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Author Jalid Sehouli

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Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group.

Fabian Trillsch, Sven Mahner, Bastian Czogalla, Miriam Rottmann, Radoslav Chekerov, Elena Ioana Braicu, Gülten Oskay-Öczelik, Pauline Wimberger, Rolf Richter, Jalid Sehouli,

<h4>Objective</h4>Patients with platinum-resistant ovarian cancer (PROC) have a high need for reliable prognostic markers. Since significance of primary platinum resistance (PPR) versus secondary platinum resistance (SPR) was identified for patients receiving anti-angiogenic therapy, it has not been confirmed for chemotherapy only.<h4>Methods</h4>PROC patients from 3 prospective trials of the NOGGO study ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e37]

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Prognostic Value and Therapeutic Implications of Pleural Carcinosis and Malignant Pleural Effusion in Advanced Epithelial Ovarian Cancer.

Sara Nasser, Christina Fotopoulou, Rolf Richter, Jana Kaulich, Elena Braicu, Carmen Beteta, Jessica Olschewski, Aygun Babayeva, Jalid Sehouli,

<h4>Aim</h4>To demonstrate the prognostic value of pleural carcinosis/effusion in a cohort of patients with advanced epithelial ovarian cancer (EOC) and the associated therapeutic implications.<h4>Patients and methods</h4>Overall, data for 388 patients with EOC with confirmed malignant pleural effusion (MPE) or pleural carcinosis were retrospectively analyzed. Exclusion criteria were non-epithelial ovarian malignancies ... Read more >>

Anticancer Res (Anticancer research)
[2021, 41(4):2033-2038]

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Role of Pelvic Lymph Node Resection in Vulvar Squamous Cell Cancer: A Subset Analysis of the AGO-CaRE-1 Study.

Linn Woelber, Mareike Bommert, Philipp Harter, Katharina Prieske, Christine Zu Eulenburg, Julia Jueckstock, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Matthias Beckmann, Alexander Mustea, Werner Meier, Sven Mahner, Anna Jaeger,

<h4>Background</h4>As the population at risk for pelvic nodal involvement remains poorly described, the role of pelvic lymphadenectomy (LAE) in vulvar squamous cell cancer (VSCC) has been a matter of discussion for decades.<h4>Methods</h4>In the AGO-CaRE-1 study, 1618 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB or higher primary ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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Classification of Molecular Subtypes of High-Grade Serous Ovarian Cancer by MALDI-Imaging.

Wanja Kassuhn, Oliver Klein, Silvia Darb-Esfahani, Hedwig Lammert, Sylwia Handzik, Eliane T Taube, Wolfgang D Schmitt, Carlotta Keunecke, David Horst, Felix Dreher, Joshy George, David D Bowtell, Oliver Dorigo, Michael Hummel, Jalid Sehouli, Nils Blüthgen, Hagen Kulbe, Elena I Braicu,

Despite the correlation of clinical outcome and molecular subtypes of high-grade serous ovarian cancer (HGSOC), contemporary gene expression signatures have not been implemented in clinical practice to stratify patients for targeted therapy. Hence, we aimed to examine the potential of unsupervised matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) to stratify ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(7):]

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Immunogenicity and safety of a nine-valent human papillomavirus vaccine in women 27-45 years of age compared to women 16-26 years of age: An open-label phase 3 study.

Elmar A Joura, Angels Ulied, Corinne Vandermeulen, Milagrosa Rua Figueroa, Ilkka Seppä, Juan José Hernandez Aguado, Anitta Ahonen, Olaf Reich, Miia Virta, Antonino Perino, Merce Peris Tuser, Klaus Peters, Massimo Origoni, Francesco Raspagliesi, Wiebren A A Tjalma, Philippe Tummers, Linn Woelber, Pekka Nieminen, Pierre van Damme, Jalid Sehouli, Gabriel Fiol Ruiz, Sara Brucker, Tanja Fehm, Kyeongmi Cheon, Sonali Rawat, Alain Luxembourg, Frederick Wittke,

<h4>Background</h4>Efficacy of the nine-valent human papillomavirus (9vHPV; HPV types 6/11/16/18/31/33/45/52/58) vaccine was demonstrated in a phase 3 study in women 16-26 years of age. We present a phase 3 immunogenicity and safety study of the 9vHPV vaccine in women 27-45 versus 16-26 years of age.<h4>Methods</h4>This international, open-label study (NCT03158220) was conducted in ... Read more >>

Vaccine (Vaccine)
[2021, :]

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Secondary malignancies in long-term ovarian cancer survivors: results of the 'Carolin meets HANNA' study.

