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Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis.

Juan A Aguilar, Julia Cassani, Fay Probert, Jacqueline Palace, Tim D W Claridge, Adolfo Botana, Alan M Kenwright,

Analysis of metabolites in biofluids using nuclear magnetic resonance often requires the suppression of obscuring signals arising from water and macromolecules. This paper analyses the limitations of the pulse sequence most commonly used to achieve such suppression (presat-CPMG) and proposes new pulse sequences that do not share those limitations. The ... Read more >>

Analyst (The Analyst)
[2019, 144(24):7270-7277]

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Distinguishing neurosarcoidosis from multiple sclerosis based on CSF analysis: A retrospective cohort study.

Tarunya Arun, Laura Pattison, Jacqueline Palace,

OBJECTIVE:To characterize a cohort of patients with neurosarcoidosis with particular focus on CSF analysis and to investigate whether CSF values could help in distinguishing it from multiple sclerosis (MS). METHODS:This retrospective cohort study enrolled 85 patients with a diagnosis of neurosarcoidosis (possible, probable, or definite). CSF total protein, white cell ... Read more >>

Neurology (Neurology)
[2020, :]

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Seasonal distribution of attacks in aquaporin-4 antibody disease and myelin-oligodendrocyte antibody disease.

Giordani Rodrigues Dos Passos, Liene Elsone, Sebastian Luppe, Joanna Kitley, Silvia Messina, Pedro María Rodríguez Cruz, Katharine Harding, Kerry Mutch, Maria Isabel Leite, Neil Robertson, Anu Jacob, Jacqueline Palace,

BACKGROUND:Seasonal variation in incidence and exacerbations has been reported for neuroinflammatory conditions such as multiple sclerosis and acute disseminated encephalomyelitis (ADEM). It is unknown whether seasonality also influences aquaporin-4 antibody (AQP4-Ab) disease and myelin-oligodendrocyte antibody (MOG-Ab) disease. OBJECTIVE:We examined the seasonal distribution of attacks in AQP4-Ab disease and MOG-Ab disease. ... Read more >>

J. Neurol. Sci. (Journal of the neurological sciences)
[2020, 415:116881]

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Factors associated with fatigue in CNS inflammatory diseases with AQP4 and MOG antibodies.

Tianrong Yeo, Giordani Rodrigues Dos Passos, Louwai Muhammed, Rosie Everett, Sandra Reeve, Silvia Messina, Fay Probert, Maria Isabel Leite, Jacqueline Palace,

OBJECTIVE:Fatigue is a common and disabling symptom amongst people with multiple sclerosis, however it has not been compared across the central nervous system (CNS) inflammatory diseases associated with aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antibodies (Ab). We explored the factors associated with fatigue within and across the two diseases, ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(3):375-383]

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242nd ENMC International Workshop: Diagnosis and management of juvenile myasthenia gravis Hoofddorp, the Netherlands, 1-3 March 2019.

Pinki Munot, Stephanie A Robb, Erik H Niks, Jacqueline Palace, ,

Neuromuscul. Disord. (Neuromuscular disorders : NMD)
[2020, 30(3):254-264]

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Distinct influence of different vascular risk factors on white matter brain lesions in multiple sclerosis.

Ruth Geraldes, Maciej Juryńczyk, Giordani Dos Passos, Alexander Prichler, Karen Chung, Marloes Hagens, Serena Ruggieri, Elena Huerga, Jaume Sastre-Garriga, Christian Enzinger, Declan T Chard, Frederik Barkhof, Claudio Gasperini, Alex Rovira, Gabriele C DeLuca, Jacqueline Palace, ,

OBJECTIVE:To determine if vascular risk factor (VRF), that is, smoking, arterial hypertension (HT), dyslipidaemia and diabetes, have an effect on multiple sclerosis (MS) pathology as measured by MS typical brain lesions, we have compared brain MRIs from patients with MS with and without VRF age-matched and sex-matched. METHODS:Brain MRIs from ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(4):388-391]

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Prodromal headache in MOG-antibody positive optic neuritis.

