Full Text Journal Articles by
Author Jakub Fronczek

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Myocardial injury after noncardiac surgery - an update.

Wojciech Szczeklik, Jakub Fronczek,

<h4>Purpose of review</h4>After successfully reducing mortality in the operating room, the time has come for anesthesiologists to conquer postoperative complications. This review aims to raise awareness about myocardial injury after noncardiac surgery (MINS), its definition, diagnosis, clinical importance, and treatment.<h4>Recent findings</h4>MINS, defined as an elevated postoperative troponin judged to be ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):381-386]

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Preoperative levels of natriuretic peptides and the incidence of postoperative atrial fibrillation after noncardiac surgery: a prospective cohort study.

Wojciech Szczeklik, Yannick LeManach, Jakub Fronczek, Kamil Polok, David Conen, Finlay A McAlister, Sadeesh Srinathan, Pablo Alonso-Coello, Bruce Biccard, Emmanuelle Duceppe, Diane Heels-Ansdell, Jacek Górka, Shirley Pettit, Pavel S Roshanov, P J Devereaux,

<h4>Background</h4>Postoperative atrial fibrillation (POAF) is associated with clinically significant short- and long-term complications after noncardiac surgery. Our aim was to describe the incidence of clinically important POAF after noncardiac surgery and establish the prognostic value of N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in this context.<h4>Methods</h4>The Vascular events In noncardiac Surgery patIents ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2020, 192(49):E1715-E1722]

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Perioperative cardiovascular complications rate and activity of coagulation and fibrinolysis among patients undergoing vascular surgery for peripheral artery disease and abdominal aortic aneurysm.

Kamil Polok, Jacek Górka, Jakub Fronczek, Teresa Iwaniec, Karolina Górka, Wojciech Szczeklik,

<h4>Objectives</h4>To compare preoperative coagulation and fibrinolysis activity and incidence of perioperative complications between patients undergoing vascular procedures for peripheral artery disease and abdominal aortic aneurysm.<h4>Methods</h4>This is a substudy of a prospective observational cohort study (VISION; NCT00512109) in which we recruited patients aged ≥45 years, undergoing surgery for peripheral artery disease and ... Read more >>

Vascular (Vascular)
[2021, 29(1):134-142]

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Remdesivir use in patients with coronavirus COVID-19 disease: a systematic review and meta-analysis of the Chinese Lancet trial with the NIH trial

Paul Elias Alexander, Joshua Piticaru, Kimberley Lewis, Komal Aryal, Priya Thomas, Wojciech Szczeklik, Jakub Fronczek, Kamil Polok, Waleed Alhazzani, Manoj Mammen,

<h4>Background</h4> Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus SARS-CoV-2, has led to significant global mortality and morbidity. Until now, no treatment has proven to be effective in COVID-19. To explore whether the use of remdesivir, initially an experimental broad-spectrum antiviral, is effective in the treatment of hospitalized patients ... Read more >>

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Time from admission to surgery in Polish patients with hip fractures: temporal trends in the last decade and association with duration of hospitalization and in-hospital mortality.

Kamil Polok, Zbigniew Pilecki, Halina Kutaj-Wąsikowska, Barbara Kutryba, Rosa Sunol, Grzegorz Pilecki, Jacek Górka, Jakub Fronczek, Wojciech Szczeklik,

<h4>Introduction</h4>Hip fracture is an important cause of morbidity and mortality among elderly patients worldwide. It poses a particular challenge for healthcare systems with limited financial and human resources.<h4>Objectives</h4>The aim of the study was to assess factors associated with the length of hospital stay and in‑hospital mortality, focusing on the time ... Read more >>

Pol Arch Intern Med (Polish archives of internal medicine)
[2020, 130(6):506-511]

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Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study.

Mercedes Ibarz, Ariane Boumendil, Lenneke E M Haas, Marian Irazabal, Hans Flaatten, Dylan W de Lange, Alessandro Morandi, Finn H Andersen, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zaferidis, Bertrand Guidet, Antonio Artigas, ,

BACKGROUND:The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. We aimed to determine ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2020, 10(1):56]

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Changes in neoadjuvant chemotherapy utilization in muscle invasive bladder cancer treatment: a tertiary center retrospective study.

Katarzyna Gronostaj, Anna Katarzyna Czech, Jakub Fronczek, Tomasz Wiatr, Mikołaj Przydacz, Przemysław Dudek, Łukasz Curyło, Wojciech Szczeklik, Piotr Chłosta,

Introduction:The year 2015 brought a major shift in the national health care system in Poland - the diagnosis and treatment of patients with malignant diseases became a priority. Close multidisciplinary collaboration was facilitated to optimize patients' care. The aim of this study was to investigate temporal changes in neoadjuvant chemotherapy ... Read more >>

Cent European J Urol (Central European journal of urology)
[2020, 73(1):13-18]

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Attitudes of healthcare professionals towards the introduction of rapid response teams in Poland: a survey study after 6 months of a pilot program in 25 hospitals.

