Full Text Journal Articles by
Author Jagidesa Moodley

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Pre-delivery angiogenic factors and their association with peripartum perceived stress and pain in pre-eclampsia with severe features and normotensive pregnancies.

Nnabuike Chibuoke Ngene, Jagidesa Moodley,

<h4>Objective</h4>To determine if any of maternal pre-delivery soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PIGF) or sFlt-1/PIGF ratio correlate with either perceived stress scale (PSS) or verbal numeric rating scale pain scores (VNRS).<h4>Methods</h4>Among 50 severe pre-eclamptic and 90 normotensive pregnant women observed from ≤48 hours before delivery until day ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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The association of NPHS1 and ACNT4 gene polymorphisms with pre-eclampsia.

Olive P Khaliq, Tadashi Konoshita, Jagidesa Moodley, Thajasvarie Naicker,

<h4>Objective</h4>The main objective of this study is to investigate the association of the NPHS1 gene polymorphisms (rs437168) and ACTN4 (rs3745895) in the pathogenesis of PE in women of African Ancestry.<h4>Materials and methods</h4>637 blood samples, normotensive pregnant (n = 280) and pre-eclampsia (n = 357) were included. The PE group was sub-divided into early onset ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2021, 266:9-14]

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HIV Associated Preeclampsia: A Multifactorial Appraisal.

Thajasvarie Naicker, Nalini Govender, Tashlen Abel, Nitalia Naidoo, Merantha Moodley, Yazira Pillay, Shoohana Singh, Olive Pearl Khaliq, Jagidesa Moodley,

<i>Introduction:</i> This review explores angiogenesis, vascular dysfunction, the complement system, RAAS, apoptosis and NETosis as potential pathways that are dysregulated during preeclampsia, HIV infection and ART usage. <i>Results:</i> HIV-1 accessory and matrix proteins are protagonists for the elevation of oxidative stress, apoptosis, angiogenesis, and elevation of adhesion markers. Despite the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

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Induction of labour in low-resource settings.

Nnabuike Chibuoke Ngene, Jagidesa Moodley,

Due to the disparity in resource availability between low- and high-resource settings, practice recommendations relevant to high-income countries are not always relevant and often need to be adapted to low-resource settings. The adaptation applies to induction of labour (IOL) which is an obstetric procedure that deserves special attention because it ... Read more >>

Best Pract Res Clin Obstet Gynaecol (Best practice & research. Clinical obstetrics & gynaecology)
[2021, :]

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A Narrative Review of the Renin-Angiotensin-Aldosterone System in the Placenta and Placental Bed of HIV Infected Women of African Ancestry with Preeclampsia.

Shoohana Singh, Jagidesa Moodley, Olive Pearl Khaliq, Thajasvarie Naicker,

<h4>Purpose of review</h4>Both HIV infection and preeclampsia (PE), a pregnancy-specific disorder of hypertension and multi-system organ involvement, have high prevalence rates especially in low-to-middle-income countries. The immunoexpression of specific renin-angiotensin-aldosterone system (RAAS) receptors in the placenta and placental bed interface may forecast the risk of PE.<h4>Recent findings</h4>Preeclampsia is a leading ... Read more >>

Curr Hypertens Rep (Current hypertension reports)
[2021, 23(8):39]

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The effects of mode of delivery on causes of postpartum haemorrhage.

Nnabuike Chibuoke Ngene, Jagidesa Moodley, Lameck Chinula, Mushi Matjila,

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2021, 264:388]

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Perspectives on COVID-19 vaccination for pregnant women in South Africa.

Mehreen Hunter, Jagidesa Moodley, Neil Moran,

Coronavirus disease 2019 (COVID-19) is a pandemic that has created a global health crisis and upended conventional methodologies, both in the governance and clinical structures of Health Care Systems. The spread of COVID-19 has necessitated a coordinated public health response in an effective, extensive and expedited vaccination rollout strategy with ... Read more >>

Afr J Prim Health Care Fam Med (African journal of primary health care & family medicine)
[2021, 13(1):e1-e3]

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Raising awareness about the unintended consequences of hand sanitiser in children.

Olive Khaliq, Princess Z Mkhize, Jagidesa M Moodley,

The use of hand sanitisers is common practice to prevent the spread of coronavirus disease 2019 (COVID-19). However, the safety thereof requires consideration as this may be hazardous in children. Recent studies have shown that the misuse and increased unsupervised availability of alcohol-based hand sanitisers may result in adverse events ... Read more >>

S Afr Fam Pract (2004) (South African family practice : official journal of the South African Academy of Family Practice/Primary Care)
[2021, 63(1):e1-e3]

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Misrepresentation about vaccines that are scaring women.