Susanna Asseyer, Josh Hamblin, Silvia Messina, Romina Mariano, Nadja Siebert, Rosie Everett, Wilhelm Küker, Judith Bellmann-Strobl, Klemens Ruprecht, Sven Jarius, Maria Isabel Leite, Alexander U Brandt, Friedemann Paul, Jacqueline Palace,

BACKGROUND:Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) disease is an inflammatory autoimmune condition of the central nervous system, defined by antibodies (Abs) against MOG. Of the various clinical phenotypes optic neuritis (ON) is the commonest. We have observed that some patients with MOG-Ab ON present with a severe associated headache. OBJECTIVE:To highlight ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 40:101965]

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International multicenter examination of MOG antibody assays.

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan, Jessica Sagen, James P Fryer, John Mills, Bianca Teegen, Swantje Mindorf, Nora Ritter, Ulrike Krummrei, Winfried Stöcker, Juliane Eggert, Eoin P Flanagan, Melanie Ramberger, Harald Hegen, Kevin Rostasy, Thomas Berger, Maria Isabel Leite, Jacqueline Palace, Sarosh R Irani, Russell C Dale, Christian Probst, Monika Probst, Fabienne Brilot, Sean J Pittock, Patrick Waters,

OBJECTIVE:To compare the reproducibility of 11 antibody assays for immunoglobulin (Ig) G and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG and MOG-IgM) from 5 international centers. METHODS:The following samples were analyzed: MOG-IgG clearly positive sera (n = 39), MOG-IgG low positive sera (n = 39), borderline negative sera (n = 13), ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(2):]

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Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial.

Jeremy Chataway, Floriana De Angelis, Peter Connick, Richard A Parker, Domenico Plantone, Anisha Doshi, Nevin John, Jonathan Stutters, David MacManus, Ferran Prados Carrasco, Frederik Barkhof, Sebastien Ourselin, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Gavin Giovannoni, Claudia Angela Gandini Wheeler-Kingshott, Clive Hawkins, Basil Sharrack, Roger Bastow, Christopher J Weir, Nigel Stallard, Siddharthan Chandran, ,

BACKGROUND:Neurodegeneration is the pathological substrate that causes major disability in secondary progressive multiple sclerosis. A synthesis of preclinical and clinical research identified three neuroprotective drugs acting on different axonal pathobiologies. We aimed to test the efficacy of these drugs in an efficient manner with respect to time, cost, and patient ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(3):214-225]

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β2-Adrenergic receptor agonists ameliorate the adverse effect of long-term pyridostigmine on neuromuscular junction structure.

An E Vanhaesebrouck, Richard Webster, Susan Maxwell, Pedro M Rodriguez Cruz, Judith Cossins, James Wickens, Wei-Wei Liu, Hakan Cetin, Jonathan Cheung, Hayley Ramjattan, Jacqueline Palace, David Beeson,

Acetylcholine receptor deficiency is the most common form of the congenital myasthenic syndromes, a heterogeneous collection of genetic disorders of neuromuscular transmission characterized by fatiguable muscle weakness. Most patients with acetylcholine receptor deficiency respond well to acetylcholinesterase inhibitors; however, in some cases the efficacy of acetylcholinesterase inhibitors diminishes over time. ... Read more >>

Brain (Brain : a journal of neurology)
[2019, 142(12):3713-3727]

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Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure.

Pedro M Rodríguez Cruz, Judith Cossins, Jonathan Cheung, Susan Maxwell, Sandeep Jayawant, Ruth Herbst, Dominic Waithe, Alexandr P Kornev, Jacqueline Palace, David Beeson,

MUSK encodes the muscle-specific receptor tyrosine kinase (MuSK), a key component of the agrin-LRP4-MuSK-DOK7 signaling pathway, which is essential for the formation and maintenance of highly specialized synapses between motor neurons and muscle fibers. We report a patient with severe early-onset congenital myasthenic syndrome and two novel missense mutations in ... Read more >>

