing emergency caesarean section is a complex topic about which there is a paucity of evidence-based recommendations. The adverse effects of inadvertent peri-operative hypothermia are well described. Hyperthermia is also associated with adverse neonatal outcomes, an increased risk of obstetric intervention and increased treatment for suspected ... Read more >>

Int J Obstet Anesth (International journal of obstetric anesthesia)
[2021, 46:102963]

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