Jagidesa Moodley, Olive P Khaliq, Princess Z Mkhize,

The coronavirus disease 2019 (COVID-19) pandemic has contributed greatly to morbidity and mortality worldwide. The production of COVID-19 vaccines has been tested for efficacy and safety via clinical trials. However, false information on the side effects of the vaccine has been spread via social media, creating fear of vaccination. Currently, ... Read more >>

Afr J Prim Health Care Fam Med (African journal of primary health care & family medicine)
[2021, 13(1):e1-e2]

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The Involvement of MicroRNAs in SARS-CoV-2 Infection Comorbid with HIV-Associated Preeclampsia.

Tashlen Abel, Jagidesa Moodley, Thajasvarie Naicker,

<h4>Purpose of review</h4>This review investigated the potential role of microRNAs (miRNAs) in the synergy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, preeclampsia (PE), and human immunodeficiency virus (HIV) infection. Maternal health is a great concern when treating pregnant women fighting this triad of diseases, which is highly prevalent ... Read more >>

Curr Hypertens Rep (Current hypertension reports)
[2021, 23(4):20]

Cited: 1 time

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The function of adipsin and C9 protein in the complement system in HIV-associated preeclampsia.

Mikyle David, Jagidesa Moodley, Thajasvarie Naicker,

<h4>Objective</h4>In preeclampsia, there are excessive complement components expressed due to increased complement activation; therefore, this study investigated the concentration of adipsin and C9 in HIV-associated preeclampsia.<h4>Method</h4>The study population (n = 76) was stratified by pregnancy type (normotensive pregnant and preeclampsia) and by HIV status. Serum was assayed for the concentration of adipsin ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

Cited: 1 time

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The Renin-Angiotensin System, Hypertension, and SARS-CoV-2 Infection: a Review.

Premjith Gathiram, Irene Mackraj, Jagidesa Moodley,

<h4>Purpose of review</h4>This review focuses on the associations between the renin-angiotensin system, hypertension, and severe acute respiratory syndrome (SARS-COV-2) infection. A brief prelude on the current state of affairs with COVID-19 is given. In addition to an overview of ACE2, Ang II, and Ang (1-7), this review presents a brief ... Read more >>

Curr Hypertens Rep (Current hypertension reports)
[2021, 23(4):17]

Cited: 1 time

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Correction to: The Renin-Angiotensin System, Hypertension, and SARS-CoV-2 Infection: a Review.

Premjith Gathiram, Irene Mackraj, Jagidesa Moodley,

Curr Hypertens Rep (Current hypertension reports)
[2021, 23(4):23]

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Current Updates on Pre-eclampsia: Maternal and Foetal Cardiovascular Diseases Predilection, Science or Myth? : Future cardiovascular disease risks in mother and child following pre-eclampsia.

Samson A Odukoya, Jagidesa Moodley, Thajasvarie Naicker,

<h4>Purpose of review</h4>Cardiovascular diseases (CVD), including pre-eclampsia (PE), remain the major cause of death and morbidity in women. This review elucidates the current knowledge, state of research and scientific information available on the post-event implications and complications of PE regarding maternal and foetal cardiovascular health. Does PE expose, predispose or ... Read more >>

Curr Hypertens Rep (Current hypertension reports)
[2021, 23(3):16]

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Expression of plasma nuclear factor-kappa B cells (NF-κB) and Inhibitory subunit kappa B alpha (IκB-α) in HIV-associated pre-eclampsia.

Bambanani Zozo, Nalini Govender, Jagidesa Moodley, Thajasvarie Naicker,

<b>Objective:</b>To investigate the expression of plasma NF-κB and the inhibitory subunit IκB-α in HIV-associated pre-eclampsia. <b>Method:</b> This retrospective study examined plasma NF-κB and IκB-α expression expressed as Mean Fluorescence Intensity (MFI) in normotensive (n = 32) and pre-eclamptic (n = 34) pregnant women stratified by HIV status. <b>Results:</b> A significant decrease in the level ... Read more >>

Hypertens Pregnancy (Hypertension in pregnancy)
[2021, 40(1):15-20]

Cited: 1 time

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The role of soluble E-selectin in HIV associated preeclampsia.

Girija Naidoo, Olive P Khaliq, Jagidesa Moodley, Thajasvarie Naicker,

<h4>Objective</h4>To determine the serum concentration of soluble E-selectin (sE-selectin) in HIV associated preeclampsia.<h4>Study design</h4>The study population (n = 72) consisted of normotensive pregnant (n = 36) and preeclamptic (n = 36) women stratified by HIV status (negative vs. positive). Serum concentrations of sE-selectin were quantified using the MilliPlex multiplex immunoassay ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2021, 257:64-69]

Cited: 1 time

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Placental Microbial Colonization and Its Association With Pre-eclampsia.

