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Author Jalid Sehouli

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Randomized Trial of Cytoreductive Surgery for Relapsed Ovarian Cancer.

Philipp Harter, Jalid Sehouli, Ignace Vergote, Gwenael Ferron, Alexander Reuss, Werner Meier, Stefano Greggi, Berit J Mosgard, Frederic Selle, Frédéric Guyon, Christophe Pomel, Fabrice Lécuru, Rongyu Zang, Elisabeth Avall-Lundqvist, Jae-Weon Kim, Jordi Ponce, Francesco Raspagliesi, Gunnar Kristensen, Jean-Marc Classe, Peter Hillemanns, Pernille Jensen, Annette Hasenburg, Sadaf Ghaem-Maghami, Mansoor R Mirza, Bente Lund, Alexander Reinthaller, Ana Santaballa, Adeola Olaitan, Felix Hilpert, Andreas du Bois, ,

<h4>Background</h4>Treatment for patients with recurrent ovarian cancer has been mainly based on systemic therapy. The role of secondary cytoreductive surgery is unclear.<h4>Methods</h4>We randomly assigned patients with recurrent ovarian cancer who had a first relapse after a platinum-free interval (an interval during which no platinum-based chemotherapy was used) of 6 months ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(23):2123-2131]

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Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium.

Eva Obermayr, Elena Ioana Braicu, Stephan Polterauer, Liselore Loverix, Nicole Concin, Linn Woelber, Sven Mahner, Jalid Sehouli, Toon Van Gorp, Ignace Vergote, Robert Zeillinger, Stefanie Aust,

We investigated the prognostic role of systemic characteristics for cancer exhaustion and the presence of circulating tumor cells (CTCs) in primary epithelial ovarian cancer (EOC) patients. We included 185 patients in this multicenter study with a median follow-up time of 10.25 years. Albumin, c-reactive protein (CRP) and the kynurenine to ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(23):]

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Correction to: Preoperative quality of life as prediction for severe postoperative complications in gynecological cancer surgery: results of a prospective study.

Jalid Sehouli, Kathrin Heise, Rolf Richter, Hannah Woopen, Louise Anders, Melisa Guelhan Inci,

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

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Neurogenic Inflammation in the Context of Endometriosis-What Do We Know?

Renata Voltolini Velho, Eliane Taube, Jalid Sehouli, Sylvia Mechsner,

Endometriosis (EM) is an estrogen-dependent disease characterized by the presence of epithelial, stromal, and smooth muscle cells outside the uterine cavity. It is a chronic and debilitating condition affecting ~10% of women. EM is characterized by infertility and pain, such as dysmenorrhea, chronic pelvic pain, dyspareunia, dysuria, and dyschezia. Although ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(23):]

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European Society of Gynaecological Oncology quality indicators for the surgical treatment of endometrial carcinoma.

Nicole Concin, François Planchamp, Nadeem R Abu-Rustum, Beyhan Ataseven, David Cibula, Anna Fagotti, Christina Fotopoulou, Pawel Knapp, Christian Marth, Philippe Morice, Denis Querleu, Jalid Sehouli, Artem Stepanyan, Cagatay Taskiran, Ignace Vergote, Pauline Wimberger, Ignacio Zapardiel, Jan Persson,

<h4>Background</h4>Quality of surgical care as a crucial component of a comprehensive multi-disciplinary management improves outcomes in patients with endometrial carcinoma, notably helping to avoid suboptimal surgical treatment. Quality indicators (QIs) enable healthcare professionals to measure their clinical management with regard to ideal standards of care.<h4>Objective</h4>In order to complete its set ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(12):1508-1529]

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Adjuvant radiotherapy and local recurrence in vulvar cancer - a subset analysis of the AGO-CaRE-1 study.

Linn Woelber, Katharina Prieske, Christine Zu Eulenburg, Stefanie Corradini, Cordula Petersen, Mareike Bommert, Thomas Blankenstein, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Matthias W Beckmann, Alexander Mustea, Sven Mahner, Anna Jaeger,

<h4>Background</h4>The impact of adjuvant radiotherapy (RT) to the vulva with regard to prognosis and local recurrence in patients with vulvar squamous cell cancer (VSCC) is poorly described.<h4>Patients and methods</h4>In the AGO-CaRE-1 study 1618 patients with primary VSCC FIGO stage ≥ IB, treated between 1998-2008, were documented. In this retrospective subanalysis, ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2022, 164(1):68-75]

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Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique.

Mustafa Zelal Muallem, Ahmad Sayasneh, Robert Armbrust, Jalid Sehouli, Andrea Miranda,

(1) Background: Sentinel lymph node staging (SLN) with indocyanine green (ICG) in cervical cancer is the standard of care in most national and international guidelines. However, the vast majority of relevant studies about the safety and feasibility of this method are conducted on minimally invasive surgery; (2) Methods: This study ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.