Hum. Mutat. (Human mutation)
[2020, 41(3):619-631]

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An international multicenter examination of MOG antibody assays

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan, Jessica Sagen, Jim Fryer, John Mills, Bianca Tegen, Swantje Mindorf, Nora Ritter, Ulrike Krummrei, Winfried Stocker, Juliane Eggert, Eoin Flanagan, Melanie Ramberger, Harald Hegen, Kevin Rostasy, Thomas Berger, Isabel Leite, Jacqueline Palace, Sarosh Irani, Russell Dale, Christian Probst, Monika Probst, Fabienne Brilot, Sean Pittock, Patrick Waters,

Objectives: To compare the reproducibility of 11 antibody assays for IgG and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG, MOG-IgM) from five international centers. Methods: The following samples were analyzed: MOG-IgG clearly positive sera (n=39), MOG-IgG low positive sera (n=39), borderline negative sera (n=13), clearly negative sera (n=40), and healthy ... Read more >>

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The frequency of longitudinally extensive transverse myelitis in MS: A population-based study.

Solmaz Asnafi, P Pearse Morris, Elia Sechi, Sean J Pittock, Brian G Weinshenker, Jacqueline Palace, Silvia Messina, Eoin P Flanagan,

BACKGROUND:Determining the frequency of longitudinally-extensive transverse myelitis (LETM: T2-lesion ≥3 vertebral segments) in multiple sclerosis (MS) is essential to assess its utility in differentiating from aquaporin-4-IgG (AQP4-IgG) positive neuromyelitis optica spectrum disorder (NMOSD) and myelin-oligodendrocyte-glycoprotein-IgG (MOG-IgG) myelitis. We sought to determine the frequency of LETM in MS during a myelitis ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 37:101487]

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Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder.

Takashi Yamamura, Ingo Kleiter, Kazuo Fujihara, Jacqueline Palace, Benjamin Greenberg, Beata Zakrzewska-Pniewska, Francesco Patti, Ching-Piao Tsai, Albert Saiz, Hayato Yamazaki, Yuichi Kawata, Padraig Wright, Jerome De Seze,

BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system and is associated with autoantibodies to anti-aquaporin-4 (AQP4-IgG) in approximately two thirds of patients. Interleukin-6 is involved in the pathogenesis of the disorder. Satralizumab is a humanized monoclonal antibody targeting the interleukin-6 receptor. The efficacy of ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(22):2114-2124]

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Classifying the antibody-negative NMO syndromes: Clinical, imaging, and metabolomic modeling.

Tianrong Yeo, Fay Probert, Maciej Jurynczyk, Megan Sealey, Ana Cavey, Timothy D W Claridge, Mark Woodhall, Patrick Waters, Maria Isabel Leite, Daniel C Anthony, Jacqueline Palace,

OBJECTIVE:To determine whether unsupervised principal component analysis (PCA) of comprehensive clinico-radiologic data can identify phenotypic subgroups within antibody-negative patients with overlapping features of multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSDs), and to validate the phenotypic classifications using high-resolution nuclear magnetic resonance (NMR) plasma metabolomics with inference to underlying ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(6):e626]

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Clinically relevant cranio-caudal patterns of cervical cord atrophy evolution in MS.

Maria A Rocca, Paola Valsasina, Alessandro Meani, Claudio Gobbi, Chiara Zecca, Àlex Rovira, Xavier Montalban, Hugh Kearney, Olga Ciccarelli, Lucy Matthews, Jacqueline Palace, Antonio Gallo, Alvino Bisecco, Achim Gass, Philipp Eisele, Carsten Lukas, Barbara Bellenberg, Frederik Barkhof, Hugo Vrenken, Paolo Preziosa, Giancarlo Comi, Massimo Filippi, ,

OBJECTIVE:To characterize the distribution and regional evolution of cervical cord atrophy in patients with multiple sclerosis (MS) in a multicenter dataset. METHODS:MRI and clinical evaluations were acquired from 179 controls and 435 patients (35 clinically isolated syndromes [CIS], 259 relapsing-remitting multiple sclerosis [RRMS], 99 secondary progressive multiple sclerosis [SPMS], and ... Read more >>

Neurology (Neurology)
[2019, 93(20):e1852-e1866]

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Comparison of Clinical Outcomes of Transverse Myelitis Among Adults With Myelin Oligodendrocyte Glycoprotein Antibody vs Aquaporin-4 Antibody Disease.

