Full Text Journal Articles by
Author James A Seddon

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Evaluation of Ceftriaxone Plus Avibactam in an Intracellular Hollow Fiber Model of Tuberculosis: Implications for the Treatment of Disseminated and Meningeal Tuberculosis in Children.

Shashikant Srivastava, Johanna van Zyl, Kayle Cirrincione, Katherine Martin, Tania Thomas, Devyani Deshpande, Jan-William Alffenaar, James A Seddon, Tawanda Gumbo,

BACKGROUND:Ceftazidime-avibactam is an effective agent for the treatment of tuberculosis (TB) but requires frequent administration because of a short half-life. Due to a longer half-life, ceftriaxone could allow intermittent dosing. METHODS:First, we identified the MIC of ceftriaxone with 15 mg/L avibactam in 30 clinical Mycobacterium tuberculosis isolates. Next, 2 ceftriaxone exposure-effect ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(12):1092-1100]

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Access to paediatric formulations for the treatment of childhood tuberculosis.

Madlen Nash, Christophe Perrin, James A Seddon, Jennifer Furin, Janika Hauser, Ben Marais, Ian Kitai, Jeffrey Starke, Lindsay McKenna,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(12):855-857]

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Opportunities for Mobile App-Based Adherence Support for Children With Tuberculosis in South Africa.

Rachel M Morse, Hanlie Myburgh, David Reubi, Ava E Archey, Leletu Busakwe, Anthony J Garcia-Prats, Anneke C Hesseling, Stephanie Jacobs, Sharon Mbaba, Kyla Meyerson, James A Seddon, Marieke M van der Zalm, Dillon T Wademan, Graeme Hoddinott,

Tuberculosis is the number one infectious cause of death globally. Young children, generally those younger than 5 years, are at the highest risk of progressing from tuberculosis infection to tuberculosis disease and of developing the most severe forms of tuberculosis. Most current tuberculosis drug formulations have poor acceptability among children ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2020, 8(11):e19154]

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Xpert MTB/RIF Ultra for the Diagnosis of Tuberculous Meningitis: A Small Step Forward.

Joseph Donovan, Fiona V Cresswell, Nguyen Thuy Thuong Thuong, David R Boulware, Guy E Thwaites, Nathan C Bahr, ,

The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. The first comparative study of the new GeneXpert MTB/RIF Ultra (Xpert Ultra) for TBM diagnosis suggested increased sensitivity of Xpert Ultra. Two subsequent studies ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(8):2002-2005]

Cited: 1 time

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Multidrug-resistant tuberculosis in children and adolescents: current strategies for prevention and treatment.

James A Seddon, Sarah Johnson, Megan Palmer, Marieke M van der Zalm, Elisa Lopez-Varela, Jennifer Hughes, H Simon Schaaf,

INTRODUCTION:An estimated 30,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, with only a small proportion diagnosed and treated. This field has historically been neglected due to the perception that children with MDR-TB are challenging to diagnose and treat. Diagnostic and therapeutic developments in adults have improved pediatric management, yet ... Read more >>

Expert Rev Respir Med (Expert review of respiratory medicine)
[2020, :1-17]

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Abdominal Involvement in Children With Bacteriologically Confirmed Tuberculosis: A Five-year Experience From Cape Town, South Africa.

Giulia Sartoris, James A Seddon, Helena Rabie, Etienne D Nel, Giuseppe Losurdo, H Simon Schaaf,

BACKGROUND:Abdominal tuberculosis (TB) in children is poorly described and often poses a diagnostic challenge. We evaluated abdominal involvement in children presenting with bacteriologically confirmed TB. METHODS:We undertook a retrospective study at Tygerberg Hospital, Cape Town, from January 1, 2014, through December 31, 2018, of all children (<13 years) diagnosed with ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(10):914-919]

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International Survey Reveals Opportunities to Improve Tuberculous Meningitis Management and the Need for Standardized Guidelines.