Wojciech Szczeklik, Jakub Fronczek, Jacek Górka, Aleksandra Banaszewska, Piotr Gałkin, Waldemar Goździk, Bartosz Kudliński, Halina Kutaj-Wąsikowska, Maria Nowina-Konopka, Kamil J Polok, Aleksandra Wołk-Popielska, Anna Włudarczyk, Roman Jaeschke,

Pol Arch Intern Med (Polish archives of internal medicine)
[2019, 129(12):949-955]

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Rapid Response Teams-Rethinking Expectations.

Jacek Górka, Jakub Fronczek, Kamil Polok, Roman Jaeschke, Wojciech Szczeklik,

Crit Care Med (Critical care medicine)
[2020, 48(2):e152]

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Five Issues With the Cardiovascular Risk Index.

Jakub Fronczek, Pavel S Roshanov, Benjamin Y Andrew, Kamil J Polok, Wojciech Szczeklik,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2019, 74(18):2327-2328]

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Concentration of meropenem in patients with sepsis and acute kidney injury before and after initiation of continuous renal replacement therapy: a prospective observational trial.

Ilona Nowak-Kózka, Kamil J Polok, Jacek Górka, Jakub Fronczek, Anna Gielicz, Bożena Seczyńska, Mirosław Czuczwar, Bartosz Kudliński, Wojciech Szczeklik,

BACKGROUND:The effect of renal replacement therapy on drug concentrations in patients with sepsis has not been fully elucidated because the pharmacokinetic properties of many antimicrobials are influenced by both pathophysiological and treatment-related factors. The aim of this study was to determine meropenem concentrations in patients with sepsis before and after ... Read more >>

Pharmacol Rep (Pharmacological reports : PR)
[2020, 72(1):147-155]

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The Prognostic Value of Tumor Regression Grades Combined With TNM Classification in Patients With Muscle-Invasive Bladder Cancer Who Underwent Neoadjuvant Chemotherapy Followed by Radical Cystectomy.

Katarzyna Gronostaj, Anna K Czech, Jakub Fronczek, Artur Drobniak, Krzysztof Okon, Piotr L Chlosta, Wojciech Szczeklik,

<h4>Introduction</h4>Tumor regression grades (TRGs) quantify the pathologic response to neoadjuvant chemotherapy (NAC). The aim of the study was to investigate the prognostic value of TRGs in combination with the TNM classification in an independent cohort of patients with muscle-invasive bladder cancer (MIBC) treated with NAC followed by radical cystectomy (RC) ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2019, 17(6):e1203-e1211]

Cited: 1 time

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Identification of potential prognostic factors for absence of residual disease in the second resection of T1 bladder cancer.

Anna Katarzyna Czech, Katarzyna Gronostaj, Jakub Frydrych, Jakub Fronczek, Mikołaj Przydacz, Tomasz Wiatr, Łukasz Curyło, Przemysław Dudek, Jerzy Gąsowski, Piotr L Chłosta,

<h4>Introduction</h4>The aim of this single centre retrospective study was to analyse the results of second resection (repeat transurethral resection of bladder tumour - reTURBT) after a macroscopically complete resection of T1 urothelial bladder tumour and to identify prognostic factors for absence of residual disease (T0) in the second resection of ... Read more >>

Cent European J Urol (Central European journal of urology)
[2019, 72(3):252-257]

Cited: 1 time

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Implementation of neoadjuvant chemotherapy in muscle invasive bladder cancer treatment in Poland: a single institution retrospective study.

Katarzyna Gronostaj, Anna Katarzyna Czech, Jakub Fronczek, Tomasz Wiatr, Mikolaj Przydacz, Przemyslaw Dudek, Lukasz Curylo, Wojciech Szczeklik, Piotr Chlosta,

Introduction:Even though the survival benefit of neoadjuvant chemotherapy (NAC) in the treatment of muscle invasive bladder cancer (MIBC) is well established, NAC has not been widely used in Poland until recently. The aim of our study was to evaluate the utilization of NAC and its association with survival in MIBC. ... Read more >>

Cent European J Urol (Central European journal of urology)
[2019, 72(2):100-105]

Cited: 2 times

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Impact of Arterial Procedures on Coagulation and Fibrinolysis - A Pilot Study.

