Full Text Journal Articles by
Author James J Galligan

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Sirtuin 2 Regulates Protein LactoylLys Modifications.

Erin Q Jennings, Jason D Ray, Christopher J Zerio, Marissa N Trujillo, David M McDonald, Eli Chapman, David A Spiegel, James J Galligan,

Post-translational modifications (PTMs) play roles in both physiological and pathophysiological processes through the regulation of enzyme structure and function. We recently identified a novel PTM, lactoylLys, derived through a nonenzymatic mechanism from the glycolytic by-product, lactoylglutathione. Under physiologic scenarios, glyoxalase 2 prevents the accumulation of lactoylglutathione and thus lactoylLys modifications. ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2021, 22(12):2102-2106]

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Colonic 5-HT4 receptors are targets for novel prokinetic drugs.

James J Galligan,

5-HT<sub>4</sub> receptors are G protein-coupled receptors that link to the stimulatory protein Gs which activates adenylate cyclase to increase intracellular cyclic AMP which then activates protein kinase A (PKA). 5-HT<sub>4</sub> receptors are expressed by neurons in the central and peripheral nervous systems especially the enteric nervous system (ENS). In general, ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, 33(4):e14125]

Cited: 0 times

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Trisomy 21 impairs PGE2 production in dermal fibroblasts.

John O Marentette, Colin C Anderson, Kendra M Prutton, Erin Q Jennings, Abhishek K Rauniyar, James J Galligan, James R Roede,

The triplication of human chromosome 21 results in Down syndrome (DS), the most common genetic form of intellectual disability. This aneuploid condition also results in an enhanced risk of a spectrum of comorbid conditions, such as leukemia, early onset Alzheimer's disease, and diabetes. Individuals with DS also display an increased ... Read more >>

Prostaglandins Other Lipid Mediat (Prostaglandins & other lipid mediators)
[2021, 153:106524]

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Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling.

Siennah R Miller, Xiaohong Zhang, Raymond K Hau, Joseph L Jilek, Erin Q Jennings, James J Galligan, Daniel H Foil, Kimberley M Zorn, Sean Ekins, Stephen H Wright, Nathan J Cherrington,

Equilibrative nucleoside transporters (ENTs) 1 and 2 facilitate nucleoside transport across the blood-testis barrier (BTB). Improving drug entry into the testes with drugs that use endogenous transport pathways may lead to more effective treatments for diseases within the reproductive tract. In this study, CRISPR/CRISPR-associated protein 9 was used to generate ... Read more >>

Mol Pharmacol (Molecular pharmacology)
[2021, 99(2):147-162]

Cited: 2 times

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An Azidoribose Probe to Track Ketoamine Adducts in Histone Ribose Glycation.

Igor Maksimovic, Qingfei Zheng, Marissa N Trujillo, James J Galligan, Yael David,

Reactive cellular metabolites can modify macromolecules and form adducts known as nonenzymatic covalent modifications (NECMs). The dissection of the mechanisms, regulation, and consequences of NECMs, such as glycation, has been challenging due to the complex and often ambiguous nature of the adducts formed. Specific chemical tools are required to directly ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(22):9999-10007]

Cited: 1 time

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Spinal cord injury alters purinergic neurotransmission to mesenteric arteries in rats.

Sutheera Sangsiri, Hui Xu, Roxanne Fernandes, Greg D Fink, Heidi L Lujan, Stephen E DiCarlo, James J Galligan,

Complications associated with spinal cord injury (SCI) result from unregulated reflexes below the lesion level. Understanding neurotransmission distal to the SCI could improve quality of life by mitigating complications. The long-term impact of SCI on neurovascular transmission is poorly understood, but reduced sympathetic activity below the site of SCI enhances ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2020, 318(2):H223-H237]

Cited: 0 times

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Effects of high-fat diet on sympathetic neurotransmission in mesenteric arteries from Dahl salt-sensitive rat.