Romina Mariano, Silvia Messina, Kurun Kumar, Wilhelm Kuker, Maria Isabel Leite, Jacqueline Palace,

Importance:Recognizing the differences between transverse myelitis (TM) associated with myelin oligodendrocyte glycoprotein (MOG) antibody (Ab) disease vs aquaporin-4 (AQP4)-Ab disease and prognosticating patients within each group may be an important factor for better clinical treatment for these respective patients. Objectives:To compare the clinical and radiological findings of the first TM ... Read more >>

JAMA Netw Open (JAMA network open)
[2019, 2(10):e1912732]

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Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral.

Marcello Moccia, Ferran Prados, Massimo Filippi, Maria A Rocca, Paola Valsasina, Wallace J Brownlee, Chiara Zecca, Antonio Gallo, Alex Rovira, Achim Gass, Jacqueline Palace, Carsten Lukas, Hugo Vrenken, Sebastien Ourselin, Claudia A M Gandini Wheeler-Kingshott, Olga Ciccarelli, Frederik Barkhof, ,

OBJECTIVE:Spinal cord atrophy is a clinically relevant feature of multiple sclerosis (MS), but longitudinal assessments on magnetic resonance imaging using segmentation-based methods suffer from measurement variability, especially in multicenter studies. We compared the generalized boundary shift integral (GBSI), a registration-based method, with a standard segmentation-based method. METHODS:Baseline and 1-year spinal ... Read more >>

Ann. Neurol. (Annals of neurology)
[2019, 86(5):704-713]

Cited: 1 time

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Lifespan normative data on rates of brain volume changes.

Marco Battaglini, Giordano Gentile, Ludovico Luchetti, Antonio Giorgio, Hugo Vrenken, Frederik Barkhof, Keith S Cover, Rohit Bakshi, Renxin Chu, Maria Pia Sormani, Christian Enzinger, Stefan Ropele, Olga Ciccarelli, Claudia Wheeler-Kingshott, Marios Yiannakas, Massimo Filippi, Maria Assunta Rocca, Paolo Preziosa, Antonio Gallo, Alvino Bisecco, Jacqueline Palace, Yazhuo Kong, Dana Horakova, Manuela Vaneckova, Claudio Gasperini, Serena Ruggieri, Nicola De Stefano, ,

We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 ... Read more >>

Neurobiol. Aging (Neurobiology of aging)
[2019, 81:30-37]

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Eculizumab in Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder.

Sean J Pittock, Achim Berthele, Kazuo Fujihara, Ho Jin Kim, Michael Levy, Jacqueline Palace, Ichiro Nakashima, Murat Terzi, Natalia Totolyan, Shanthi Viswanathan, Kai-Chen Wang, Amy Pace, Kenji P Fujita, Róisín Armstrong, Dean M Wingerchuk,

BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, autoimmune, inflammatory disorder that typically affects the optic nerves and spinal cord. At least two thirds of cases are associated with aquaporin-4 antibodies (AQP4-IgG) and complement-mediated damage to the central nervous system. In a previous small, open-label study involving patients with AQP4-IgG-positive ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(7):614-625]

Cited: 3 times

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The clinical spectrum of the congenital myasthenic syndrome resulting from COL13A1 mutations.