Elizabeth W Tucker, Suzaan Marais, James A Seddon, Reinout van Crevel, Ahmad Rizal Ganiem, Rovina Ruslami, Wenhong Zhang, Feng Sun, Xian Zhou, Regan S Solomons, Fiona V Cresswell, Jo Wilmshurst, Ursula Rohlwink,

Background:Tuberculous meningitis (TBM) is a medical emergency, yet there are no standardized treatment guidelines for the medical or neurosurgical management of these patients and little data on neurocritical care. We conducted an international survey to understand current medical and neurosurgical TBM management and resource availability to provide baseline data needed ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(11):ofaa445]

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Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease.

Davaasambuu Ganmaa, Buyanjargal Uyanga, Xin Zhou, Garmaa Gantsetseg, Baigali Delgerekh, Davaasambuu Enkhmaa, Dorjnamjil Khulan, Saranjav Ariunzaya, Erdenebaatar Sumiya, Batbileg Bolortuya, Jutmaan Yanjmaa, Tserenkhuu Enkhtsetseg, Ankhbat Munkhzaya, Murneren Tunsag, Polyna Khudyakov, James A Seddon, Ben J Marais, Ochirbat Batbayar, Ganbaatar Erdenetuya, Bazarsaikhan Amarsaikhan, Donna Spiegelman, Jadambaa Tsolmon, Adrian R Martineau,

BACKGROUND:Vitamin D metabolites support innate immune responses to Mycobacterium tuberculosis. Data from phase 3, randomized, controlled trials of vitamin D supplementation to prevent tuberculosis infection are lacking. METHODS:We randomly assigned children who had negative results for M. tuberculosis infection according to the QuantiFERON-TB Gold In-Tube assay (QFT) to receive a ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(4):359-368]

Cited: 1 time

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Concordance of drug resistance profiles between persons with drug-resistant tuberculosis and their household contacts: a systematic review and meta-analysis.

Silvia S Chiang, Meredith B Brooks, Helen E Jenkins, Dana Rubenstein, James A Seddon, Brittney J van de Water, Michael M Lindeborg, Mercedes C Becerra, Courtney M Yuen,

BACKGROUND:Household contacts of patients with drug-resistant tuberculosis are at high risk for being infected with Mycobacterium tuberculosis and for developing tuberculosis disease. To guide regimen composition for the empirical treatment of tuberculosis infection and disease in these household contacts, we estimated drug resistance profile concordance between index patients with drug-resistant ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Protecting children in low-income and middle-income countries from COVID-19.

Salahuddin Ahmed, Tisungane Mvalo, Samuel Akech, Ambrose Agweyu, Kevin Baker, Naor Bar-Zeev, Harry Campbell, William Checkley, Mohammod Jobayer Chisti, Tim Colbourn, Steve Cunningham, Trevor Duke, Mike English, Adegoke G Falade, Nicholas Ss Fancourt, Amy S Ginsburg, Hamish R Graham, Diane M Gray, Madhu Gupta, Laura Hammitt, Anneke C Hesseling, Shubhada Hooli, Abdul-Wahab Br Johnson, Carina King, Miles A Kirby, Claudio F Lanata, Norman Lufesi, Grant A Mackenzie, John P McCracken, Peter P Moschovis, Harish Nair, Osawaru Oviawe, William S Pomat, Mathuram Santosham, James A Seddon, Lineo Keneuoe Thahane, Brian Wahl, Marieke Van der Zalm, Charl Verwey, Lay-Myint Yoshida, Heather J Zar, Stephen Rc Howie, Eric D McCollum,

BMJ Glob Health (BMJ global health)
[2020, 5(5):]

Cited: 1 time

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Risk-benefit analysis of tuberculosis infection testing for household contact management in high-burden countries: a mathematical modelling study.

