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Author Jae Won Shin

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Matrix mechanics and water permeation regulate extracellular vesicle transport.

Stephen Lenzini, Raymond Bargi, Gina Chung, Jae-Won Shin,

Cells release extracellular vesicles (EVs) to communicate over long distances, which requires EVs to traverse the extracellular matrix (ECM). However, given that the size of EVs is usually larger than the mesh size of the ECM, it is not clear how they can travel through the dense ECM. Here we ... Read more >>

Nat Nanotechnol (Nature nanotechnology)
[2020, 15(3):217-223]

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Continuous Renal Replacement Therapy (CRRT) in Children and the Specialized CRRT Team: A 14-Year Single-Center Study.

Keum Hwa Lee, In Suk Sol, Jung Tak Park, Ji Hong Kim, Jae Won Shin, Mi Rireu Park, Jae Hyun Lee, Yoon Hee Kim, Kyung Won Kim, Jae Il Shin,

Continuous renal replacement therapy (CRRT) has been used as an important intervention in critically ill children. Our center has the only specialized CRRT team (SCT) for children in Korea, which consists of pediatric intensivists, a pediatric nephrologist and CRRT-specialized-nurses. This study was a retrospective single-center analysis, including all pediatric patients ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 9(1):]

Cited: 0 times

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Potential applications of graphene-based nanomaterials as adsorbent for removal of volatile organic compounds.

Vanish Kumar, Yoon-Seo Lee, Jae-Won Shin, Ki-Hyun Kim, Deepak Kukkar, Yiu Fai Tsang,

In recent years, graphene-based materials (GBMs) have been regarded as the core technology in diverse research fields. Consequently, the demand for large-scale synthesis of GBMs has been increasing continuously for various fields of industry. These materials have become a competitive adsorbent for the removal of environmental pollutants with improved adsorption ... Read more >>

Environ Int (Environment international)
[2020, 135:105356]

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Leveraging Biomaterial Mechanics to Improve Pluripotent Stem Cell Applications for Tissue Engineering.

Stephen Lenzini, Daniel Devine, Jae-Won Shin,

A primary goal in tissue engineering is to develop functional tissues by recapitulating salient features of complex biological systems that exhibit a diverse range of physical forces. Induced pluripotent stem cells (iPSCs) are promising autologous cell sources to execute these developmental programs and their functions; however, cells require an extracellular ... Read more >>

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2019, 7:260]

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Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation.

Angelo S Mao, Berna Özkale, Nisarg J Shah, Kyle H Vining, Tiphaine Descombes, Liyuan Zhang, Christina M Tringides, Sing-Wan Wong, Jae-Won Shin, David T Scadden, David A Weitz, David J Mooney,

Mesenchymal stem cell (MSC) therapies demonstrate particular promise in ameliorating diseases of immune dysregulation but are hampered by short in vivo cell persistence and inconsistencies in phenotype. Here, we demonstrate that biomaterial encapsulation into alginate using a microfluidic device could substantially increase in vivo MSC persistence after intravenous (i.v.) injection. ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2019, 116(31):15392-15397]

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Ultrafast charge transfer coupled with lattice phonons in two-dimensional covalent organic frameworks.

Tae Wu Kim, Sunhong Jun, Yoonhoo Ha, Rajesh K Yadav, Abhishek Kumar, Chung-Yul Yoo, Inhwan Oh, Hyung-Kyu Lim, Jae Won Shin, Ryong Ryoo, Hyungjun Kim, Jeongho Kim, Jin-Ook Baeg, Hyotcherl Ihee,

Covalent organic frameworks (COFs) have emerged as a promising light-harvesting module for artificial photosynthesis and photovoltaics. For efficient generation of free charge carriers, the donor-acceptor (D-A) conjugation has been adopted for two-dimensional (2D) COFs recently. In the 2D D-A COFs, photoexcitation would generate a polaron pair, which is a precursor ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):1873]

Cited: 1 time

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Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis.