Kamil Jurand Polok, Jacek Górka, Jakub Fronczek, Karolina Górka, Bogusz Kaczmarek, Teresa Iwaniec, Paweł Iwaszczuk, Jacek Musiał, Wojciech Szczeklik,

<h4>Objective</h4>The main goal of our study was to assess the impact of vascular procedures on the activity of hemostatic and fibrinolytic pathways.<h4>Methods</h4>We enrolled 38 patients with ≥ 45 years old undergoing surgery for abdominal aortic aneurysm or peripheral artery disease under general or regional anesthesia and who were hospitalized at ... Read more >>

Braz J Cardiovasc Surg (Brazilian journal of cardiovascular surgery)
[2019, 34(3):327-334]

Cited: 1 time

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Introduction of rapid response teams in Poland.

Wojciech Szczeklik, Jakub Fronczek, Jacek Górka, Aleksandra Banaszewska, Piotr Gałkin, Waldemar Goździk, Bartosz Kudliński, Halina Kutaj-Wąsikowska, Kamil Polok, Anna Włudarczyk, Maria Nowina-Konopka, Aleksandra Wołk-Popielska, Roman Jaeschke,

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2019, 51(3):178-185]

Cited: 1 time

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Thyroid hormones as potential prognostic factors in sepsis.

Maria Foks, Alicja Dudek, Kamil Polok, Ilona Nowak-Kózka, Jakub Fronczek, Wojciech Szczeklik,

<h4>Background</h4>Sepsis is a life-threatening organ dysfunction caused by a dysregulated host reaction to infection. There is an upward trend in sepsis prevalence and mortality worldwide. Sepsis causes hypoxia, which reduces the ability of cells to produce ATP. This process is also influenced by thyroid hormones. Some of the previous studies ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2019, 51(3):205-209]

Cited: 2 times

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Correction to: Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit.

Bertrand Guidet, Hans Flaatten, Ariane Boumendil, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zafeiridis, Dylan W De Lange, ,

In the original publication Dr Patrick Meybohm of the Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Frankfurt University Hospital, Frankfurt, Germany was inadvertently omitted from the list of investigators. ... Read more >>

Intensive Care Med (Intensive care medicine)
[2018, 44(9):1598-1601]

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Frailty is associated with an increased mortality among patients ≥ 80 years old treated in Polish ICUs

Jakub Fronczek, Kamil Jurand Polok, Ilona Nowak-Kózka, Anna Włudarczyk, Jacek Górka, Mirosław Czuczwar, Paweł Krawczyk, Mirosław Ziętkiewicz, Łukasz R Nowak, Maciej Żukowski, Katarzyna Kotfis, Katarzyna Cwyl, Ryszard Gajdosz, Romuald Bohatyrewicz, Jowita Biernawska, Paweł Grudzień, Paweł Nasiłowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Wawrzyniak, Marek Wnuk, Dariusz Maciejewski, Dorota Studzińska, Szymon Bernas, Mariusz Piechota, Waldemar Machała, Marta Serwa, Maria Wujtewicz, Jan Stefaniak, Małgorzata Szymkowiak, Ryszard Gawda, Barbara Adamik, Natalia Kozera, Waldemar Goździk, Hans Flaatten, Wojciech Szczeklik,

<h4>Background</h4>The increasing population of very old intensive care patients (VIPs) is a major challenge currently faced by clinicians and policymakers. Reliable indicators of VIPs' prognosis and purposefulness of their admission to the intensive care unit (ICU) are urgently needed.<h4>Methods</h4>This is a report from the Polish sample of the VIP1 multicentre ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2018, 50(4):245-251]

Cited: 3 times

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Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit.

Bertrand Guidet, Hans Flaatten, Ariane Boumendil, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zafeiridis, Dylan W De Lange, ,

PURPOSE:To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. METHODS:This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. RESULTS:LST limitation was identified in 1356/5021 (27.2%) ... Read more >>

Intensive Care Med (Intensive care medicine)
[2018, 44(7):1027-1038]

Cited: 13 times

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Myocardial Infarction After Vascular Surgery: A Systematic Troponin Surveillance and a Uniform Definition Is Needed.

Kamil Polok, Jakub Fronczek, Wojciech Szczeklik,

JAMA Surg (JAMA surgery)
[2018, 153(5):496]

Cited: 1 time

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Myocardial Injury is More Common than Deep Venous Thrombosis after Vascular Surgery and is Associated with a High One Year Mortality Risk.

Jacek Górka, Kamil Polok, Jakub Fronczek, Karolina Górka, Mateusz Kózka, Paweł Iwaszczuk, Marzena Frołow, P J Devereaux, Bruce Biccard, Jacek Musiał, Wojciech Szczeklik,

<h4>Objective/background</h4>Venous thromboembolism (VTE) has been considered the dominant major life threatening vascular complication after non-cardiac surgery, but recent studies have shifted the emphasis toward myocardial injury after non-cardiac surgery (MINS) as a common adverse event in the peri-operative setting. The aim of the present study was to compare the incidence ... Read more >>

Eur J Vasc Endovasc Surg (European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery)
[2018, 56(2):264-270]

Cited: 2 times

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