Hannah Woopen, Carolin Rolf, Elena Ioana Braicu, Nina Buttmann-Schweiger, Benjamin Barnes, Joanna Baum, Klaus Pietzner, Klaus Kraywinkel, Jalid Sehouli,

<h4>Objective</h4>To evaluate the rate of secondary malignancies in long-term survivors with ovarian cancer.<h4>Methods</h4>Long-term survivors with ovarian cancer (survival ≥8 years after initial diagnosis) with multiple malignancies were identified within the Tumorbank Ovarian Cancer and our study 'Carolin meets HANNA - Holistic Analyses of Long-term Survivors with Ovarian Cancer'.<h4>Results</h4>Of a total ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, :]

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Gynecologic oncology on the global health agenda: A wake-up call.

Andreas Ullrich, Murat Gültekin, Ibrahima Teguete, Edward L Trimble, Jalid Sehouli,

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Frailty Index for prediction of surgical outcome in ovarian cancer: Results of a prospective study.

Melisa Guelhan Inci, Louise Anders, Hannah Woopen, Rolf Richter, Duygu Guzel, Robert Armbrust, Jalid Sehouli,

<h4>Background</h4>Complete macroscopic tumor resection is the strongest prognostic factor for patients with ovarian cancer, which requires complex surgery for achievement. Based on the mostly advanced tumor stage and high symptom burden many patients are classified as frail which may limit optimal surgical outcome. Aim of this study is to evaluate ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Age, treatment and prognosis of patients with squamous cell vulvar cancer (VSCC) - analysis of the AGO-CaRE-1 study.

Katharina Prieske, Linn Woelber, Mustafa Zelal Muallem, Christine Eulenburg, Julia Kathrin Jueckstock, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Matthias Beckmann, Alexander Mustea, Werner Meier, Philipp Harter, Pauline Wimberger, Jalid Sehouli, Sven Mahner,

<h4>Background</h4>Despite an increasing incidence with simultaneous decreasing age of onset, vulvar squamous cell carcinoma (VSCC) is still a disease that mainly effects the elderly population. Data on the association of age with prognosis and treatment patterns in VSCC are sparse.<h4>Methods</h4>This is an analysis of the AGO-CaRE-1 cohort. Patients with VSCC ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Patient-Reported Outcomes (PROs) and Health-Related Quality of Life (HR-QoL) in Patients with Ovarian Cancer: What Is Different Compared to Healthy Women?

Melisa Guelhan Inci, Rolf Richter, Kathrin Heise, Ricarda Dukatz, Hannah Woopen, Jalid Sehouli,

<h4>Introduction</h4>The aim of this analysis was to evaluate the health-related quality of life (HR-QoL) in patients with ovarian cancer using a patient-reported outcome (PRO) based questionnaire and to compare it to the healthy female population in Germany and to other ovarian cancer patients worldwide. Additionally, we looked for differences in ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(4):]

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Evaluation of Biomarkers in Myoma Patients: A Prospective Study Investigating the Role of LDH, CA 125, and IGF-1 after Uterus-Preserving Surgical Therapy.

Michaela Jacob, Rolf Richter, Jalid Sehouli, Matthias David,

<h4>Objective</h4>Myomas are one of the most common tumors of the lower abdomen in women. At present, sonography and clinical examination are the prevalent diagnostic standards for these tumors, and no biomarkers have been established yet. The primary aim of this study was to determine if the surgical removal of myomas ... Read more >>

Gynecol Obstet Invest (Gynecologic and obstetric investigation)
[2021, :1-8]

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[Use of emergency rooms by so-called multiple users: results of a prospective study with special consideration of the migration status].

Matthias David, Rolf Richter, Baharan Naghavi, Theda Borde, Oliver Razum, Rajan Somasundaram, Hendrike Stein, Jalid Sehouli,

<h4>Objectives</h4>Can we identify predictive factors for the group of so-called multiple users (MU; 4 and more uses of an emergency department [ED] in the past 12 months)? Are people with a migration background more likely to be classified in the MU group?<h4>Methodology</h4>Included were consecutive patients who visited three EDs in Berlin from ... Read more >>

Notf Rett Med (Notfall & rettungsmedizin)
[2021, :1-7]

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ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma.