Kibrom M Alula, Rebecca Biltz, Hui Xu, Hannah Garver, Erinn L Laimon-Thomson, Gregory D Fink, James J Galligan,

Obesity hypertension is driven by sympathetic neurotransmission to the heart and blood vessels. We tested the hypothesis that high-fat diet (HFD)-induced hypertension is driven by sympathetic neurotransmission to mesenteric arteries (MA) in male but not female Dahl salt-sensitive (Dahl ss) rat. Rats were fed a control diet (CD; 10 kcal% from ... Read more >>

Auton Neurosci (Autonomic neuroscience : basic & clinical)
[2019, 222:102599]

Cited: 2 times

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Erratum: Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.

James A Wepy, James J Galligan, Phillip J Kingsley, Shu Xu, Michael C Goodman, Keri A Tallman, Carol A Rouzer, Lawrence J Marnett,

J Lipid Res (Journal of lipid research)
[2019, 60(7):1345]

Cited: 0 times

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Optogenetic analysis of neuromuscular transmission in the colon of ChAT-ChR2-YFP BAC transgenic mice.

Alberto L Perez-Medina, James J Galligan,

Propulsion of luminal content along the gut requires coordinated contractions and relaxations of gastrointestinal smooth muscles controlled by the enteric nervous system. Activation of excitatory motor neurons (EMNs) causes muscle contractions, whereas inhibitory motor neuron (IMN) activation causes muscle relaxation. EMNs release acetylcholine (ACh), which acts at muscarinic receptors on ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2019, 317(5):G569-G579]

Cited: 3 times

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Cannabinoid-induced relief of hypermotility in a rat model of the irritable bowel syndrome.

James J Galligan,

Cannabinoid-2 receptor agonists may be useful in treating intestinal motility disorders. ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2019, 31(6):e13613]

Cited: 0 times

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NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis.

Vladimir Grubišić, Alberto L Perez-Medina, David E Fried, Jean Sévigny, Simon C Robson, James J Galligan, Brian D Gulbransen,

ATP is both an important mediator of physiological gut functions such as motility and epithelial function, and a key danger signal that mediates cell death and tissue damage. The actions of extracellular ATP are regulated through the catalytic functions extracellular nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), -2, -3, and -8, which ultimately ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2019, 317(3):G314-G332]

Cited: 4 times

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Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.

James A Wepy, James J Galligan, Philip J Kingsley, Shu Xu, Michael C Goodman, Keri A Tallman, Carol A Rouzer, Lawrence J Marnett,

Lysophospholipids (LysoPLs) are bioactive lipid species involved in cellular signaling processes and the regulation of cell membrane structure. LysoPLs are metabolized through the action of lysophospholipases, including lysophospholipase A1 (LYPLA1) and lysophospholipase A2 (LYPLA2). A new X-ray crystal structure of LYPLA2 compared with a previously published structure of LYPLA1 demonstrated ... Read more >>

J Lipid Res (Journal of lipid research)
[2019, 60(2):360-374]

Cited: 3 times

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Chromatin Modifications in Toxicology.

James J Galligan,

Histone modifications regulate chromatin structure and function. Primary and secondary metabolites stemming from environmental and chemical exposures may play a critical role in the underlying epigenomic state of a cell through covalent histone modifications. Future investigations should be focused on characterizing the "Histone Code" when performing toxicogenomic analyses. ... Read more >>

Chem Res Toxicol (Chemical research in toxicology)
[2019, 32(5):794-795]

Cited: 0 times

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5-HT3 receptor signaling in serotonin transporter-knockout rats: a female sex-specific animal model of visceral hypersensitivity.

Nadine El-Ayache, James J Galligan,

The irritable bowel syndrome (IBS) is a functional gastrointestinal motor and visceral sensation disorder that is more common in women than men. Female serotonin transporter (SERT)-gene knockout (KO) rats exhibit hypersensitivity to colorectal balloon distention (CRD) that mimics colonic hypersensitivity occurring in female IBS patients. Alosetron (5-HT<sub>3</sub> receptor antagonist) is ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2019, 316(1):G132-G143]

Cited: 2 times

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Profiling of Methylglyoxal Blood Metabolism and Advanced Glycation End-Product Proteome Using a Chemical Probe.