Gwang Hun Jeong, Keum Hwa Lee, I Re Lee, Ji Hyun Oh, Dong Wook Kim, Jae Won Shin, Andreas Kronbichler, Michael Eisenhut, Hans J van der Vliet, Omar Abdel-Rahman, Brendon Stubbs, Marco Solmi, Nicola Veronese, Elena Dragioti, Ai Koyanagi, Joaquim Radua, Jae Il Shin,

Capillary leak syndrome (CLS) is a rare disease with profound vascular leakage, which can be associated with a high mortality. There have been several reports on CLS as an adverse effect of anti-cancer agents and therapy, but the incidence of CLS according to the kinds of anti-cancer drugs has not ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(2):]

Cited: 1 time

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Systemic Capillary Leak Syndrome (Clarkson Syndrome) in Cancer Patients: A Systematic Review.

Jae Il Shin, Keum Hwa Lee, I Re Lee, Ji Hyun Oh, Dong Wook Kim, Jae Won Shin, Tae Seong Eo, Andreas Kronbichler, Michael Eisenhut, Hans J van der Vliet,

Systemic capillary leak syndrome (SCLS) is a rare disease characterized by shock caused by capillary hyperpermeability. The disease can occur in cancer patients and effective therapeutic strategies have not been established yet. The aim of the study was to analyze the clinical and laboratory data, treatment modalities, and mortality rate ... Read more >>

J Clin Med (Journal of clinical medicine)
[2018, 7(11):]

Cited: 1 time

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N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.

Kevin Kruse, Quinn S Lee, Ying Sun, Jeff Klomp, Xiaoyan Yang, Fei Huang, Mitchell Y Sun, Shuangping Zhao, Zhigang Hong, Stephen M Vogel, Jae-Won Shin, Deborah E Leckband, Leon M Tai, Asrar B Malik, Yulia A Komarova,

Vascular endothelial (VE)-cadherin forms homotypic adherens junctions (AJs) in the endothelium, whereas N-cadherin forms heterotypic adhesion between endothelial cells and surrounding vascular smooth muscle cells and pericytes. Here we addressed the question whether both cadherin adhesion complexes communicate through intracellular signaling and contribute to the integrity of the endothelial barrier. ... Read more >>

J. Cell Biol. (The Journal of cell biology)
[2019, 218(1):299-316]

Cited: 2 times

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Squeezing cells through the epigenetic machinery.

Jae-Won Shin,

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(34):8472-8474]

Cited: 0 times

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Perspective: Biophysical regulation of cancerous and normal blood cell lineages in hematopoietic malignancies.

Sing Wan Wong, Stephen Lenzini, Jae-Won Shin,

It is increasingly appreciated that physical forces play important roles in cancer biology, in terms of progression, invasiveness, and drug resistance. Clinical progress in treating hematological malignancy and in developing cancer immunotherapy highlights the role of the hematopoietic system as a key model in devising new therapeutic strategies against cancer. ... Read more >>

APL Bioeng (APL Bioengineering)
[2018, 2(3):031802]

Cited: 1 time

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In Situ High-Resolution Transmission Electron Microscopy (TEM) Observation of Sn Nanoparticles on SnO2 Nanotubes Under Lithiation.

Jun Young Cheong, Joon Ha Chang, Sung Joo Kim, Chanhoon Kim, Hyeon Kook Seo, Jae Won Shin, Jong Min Yuk, Jeong Yong Lee, Il-Doo Kim,

We trace Sn nanoparticles (NPs) produced from SnO2 nanotubes (NTs) during lithiation initialized by high energy e-beam irradiation. The growth dynamics of Sn NPs is visualized in liquid electrolytes by graphene liquid cell transmission electron microscopy. The observation reveals that Sn NPs grow on the surface of SnO2 NTs via ... Read more >>

Microsc. Microanal. (Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada)
[2017, 23(6):1107-1115]

Cited: 1 time

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How Long Does Antimycobacterial Antibiotic-loaded Bone Cement Have In Vitro Activity for Musculoskeletal Tuberculosis?