Nicole Concin, Carien L Creutzberg, Ignace Vergote, David Cibula, Mansoor Raza Mirza, Simone Marnitz, Jonathan A Ledermann, Tjalling Bosse, Cyrus Chargari, Anna Fagotti, Christina Fotopoulou, Antonio González-Martín, Sigurd F Lax, Domenica Lorusso, Christian Marth, Philippe Morice, Remi A Nout, Dearbhaile E O'Donnell, Denis Querleu, Maria Rosaria Raspollini, Jalid Sehouli, Alina E Sturdza, Alexandra Taylor, Anneke M Westermann, Pauline Wimberger, Nicoletta Colombo, François Planchamp, Xavier Matias-Guiu,

A European consensus conference on endometrial carcinoma was held in 2014 to produce multidisciplinary evidence-based guidelines on selected questions. Given the large body of literature on the management of endometrial carcinoma published since 2014, the European Society of Gynaecological Oncology (ESGO), the European SocieTy for Radiotherapy & Oncology (ESTRO) and ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2021, 478(2):153-190]

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Impact of clinical factors and surgical outcome on long-term survival in high-grade serous ovarian cancer: a multicenter analysis.

Joanna Baum, Elena Ioana Braicu, Oliver Hunsicker, Ignace Vergote, Nicole Concin, Els Van Nieuwenhuysen, Aarne Feldheiser, Patriciu Achimas-Cadariu, Silvia Darb-Esfahani, Astrid Berger, Bogdan Fetica, Sven Mahner, Andrea Papadia, Linn Wölber, Maria Luisa Gasparri, Adriaan Vanderstichele, Pierluigi Benedetti Panici, Michael D Mueller, Ilary Ruscito, Hannah Woopen, Jalid Sehouli,

<h4>Introduction</h4>Long-term survivors of ovarian cancer are a unique group of patients in whom prognostic factors for long-term survival have been poorly described. Such factors may provide information for a more personalized therapeutic approach. The objective of this study is to determine further characteristics of long-term survivors with high-grade serous ovarian ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, :]

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Effects of sarcopenia and malnutrition on morbidity and mortality in gynecologic cancer surgery: results of a prospective study.

Jalid Sehouli, Kristina Mueller, Rolf Richter, Markus Anker, Hannah Woopen, Julia Rasch, Jacek P Grabowski, Eva Prinz-Theissing, Melisa Guelhan Inci,

<h4>Background</h4>Malnutrition and sarcopenia often occur simultaneously in cancer patients and are thought to have harmful effects on both surgical and oncological outcomes. Therefore, we want to evaluate the effects of sarcopenia and malnutrition on severe postoperative complications and overall survival in gynecologic cancer patients.<h4>Methods</h4>We assessed nutritional parameters and run a ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2021, :]

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Effects of epigallocatechin gallate-enriched green tea extract capsules in uterine myomas: results of an observational study.

Rebekka Biro, Rolf Richter, Miriam Ortiz, Jalid Sehouli, Matthias David,

<h4>Purpose</h4>The daily ingestion of green tea extract (GTE) capsules in women with oligo- or asymptomatic uterine myomas was monitored over 6 months with regard to their quality of life, myoma-associated complaints and side effects.<h4>Methods</h4>The participants were interviewed and examined at the beginning of the study (T1) and then again after 6 months ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

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ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma.

Nicole Concin, Xavier Matias-Guiu, Ignace Vergote, David Cibula, Mansoor Raza Mirza, Simone Marnitz, Jonathan Ledermann, Tjalling Bosse, Cyrus Chargari, Anna Fagotti, Christina Fotopoulou, Antonio Gonzalez Martin, Sigurd Lax, Domenica Lorusso, Christian Marth, Philippe Morice, Remi A Nout, Dearbhaile O'Donnell, Denis Querleu, Maria Rosaria Raspollini, Jalid Sehouli, Alina Sturdza, Alexandra Taylor, Anneke Westermann, Pauline Wimberger, Nicoletta Colombo, François Planchamp, Carien L Creutzberg,

A European consensus conference on endometrial carcinoma was held in 2014 to produce multidisciplinary evidence-based guidelines on selected questions. Given the large body of literature on the management of endometrial carcinoma published since 2014, the European Society of Gynaecological Oncology (ESGO), the European SocieTy for Radiotherapy & Oncology (ESTRO) and ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 154:327-353]

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ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma.