Christian Sibbersen, Anne-Mette Schou Oxvig, Sarah Bisgaard Olesen, Camilla Bak Nielsen, James J Galligan, Karl Anker Jørgensen, Johan Palmfeldt, Mogens Johannsen,

Methylglyoxal (MG) is quantitatively the most important precursor to advanced glycation end-products (AGEs), and evidence is accumulating that it is also a causally linked to diabetes and aging related diseases. Living systems primarily reside on the glyoxalase system to detoxify MG into benign d-lactate. The flux to either glycation or ... Read more >>

ACS Chem Biol (ACS chemical biology)
[2018, 13(12):3294-3305]

Cited: 6 times

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Sex Differences in Renal Inflammation and Injury in High-Fat Diet-Fed Dahl Salt-Sensitive Rats.

Roxanne Fernandes, Hannah Garver, Jack R Harkema, James J Galligan, Gregory D Fink, Hui Xu,

We examined the impact of sex on high-fat diet (HFD)-induced renal alterations in Dahl salt-sensitive and Sprague Dawley rats. In Dahl rats, HFD (60% kcal from fat for 24-26 weeks starting at weaning) significantly and equally increased blood pressure in males and females when compared with rats fed a control ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2018, 72(5):e43-e52]

Cited: 13 times

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Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks.

James J Galligan, James A Wepy, Matthew D Streeter, Philip J Kingsley, Michelle M Mitchener, Orrette R Wauchope, William N Beavers, Kristie L Rose, Tina Wang, David A Spiegel, Lawrence J Marnett,

Histone posttranslational modifications (PTMs) regulate chromatin dynamics, DNA accessibility, and transcription to expand the genetic code. Many of these PTMs are produced through cellular metabolism to offer both feedback and feedforward regulation. Herein we describe the existence of Lys and Arg modifications on histones by a glycolytic by-product, methylglyoxal (MGO). ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(37):9228-9233]

Cited: 30 times

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Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA.

Orrette R Wauchope, Michelle M Mitchener, William N Beavers, James J Galligan, Jeannie M Camarillo, William D Sanders, Philip J Kingsley, Ha-Na Shim, Thomas Blackwell, Thong Luong, Mark deCaestecker, Joshua P Fessel, Lawrence J Marnett,

Reactive oxygen species (ROS) are formed in mitochondria during electron transport and energy generation. Elevated levels of ROS lead to increased amounts of mitochondrial DNA (mtDNA) damage. We report that levels of M1dG, a major endogenous peroxidation-derived DNA adduct, are 50-100-fold higher in mtDNA than in nuclear DNA in several ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2018, 46(7):3458-3467]

Cited: 9 times

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Macrophage-dependent impairment of α2-adrenergic autoreceptor inhibition of Ca2+ channels in sympathetic neurons from DOCA-salt but not high-fat diet-induced hypertensive rats.

Ryan K Mui, Roxanne N Fernandes, Hannah G Garver, Nico Van Rooijen, James J Galligan,

DOCA-salt and obesity-related hypertension are associated with inflammation and sympathetic nervous system hyperactivity. Prejunctional α2-adrenergic receptors (α2ARs) provide negative feedback to norepinephrine release from sympathetic nerves through inhibition of N-type Ca2+ channels. Increased neuronal norepinephrine release in DOCA-salt and obesity-related hypertension occurs through impaired α2AR signaling; however, the mechanisms involved ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2018, 314(4):H863-H877]

Cited: 4 times

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Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

William N Beavers, Kristie L Rose, James J Galligan, Michelle M Mitchener, Carol A Rouzer, Keri A Tallman, Connor R Lamberson, Xiaojing Wang, Salisha Hill, Pavlina T Ivanova, H Alex Brown, Bing Zhang, Ned A Porter, Lawrence J Marnett,

