Full Text Journal Articles by
Author Jaclyn N Escudero

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Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis.

Sylvia M LaCourse, Daniel Leon, Nuttada Panpradist, Barbra A Richardson, Elizabeth Maleche-Obimbo, Jerphason Mecha, Daniel Matemo, Jaclyn N Escudero, John Kinuthia, Barry Lutz, Grace John-Stewart,

We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal secondary education, HIV suppression and no reported missed doses in past ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):e43-e45]

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Influences on early discontinuation and persistence of daily oral PrEP use among Kenyan adolescent girls and young women: a qualitative evaluation from a PrEP implementation program.

Jillian Pintye, Gabrielle O'Malley, John Kinuthia, Felix Abuna, Jaclyn N Escudero, Melissa Mugambi, Mercy Awuor, Annabell Dollah, Julia C Dettinger, Pamela Kohler, Grace John-Stewart, Kristin Beima-Sofie,

<h4>Background</h4>Discontinuation of daily oral PrEP is frequent among adolescent girls and young women (AGYW) in African settings. We explored factors influencing early PrEP discontinuation and persistence among Kenyan AGYW who accepted PrEP within a programmatic setting.<h4>Methods</h4>We conducted in-depth interviews (IDI) with AGYW (aged 15-24 years) who accepted PrEP from 4 ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, :]

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Community Perceptions About Use of Pre-exposure Prophylaxis Among Adolescent Girls and Young Women in Kenya.

Jaclyn N Escudero, Julia C Dettinger, Jillian Pintye, John Kinuthia, Harison Lagat, Felix Abuna, Pamela Kohler, Jared M Baeten, Gabrielle O╩╝Malley, Grace C John-Stewart, Kristin M Beima-Sofie,

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2020, 31(6):669-677]

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A randomized controlled trial of isoniazid to prevent Mycobacterium tuberculosis infection in Kenyan HIV-exposed uninfected infants.

Sylvia M LaCourse, Barbra A Richardson, John Kinuthia, A J Warr, Elizabeth Maleche-Obimbo, Daniel Matemo, Lisa M Cranmer, Jerphason Mecha, Jaclyn N Escudero, Thomas R Hawn, Grace John-Stewart,

<h4>Background</h4>HIV-exposed uninfected (HEU) infants in endemic settings are at high risk of tuberculosis (TB). For infants, progression from primary M. tuberculosis infection to TB disease can be rapid. We assessed whether isoniazid (INH) prevents primary Mtb infection.<h4>Methods</h4>We conducted a randomized non-blinded controlled trial enrolling HEU infants 6 weeks of age ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Infant TB Infection Prevention Study (iTIPS): a randomised trial protocol evaluating isoniazid to prevent M. tuberculosis infection in HIV-exposed uninfected children.

Sylvia M LaCourse, Barbra A Richardson, John Kinuthia, A J Warr, Elizabeth Maleche-Obimbo, Daniel Matemo, Lisa M Cranmer, Jaclyn N Escudero, Thomas R Hawn, Grace C John-Stewart,

INTRODUCTION:HIV-exposed uninfected (HEU) infants in tuberculosis (TB) endemic settings are at high risk of Mycobacterium tuberculosis (Mtb) infection and TB disease, even in the absence of known Mtb exposure. Because infancy is a time of rapid progression from primary infection to active TB disease, it is important to define when ... Read more >>

BMJ Open (BMJ open)
[2020, 10(1):e034308]

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