Nicole Concin, Xavier Matias-Guiu, Ignace Vergote, David Cibula, Mansoor Raza Mirza, Simone Marnitz, Jonathan Ledermann, Tjalling Bosse, Cyrus Chargari, Anna Fagotti, Christina Fotopoulou, Antonio Gonzalez Martin, Sigurd Lax, Domenica Lorusso, Christian Marth, Philippe Morice, Remi A Nout, Dearbhaile O'Donnell, Denis Querleu, Maria Rosaria Raspollini, Jalid Sehouli, Alina Sturdza, Alexandra Taylor, Anneke Westermann, Pauline Wimberger, Nicoletta Colombo, François Planchamp, Carien L Creutzberg,

A European consensus conference on endometrial carcinoma was held in 2014 to produce multi-disciplinary evidence-based guidelines on selected questions. Given the large body of literature on the management of endometrial carcinoma published since 2014, the European Society of Gynaecological Oncology (ESGO), the European SocieTy for Radiotherapy and Oncology (ESTRO), and ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(1):12-39]

Cited: 11 times

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Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2: results of the observational AGO-TR1 study (NCT02222883).

Jan Hauke, Philipp Harter, Corinna Ernst, Alexander Burges, Sandra Schmidt, Alexander Reuss, Julika Borde, Nikolaus De Gregorio, Dimo Dietrich, Ahmed El-Balat, Mohamad Kayali, Heidrun Gevensleben, Felix Hilpert, Janine Altmüller, André Heimbach, Werner Meier, Birgid Schoemig-Markiefka, Holger Thiele, Rainer Kimmig, Peter Nürnberg, Karin Kast, Lisa Richters, Jalid Sehouli, Rita K Schmutzler, Eric Hahnen,

Variant-specific loss of heterozygosity (LOH) analyses may be useful to classify <i>BRCA1/2</i> germline variants of unknown significance (VUS). The sensitivity and specificity of this approach, however, remains unknown. We performed comparative next-generation sequencing analyses of the <i>BRCA1/2</i> genes using blood-derived and tumour-derived DNA of 488 patients with ovarian cancer enrolled ... Read more >>

J Med Genet (Journal of medical genetics)
[2020, :]

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Patients' subjective assessment as a decisive predictor of malignancy in pelvic masses: results of a multicentric, prospective pelvic mass study.

Elisa Koch, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Gerhard Nohe, Bodo Müller, Janine Boeneß-Zaloum, Kerstin Ames, Frank Chen, Carmen Beteta, Kati Hasenbein, Adak Pirmorady, Mathias Zimmermann, Desislava Dimitrova, Rudolf Tauber, Jalid Sehouli, Catherine Linn Knieper, Elena Ioana Braicu,

<h4>Objective</h4>The prognosis for ovarian cancer patients remains poor. A key to maximizing survival rates is early detection and treatment. This requires an accurate prediction of malignancy. Our study seeks to improve the accuracy of prediction by focusing on early subjective assessment of malignancy. We therefore investigated the assessment of patients ... Read more >>

J Psychosom Obstet Gynaecol (Journal of psychosomatic obstetrics and gynaecology)
[2020, :1-6]

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Surgical versus clinical staging prior to primary chemoradiation in patients with cervical cancer FIGO stages IIB-IVA: oncologic results of a prospective randomized international multicenter (Uterus-11) intergroup study.

Simone Marnitz, Audrey Tieko Tsunoda, Peter Martus, Marcelo Vieira, Renato Jose Affonso Junior, João Nunes, Volker Budach, Hermann Hertel, Alexander Mustea, Jalid Sehouli, Jens-Peter Scharf, Uwe Ulrich, Andreas Ebert, Iris Piwonski, Christhardt Kohler,

<h4>Objective</h4>Revised staging of patients with locally advanced cervical cancer is based on clinical examination, imaging, and potential surgical findings. A known limitation of imaging techniques is an appreciable rate of understaging. In contrast, surgical staging may provide more accurate information on lymph node involvement. The aim of this prospective study ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(12):1855-1861]

Cited: 1 time

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Perspectives, fears and expectations of patients with gynaecological cancers during the COVID-19 pandemic: A Pan-European study of the European Network of Gynaecological Cancer Advocacy Groups (ENGAGe).