Jae Hoo Lee, Chang Dong Han, Sang-Nae Cho, Ick Hwan Yang, Woo Suk Lee, Seung-Hun Baek, Jae Won Shin, Khalid Elfadil Ibrahim Husein, Kwan Kyu Park,

BACKGROUND:Antibiotic-loaded bone cement is accepted as an effective treatment modality for musculoskeletal tuberculosis. However, comparative information regarding combinations and concentrations of second-line antimycobacterial drugs, such as streptomycin and amoxicillin and clavulanic acid, are lacking. QUESTIONS/PURPOSES:(1) In antibiotic-loaded cement, is there effective elution of streptomycin and Augmentin® (amoxicillin and clavulanic acid) ... Read more >>

Clin. Orthop. Relat. Res. (Clinical orthopaedics and related research)
[2017, 475(11):2795-2804]

Cited: 0 times

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Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures.

Jae Won Shin, Yun Seob Jung, Kyungsoo Park, Soon Min Lee, Ho Seon Eun, Min Soo Park, Kook In Park, Ran Namgung,

The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM.A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was ... Read more >>

Korean J Pediatr (Korean journal of pediatrics)
[2017, 60(2):50-54]

Cited: 1 time

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Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation.

Angelo S Mao, Jae-Won Shin, David J Mooney,

The mechanical properties of the microenvironment and direct contact-mediated cell-cell interactions are two variables known to be important in the determination of stem cell differentiation fate, but little is known about the interplay of these cues. Here, we use a micropatterning approach on polyacrylamide gels of tunable stiffnesses to study ... Read more >>

Biomaterials (Biomaterials)
[2016, 98:184-191]

Cited: 35 times

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Improving Stem Cell Therapeutics with Mechanobiology.

Jae-Won Shin, David J Mooney,

In recent years, it has become clear that mechanical cues play an integral role in maintaining stem cell functions. Here we discuss how integrating physical approaches and engineering principles in stem cell biology, including culture systems, preclinical models, and functional assessment, may improve clinical application in regenerative medicine. ... Read more >>

Cell Stem Cell (Cell stem cell)
[2016, 18(1):16-19]

Cited: 9 times

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Simultaneous Chemical and Optical Patterning of Polyacrylonitrile Film by Vapor-Based Reaction.

Jae-Won Shin, Choonghyeon Lee, Sang-Ho Cha, Jyongsik Jang, Kyung Jin Lee,

The surface of polyacrylonitrile (PAN) film is treated with ethyleneamines (EDA) in a simple chemical vapor phase reaction. Successful introduction of amine functional groups on the cyano group of PAN backbone is verified by FT-IR and NMR measurements. Further UV-vis and photoluminescence analyses show a red shift of the emission ... Read more >>

Macromol Rapid Commun (Macromolecular rapid communications)
[2015, 36(12):1192-1199]

Cited: 1 time

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Stem cell mechanobiology: diverse lessons from bone marrow.

Irena L Ivanovska, Jae-Won Shin, Joe Swift, Dennis E Discher,

A stem cell niche is defined by various chemical and physical features that influence whether a stem cell remains quiescent, divides, or differentiates. We review mechanical determinants that affect cell fate through actomyosin forces, nucleoskeleton remodeling, and mechanosensitive translocation of transcription factors. Current methods for physical characterization of tissue microenvironments ... Read more >>

Trends Cell Biol. (Trends in cell biology)
[2015, 25(9):523-532]

Cited: 31 times

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Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin.

Amnon Buxboim, Joe Swift, Jerome Irianto, Kyle R Spinler, P C Dave P Dingal, Avathamsa Athirasala, Yun-Ruei C Kao, Sangkyun Cho, Takamasa Harada, Jae-Won Shin, Dennis E Discher,

Tissue microenvironments are characterized not only in terms of chemical composition but also by collective properties such as stiffness, which influences the contractility of a cell, its adherent morphology, and even differentiation. The nucleoskeletal protein lamin-A,C increases with matrix stiffness, confers nuclear mechanical properties, and influences differentiation of mesenchymal stem ... Read more >>

Curr. Biol. (Current biology : CB)
[2014, 24(16):1909-1917]

Cited: 96 times

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Robotic versus laparoscopic intersphincteric resection for low rectal cancer: comparison of the operative, oncological, and functional outcomes.

