Full Text Journal Articles by
Author Jacob W McCabe

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Selective regulation of human TRAAK channels by biologically active phospholipids.

Samantha Schrecke, Yun Zhu, Jacob W McCabe, Mariah Bartz, Charles Packianathan, Minglei Zhao, Ming Zhou, David Russell, Arthur Laganowsky,

TRAAK is an ion channel from the two-pore domain potassium (K2P) channel family with roles in maintaining the resting membrane potential and fast action potential conduction. Regulated by a wide range of physical and chemical stimuli, the affinity and selectivity of K2P4.1 toward lipids remains poorly understood. Here we show ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Discovery of Potent Charge-Reducing Molecules for Native Ion Mobility Mass Spectrometry Studies.

Jixing Lyu, Yang Liu, Jacob W McCabe, Samantha Schrecke, Lei Fang, David H Russell, Arthur Laganowsky,

There is growing interest in the characterization of protein complexes and their interactions with ligands using native ion mobility mass spectrometry. A particular challenge, especially for membrane proteins, is preserving noncovalent interactions and maintaining native-like structures. Different approaches have been developed to minimize activation of protein complexes by manipulating charge ... Read more >>

Anal. Chem. (Analytical chemistry)
[2020, 92(16):11242-11249]

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