Courtney M Yuen, James A Seddon, Salmaan Keshavjee, Peter J Dodd,

BACKGROUND:Preventive therapy for tuberculosis reduces the risk of disease in people who have been infected but who are not sick. Countries with a high burden of tuberculosis that are expanding preventive therapy use must decide how tuberculosis infection testing should be used for risk stratification among household contacts of patients ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2020, 8(5):e672-e680]

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Preventing tuberculosis in children: A global health emergency.

Anja Reuter, James A Seddon, Ben J Marais, Jennifer Furin,

It is estimated that 20 million children are exposed to tuberculosis (TB) each year, making TB a global paediatric health emergency. TB preventative efforts have long been overlooked. With the view of achieving "TB elimination" in "our lifetime", this paper explores challenges and potential solutions in the TB prevention cascade, ... Read more >>

Paediatr Respir Rev (Paediatric respiratory reviews)
[2020, 36:44-51]

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Maternal and infant outcomes among pregnant women treated for multidrug/rifampicin-resistant tuberculosis in South Africa.

Marian Loveday, Jennifer Hughes, Babu Sunkari, Iqbal Master, Sindisiwe Hlangu, Tarylee Reddy, Sunitha Chotoo, Nathan Green, James A Seddon,

BACKGROUND:Data on safety and efficacy of second-line tuberculosis drugs in pregnant women and their infants are severely limited due to exclusion from clinical trials and expanded access programmes. METHODS:Pregnant women starting treatment for multidrug/rifampicin-resistant (MDR/RR)-tuberculosis at King Dinuzulu Hospital in KwaZulu-Natal, South Africa from 1 January 2013 - 31 December ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis.

Leonardo Martinez, Olivia Cords, C Robert Horsburgh, Jason R Andrews, ,

BACKGROUND:Tens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children. The effectiveness of contact investigations and preventive therapy remains poorly understood. METHODS:In this systematic review and meta-analysis, we investigated the development of ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10228):973-984]

Cited: 1 time

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Decision-making in the diagnosis of tuberculous meningitis.

Tom H Boyles, Lutgarde Lynen, James A Seddon, ,

Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB) but diagnosis is difficult and delays in initiating therapy increase mortality. All currently available tests are imperfect; culture of Mycobacterium tuberculosis from the cerebrospinal fluid (CSF) is considered the most accurate test but is often negative, even when disease ... Read more >>

Wellcome Open Res (Wellcome open research)
[2020, 5:11]

Cited: 0 times

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Abdominal Tuberculosis in Children: Challenges, Uncertainty, and Confusion.

Giulia Sartoris, James A Seddon, Helena Rabie, Etienne D Nel, H Simon Schaaf,

The diagnosis of abdominal tuberculosis (TB) is challenging, and the prevalence of abdominal TB in children is likely underestimated. It may present with nonspecific abdominal symptoms and signs, but children who present with pulmonary TB may have additional abdominal subclinical involvement. Diagnosis is specifically challenging because none of the available ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2020, 9(2):218-227]

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Knowledge gaps and research priorities in tuberculous meningitis.

James A Seddon, Robert Wilkinson, Reinout van Crevel, Anthony Figaji, Guy E Thwaites, ,

Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), accounting for around 1-5% of the global TB caseload, with mortality of approximately 20% in children and up to 60% in persons co-infected with human immunodeficiency virus even in those treated. Relatively few centres of excellence in ... Read more >>

Wellcome Open Res (Wellcome open research)
[2019, 4:188]

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Tuberculous meningitis: new tools and new approaches required.

James A Seddon, Guy E Thwaites, ,

Tuberculous meningitis is the most severe form of tuberculosis and causes widespread mortality and morbidity. Understanding of the epidemiology and pathogenesis is incomplete, and the optimal diagnosis and treatment are poorly defined. To generate research collaboration and coordination, as well as to promote sharing of ideas and advocacy efforts, the ... Read more >>

Wellcome Open Res (Wellcome open research)
[2019, 4:181]

Cited: 1 time

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Adolescent tuberculosis.