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<h4>Background</h4>Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction.<h4>Methods</h4>This international, prospective, cohort ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, 22(11):1507-1517]

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Bevacizumab Combined with Platinum-Taxane Chemotherapy as First-Line Treatment for Advanced Ovarian Cancer: Results of the NOGGO Non-Interventional Study (OTILIA) in 824 Patients.

Jalid Sehouli, Alexander Mustea, Guelten Oskay-Özcelik, Maren Keller, Rolf Richter, Oliver Tomé, Hannah Woopen, Ann-Katrin Sommer-Joos, Jacek P Grabowski, Robert Armbrust, Pauline Wimberger,

In the single-arm non-interventional OTILIA study, patients with newly diagnosed International Federation of Gynecology and Obstetrics (FIGO) stage IIIB-IV ovarian cancer received bevacizumab (15 mg/kg every 3 weeks for up to 15 months) and standard carboplatin-paclitaxel. The primary aim was to assess safety and progression-free survival (PFS). Subgroup analyses according ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(19):]

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Lipid Reprogramming Induced by TFEB-ERRα Axis Enhanced Membrane Fluidity to Promote EC Progression

Xiaodan Mao, Huifang Lei, Tianjin Yi, Pingping Su, Shuting Tang, Yao Tong, Binhua Dong, Guanyu Ruan, Alexander Mustea, Jalid Sehouli, Pengming Sun,

<h4>Background: </h4> Endometrial cancer (EC) is one of the most common tumors in women. Estrogen-related receptor α (ERRα) has been reported to play a critical role in EC progression. However, the underlying mechanism of ERRα-mediated lipid reprogramming in EC remains elusive. Here, we show that transcription factor EB (TFEB)-ERRα axis ... Read more >>

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Survival outcomes of women with grade 3 endometrioid endometrial cancer: the impact of adjuvant treatment strategies.

Kemal Gungorduk, Jumana Muallem, Osman Aşıcıoğlu, Varol Gülseren, Ümran Küçükgöz Güleç, Mehmet Mutlu Meydanlı, Jalid Sehouli, Aykut Özdemir, Hanifi Şahin, Ghanim Khatib, Andrea Miranda, Nurettin Boran, Taylan Şenol, Nuri Yıldırım, Taner Turan, Tufan Oge, Salih Taşkın, Mehmet Ali Vardar, Ali Ayhan, Mustafa Zelal Muallem,

<h4>Aim</h4>This multicenter investigation was performed to evaluate the adjuvant treatment options, prognostic factors, and patterns of recurrence in patients with grade 3 endometrioid endometrial cancer (G3-EEC).<h4>Materials and methods</h4>The medical reports of patients undergoing at least total hysterectomy and salpingo-oophorectomy for G3-EEC between 1996 and 2018 at 11 gynecological oncology centers ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

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European Society of Gynaecological Oncology guidelines for the peri-operative management of advanced ovarian cancer patients undergoing debulking surgery.

Christina Fotopoulou, François Planchamp, Tugce Aytulu, Luis Chiva, Alessandro Cina, Önder Ergönül, Anna Fagotti, Dimitrios Haidopoulos, Annette Hasenburg, Cathy Hughes, Pawel Knapp, Philippe Morice, Stephanie Schneider, Jalid Sehouli, Emmanouil Stamatakis, Stephanie Suria, Cagatay Taskiran, Ralf Ulrich Trappe, Jeremy Campbell,

The European Society of Gynaecological Oncology (ESGO) developed and established for the first time in 2016, and updated in 2020, quality indicators for advanced ovarian cancer surgery to audit and improve clinical practice in Europe and beyond. As a sequela of the continuous effort to improve oncologic care in patients ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(9):1199-1206]

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Perinatal Data of Refugee Women from the Gynaecology Department of Charité University Hospital Berlin Compared with German Federal Analysis.

Ola Ammoura, Jalid Sehouli, Christine Kurmeyer, Rolf Richter, Nadja Kutschke, Wolfgang Henrich, Melisa Guelhan Inci,

<b>Introduction</b> The aim of this study was to record the perinatal data of refugee women at Charité Hospital, Berlin, and to evaluate possible differences in pre-, peri- and postnatal outcomes compared with indigenous women. <b>Material and Methods</b> All pregnant women who gave birth in the period from 1 January 2014 ... Read more >>

Geburtshilfe Frauenheilkd (Geburtshilfe und Frauenheilkunde)
[2021, 81(11):1238-1246]

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Chondroitin Sulfate Disaccharides, a Serum Marker for Primary Serous Epithelial Ovarian Cancer.

