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Drive-Through Screening Center for COVID-19: a Safe and Efficient Screening System against Massive Community Outbreak.

Ki Tae Kwon, Jae Hoon Ko, Heejun Shin, Minki Sung, Jin Yong Kim,

As the coronavirus disease 2019 (COVID-19) outbreak is ongoing, the number of individuals to be tested for COVID-19 is rapidly increasing. For safe and efficient screening for COVID-19, drive-through (DT) screening centers have been designed and implemented in Korea. Herein, we present the overall concept, advantages, and limitations of the ... Read more >>

J. Korean Med. Sci. (Journal of Korean medical science)
[2020, 35(11):e123]

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Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea.

Jin Yong Kim, Jae Hoon Ko, Yeonjae Kim, Yae Jean Kim, Jeong Min Kim, Yoon Seok Chung, Heui Man Kim, Myung Guk Han, So Yeon Kim, Bum Sik Chin,

As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral ... Read more >>

J. Korean Med. Sci. (Journal of Korean medical science)
[2020, 35(7):e86]

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Severe Thrombocytopenia in a Patient with COVID-19.

Eliel Nham, Jae Hoon Ko, Byeong Ho Jeong, Kyungmin Huh, Sun Young Cho, Cheol In Kang, Doo Ryeon Chung, Kyong Ran Peck,

Coronavirus disease 2019 (COVID-19) outbreak is spreading rapidly all over the world, being a major threat to public health. Since clinical feature of COVID-19 has not been fully evaluated yet, empirical antibacterial agents are frequently combined for the treatment of COVID-19 in addition to antiviral agents, concerning co-existing bacterial pathogens. ... Read more >>

Infect Chemother (Infection & chemotherapy)
[2020, :]

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Clinical factors influencing the performance of bacterial multiplex polymerase chain reaction in patients with community-onset pneumonia.

Ga Eun Park, Kyong Ran Peck, Jae-Hoon Ko, Cheol-In Kang, Sun Young Cho, Doo Ryeon Chung, Nam Yong Lee,

The etiologic diagnostic yield of community-onset pneumonia (COP) using conventional methods is low. Bacterial multiplex polymerase chain reaction (mPCR) has been shown to be more sensitive than conventional methods. This study assessed the clinical factors influencing bacterial mPCR results in patients with COP. Patients with COP admitted to a tertiary ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2020, :]

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Nano- And Microfiber-Based Fully Fabric Triboelectric Nanogenerator For Wearable Devices.

Jong Hyuk Bae, Hyun Ju Oh, Jinkyu Song, Do Kun Kim, Byeong Jin Yeang, Jae Hoon Ko, Seong Hun Kim, Woosung Lee, Seung Ju Lim,

The combination of the triboelectric effect and static electricity as a triboelectric nanogenerator (TENG) has been extensively studied. TENGs using nanofibers have advantages such as high surface roughness, porous structure, and ease of production by electrospinning; however, their shortcomings include high-cost, limited yield, and poor mechanical properties. Microfibers are produced ... Read more >>

Polymers (Basel) (Polymers)
[2020, 12(3):]

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Impact of difficult-to-treat resistance in gram-negative bacteremia on mortality: retrospective analysis of nationwide surveillance data.

Kyungmin Huh, Doo Ryeon Chung, Young Eun Ha, Jae-Hoon Ko, Si-Ho Kim, Min-Ji Kim, Hee Jae Huh, Nam Yong Lee, Sun Young Cho, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song, ,

BACKGROUND:Clinically relevant categorization of antimicrobial resistance is critical to mitigating the threat it poses. Difficult-to-treat resistance (DTR) is a recently proposed category defined as non-susceptibility to all first-line antibiotic agents. METHODS:A retrospective study was conducted with non-duplicate cases of gram-negative bloodstream infection (GNBSI) caused by four major taxa (Escherichia coli, ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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1701. Differences in Diagnostic Performance of β-d-Glucan Testing in Patients with Varying Degrees of Susceptibility to Invasive Fungal Infections.

Eliel Nham, Si-Ho Kim, Hyunjoo Lee, Jae-Hoon Ko, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck,

AbstractBackgroundUsefulness of β-d-glucan (BDG) testing in high-risk patients for invasive fungal infection (IFI) diagnosis has been well demonstrated. However, data on its usefulness in patients without risk factors are limited. We evaluated differences in the diagnostic performance of BDG testing in patients with varying degrees of susceptibility to IFI.MethodsFrom April ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S623-S623]

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Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018.