Kathryn J Snow, Andrea T Cruz, James A Seddon, Rashida A Ferrand, Silvia S Chiang, Jennifer A Hughes, Beate Kampmann, Steve M Graham, Peter J Dodd, Rein M Houben, Justin T Denholm, Susan M Sawyer, Katharina Kranzer,

Adolescence is characterised by a substantial increase in the incidence of tuberculosis, a known fact since the early 20th century. Most of the world's adolescents live in low-income and middle-income countries where tuberculosis remains common, and where they comprise a quarter of the population. Despite this, adolescents have not yet ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(1):68-79]

Cited: 2 times

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Management of intracranial tuberculous mass lesions: how long should we treat for?

Suzaan Marais, Ronald Van Toorn, Felicia C Chow, Abi Manesh, Omar K Siddiqi, Anthony Figaji, Johan F Schoeman, Graeme Meintjes, ,

Tuberculous intracranial mass lesions are common in settings with high tuberculosis (TB) incidence and HIV prevalence. The diagnosis of such lesions, which include tuberculoma and tuberculous abscesses, is often presumptive and based on radiological features, supportive evidence of TB elsewhere and response to TB treatment. However, the treatment response is ... Read more >>

Wellcome Open Res (Wellcome open research)
[2019, 4:158]

Cited: 1 time

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The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes.

James A Seddon, Lillian Tugume, Regan Solomons, Kameshwar Prasad, Nathan C Bahr, ,

Tuberculous meningitis (TBM) results from dissemination of M. tuberculosis to the cerebrospinal fluid (CSF) and meninges. Ischaemia, hydrocephalus and raised intracranial pressure frequently result, leading to extensive brain injury and neurodisability. The global burden of TBM is unclear and it is likely that many cases are undiagnosed, with many treated ... Read more >>

Wellcome Open Res (Wellcome open research)
[2019, 4:167]

Cited: 2 times

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European guidance on drug-resistant tuberculosis in children and adolescents.

Matthias I Gröschel, James A Seddon, Satria A Prabowo, Giovanni B Migliori, Stephen M Graham, Martin van den Boom, Masoud Dara,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(1):9-11]

Cited: 0 times

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The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis.

Keertan Dheda, Tawanda Gumbo, Gary Maartens, Kelly E Dooley, Megan Murray, Jennifer Furin, Edward A Nardell, Robin M Warren, ,

The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was published in 2017, which comprehensively reviewed and provided recommendations on various aspects of the disease. Several key new developments regarding drug-resistant tuberculosis are outlined in this Commission Update. The WHO guidelines on treating drug-resistant tuberculosis were updated in 2019 with a ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(9):820-826]

Cited: 8 times

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Acceptability of a Novel Levofloxacin Dispersible Tablet Formulation in Young Children Exposed to Multidrug-resistant Tuberculosis.

Susan E Purchase, Anthony J Garcia-Prats, Petra De Koker, Heather R Draper, Muhammad Osman, James A Seddon, H Simon Schaaf, Anneke C Hesseling,

Levofloxacin is used for the treatment and prevention of multidrug-resistant tuberculosis in children, but current adult formulations are poorly palatable. A questionnaire administered to caregivers of 27 children taking a novel 100 mg dispersible taste-masked levofloxacin tablet found the new formulation to be more palatable (69%) and easier to prepare (81%) ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(6):608-610]

Cited: 0 times

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The evolving research agenda for paediatric tuberculosis infection.

James A Seddon, Elizabeth Whittaker, Beate Kampmann, Deborah A Lewinsohn, Muhammad Osman, Anneke C Hesseling, Roxana Rustomjee, Farhana Amanullah,

Following exposure to tuberculosis and subsequent infection, children often progress to tuberculosis disease more rapidly than adults. And yet the natural history of tuberculosis in children, as a continuum from exposure to infection and then to disease, is poorly understood. Children are rarely diagnosed with tuberculosis infection in routine care ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2019, 19(9):e322-e329]

Cited: 1 time

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