Kehinde S Olaniyi, Jagidesa Moodley, Yesholata Mahabeer, Irene Mackraj,

The existence and role of the microbiome in regulating physiological and pathophysiological conditions including metabolism, energy homeostasis, immune tolerance, behavior, obesity, diabetes, and cardiovascular-related diseases is of immense interest. It is now clear that the human placenta is not sterile, but rather colonized with microbes. The placental and vaginal microbiomes ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2020, 10:413]

Cited: 1 time

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The Role of the Renin-Angiotensin-Aldosterone System in Preeclampsia: a Review.

Premjith Gathiram, Jagidesa Moodley,

<h4>Purpose of review</h4>Preeclampsia (PE) is a complex human pregnancy-specific condition and is clinically characterized by new onset hypertension and proteinuria in the second half of pregnancy. The precise etiology of PE is unknown, but much of the pathophysiology has been elucidated, and it is accepted that the disorder is multifactorial ... Read more >>

Curr Hypertens Rep (Current hypertension reports)
[2020, 22(11):89]

Cited: 2 times

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The hazards of conducting induction of labour in high-risk pregnancies at district hospitals in low- and middle-income countries: lessons to learn from a case report.

Nnabuike Chibuoke Ngene, Jagidesa Moodley,

<h4>Background</h4>Induction of labour (IOL) is an obstetric procedure that should be conducted in a healthcare facility with the capacity to provide optimal care based on the patient risk status. Inadequate monitoring, untimely procedure and lack of readily available and experienced medical staff to participate in the care of the patient ... Read more >>

Afr Health Sci (African health sciences)
[2020, 20(3):1237-1240]

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Maternal deaths due to eclampsia in teenagers: Lessons from assessment of maternal deaths in South Africa.

Jagidesa Moodley, Nnabuike C Ngene,

<h4>Background</h4>Eclampsia remains a major cause of maternal mortality, particularly in teenage pregnancies. Healthcare professionals providing antenatal must regard teenagers as a high risk group for the pre-eclampsia-eclampsia syndrome.<h4>Setting</h4>Data extracted from the South African Saving Mothers Report: 2014-2016.<h4>Aim</h4>To establish the clinical details in teenage maternal deaths owing to eclampsia.<h4>Method</h4>Retrospective review of ... Read more >>

Afr J Prim Health Care Fam Med (African journal of primary health care & family medicine)
[2020, 12(1):e1-e6]

Cited: 2 times

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Improving the safety of induction of labor in low-resource settings using a 20-point toolkit.

Nnabuike Chibuoke Ngene, Jagidesa Moodley,

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, 151(2):300-301]

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Pre-eclampsia with severe features: management of antihypertensive therapy in the postpartum period.

Nnabuike Chibuoke Ngene, Jagidesa Moodley,

<h4>Introduction</h4>there is variance in both the types and combinations of antihypertensive drugs used for managing pre-eclampsia in the postpartum period. Knowledge of the most common and suitable single or combination antihypertensive drug therapies in the postpartum period will minimize harmful effects, promote adherence to medications, overcome any fears that lactating ... Read more >>

Pan Afr Med J (The Pan African medical journal)
[2020, 36:216]

Cited: 2 times

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Primary care providers and hypertension in pregnancy: Reflections on a patient encounter.

Jagidesa Moodley, Prakash Jugnanden, Mergan Naidoo, Nnabuike C Ngene,

In South Africa, large numbers of individuals with medical emergencies initially visit a general practitioner or family physician. In the case of maternity care, this may occasionally involve acute onset of severe hypertension during the antenatal period. Primary care providers (PCPs) are therefore faced with the conundrum of treating and ... Read more >>

S Afr Fam Pract (2004) (South African family practice : official journal of the South African Academy of Family Practice/Primary Care)
[2020, 62(1):e1-e3]

Cited: 1 time

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HLA-G Polymorphisms Associated with HIV Infection and Preeclampsia in South Africans of African Ancestry.

Wendy N Phoswa, Veron Ramsuran, Thajasvarie Naicker, Ravesh Singh, Jagidesa Moodley,

<h4>Objectives</h4>HLA-G, part of the major histocompatibility complex (MHC), is associated with the risk of developing preeclampsia (PE). In this study, we determined the contribution of specific HLA-G polymorphisms on the risk of developing preeclampsia in HIV-infected and uninfected South Africans of African ancestry.<h4>Methods</h4>One hundred and ninety-three women of African ancestry ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:1697657]

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Role of basic fibroblast growth factor in human immunodeficiency virus associated pre-eclampsia.

Charline M Sangany, Jagidesa Moodley, Onankoy A Onyagunga, Thajasvarie Naicker,

<h4>Aim</h4>Cell signaling is vital to ensure successful trophoblast invasion. This study assessed the level of serum basic fibroblast growth factor (FGF-2) in human immunodeficiency virus (HIV) associated pre-eclampsia (PE).<h4>Methods</h4>Using a Bio-plex Multiplex Immunoassay, FGF-2 (pg/mL) was analyzed in blood sera collected from 80 pregnant women attending a large regional hospital ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2020, 46(8):1292-1297]

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