Jae-Hoon Ko, Hyeong-Taek Woo, Hong Sang Oh, Song Mi Moon, Joon Young Choi, Jeong Uk Lim, Donghoon Kim, Junsu Byun, Soon-Hwan Kwon, Daeyoun Kang, Jung Yeon Heo, Kyong Ran Peck,

Background/Aims:Human adenovirus type 55 (HAdV-55), an emerging epidemic strain, has caused several large outbreaks in the Korean military since 2014, and HAdV-associated acute respiratory illness (HAdV-ARI) has been continuously reported thereafter. Methods:To evaluate the epidemiologic characteristics of HAdV-ARI in the Korean military, we analyzed respiratory virus polymerase chain reaction (RV-PCR) ... Read more >>

Korean J. Intern. Med. (The Korean journal of internal medicine)
[2019, :]

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Treatment of community-onset pneumonia in neutropenic cancer patients: β-lactam monotherapy versus combination antibiotic regimens.

Hyeri Seok, Jae-Hoon Ko, Kyong Ran Peck, Ji-Yeon Kim, Ji Hye Lee, Ga Eun Park, Sun Young Cho, Cheol-In Kang, Nam Yong Lee, Doo Ryeon Chung,

Background:Although β-lactam monotherapy may be sufficient in non-critically ill patients with community-acquired pneumonia, the value of combination antibiotic regimens in community-onset neutropenic pneumonia remains unclear. Methods:A retrospective cohort study was conducted to compare the effects of combination antibiotic regimens to those of β-lactam monotherapy in cancer patients with community-onset neutropenic ... Read more >>

Pneumonia (Nathan) (Pneumonia (Nathan Qld.))
[2019, 11:2]

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Effects of environmental disinfection on the isolation of vancomycin-resistant Enterococcus after a hospital-associated outbreak of Middle East respiratory syndrome.

Jae-Hoon Ko, Si-Ho Kim, Nam Yong Lee, Yae-Jin Kim, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck,

Environmental disinfection with sodium hypochlorite and hydrogen peroxide vapor was performed after a hospital-associated outbreak of Middle East respiratory syndrome. Although only 11% of total beds were disinfected, the isolation and vancomycin-resistance rates of Enterococcus spp significantly decreased for 2 months, whereas other multidrug-resistant organisms did not. ... Read more >>

Am J Infect Control (American journal of infection control)
[2019, 47(12):1516-1518]

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Poor prognosis of Candida tropicalis among non-albicans candidemia: a retrospective multicenter cohort study, Korea.

Jae-Hoon Ko, Dong Sik Jung, Ji Yeon Lee, Hyun Ah Kim, Seong Yeol Ryu, Sook-In Jung, Eun-Jeong Joo, Shinhye Cheon, Yeon-Sook Kim, Shin-Woo Kim, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Nam Yong Lee, Kyong Ran Peck,

To evaluate clinical features and prognostic factors of non-albicans candidemia, we conducted a retrospective multicenter cohort study at 7 university hospitals in Korea from January 2010 to February 2016. A total of 721 patients with non-albicans candidemia were included in the analysis. C. tropicalis was most commonly identified (36.5%), followed ... Read more >>

Diagn. Microbiol. Infect. Dis. (Diagnostic microbiology and infectious disease)
[2019, 95(2):195-200]

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Evaluation of a Carbapenem-Saving Strategy Using Empirical Combination Regimen of Piperacillin-Tazobactam and Amikacin in Hemato-Oncology Patients.

Jae-Hoon Ko, Si-Ho Kim, Cheol-In Kang, Sun Young Cho, Nam Yong Lee, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song,

We implemented a carbapenem-saving strategy in hemato-oncology patients from 2013, using an empirical combination of piperacillin-tazobactam and amikacin for high-risk hemato-oncology patients with febrile neutropenia, who remain hemodynamically unstable > 72 hours despite initial cefepime treatment. All-cause mortality was not different between the two periods (6.54 and 6.57 deaths per ... Read more >>

J. Korean Med. Sci. (Journal of Korean medical science)
[2019, 34(2):e17]

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Efficacy of inhaled ciprofloxacin agents for the treatment of bronchiectasis: a systematic review and meta-analysis of randomized controlled trials.

Jeong Uk Lim, Seung Wook Hong, Jae-Hoon Ko,

BACKGROUND:The efficacy of inhaled ciprofloxacin agents in the treatment of patients with bronchiectasis is controversial. The objective of the study was to review systematically the efficacy of inhaled ciprofloxacin agents in patients with bronchiectasis. METHODS:We searched PubMed, EMBASE, and Cochrane Library databases for randomized controlled trials (RCTs) evaluating inhaled ciprofloxacin ... Read more >>

Ther Adv Respir Dis (Therapeutic advances in respiratory disease)
[2019, 13:1753466619875930]

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2149. Real-Time Nationwide Surveillance for Antimicrobial Resistance of Major Pathogens Using Automated Data Collection System in Korea: A KARS-Net Study.

