Full Text Journal Articles by
Author Jacob M Wozniak

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Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules.

Wesley W Wang, Li-Yun Chen, Jacob M Wozniak, Appaso M Jadhav, Hayden Anderson, Taylor E Malone, Christopher G Parker,

Protein acetylation is a central event in orchestrating diverse cellular processes. However, current strategies to investigate protein acetylation in cells are often nonspecific or lack temporal and magnitude control. Here, we developed an acetylation tagging system, AceTAG, to induce acetylation of targeted proteins. The AceTAG system utilizes bifunctional molecules to ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, 143(40):16700-16708]

Cited: 1 time

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Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption.

Cara C Rada, Hilda Mejia-Pena, Neil J Grimsey, Isabel Canto Cordova, Joshua Olson, Jacob M Wozniak, David J Gonzalez, Victor Nizet, JoAnn Trejo,

Vascular inflammation causes endothelial barrier disruption and tissue edema. Several inflammatory mediators act through G protein–coupled receptors (GPCRs), including protease-activated receptor-1 (PAR1), to elicit inflammatory responses. The activation of PAR1 by its ligand thrombin stimulates proinflammatory, p38 mitogen-activated protein kinase (MAPK) signaling that promotes endothelial barrier disruption. Through mass spectrometry ... Read more >>

Sci Signal (Science signaling)
[2021, 14(698):eabc1044]

Cited: 2 times

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