Full Text Journal Articles by
Author Jaime M C Gard

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Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell-Cell Biophysical Properties in Prostate Cancer.

Cynthia S Rubenstein, Jaime M C Gard, Mengdie Wang, Julie E McGrath, Nadia Ingabire, James P Hinton, Kendra D Marr, Skyler J Simpson, Raymond B Nagle, Cindy K Miranti, Noel A Warfel, Joe G N Garcia, Hina Arif-Tiwari, Anne E Cress,

Human prostate cancer confined to the gland is indolent (low-risk), but tumors outside the capsule are aggressive (high-risk). Extracapsular extension requires invasion within and through a smooth muscle-structured environment. Because integrins respond to biomechanical cues, we used a gene editing approach to determine if a specific region of laminin-binding α6β1 ... Read more >>

Cancer Res. (Cancer research)
[2019, 79(18):4703-4714]

Cited: 0 times

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Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions.

Mengdie Wang, James P Hinton, Jaime M C Gard, Joe G N Garcia, Beatrice S Knudsen, Raymond B Nagle, Anne E Cress,

Integrin α6β4 is an essential, dynamic adhesion receptor for laminin 332 found on epithelial cells, required for formation of strong cell-extracellular matrix (ECM) adhesion and induced migration, and coordinated by regions of the β4C cytoplasmic domain. β4E, a unique splice variant of β4 expressed in normal tissue, contains a cytoplasmic ... Read more >>

Mol. Biol. Cell (Molecular biology of the cell)
[2019, 30(7):838-850]

Cited: 1 time

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Targeting the Cohesive Cluster Phenotype in Chordoma via β1 Integrin Increases Ionizing Radiation Efficacy.

William L Harryman, Jaime M C Gard, Kelvin W Pond, Skyler J Simpson, Lucas H Heppner, Daniel Hernandez-Cortes, Andrew S Little, Jennifer M Eschbacher, Anne E Cress,

Chordoma is a rare, radiation-resistant, skull-base and spinal tumor with high local recurrence containing mixed cell-adhesion phenotypes. We characterized DNA damage response (DDR) signaling (γH2AX, pKAP1, pATM) and survival response to ionizing radiation (IR) in human chordoma samples (42 resections, 23 patients) to test if blocking cell adhesion sensitizes U-CH1 ... Read more >>

Neoplasia (Neoplasia (New York, N.Y.))
[2017, 19(11):919-927]

Cited: 3 times

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Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells.

Lipsa Das, Todd A Anderson, Jaime M C Gard, Isis C Sroka, Stephanie R Strautman, Raymond B Nagle, Colm Morrissey, Beatrice S Knudsen, Anne E Cress,

Laminin binding integrins α6 (CD49f) and α3 (CD49c) are persistently but differentially expressed in prostate cancer (PCa). Integrin internalization is an important determinant of their cell surface expression and function. Using flow cytometry, and first order kinetic modeling, we quantitated the intrinsic internalization rates of integrin subunits in a single ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2017, 118(5):1038-1049]

Cited: 13 times

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Schwann Cells Increase Prostate and Pancreatic Tumor Cell Invasion Using Laminin Binding A6 Integrin.

Isis C Sroka, Harsharon Chopra, Lipsa Das, Jaime M C Gard, Raymond B Nagle, Anne E Cress,

Human pancreatic and prostate cancers metastasize along nerve axons during perineural invasion. The extracellular matrix laminin class of proteins is an abundant component of both myelinated and non-myelinated nerves. Analysis of human pancreatic and prostate tissue revealed both perineural and endoneural invasion with Schwann cells surrounded or disrupted by tumor, ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2016, 117(2):491-499]

Cited: 8 times

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Macrophage-dependent cleavage of the laminin receptor α6β1 in prostate cancer.

Isis C Sroka, Cynthia P Sandoval, Harsharon Chopra, Jaime M C Gard, Sangita C Pawar, Anne E Cress,

The laminin-binding integrin α6β1 plays a major role in determining the aggressive phenotype of tumor cells during metastasis. Our previous work has shown that cleavage of the α6β1 integrin to produce the structural variant α6pβ1 on tumor cell surfaces is mediated by the serine protease urokinase plasminogen activator (uPA). Cleavage ... Read more >>

Mol. Cancer Res. (Molecular cancer research : MCR)
[2011, 9(10):1319-1328]

Cited: 15 times

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ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.

Jennifer D Cohen, Jaime M C Gard, Raymond B Nagle, Justin D Dietrich, Terrence J Monks, Serrine S Lau,

The mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase signaling cascades have been implicated in a number of human cancers. The tumor suppressor gene tuberous sclerosis-2 (Tsc-2) functions as a negative regulator of mTOR. Critical proteins in both pathways are activated following treatment of Eker rats (Tsc-2(EK/+)) with the ... Read more >>

Toxicol. Sci. (Toxicological sciences : an official journal of the Society of Toxicology)
[2011, 124(1):75-87]

Cited: 12 times

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The antitumor agent imexon activates antioxidant gene expression: evidence for an oxidative stress response.

Amanda F Baker, Terry Landowski, Robert Dorr, Wendy R Tate, Jaime M C Gard, Breonna E Tavenner, Tomislov Dragovich, Amy Coon, Garth Powis,

The aim of this study was to identify biomarkers that may be predictive for the clinical activity of the redox-active antitumor agent imexon.cDNA microarray and quantitative real-time PCR were used to identify global changes in gene expression in peripheral blood mononuclear cells (PBMC) collected from patients treated with imexon during ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2007, 13(11):3388-3394]

Cited: 11 times

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