Karina Biskup, Caroline Stellmach, Elena Ioana Braicu, Jalid Sehouli, Véronique Blanchard,

Glycosaminoglycans are long polysaccharidic chains, which are mostly present in connective tissues. Modified GAG expression in tissues surrounding malignant cells has been shown to contribute to tumor progression, aggressive status and metastasis in many types of cancer. Ovarian cancer is one of the most lethal gynecological malignancies due to its ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(7):]

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EUS-guided Transgastric Drainage to Manage a Postoperative Pancreatic Fistula After Distal Pancreatectomy and Splenectomy in Recurrent Ovarian Cancer: A Case Report.

Andrea Miranda, Christian Jürgensen, Radoslav Chekerov, Sascha Chopra, Bernhard Gebauer, Jalid Sehouli,

<h4>Background/aim</h4>Postoperative pancreatic fistula after distal pancreatectomy represents the most frequent procedure-related complication; however, a standard treatment is currently not available.<h4>Case report</h4>We herein report a case of postoperative pancreatic fistula after distal pancreatectomy and splenectomy in a patient affected by a platinum-sensitive ovarian cancer recurrence. The 59-year-old patient developed a pancreatic ... Read more >>

Anticancer Res (Anticancer research)
[2021, 41(7):3649-3656]

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ECOG and BMI as preoperative risk factors for severe postoperative complications in ovarian cancer patients: results of a prospective study (RISC-GYN-trial).

Melisa Guelhan Inci, Julia Rasch, Hannah Woopen, Kristina Mueller, Rolf Richter, Jalid Sehouli,

<h4>Background</h4>Accompanying co-morbidities in patients with ovarian cancer are of major relevance for scheduling debulking surgery, especially in the anesthesiological consultations. Aim of this study was to evaluate the impact of co-morbidities and patient characteristics on postoperative complications.<h4>Methods</h4>Patients undergoing maximal cytoreductive surgery were prospectively enrolled from October 2015 to January 2017. ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, 304(5):1323-1333]

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The Long-Term Prognostic Significance of Circulating Tumor Cells in Ovarian Cancer-A Study of the OVCAD Consortium.

Eva Obermayr, Angelika Reiner, Burkhard Brandt, Elena Ioana Braicu, Alexander Reinthaller, Liselore Loverix, Nicole Concin, Linn Woelber, Sven Mahner, Jalid Sehouli, Ignace Vergote, Robert Zeillinger,

<h4>Introduction</h4>We previously reported the prognostic impact of circulating tumor cells (CTCs) in a multicenter study on minimal residual disease in primary ovarian cancer. With additional follow-up data, we evaluated the combined CTC approach (CTCs<sup>combo</sup>), in particular for the patients who had survived more than five years.<h4>Material and methods</h4>Blood samples taken ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(11):]

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Prevalence of human papillomavirus detection in ovarian cancer: a meta-analysis.

Soumia Cherif, Abdessamad Amine, Sarah Thies, Eliane T Taube, Elena Ioana Braicu, Jalid Sehouli, Andreas M Kaufmann,

We conducted a meta-analysis of published data to update and estimate the prevalence of HPV in ovarian cancer. A comprehensive literature search was performed according to the PRISMA guidelines. Eligible articles published from 1989 until 2020 by searching Web of Sciences, Pubmed, Embase, and the Cochrane Library Central databases were ... Read more >>

Eur J Clin Microbiol Infect Dis (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2021, 40(9):1791-1802]

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Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group.

Fabian Trillsch, Sven Mahner, Bastian Czogalla, Miriam Rottmann, Radoslav Chekerov, Elena Ioana Braicu, Gülten Oskay-Öczelik, Pauline Wimberger, Rolf Richter, Jalid Sehouli,

<h4>Objective</h4>Patients with platinum-resistant ovarian cancer (PROC) have a high need for reliable prognostic markers. Since significance of primary platinum resistance (PPR) versus secondary platinum resistance (SPR) was identified for patients receiving anti-angiogenic therapy, it has not been confirmed for chemotherapy only.<h4>Methods</h4>PROC patients from 3 prospective trials of the NOGGO study ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e37]

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Functional changes of immune cells: signal of immune tolerance of the ectopic lesions in endometriosis?

Renata Voltolini Velho, Nicolette Halben, Radoslav Chekerov, Jacqueline Keye, Johanna Plendl, Jalid Sehouli, Sylvia Mechsner,

<h4>Research question</h4>What is the potential role of immune cells and their inflammatory cytokines in the pathogenesis, development and establishment of endometriosis?<h4>Design</h4>Peritoneal fluid from 59 women (43 with endometriosis and 16 controls) who had undergone laparoscopic surgery was analysed. Changes in the population of innate and adaptive immune cells, cytokines, chemokines ... Read more >>

Reprod Biomed Online (Reproductive biomedicine online)
[2021, 43(2):319-328]

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Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer: Placebo-Controlled Randomized Phase III Trial (IMagyn050/GOG 3015/ENGOT-OV39).