Murat Gultekin, Sertac Ak, Ali Ayhan, Aleksandra Strojna, Andrei Pletnev, Anna Fagotti, Anna Myriam Perrone, B Emre Erzeneoglu, B Esat Temiz, Birthe Lemley, Burcu Soyak, Cathy Hughes, David Cibula, Dimitrios Haidopoulos, Donal Brennan, Edoardo Cola, Elzbieta van der Steen-Banasik, Esra Urkmez, Huseyin Akilli, Ignacio Zapardiel, Icó Tóth, Jalid Sehouli, Kamil Zalewski, Kiarash Bahremand, Luis Chiva, Mansoor Raza Mirza, Maria Papageorgiou, Novak Zoltan, Petra Adámková, Philippe Morice, Sonia Garrido-Mallach, Utku Akgor, Vasilis Theodoulidis, Zafer Arik, Karina D Steffensen, Christina Fotopoulou,

<h4>Background</h4>The impact of the COVID-19 pandemic on European gynaecological cancer patients under active treatment or follow-up has not been documented. We sought to capture the patient perceptions of the COVID-19 implications and the worldwide imposed treatment modifications.<h4>Methods</h4>A patient survey was conducted in 16 European countries, using a new COVID-19-related questionnaire, ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(1):208-219]

Cited: 2 times

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Nerve-Sparing Systematic Lymph Node Dissection in Gynaecological Oncology: An Innovative Neuro-Anatomical and Surgical Protocol for Enhanced Functional Outcomes.

Mustafa Zelal Muallem, Yasser Diab, Thomas Jöns, Jalid Sehouli, Jumana Muallem,

Whilst systematic lymph node dissection has been less prevalent in gynaecological cancer cases in the last few years, there is still a good number of cases that mandate a systematic lymph node dissection for diagnostic and therapeutic purposes. In all of these cases, it is crucial to perform the procedure ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(11):]

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Pelvic Lymphadenectomy in Vulvar Cancer - Does it make sense?

Linn Woelber, Mareike Bommert, Katharina Prieske, Inger Fischer, Christine Zu Eulenburg, Eik Vettorazzi, Philipp Harter, Julia Jueckstock, Felix Hilpert, Niko de Gregorio, Severine Iborra, Jalid Sehouli, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Matthias Beckmann, Alexander Mustea, Werner Meier, Pauline Wimberger, Lars Hanker, Ulrich Canzler, Tanja Fehm, Alexander Luyten, Martin Hellriegel, Jens Kosse, Christoph Heiss, Peer Hantschmann, Peter Mallmann, Berno Tanner, Jacobus Pfisterer, Sven Mahner, Barbara Schmalfeldt, Anna Jaeger,

Since the publication of the updated German guideline in 2015, the recommendations for performing pelvic lymphadenectomy (LAE) in patients with vulvar cancer (VSCC) have changed considerably. The guideline recommends surgical lymph node staging in all patients with a higher risk of pelvic lymph node involvement. However, the current data do ... Read more >>

Geburtshilfe Frauenheilkd (Geburtshilfe und Frauenheilkunde)
[2020, 80(12):1221-1228]

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BRCA1 Promoter Methylation and Clinical Outcomes in Ovarian Cancer: An Individual Patient Data Meta-Analysis.

Roshni D Kalachand, Britta Stordal, Stephen Madden, Benjamin Chandler, Julie Cunningham, Ellen L Goode, Ilary Ruscito, Elena I Braicu, Jalid Sehouli, Atanas Ignatov, Herbert Yu, Dionyssios Katsaros, Gordon B Mills, Karen H Lu, Mark S Carey, Kirsten M Timms, Jolanta Kupryjanczyk, Iwona K Rzepecka, Agnieszka Podgorska, Jessica N McAlpine, Elizabeth M Swisher, Sarah S Bernards, Ciaran O'Riain, Sharon O'Toole, John J O'Leary, David D Bowtell, David M Thomas, Katharina Prieske, Simon A Joosse, Linn Woelber, Parvesh Chaudhry, Norman Häfner, Ingo B Runnebaum, Bryan T Hennessy,

<h4>Background</h4>BRCA1 methylation has been associated with homologous recombination deficiency, a biomarker of platinum sensitivity. Studies evaluating BRCA1-methylated tubal and ovarian cancer (OC) do not consistently support improved survival following platinum chemotherapy. We examine the characteristics of BRCA1-methylated OC in a meta-analysis of individual participant data.<h4>Methods</h4>Data of 2636 participants across 15 ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2020, 112(12):1190-1203]

Cited: 3 times

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