Kyungmin Huh, Young Eun Ha, Doo Ryeon Chung, Jae-Hoon Ko, Hyunsoo Kim, Dongeun Yong, Kyungwon Lee, Hee Jae Huh, Nam Yong Lee, Suhyun Oh, Sukbin Jang, Seokjun Mun, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song,

AbstractBackgroundInformation on the most current status of antimicrobial resistance (AMR) in local and national levels has critical importance. However, collection and analysis of a large number of antimicrobial susceptibility test (AST) results often results in additional workload in healthcare facilities and latency in final reporting. We sought to develop an ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S632-S633]

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Pathogenic significance of hemorrhagic pneumonia in hematologic malignancy patients with Stenotrophomonas maltophilia bacteremia: clinical and microbiological analysis.

Si-Ho Kim, Min Kyeong Cha, Cheol-In Kang, Jae-Hoon Ko, Kyungmin Huh, Sun Young Cho, Doo Ryeon Chung, Kyong Ran Peck,

Hemorrhagic pneumonia (HP) is known as the clinical manifestation of Stenotrophomonas maltophilia infection, while catheter-related blood stream infection (CRBSI) is the common clinical presentation of S. maltophilia bacteremia (SMB). The purpose of this study is to evaluate the risk factors for mortality in hematologic malignancy patients with SMB and to ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2019, 38(2):285-295]

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1185. Impact of Bloodstream Infections Caused by Multidrug-resistant Organisms on Performance Status: A KARS-Net Study.

Kyungmin Huh, Doo Ryeon Chung, Jae-Hoon Ko, Young Eun Ha, Si-Ho Kim, Suhyun Oh, Sukbin Jang, Seokjun Mun, Hee Jae Huh, Nam Yong Lee, Sun Young Cho, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song,

AbstractBackgroundInfections caused by multidrug-resistant (MDR) organisms are associated with poorer clinical outcomes and higher economic burden. However, there has been limited data on the impact of MDR infection on the performance status of patients.MethodsPatients with bloodstream infections by and have been identified prospectively as a part of a ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S358-S358]

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Changing epidemiology of non-albicans candidemia in Korea.

Jae-Hoon Ko, Dong Sik Jung, Ji Yeon Lee, Hyun Ah Kim, Seong Yeol Ryu, Sook-In Jung, Eun-Jeong Joo, Shinhye Cheon, Yeon-Sook Kim, Shin-Woo Kim, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Nam Yong Lee, Kyong Ran Peck,

An epidemiologic surveillance of non-albicans candidemia for a 6-year period was conducted in Korea. Compared to the published epidemiologic data for the previous 6 years, an increase of C. glabrata (from 21.3% to 28.5%) and a decrease of C. parapsilosis (from 36.5% to 24.7%) were noticed. During the study period, C. tropicalis (36.4%) ... Read more >>

J. Infect. Chemother. (Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy)
[2019, 25(5):388-391]

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Clinical effectiveness of carbapenems versus alternative antibiotics for treating ESBL-producing Enterobacteriaceae bacteraemia: a systematic review and meta-analysis.

Soo Kyung Son, Na Rae Lee, Jae-Hoon Ko, Jae Ki Choi, Soo-Youn Moon, Eun Jeong Joo, Kyong Ran Peck, Dong Ah Park,

Objectives:The widespread administration of carbapenems to patients with ESBL-producing Enterobacteriaceae bacteraemia (ESBL-B) has accelerated the emergence of carbapenem-resistant Enterobacteriaceae. This study aimed to systematically review recently published data to evaluate the clinical effectiveness of carbapenems, compared with other antibiotics, in the treatment of ESBL-B. Methods:We searched the Ovid-Medline, Ovid-Embase, Cochrane ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2018, 73(10):2631-2642]

Cited: 3 times

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Comparison of virulence between matt and mucoid colonies of Klebsiella pneumoniae coproducing NDM-1 and OXA-232 isolated from a single patient.

Haejeong Lee, Jin Yang Baek, So Yeon Kim, HyunJi Jo, KyeongJin Kang, Jae-Hoon Ko, Sun Young Cho, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song, Kwan Soo Ko,

Nine Klebsiella pneumoniae isolates coproducing NDM-1 and OXA-232 carbapenemases were successively isolated from a single patient. Although they were isolated simultaneously and were isogenic, they presented different colony phenotypes (matt and mucoid). All nine isolates were resistant to most antibiotics except colistin and fosfomycin. In addition, matt-type isolates were resistant ... Read more >>

J. Microbiol. (Journal of microbiology (Seoul, Korea))
[2018, 56(9):665-672]

Cited: 1 time

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Evaluation of Methicillin-Resistance Rates among Community-associated Staphylococcus aureus Infections in Korean Military Personnel.