Kathleen N Moore, Michael Bookman, Jalid Sehouli, Austin Miller, Charles Anderson, Giovanni Scambia, Tashanna Myers, Cagatay Taskiran, Katina Robison, Johanna Mäenpää, Lyndsay Willmott, Nicoletta Colombo, Jessica Thomes-Pepin, Michalis Liontos, Michael A Gold, Yolanda Garcia, Sudarshan K Sharma, Christopher J Darus, Carol Aghajanian, Aikou Okamoto, Xiaohua Wu, Rustem Safin, Fan Wu, Luciana Molinero, Vidya Maiya, Victor K Khor, Yvonne G Lin, Sandro Pignata,

<h4>Purpose</h4>To evaluate the addition of the humanized monoclonal antiprogrammed death ligand-1 (PD-L1) antibody, atezolizumab, to platinum-based chemotherapy and bevacizumab in newly diagnosed stage III or IV ovarian cancer (OC).<h4>Methods</h4>This multicenter placebo-controlled double-blind randomized phase III trial (ClinicalTrials.gov identifier: NCT03038100) enrolled patients with newly diagnosed untreated International Federation of Gynecology and ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, 39(17):1842-1855]

Cited: 10 times

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Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11.

Robert Armbrust, Frank Chen, Rolf Richter, Mustafa Zela Muallem, Alexander Mustea, Bernd Holthaus, Jalid Sehouli,

Minimally invasive surgery (MIS) has become the standard approach in early stage cervical cancer (ECC). However, the recently published "LACC" trial and even others could show inferior PFS and OS of MIS compared to open radical hysterectomy. The results led to a widespread debate about the best surgical approach in ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):9774]

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The Prevention of Positioning Injuries During Gynecologic Surgery. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/077, October 2020).

Markus C Fleisch, Werner Bader, Kai Balzer, Luisa Bennefeld, Carsten Boeing, Dorothee Bremerich, Paul Gass, Verena Geissbuehler, Martin C Koch, Monika J Nothacker, Klaus Pietzner, Stefan P Renner, Thomas Römer, Stephan Roth, Florian Schütz, Wilhelm Schulte-Mattler, Jalid Sehouli, Kristina Lippach, Karl Tamussino, Alexander Teichmann, Clemens Tempfer, Marc Thill, Hans-Rudolf Tinneberg, Konstantinos Zarras,

<b>Purpose</b> Positioning injuries are relatively common, forensically highly relevant complications of gynecologic surgery. The aim of this official AWMF S2k-guideline is to provide statements and recommendations on how to prevent positioning injuries using the currently available literature. The literature was evaluated by an interdisciplinary group of experts from professional medical ... Read more >>

Geburtshilfe Frauenheilkd (Geburtshilfe und Frauenheilkunde)
[2021, 81(4):447-468]

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Plasma calcitonin gene-related peptide (CGRP) in migraine and endometriosis during the menstrual cycle.

Bianca Raffaelli, Lucas Hendrik Overeem, Jasper Mecklenburg, Maxi Dana Hofacker, Henriette Knoth, Claus Peter Nowak, Lars Neeb, Andreas Dietmar Ebert, Jalid Sehouli, Sylvia Mechsner, Uwe Reuter,

<h4>Objective</h4>Migraine, endometriosis, and the comorbidity of both are frequent pain disorders of special relevance for women. The neuropeptide calcitonin gene-related peptide (CGRP) is critically involved in migraine, and circumstantial evidence suggests a role in endometriosis. We assessed CGRP levels at different times of menstrual cycle in four groups: healthy women, ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2021, 8(6):1251-1259]

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A Novel Two-Lipid Signature Is a Strong and Independent Prognostic Factor in Ovarian Cancer.

Liina Salminen, Elena Ioana Braicu, Mitja Lääperi, Antti Jylhä, Sinikka Oksa, Sakari Hietanen, Jalid Sehouli, Hagen Kulbe, Andreas du Bois, Sven Mahner, Philipp Harter, Olli Carpén, Kaisa Huhtinen, Johanna Hynninen, Mika Hilvo,

Epithelial ovarian cancer (EOC) generally responds well to oncological treatments, but the eventual development of a refractory disease is a major clinical problem. Presently, there are no prognostic blood-based biomarkers for the stratification of EOC patients at the time of diagnosis. We set out to assess and validate the prognostic ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(8):]

Cited: 1 time

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