Pedro M Rodríguez Cruz, Judith Cossins, Eduardo de Paula Estephan, Francina Munell, Kathryn Selby, Michio Hirano, Reza Maroofin, Mohammad Yahya Vahidi Mehrjardi, Gabriel Chow, Aisling Carr, Adnan Manzur, Stephanie Robb, Pinki Munot, Wei Wei Liu, Siddharth Banka, Harry Fraser, Christian De Goede, Edmar Zanoteli, Umbertina Conti Reed, Abigail Sage, Margarida Gratacos, Alfons Macaya, Marina Dusl, Jan Senderek, Ana Töpf, Monika Hofer, Ravi Knight, Sithara Ramdas, Sandeep Jayawant, Hans Lochmüller, Jacqueline Palace, David Beeson,

Next generation sequencing techniques were recently used to show mutations in COL13A1 cause synaptic basal lamina-associated congenital myasthenic syndrome type 19. Animal studies showed COL13A1, a synaptic extracellular-matrix protein, is involved in the formation and maintenance of the neuromuscular synapse that appears independent of the Agrin-LRP4-MuSK-DOK7 acetylcholine receptor clustering pathway. ... Read more >>

Brain (Brain : a journal of neurology)
[2019, 142(6):1547-1560]

Cited: 1 time

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Outcome prediction models in AQP4-IgG positive neuromyelitis optica spectrum disorders.

Jacqueline Palace, Dan-Yu Lin, Donglin Zeng, Masoud Majed, Liene Elsone, Shahd Hamid, Silvia Messina, Tatsuro Misu, Jessica Sagen, Daniel Whittam, Yoshiki Takai, Maria Isabel Leite, Brian Weinshenker, Philippe Cabre, Anu Jacob, Ichiro Nakashima, Kazuo Fujihara, Sean J Pittock,

Pathogenic antibodies targeting the aquaporin-4 water channel on astrocytes are associated with relapsing inflammatory neuromyelitis optica spectrum disorders. The clinical phenotype is characterized by recurrent episodes of optic neuritis, longitudinally extensive transverse myelitis, area postrema attacks and less common brainstem and cerebral events. Patients often develop major residual disability from ... Read more >>

Brain (Brain : a journal of neurology)
[2019, 142(5):1310-1323]

Cited: 2 times

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Myasthenia gravis.

Nils Erik Gilhus, Socrates Tzartos, Amelia Evoli, Jacqueline Palace, Ted M Burns, Jan J G M Verschuuren,

Myasthenia gravis (MG) is an autoimmune disease caused by antibodies against the acetylcholine receptor (AChR), muscle-specific kinase (MuSK) or other AChR-related proteins in the postsynaptic muscle membrane. Localized or general muscle weakness is the predominant symptom and is induced by the antibodies. Patients are grouped according to the presence of ... Read more >>

Nat Rev Dis Primers (Nature reviews. Disease primers)
[2019, 5(1):30]

Cited: 6 times

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Visibility and representation of women in multiple sclerosis research.

Alison Thomson, Rachel Horne, Christine Chung, Monica Marta, Gavin Giovannoni, Jacqueline Palace, Ruth Dobson,

OBJECTIVE:To establish the gender distribution of multiple sclerosis (MS) researchers across high-impact neurologic publications, MS-specific journals, and the European Committee for Treatment and Research in MS (ECTRIMS). METHODS:Journal editorial boards and contents were retrieved online to assess first-named and senior authors. Published tables of contents for each journal from 2017 ... Read more >>

Neurology (Neurology)
[2019, 92(15):713-719]

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A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis.

Shelly Coe, Jo Cossington, Johnny Collett, Andrew Soundy, Hooshang Izadi, Martin Ovington, Luke Durkin, Maja Kirsten, Miriam Clegg, Ana Cavey, Derick T Wade, Jacqueline Palace, Gabriele C DeLuca, Kim Chapman, Jane-Marie Harrison, Elizabeth Buckingham, Helen Dawes,

The impact of flavonoids on fatigue has not been investigated in relapsing and remitting multiple sclerosis (RRMS). OBJECTIVE:To determine the feasibility and estimate the potential effect of flavonoid-rich cocoa on fatigue and fatigability in RRMS. METHODS:A randomised double-blind placebo-controlled feasibility study in people recently diagnosed with RRMS and fatigue, throughout ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2019, 90(5):507-513]

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