Jae-Hoon Ko, Song Mi Moon,

To evaluate methicillin-resistance (MR) rates among community-associated (CA) Staphylococcus aureus infections in the Korean military, we screened electronic medical records of 223 patients with S. aureus infection in a military referral hospital from 2012 to 2017. During the study period, MR rates did not change annually, and were not different ... Read more >>

J. Korean Med. Sci. (Journal of Korean medical science)
[2018, 33(39):e250]

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Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience.

Jae-Hoon Ko, Hyeri Seok, Sun Young Cho, Young Eun Ha, Jin Yang Baek, So Hyun Kim, Yae-Jean Kim, Jin Kyeong Park, Chi Ryang Chung, Eun-Suk Kang, Duck Cho, Marcel A Müller, Christian Drosten, Cheol-In Kang, Doo Ryeon Chung, Jae-Hoon Song, Kyong Ran Peck,

BACKGROUND:The effects of convalescent plasma (CP) infusion, one of the treatment options for severe Middle East respiratory syndrome coronavirus (MERS-CoV) infections, have not yet been evaluated. METHODS:Serological responses of CP-infused MERS patients during the 2015 Korean MERS outbreak at a tertiary care centre were evaluated. Serological activity was evaluated with ... Read more >>

Antivir. Ther. (Lond.) (Antiviral therapy)
[2018, 23(7):617-622]

Cited: 1 time

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Importance of Specimen Type and Quality in Diagnosing Middle East Respiratory Syndrome.

Hee Jae Huh, Jae Hoon Ko, Young Eun Kim, Chang Hun Park, Geehay Hong, Rihwa Choi, Shinae Yu, Sun Young Cho, Ji Man Kang, Myoung Keun Lee, Chang Seok Ki, Eun Suk Kang, Nam Yong Lee, Jong Won Kim, Yae Jean Kim, Young Eun Ha, Cheol In Kang, Doo Ryeon Chung, Kyong Ran Peck, Jae Hoon Song,

Ann Lab Med (Annals of laboratory medicine)
[2017, 37(1):81-83]

Cited: 2 times

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Differential Cell Count and CRP Level in Blood as Predictors for Middle East Respiratory Syndrome Coronavirus Infection in Acute Febrile Patients during Nosocomial Outbreak.

Ga Eun Park, Cheol In Kang, Jae Hoon Ko, Sun Young Cho, Young Eun Ha, Yae Jean Kim, Kyong Ran Peck, Jae Hoon Song, Doo Ryeon Chung,

A case-control study was performed to identify clinical predictors for Middle East respiratory syndrome coronavirus (MERS-CoV) infection among patients with acute febrile illness during the nosocomial outbreak. Patients with MERS-CoV were more likely to have monocytosis with normal white blood cell (WBC) count and lower C-reactive protein (CRP) level. Simple ... Read more >>

J. Korean Med. Sci. (Journal of Korean medical science)
[2017, 32(1):151-154]

Cited: 1 time

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Impact of high MIC of fluconazole on outcomes of Candida glabrata bloodstream infection: a retrospective multicenter cohort study.

Jae-Hoon Ko, Kyong Ran Peck, Dong Sik Jung, Ji Yeon Lee, Hyun Ah Kim, Seong Yeol Ryu, Sook-In Jung, Eun-Jeong Joo, Shinhye Cheon, Yeon-Sook Kim, Shin-Woo Kim, Sun Young Cho, Young Eun Ha, Cheol-In Kang, Doo Ryeon Chung, Nam Yong Lee, Jae-Hoon Song,

To evaluate the impacts of fluconazole minimum inhibitory concentration (MIC) according to primary antifungal agents on Candida glabrata bloodstream infection (BSI), a multicenter retrospective cohort study was conducted in Korea, concerning the time period from January 2010 to February 2016. A total of 197 adult patients with C. glabrata BSI ... Read more >>

Diagn. Microbiol. Infect. Dis. (Diagnostic microbiology and infectious disease)
[2018, 92(2):127-132]

Cited: 1 time

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Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak.

Jae-Hoon Ko, Hyeri Seok, Ga Eun Park, Ji Yeon Lee, Ji Yong Lee, Sun Young Cho, Young Eun Ha, Ji-Man Kang, Yae-Jean Kim, Cheol-In Kang, Doo Ryeon Chung, Jae-Hoon Song, Kyong Ran Peck,

To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. A total of 175 patients were closely exposed to a super-spreader, 26 of which were infected (14.9%). In a ... Read more >>

J. Infect. Chemother. (Journal of Infection and Chemotherapy)
[2018, 24(2):150-152]

Cited: 1 time

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