Byung-Eun Yoo, Jae-Sung Cho, Jae-Won Shin, Dong-Won Lee, Jung-Myun Kwak, Jin Kim, Seon-Hahn Kim,

Robotic surgery was developed to overcome the limitations of laparoscopic surgery and is increasingly used to treat low rectal cancer. In this study, we compared the operative, oncological, and functional outcomes of low rectal cancer patients who underwent robotic or laparoscopic intersphincteric resection (ISR).Prospectively collected data from low rectal cancer ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2015, 22(4):1219-1225]

Cited: 11 times

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Robotic-assisted surgery for rectal adenocarcinoma: short-term and midterm outcomes from 200 consecutive cases at a single institution.

Masayasu Hara, Kevin Sng, Byung Eun Yoo, Jae Won Shin, Dong Won Lee, Seon Hahn Kim,

BACKGROUND: Although robotic surgery is increasingly used in the management of rectal cancer, its oncologic safety remains uncertain. OBJECTIVE: We aimed to evaluate the feasibility and safety of robotic-assisted rectal cancer resection in terms of short-term and midterm outcomes. DESIGN: A prospectively collected set of samples was retrospectively evaluated. SETTINGS: ... Read more >>

Dis. Colon Rectum (Diseases of the colon and rectum)
[2014, 57(5):570-577]

Cited: 12 times

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Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium.

Ovijit Chaudhuri, Sandeep T Koshy, Cristiana Branco da Cunha, Jae-Won Shin, Catia S Verbeke, Kimberly H Allison, David J Mooney,

In vitro models of normal mammary epithelium have correlated increased extracellular matrix (ECM) stiffness with malignant phenotypes. However, the role of increased stiffness in this transformation remains unclear because of difficulties in controlling ECM stiffness, composition and architecture independently. Here we demonstrate that interpenetrating networks of reconstituted basement membrane matrix ... Read more >>

Nat Mater (Nature materials)
[2014, 13(10):970-978]

Cited: 195 times

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Virtual reality training improves da Vinci performance: a prospective trial.

Jae Sung Cho, Koo Yong Hahn, Jung Myun Kwak, Jin Kim, Se Jin Baek, Jae Won Shin, Seon Hahn Kim,

INTRODUCTION: The DV-Trainer™ (a virtual reality [VR] simulator) (Mimic Technologies, Inc., Seattle, WA) is one of several different robotic surgical training methods. We designed a prospective study to determine whether VR training could improve da Vinci(®) Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA) performance. SUBJECTS AND METHODS: Surgeons (n=12) were ... Read more >>

J Laparoendosc Adv Surg Tech A (Journal of laparoendoscopic & advanced surgical techniques. Part A)
[2013, 23(12):992-998]

Cited: 12 times

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Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells.

Jae-Won Shin, Amnon Buxboim, Kyle R Spinler, Joe Swift, David A Christian, Christopher A Hunter, Catherine Léon, Christian Gachet, P C Dave P Dingal, Irena L Ivanovska, Florian Rehfeldt, Joel Anne Chasis, Dennis E Discher,

Self-renewal and differentiation of stem cells depend on asymmetric division and polarized motility processes that in other cell types are modulated by nonmuscle myosin-II (MII) forces and matrix mechanics. Here, mass spectrometry-calibrated intracellular flow cytometry of human hematopoiesis reveals MIIB to be a major isoform that is strongly polarized in ... Read more >>

Cell Stem Cell (Cell stem cell)
[2014, 14(1):81-93]

Cited: 49 times

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Reversible colonic mucosal ischaemia in the proximal anastomotic segment following low anterior resection: lessons learned from a case.

Byung Eun Yoo, Yasuo Sakamoto, Jae Won Shin, Dong Won Lee, Jung Myun Kwak, Jin Kim, Seon Hahn Kim,

ANZ J Surg (ANZ journal of surgery)
[2013, 83(9):695-696]

Cited: 0 times

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