Determining the impact of lipid electrophile-mediated protein damage that occurs during oxidative stress requires a comprehensive analysis of electrophile targets adducted under pathophysiological conditions. Incorporation of ω-alkynyl linoleic acid into the phospholipids of macrophages prior to activation by Kdo<sub>2</sub>-lipid A, followed by protein extraction, click chemistry, and streptavidin affinity capture, ... Read more >>

ACS Chem Biol (ACS chemical biology)
[2017, 12(8):2062-2069]

Cited: 10 times

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From the exposome to mechanistic understanding of chemical-induced adverse effects.

Beate I Escher, Jörg Hackermüller, Tobias Polte, Stefan Scholz, Achim Aigner, Rolf Altenburger, Alexander Böhme, Stephanie K Bopp, Werner Brack, Wibke Busch, Marc Chadeau-Hyam, Adrian Covaci, Adolf Eisenträger, James J Galligan, Natalia Garcia-Reyero, Thomas Hartung, Michaela Hein, Gunda Herberth, Annika Jahnke, Jos Kleinjans, Nils Klüver, Martin Krauss, Marja Lamoree, Irina Lehmann, Till Luckenbach, Gary W Miller, Andrea Müller, David H Phillips, Thorsten Reemtsma, Ulrike Rolle-Kampczyk, Gerrit Schüürmann, Benno Schwikowski, Yu-Mei Tan, Saskia Trump, Susanne Walter-Rohde, John F Wambaugh,

The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external stressors. While the exposome concept has been established for human health, its principles can be extended to include broader ecological issues. The assessment of exposure is tightly ... Read more >>

Environ Int (Environment international)
[2017, 99:97-106]

Cited: 40 times

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R-Type Ca2+ channels couple to inhibitory neurotransmission to the longitudinal muscle in the guinea-pig ileum.

Eileen S Rodriguez-Tapia, Vinogran Naidoo, Matthew DeVries, Alberto Perez-Medina, James J Galligan,

<h4>New findings</h4>What is the central question of this study? Subtypes of enteric neurons are coded by the neurotransmitters they synthesize, but it is not known whether enteric neuron subtypes might also be coded by other proteins, including calcium channel subtypes controlling neurotransmitter release. What is the main finding and its ... Read more >>

Exp Physiol (Experimental physiology)
[2017, 102(3):299-313]

Cited: 1 time

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Insights into the Role of Opioid Receptors in the GI Tract: Experimental Evidence and Therapeutic Relevance.

James J Galligan, Catia Sternini,

Opioid drugs are prescribed extensively for pain treatment but when used chronically they induce constipation that can progress to opioid-induced bowel dysfunction. Opioid drugs interact with three classes of opioid receptors: mu opioid receptors (MORs), delta opioid receptors (DOR), and kappa opioid receptors (KORs), but opioid drugs mostly target the ... Read more >>

Handb Exp Pharmacol (Handbook of experimental pharmacology)
[2017, 239:363-378]

Cited: 15 times

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5-HT secretion by enterochromaffin cells is a very touching story.

James J Galligan,

J Physiol (The Journal of physiology)
[2017, 595(1):3]

Cited: 0 times

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Upregulation of L-type calcium channels in colonic inhibitory motoneurons of P/Q-type calcium channel-deficient mice.

Eileen Rodriguez-Tapia, Alberto Perez-Medina, Xiaochun Bian, James J Galligan,

Enteric inhibitory motoneurons use nitric oxide and a purine neurotransmitter to relax gastrointestinal smooth muscle. Enteric P/Q-type Ca<sup>2+</sup> channels contribute to excitatory neuromuscular transmission; their contribution to inhibitory transmission is less clear. We used the colon from tottering mice (tg/tg, loss of function mutation in the α1A pore-forming subunit of ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2016, 311(4):G763-G774]

Cited: 1 time

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